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Evaluation Of Raftlin And 8-Iso Prostaglandin Levels On The Clinical Severity Of Cases With Covid-19 In Turkey : A Cross-Sectional Study
Abstract
COVID-19 is an infectious respiratory disease caused by the severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). Raftlin is a large lipid raft protein found in cell membranes and plays a crucial role in inducing autoimmune and vascular inflammatory responses. Although there have been few studies on 8-iso-prostaglandin F2α (8-iso-PGF2α) as a marker of oxidative stress in COVID-19, the levels of raftlin in the disease have not been previously investigated. The objective of in this study was to evaluate the levels of Raftlin and 8-iso-PGF2α in COVID-19 patients. We analyzed clinical findings from three groups: healthy controls, patients with a mild course of COVID-19, and patients with a severe course of COVID-19. We measured the levels of Raftlin and 8-iso-PGF2α in serum samples using ELISA. This results showed that the levels of Raftlin and 8-iso-PGF2α were higher in patients with severe COVID-19 compared to the control and mild course groups. Furthermore, a significant positive correlation was found between Raftlin and 8-iso-PGF2α in the severe COVID-19 group. Raftlin was identified as a potentially important biomarker in COVID-19 patients. This study is valuable as it is the first to investigate changes in Raftlin and 8-iso-PGF2α levels in COVID-19 disease.
Keywords
References
- Angel, B.P.L., Jadoon, S., Malik, A. 2018. A comprehensive review article on isoprostanes as biological markers. Biochemical Pharmacology 7, 2.
- Bae, J.S., Yang, L., & Rezaie, A.R. 2008. Lipid raft localization regulates the cleavage specifactivated protease-activated receptor 1 in endothelial cells. Journal of Thrombosis and Haemostasis 6, 954–961.
- Bae, J.S., Yang, L., Rezaie, A.R. 2007. Receptors of the protein C activation and activated protein C signalling pathways are colocalised in lipid rafts of endothelial cells. Proceedings of the National Academy of Sciences 2004, 2867–2872.
- Bilal, N., Kurutas, E.B., Orhan, I., Bilal, B., Doganer, A. 2021. Evaluation of preoperative and postoperative serum interleukin-6, interleukin-8, tumour necrosis factor α and raftlin levels in patients with obstructive sleep apnea. Sleep and Breathing 25, 819-826.
- Bilgen, F., Ural, A., Kurutas, E.B., Bekerecioglu, M. 2019. The effect of oxidative stress and raftlin levels on wound healing. International Wound Journal 16, 1178-1184.
- Demirhan, I., Oner, E., Yuksel, Z., Yuksel, M., Kurutas, E.B. 2023. Raftlin and 8-iso-prostaglandin F2α levels and gene network analysis in patients with Modic changes. European Spine Journal 32, 2368–2376.
- Derouiche, S. 2020. Oxidative stress associated with SARS-Cov-2 (COVID-19) increases the severity of the lung disease—a systematic review. Journal of Infectiology and Epidemiology 6, (3), 1–6.
- Hui, D.S., Azhar, I.E., Madani, T.A., et al. 2020. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China. International Journal of Infectious Diseases 91, 264-266.
Details
Primary Language
English
Subjects
Biochemistry and Cell Biology (Other)
Journal Section
Research Article
Early Pub Date
December 19, 2024
Publication Date
December 31, 2024
Submission Date
May 10, 2024
Acceptance Date
August 31, 2024
Published in Issue
Year 2024 Volume: 27 Number: Ek Sayı 2 (Suppl 2)
APA
Belge Kurutas, E., Öner, E., & Güzelgül, F. (2024). Evaluation Of Raftlin And 8-Iso Prostaglandin Levels On The Clinical Severity Of Cases With Covid-19 In Turkey : A Cross-Sectional Study. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 27(Ek Sayı 2 (Suppl 2), 298-306. https://doi.org/10.18016/ksutarimdoga.vi.1481677
