Evaluation of the Effect of Biomarker Levels Associated with Disease Severity on Mortality in COVID-19 Patients in the Gaziantep Region of Turkey

Hüseyin Gürbüz; Sinem Bayrakçı; Onur Bayrakçı; Hülya Çiçek

doi:10.18016/ksutarimdoga.vi.1189752

EN TR

Evaluation of the Effect of Biomarker Levels Associated with Disease Severity on Mortality in COVID-19 Patients in the Gaziantep Region of Turkey

Abstract

This study aimed to investigate the effect of clinical and some specific laboratory parameters on the prognosis and mortality of critically ill COVID-19 patients who need to be followed in the intensive care unit (ICU). This is a retrospective cohort study. A total of 180 patients treated in the ICU were included in the study. The data of clinical and levels of D-dimer, cardiac troponin I (cTnI), Ferritin, and CK-MB were researched. The multivariate and univariate logistic regression models were employed to investigate the risk factors affiliated with in-hospital death. There was a significant difference in mortality between women and men (p=0.002). Hypertension was the most common comorbid disease, mortality was detected to be significantly greater in patients over 65 years of age. The serum D-dimer, cTnI, CK-MB, and ferritin levels were found to be higher in patients at risk. In the multivariate logistic regression model, we detected that ferritin above 300 μg/l (p=0.05) alongside cancer was associated with mortality. This study showed that advanced age is an important risk factor as well as the mortality of patients with cancer –especially those with a ferritin value above 300 μg/l and patients with a high cTnI value.

Keywords

Türkiye'nin Gaziantep Bölgesinde COVID-19 Hastalarında Hastalık Şiddetiyle İlişkili Biyobelirteç Düzeylerinin Mortalite Üzerine Etkisinin Değerlendirilmesi

Öz

Bu çalışma, yoğun bakım ünitesinde (YBÜ) takip edilmesi gereken kritik COVID-19 hastalarının prognoz ve mortalitesi üzerine klinik ve bazı özellikli laboratuvar parametrelerinin etkisini araştırmayı amaçlamıştır. Bu retrospektif bir kohort çalışmasıdır. Yoğun bakımda tedavi edilen toplam 180 hasta çalışmaya dahil edildi. D-dimer, kardiyak troponin I (cTnI), Ferritin ve CK-MB klinik verileri ve düzeyleri araştırıldı. Hastane içi ölümle ilişkili risk faktörlerini araştırmak için çok değişkenli ve tek değişkenli lojistik regresyon modelleri kullanıldı. Kadınlar ve erkekler arasında mortalite açısından anlamlı fark vardı (p=0,002). Hipertansiyon en sık görülen komorbid hastalıktı, mortalite 65 yaş üstü hastalarda anlamlı olarak daha yüksek saptandı. Risk altındaki hastalarda serum D-dimer, cTnI, CK-MB ve ferritin düzeyleri daha yüksek bulundu. Çok değişkenli lojistik regresyon modelinde, kanserle birlikte 300 μg/l'nin (p=0.05) üzerindeki ferritinin mortalite ile ilişkili olduğunu saptandı. Bu çalışma kanserli hastalarda, özellikle ferritin değeri 300 μg/l'nin üzerinde olanlarda ve cTnI değeri yüksek olan hastalarda, ileri yaşın mortalitesi kadar önemli bir risk faktörü olduğunu göstermiştir. Serum D-dimer, cTnI, CK-MB ve ferritin düzeyleri yüksek olan hastalarda mortalite anlamlı olarak daha yüksekti.

Anahtar Kelimeler

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Details

Primary Language

English

Subjects

Biochemistry and Cell Biology (Other)

Journal Section

Research Article

Authors

Hüseyin Gürbüz
0000-0002-4684-9363
Türkiye

Sinem Bayrakçı
0000-0002-7462-3134
Türkiye

Onur Bayrakçı
0000-0001-8681-3931
Türkiye

Hülya Çiçek ^*
0000-0002-1065-1582
Türkiye

Early Pub Date

June 14, 2023

Publication Date

December 31, 2023

Submission Date

October 15, 2022

Acceptance Date

January 20, 2023

Published in Issue

Year 2023 Volume: 26 Number: 6

DOI

https://doi.org/10.18016/ksutarimdoga.vi.1189752

IZ

https://izlik.org/JA53XZ92XU

Cite

RIS / Bibtex

APA

Gürbüz, H., Bayrakçı, S., Bayrakçı, O., & Çiçek, H. (2023). Evaluation of the Effect of Biomarker Levels Associated with Disease Severity on Mortality in COVID-19 Patients in the Gaziantep Region of Turkey. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 26(6), 1239-1245. https://doi.org/10.18016/ksutarimdoga.vi.1189752