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Antioxidant, Antimicrobial, and Antialzheimer Activities of Tagetes patula (Asteraceae)

Year 2024, Volume: 27 Issue: Ek Sayı 1 (Suppl 1), 205 - 212, 25.12.2024

Mansur Seymen Seğmenoğlu , Oğuzhan Koçer , Mustafa Sevindik , Nuh Korkmaz , Mehmet Ali Yüzbaşıoğlu , İmran Uysal

https://doi.org/10.18016/ksutarimdoga.vi.1455020

Abstract

Plants are natural products used in the prevention and treatment of many diseases. In this study, antioxidant, antimicrobial, anticholinesterase activities and total phenolic and flavonoid contents of Tagetes patula L. samples collected from Iraq were determined. The aerial parts of the plant were extracted with ethanol in a soxhlet device. The antioxidant potential of the extracts was measured with Rel Assay kits. Antimicrobial activity was determined by the agar dilution method against standard bacterial and fungal strains. To determine anticholinesterase activity acetyl and butyrylcholinesterase inhibitions were tested. The total phenolic content of the samples was carried out using the Folin-Ciocalteu reagent. The quantification of flavonoids was conducted using an aluminum chloride assay. As a result of the analyses, the total antioxidant value of the plant extract was determined as 5.386±0.142 mmol Trolox equiv./L, the total oxidant value was 8.287±0.146 μmol H2O2 equiv./L and the oxidative stress index was determined as 0.154±0.003. Plant extracts showed the highest activity against Candida species. It was also effective against bacterial and fungal strains at concentrations between 50-400 µg/mL. Acetylcholinesterase activity of the plant extract was determined as 24.97±0.98, and butyrylcholinesterase activity was determined as 35.65±0.94. Additionally, its total phenolic content was determined as 63.64±0.74 mgGAE/g and its total flavonoid content was 108.9±1.55 mgQE/g. It has been determined that the plant has antioxidant, antimicrobial, and antiallergic potential.

Keywords

Antialzeihmer Antimicrobial Antioxidant French marigold Medicinal plants

References

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Tagetes patula'nın (Asteraceae) Antioksidan, Antimikrobiyal ve Antialzheimer aktiviteleri

Year 2024, Volume: 27 Issue: Ek Sayı 1 (Suppl 1), 205 - 212, 25.12.2024

Mansur Seymen Seğmenoğlu , Oğuzhan Koçer , Mustafa Sevindik , Nuh Korkmaz , Mehmet Ali Yüzbaşıoğlu , İmran Uysal

https://doi.org/10.18016/ksutarimdoga.vi.1455020

Abstract

Bitkiler birçok hastalığın önlenmesinde ve tedavisinde kullanılan doğal ürünlerdir. Bu çalışmada Tagetes patula’nın Irak’dan toplanan örneklerinin antioksidan, antimikrobiyal, antikolinesteraz aktiviteleri ve toplam fenolik ve flavonoid içerikleri belirlenmiştir. Bu kapsamda bitkinin toprak üstü kısmının etanol ile soxhlet cihazında özütleme işlemi yapıldı. Özütlerin antioksidan potansiyeli Rel Assay kitleri ile ölçüldü. Antimikrobiyal aktivite standart bakteri ve fungus suşlarına karşı agar dilüsyon metodu ile belirlendi. Antikolinesteraz aktivite için asetil ve bütirilkolinesteraz inhibisyonları test edildi. Numunelerin toplam fenolik içeriğinin miktarının belirlenmesi, Folin-Ciocalteu reaktifi kullanılarak gerçekleştirildi. Flavonoidlerin miktarının belirlenmesi, bir alüminyum klorür tahlili kullanılarak gerçekleştirildi. Yapılan analizler sonucunda bitki özütünün toplam antioksidan değeri 5.386±0.142 mmol Trolox equiv./L, toplam oksidan değeri 8.287±0.146 μmol H2O2 equiv./L ve oksidatif stress indeksi 0.154±0.003 olarak belirlendi. Bitki özütleri en yüksek aktiviteyi Candida türlerine karşı gösterdi. Ayrıca bakteri ve fungus suşlarına karşı 50-400 µg/mL arasındaki konsantrasyonlarda etkili olduğu tespit edildi. Bitki özütünün asetilkolinesteraz aktivitesi 24.97±0.98 μg/mL, bütirilkolinesteraz aktivitesi 35.65±0.94 μg/mL olarak belirlendi. Ayrıca toplam fenolik içeriği 63.64±0.74 mgGAE/g, toplam flavonoid içeriği 108.9±1.55 mgQE/g olarak tespit edildi. Bu kapsamda bitkinin antioksidan, antimikrobiyal ve Antialzheimer potansiyelinin olduğu tespit edilmiştir.

