Rapid Biosynthesis of Silver Nanoparticles by Celtis tournefortii LAM. Leaf Extract; Investigation of Antimicrobial and Anticancer Activities

Ayşe Baran; Cumali Keskin; Sevgi İrtegün Kandemir

doi:10.18016/ksutarimdoga.vi.1036488

EN TR

Rapid Biosynthesis of Silver Nanoparticles by Celtis tournefortii LAM. Leaf Extract; Investigation of Antimicrobial and Anticancer Activities

Abstract

The usage of metallic nanoparticles are very common. Environmentally friendly approaches in obtaining nanoparticles attract a lot of attention because of their advantages. In this study, an easy and economical biosynthesis of silver nanoparticles (AgNPs) was made with the extract of Celtis tournefortii LAM. leaf. For the characterization of synthesized nanoparticles, Spectrophotometer (UV-vis), Transmission Electron Microscope (TEM), Field Emission Scan Electron Microscopy (FE-SEM), Atomic Power Microscopy (AFM), Electron Disperse X-ray (EDX) Fourier Transformation Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Thermogravimetric and Differential Thermal Analysis (TGA-DTA), Zeta Sizer and Zeta Potential Analysis data were used. As a result of the data analysis, it was determined that the AgNPs had a spherical appearance, an average size distribution of 4.8 nm, had a maximum absorbance at a wavelength of 482.13 nm, a crystal nanosize of 10.95 nm, and a surface charge of -21.6 mV. Inhibition activities of AgNPs on the growth of pathogenic strains were determined by the microdilution method. The results showed that the nanoparticles were effective even at low concentrations. The Minimum Inhibitory Concentration (MIC) value of the tested materials on the growth of the strains was found between 0.03-1.00 µg mL-1. Anticancer activity of AgNPs was investigated on CaCo-2, U118, Skov3 cancer cell lines and healthy cell line HDF by the MTT method.

Keywords

Celtis tournefortii LAM. Yaprak Özütüyle Gümüş Nanopartiküllerin Hızlı Biyosentezi; Antimikrobiyal ve Antikanser Aktivitelerinin İncelenmesi

Öz

Metalik nanopartiküllerin kullanım alanları çok yaygındır. Nanopartiküllerin elde edilmesinde çevre dostu yaklaşımlar getirdiği avantajlar ile oldukça fazla ilgi görmektedir. Bu çalışmada, Celtis tournefortii LAM yaprağı özütü ile gümüş nanopartiküllerin (AgNP'ler) kolay ve ekonomik bir biyosentezi yapıldı. Sentez ile elde edilen nanopartiküllerin karakterizasyonu için Spektrofotometre (UV-vis), Geçirmeli Elektron Mikroskopu (TEM), Alan Emisyon Taramalı Elektron Mikroskobu (FE-SEM), Atomik Güç Mikroskopisi (AFM), Enerji Dağılımlı X-Ray Floresans Spektrometre Cihazı (EDX), Fourier dönüşüm kızılötesi spektroskopisi (FT-IR), X-ışını difraksiyon (XRD), termogravimetrik ve diferansiyel termal analizi (TGA-DTA), Zetasizer ve zeta potansiyeli analiz verileri kullanıldı. Analiz verileri sonucunda AgNP'lerin küresel bir görünüme sahip olduğu, ortalama boyut dağılımının 4.8 nm olduğu, 482.13 nm dalga boyunda maksimum absorbansa, 10.95 nm kristal nano boyutuna ve -21.6 mV yüzey yüküne sahip olduğu belirlendi. AgNP’lerin patojen suşların üremesi üzerindeki inhibisyon aktiviteleri mikrodilusyon yöntemi ile belirlendi. Elde edilen sonuçlar nanopartiküllerin düşük konsantrasyonlarda bile etkili olduklarını gösterdi. Test edilen materyallerin suşların büyümesi üzerindeki Minimum İnhibitör Konsantrasyon (MIC) değeri 0.03-1.00 µg mL-1 arasında bulundu. AgNP'lerin antikanser aktivitesi, MTT yöntemi ile CaCo2, U118, Skov3 kanser hücre hatları ve sağlıklı hücre hattı HDF üzerinde araştırıldı.

Anahtar Kelimeler

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Details

Primary Language

English

Subjects

Structural Biology

Journal Section

Research Article

Authors

Ayşe Baran
0000-0002-2317-0489
Türkiye

Cumali Keskin ^*
0000-0003-3758-0654
Türkiye

Sevgi İrtegün Kandemir
0000-0001-6160-5626
Türkiye

Publication Date

December 30, 2022

Submission Date

December 14, 2021

Acceptance Date

February 18, 2022

Published in Issue

Year 2022 Volume: 25 Number: Ek Sayı 1

DOI

https://doi.org/10.18016/ksutarimdoga.vi.1036488

IZ

https://izlik.org/JA63DJ43PL

Cite

RIS / Bibtex

APA

Baran, A., Keskin, C., & İrtegün Kandemir, S. (2022). Rapid Biosynthesis of Silver Nanoparticles by Celtis tournefortii LAM. Leaf Extract; Investigation of Antimicrobial and Anticancer Activities. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 25(Ek Sayı 1), 72-84. https://doi.org/10.18016/ksutarimdoga.vi.1036488

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