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Evaluation of Biological Activities of Various Extracts of Glaucium alakirensis, Marrubium bourgaei, and Peucedanum alpinum from Türkiye

Year 2024, Volume: 27 Issue: 6, 1249 - 1261, 07.11.2024

Eda Delik , Berfin Eroğlu , Mertcan Gülben , Candan Aykurt , Burcu Emine Tefon Öztürk

https://doi.org/10.18016/ksutarimdoga.vi.1388926

Abstract

Plant species contain many secondary metabolites, and these compounds differ from species to species. These differences in the concentrations of these compounds have many health implications. Today, studies on plants' antioxidant and antibacterial effects are gaining importance. In particular, the adverse effects of some existing antibiotics and the constant development of bacterial resistance are leading to the search for new natural antimicrobial agents. In this study, methanol, ethanol, ethyl acetate, acetone, and chloroform extracts were obtained from the aerial parts of Marrubium bourgaei Boiss and Glaucium alakirensis Aykurt, K.Yıldız & A.Özçandır, and Peucedanum alpinum B.L.Burtt & Davis, species which are naturally distributed in Türkiye. The antioxidant activity of the extracts was determined by the DPPH (2,2 Difenil-1-pikrihidrazil) and ABTS (2,2' azino-bis(3-ethylbenz-thiazoline-6-sulfonic-acid)) methods, the total phenolic content by Folin-Ciocalteu method, the total flavonoid content by aluminium chloride colorimetric method, and the antibacterial activity against ten bacteria by the disc diffusion method. According to the results, methanol, ethanol, and acetone extracts had higher antioxidant activity, total phenolic, and total flavonoid contents than other extracts. However, the total flavonoid content of M. bourgaei was higher in the ethyl acetate extract. When evaluated for their antibacterial activity, ethanol, chloroform, and ethyl acetate in P. alpinum, chloroform in M. bourgaei, and methanol, chloroform, and ethyl acetate in G. alakirensis extracts showed antibacterial activity against more bacteria than others. This is the first study to evaluate and compare the total phenolic and flavonoid content, and antioxidant and antibacterial activities of 5 different extracts of these plants.

Keywords

Antibacterial-antioxidant activity Glaucium alakirensis Marrubium bourgaei Peucedanum alpinum Phenolic-flavonoid content

Ethical Statement

Not required

References

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Türkiye'den Glaucium alakirensis, Marrubium bourgaei, and Peucedanum alpinum’un Çeşitli Ekstraktlarının Biyolojik Aktivitelerinin Değerlendirilmesi

Year 2024, Volume: 27 Issue: 6, 1249 - 1261, 07.11.2024

Eda Delik , Berfin Eroğlu , Mertcan Gülben , Candan Aykurt , Burcu Emine Tefon Öztürk

