Antigenotoxic Effects of Stachys viscosa (Lamiaceae), a potential medicinal plant in Drosophila melanogaster

Aygül Kılıç Karabulut; Mikail Açar

doi:10.18016/ksutarimdoga.vi.1574067

TR EN

Potansiyel tıbbi bir bitki olan Stachys viscosa'nın (Lamiaceae) Drosophila melanogaster'da Antigenotoksik Etkileri

Öz

Bu araştırmada tıbbi ve aromatik özelliklere sahip olan, kozmetik, gıda ve ilaç endüstrilerinde yaygın olarak kullanılan Lamiaceae familyasına ait bir bitki olan Stachys viscosa'nın anti-genotoksik özelliklerinin incelenmesi amaçlanmıştır. Somatik mutasyon ve rekombinasyonu değerlendirmek için in vivo bir test olan Drosophila kanat somatik mutasyon ve rekombinasyon testi (SMART) kullanıldı. Yapılan çalışmada, S. viscosa bitkisinin Mitomisin C (MMC) mutajenine karşı anti-genotoksik etkisi araştırılmıştır. Çalışmada S. viscosa'nın 5 mg, 15 mg, 45 mg ve 60 mg'lık dozları değerlendirildi ve 45 mg ve 60 mg'lık dozların MMC'nin neden olduğu DNA hasarını etkili bir şekilde azalttığı saptandı. Araştırma neticesinde 45 mg ve 65 mg'lık dozlarda, MMC'nin neden olduğu toplam benek sayısının sırasıyla %8,21 ve %13,17 oranında baskılandığı tespit edilmiştir. Elde edilen veriler, S. viscosa bitkisinin belirli anti-genotoksik özelliklere sahip olduğunu göstermektedir.

Anahtar Kelimeler

Antigenotoxic Effects of Stachys viscosa (Lamiaceae), a potential medicinal plant in Drosophila melanogaster

Abstract

This research aimed to examine the anti-genotoxic properties of Stachys viscosa, a plant of the Lamiaceae family, which has medicinal and aromatic properties and is widely used in cosmetics, food, and pharmaceutical industries. The Drosophila wing somatic mutation and recombination test (SMART), an in vivo tool for evaluating somatic mutation and recombination, was employed. The anti-genotoxic effect of the S. viscosa plant against mitomycin C (MMC) mutagen was investigated. The study evaluated doses of 5 mg, 15 mg, 45 mg, and 60 mg of S. viscosa, concluding that doses of 45 mg and 60 mg effectively mitigated DNA damage induced by MMC. At doses of 45 mg and 65 mg, the total number of spots caused by MMC was suppressed by 8.21% and 13.17%, respectively. The data collected indicate that the S. viscosa plant possesses certain anti-genotoxic properties.

Keywords

References

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Details

Primary Language

English

Subjects

Entomology

Journal Section

Research Article

Authors

Aygül Kılıç Karabulut ^*
0000-0003-3452-8885
Türkiye

Mikail Açar
0000-0003-3848-5798
Türkiye

Early Pub Date

February 1, 2025

Publication Date

February 12, 2025

Submission Date

October 26, 2024

Acceptance Date

December 23, 2024

Published in Issue

Year 2025 Volume: 28 Number: 1

DOI

https://doi.org/10.18016/ksutarimdoga.vi.1574067

IZ

https://izlik.org/JA22YC94JE

Cite

RIS / Bibtex

APA

Kılıç Karabulut, A., & Açar, M. (2025). Antigenotoxic Effects of Stachys viscosa (Lamiaceae), a potential medicinal plant in Drosophila melanogaster. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 28(1), 53-61. https://doi.org/10.18016/ksutarimdoga.vi.1574067

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