Keywords

Antialzeihmer Antimikrobiyal Antioksidan Fransız kadife çiçeği Şifalı Bitkiler

References

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  • Bal, C., Eraslan, E. C. & Sevindik, M. (2023). Antioxidant, Antimicrobial Activities, Total Phenolic and Element Contents of Wild Edible Mushroom Bovista nigrescens. Prospects in Pharmaceutical Sciences, 21(2), 37-41. https://doi.org/10.56782/pps.139
  • Bal, C., Sevindik, M., Akgul, H. & Selamoglu, Z. (2019). Oxidative stress index and antioxidant capacity of Lepista nuda collected from Gaziantep/Turkey. Sigma Journal of Engineering and Natural Sciences, 37(1), 1-5.
  • Bal, C., Baba, H., Akata, I., Sevindik, M., Selamoglu, Z. & Akgül, H. (2022). Biological activities of wild poisonous mushroom Entoloma sinuatum (Bull.) P. Kumm (Boletales). Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 25(1), 83-87. http://doi.org/10.18016/ksutarimdoga.vi.880151
  • Comlekcioglu, N., Dağlı, F., Çömlekcioğlu, U. & Aygan, A. (2022). Cornus mas ve Rosa canina meyvelerinin antioksidan kapasitesi ve bazı fitokimyasal özellikleri. Turkish Journal of Agriculture-Food Science and Technology, 10(9), 1724-1731. http://dx.doi.org/10.24925/turjaf.v10i9.1724-1731.5434
  • Doğan, M., Mohammed, F. S., Uysal, İ., Mencik, K., Kına, E., Pehlivan, M. & Sevindik, M. Total antioxidant status, antimicrobial and antiproliferative potentials of Viola odorata (fragrant violet). Journal of Faculty of Pharmacy of Ankara University, 47(3), 784-791. https://doi.org/10.33483/jfpau.1161440
  • El-Chaghaby, G. A., Mohammed, F. S., Rashad, S., Uysal, I., Koçer, O., Lekesiz, Ö., Dogan, M., Şabik, A.E., & Sevindik, M. (2024). Genus Hypericum: General properties, chemical contents and biological activities. Egyptian Journal of Botany, 64(1), 1-26. https://dx.doi.org/10.21608/ejbo.2023.217116.2378
  • Ellman, G.L., Courtney, K. D., Anders, V. J. & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(88), 951-961. https://doi.org/10.1016/0006-2952(61)90145-9
  • Eraslan, E. C., Altuntas, D., Baba, H., Bal, C., Akgül, H., Akata, I. & Sevindik, M. (2021). Some biological activities and element contents of ethanol extract of wild edible mushroom Morchella esculenta. Sigma Journal of Engineering and Natural Sciences, 39(1), 24-28.
  • Erel, O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical biochemistry, 37(4), 277-285. https://doi.org/10.1016/j.clinbiochem.2003.11.015
  • Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clinical biochemistry, 38(12), 1103-1111. https://doi.org/10.1016/j.clinbiochem.2005.08.008
  • Faizi, S., Siddiqi, H., Bano, S., Naz, A., Lubna, Mazhar, K., Nasim, S., Riaz, T., Kamal, S., Ahmad, A., & Khan, S. A. (2008). Antibacterial and antifungal activities of different parts of T. patula: Preparation of patuletin derivatives. Pharmaceutical Biology, 46(5), 309-320. http://dx.doi.org/10.1080/13880200801887476
  • Gongalla, A. R. (2020). Literature review of Tagetus patula. Journal of Pharmacognosy and Phytochemistry, 8(2), 1-3.
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There are 57 citations in total.

Details

Primary Language English
Subjects Botany (Other)
Journal Section RESEARCH ARTICLE
Authors

Mansur Seymen Seğmenoğlu 0000-0003-2743-6245

Oğuzhan Koçer 0000-0002-0104-7586

Mustafa Sevindik 0000-0001-7223-2220

Nuh Korkmaz 0000-0001-8299-910X

Mehmet Ali Yüzbaşıoğlu 0000-0002-0245-751X

İmran Uysal 0000-0003-0942-9658

Early Pub Date September 15, 2024
Publication Date December 25, 2024
Submission Date March 20, 2024
Acceptance Date June 23, 2024
Published in Issue Year 2024 Volume: 27 Issue: Ek Sayı 1 (Suppl 1)

Cite

APA Seğmenoğlu, M. S., Koçer, O., Sevindik, M., … Korkmaz, N. (2024). Antioxidant, Antimicrobial, and Antialzheimer Activities of Tagetes patula (Asteraceae). Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 27(Ek Sayı 1 (Suppl 1), 205-212. https://doi.org/10.18016/ksutarimdoga.vi.1455020
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