https://doi.org/10.18016/ksutarimdoga.vi.1388926

Abstract

Bitki türleri birçok ikincil metabolit içerir ve içermiş oldukları bu bileşikler türden türe farklılık göstermektedir. Bitkilerin ikincil metabolitlerinin konsantrasyonlarındaki bu farklılıkların sağlık üzerinde farklı etkileri vardır. Bitkilerin antioksidan ve antibakteriyel etkileri üzerine yapılan çalışmalar günümüzde yeniden önem kazanmaktadır. Özellikle mevcut bazı antibiyotiklerin olumsuz etkileri ve sürekli olarak artan bakteriyel direnç, yeni ve doğal antimikrobiyal ajan arayışına neden olmaktadır. Bu çalışmada, Türkiye'de doğal olarak yayılış gösteren Marrubium bourgaei Boiss, Glaucium alakirensis Aykurt, K.Yıldız & A.Özçandır ve Peucedanum alpinum B.L.Burtt & Davis türlerinin toprak üstü kısımlarından metanol, etanol, etil asetat, aseton ve kloroform kullanılarak ekstraktlar elde edilmiştir. Bu ekstraktların antioksidan aktiviteleri DPPH (2,2 Difenil-1-pikrihidrazil) ve ABTS (2,2' azino-bis(3-etilbenz-tiazolin-6-sülfonik-asit)) yöntemleriyle, toplam fenolik madde içerikleri Folin-Ciocalteu yöntemiyle, toplam flavonoid madde içerikleri ise alüminyum klorür kolorimetrik yöntemi ile belirlenmiştir. Ayrıca elde edilen bu bitkisel ekstraktların antibakteriyel aktiviteleri disk difüzyon yöntemi kullanılarak on bakteri için değerlendirilmiştir. Elde edilen sonuçlara göre, bitkilerin metanol, etanol ve aseton ekstraktları diğer ekstraktlarından daha yüksek antioksidan aktivite, toplam fenolik ve flavonoid madde içeriğine sahiptir. Ancak, M. bourgaei'nin toplam flavonoid madde içeriği etil asetat ekstraktında daha yüksek bulunmuştur. Ekstraktların antibakteriyel aktiviteleri değerlendirildiğinde, P. alpinum'da etanol, kloroform ve etil asetat, M. bourgaei'de kloroform, G. alakirensis'de ise metanol, kloroform ve etil asetat ekstraktları diğer ekstraktlara göre daha fazla bakteriye karşı etkilidir. Gerçekleştirilen bu çalışma, kullanılan bu üç bitkinin beş farklı ekstraktının toplam fenolik madde içeriğini, toplam flavonoid madde içeriğini, antioksidan aktivitelerini ve antibakteriyel aktivitelerini değerlendiren ve karşılaştıran ilk çalışmadır.

Keywords

Antibakteriyel-antioksidan aktivite Glaucium alakirensis Marrubium bourgaei Peucedanum alpinum Fenolik-Flavonoid içerik

Ethical Statement

Bu makale etik kurul kararı gerektiren çalışmalar içermemektedir

References

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  • Al, M.K., Kuıate Jr, M.R., Ra, N.N., Ml, K.M., Rm, E.E., Bıyıtı, L., Ph, A.Z. (2012). Antibacterial and antioxidant properties of the methanolic extract of the leaves of Peucedanum Zenkeri (Apiaceae). Sciences, Technologie & Développement. 13(1), 36-47.
  • Alali, F.Q., Tawaha, K., El-Elimat, T., Syouf, M., El-Fayad, M., Abulaila, K., Nielsen, S.J., Wheaton, W.D., Falkinham III, J.O., Oberlies, N.H. (2007). Antioxidant activity and total phenolic content of aqueous and methanolic extracts of Jordanian plants: an ICBG project. Natural Product Research 21(12), 1121-1131.
  • Arafa, A. M., Mohamed, M. E. S., Eldahmy, S. I. (2016). The aerial parts of yellow horn poppy (Glaucium flavum Cr.) growing in Egypt: Isoquinoline alkaloids and biological activities. Journal of Pharmaceutical Sciences and Research 8(5), 323.
  • Aykurt, C., Yıldız, K., Özçandır, A., Mungan, F., Deniz, G. (2017). Glaucium alakirensis (Papaveraceae), a new species from Southern Anatolia, Turkey. Phytotaxa 295(3), 255-262. Balasundram, N., Sundram, K., Samman, S. (2006). Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food Chemistry 99(1), 191-203.
  • Balick, M. J., Cox, P. A. (1996). Plants, people, and culture: The Sciense of ethobotany. by Scientific American Library. First printing, 65-66.
  • Bardai, S. E., Lyoussi, B., Wibo, M., Morel, N. (2001). Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat. Clinical and experimental hypertension 23(4), 329-343.
  • Bauer, A. W. (1966). Antibiotic susceptibility testing by a standardized single disc method. American Journal of Clinical Pathology 45, 149-158.
  • Boulaaba, M., Kalai, F.Z., Dakhlaoui, S., Ezzine, Y., Selmi, S., Bourgou, S., Smaoui, A., Isoda, H., Ksouri, R. (2019). Antioxidant, antiproliferative and anti-inflammatory effects of Glaucium flavum fractions enriched in phenolic compounds. Medicinal Chemistry Research 28(11), 1995-2001.
  • Bouterfas, K., Mehdadi, Z., Elaoufi, M. M., Latreche, A., Benchiha, W. (2016). Antioxidant activity and total phenolic and flavonoids content variations of leaves extracts of white Horehound (Marrubium vulgare Linné) from three geographical origins. In Annales pharmaceutiques francaises, 74(6), 453-462.
  • Berber, İ., Avsar, C., Çine, N., Bozkurt, N., Elmas, E. (2013). Determination of antibacterial and antifungal activities of methanolic extracts of some plants growing in Sinop. Karaelmas Science and Engineering Journal, 3, 10-16.
  • Chemsa, A. E., Zellagui, A., Öztürk, M., Erol, E., Ceylan, O., Duru, M. E., Gherraf, N. (2016). Antibiofilm formation, antioxidant and anticholinesterase activities of essential oil and methanol extract of Marrubium deserti de Noé.. Journal of Materials and Environmental Science, 7, 993-1000.
  • Danna, C., Bazzicalupo, M., Ingegneri, M., Smeriglio, A., Trombetta, D., Burlando, B., Cornara, L. (2022). Anti-inflammatory and wound healing properties of leaf and rhizome extracts from the medicinal plant Peucedanum ostruthium (L.) WDJ Koch. Molecules, 27(13), 4271.
  • Dubick, M. A. (1986). Historical perspectives on the use of herbal preparations to promote health. The Journal of Nutrition, 116(7), 1348-1354.
  • Fu, Y., Liu, W., Soladoye, O. P. (2021). Towards innovative food processing of flavonoid compounds: Insights into stability and bioactivity. Lebensmittel-Wissenschaft & Technologie, 150, 111968.
  • Ghasemi, K., Ghasemi, Y., Ebrahimzadeh, M. A. (2009). Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues. Pakistan Journal of Pharmaceutical Sciences, 22(3), 277-281.
  • Gonelimali, F. D., Lin, J., Miao, W., Xuan, J., Charles, F., Chen, M., Hatab, S. R. (2018). Antimicrobial properties and mechanism of action of some plant extracts against food pathogens and spoilage microorganisms. Frontiers in microbiology, 9, 1639.
  • Golmakani, H., Rabbani Nasab, H., Sharifan, M., Kamali, H., Yadollahi, A. (2016). The essential oil composition and antibacterial activity of Marrubium duabense murata from north khorassan province, Iran. Journal of Essential Oil-Bearing Plants, 19(4), 963-971.
  • Hamedeyazdan, S., Sharifi, S., Nazemiyeh, H., Fathiazad, F. (2014). Evaluating antiproliferative and antioxidant activity of Marrubium crassidens. Advanced pharmaceutical bulletin, 4(Suppl 1), 459.
  • Hayat, J., Akodad, M., Moumen, A., Baghour, M., Skalli, A., Ezrari, S., Belmalha, S. (2020). Phytochemical screening, polyphenols, flavonoids and tannin content, antioxidant activities and FTIR characterization of Marrubium vulgare L. from 2 different localities of Northeast of Morocco. Heliyon, 6(11), e05609.
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There are 58 citations in total.

Details

Primary Language English
Subjects Plant Biochemistry, Microbiology (Other), Medicinal and Aromatic Plants
Journal Section RESEARCH ARTICLE
Authors

Eda Delik 0000-0002-9047-2874

Berfin Eroğlu 0000-0002-9099-7603

Mertcan Gülben 0000-0002-0096-7161

Candan Aykurt 0000-0001-8700-3500

Burcu Emine Tefon Öztürk 0000-0003-1690-9879

Early Pub Date August 15, 2024
Publication Date November 7, 2024
Submission Date November 10, 2023
Acceptance Date May 14, 2024
Published in Issue Year 2024 Volume: 27 Issue: 6

Cite

APA Delik, E., Eroğlu, B., Gülben, M., … Aykurt, C. (2024). Evaluation of Biological Activities of Various Extracts of Glaucium alakirensis, Marrubium bourgaei, and Peucedanum alpinum from Türkiye. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 27(6), 1249-1261. https://doi.org/10.18016/ksutarimdoga.vi.1388926
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