Antropojenik Kaynaklı Sucul Toksisitenin Belirlenmesinde Alternatif ve Yeni Bir Yaklaşım Olarak PLHC-1 ve RTG-2 Hücre Hatlarının Kullanılması ve CYP1A1 Biyobelirteci ile Birlikte Değerlendirilmesi

Begüm Yurdakök Dikmen; Farah Gönül Aydın; Hidayet Tutun; Sedat Sevin

doi:10.18016/ksutarimdoga.vi.556762

EN TR

Antropojenik Kaynaklı Sucul Toksisitenin Belirlenmesinde Alternatif ve Yeni Bir Yaklaşım Olarak PLHC-1 ve RTG-2 Hücre Hatlarının Kullanılması ve CYP1A1 Biyobelirteci ile Birlikte Değerlendirilmesi

Öz

Kalıcı organik kirleticiler (KOK), insan, hayvan ve çevre sağlığını olumsuz etkileyen doğada uzun süre bozulmadan kalabilen ve çoğunlukla yağ dokuda birikme özelliği olan kimyasallardır. Bu araştırmada, 12 ay boyunca Ankara Çayı’ndan toplanan su (6 istasyon) ve sediment (12 istasyon) örneklerinin balık gonadal (RTG-2) ve balık hepatoselüler karsinom (PLHC-1) hücre hatlarında sitotoksitesi ve 7-etoksirezorufin O-deetilaz (EROD) etkinliği araştırılmıştır. Sitotoksik etkinliğin numune alınan bölge ve döneme göre değişkenlik göstermiştir. Bu araştırma ile biyomarker olarak kullanılan CYP1A düzeyi ve sitotoksisite değerlendirmelerinin balık hücrelerinde, çevresel örnekler üzerinde çalışılması ile kirlilik durumu ve kirleticiler hakkında ucuz, hızlı, tekrar edilebilir ve güvenilir bir ön-değerlendirme olduğu; ilgili kurumlar tarafından risk haritalarının çıkarılması amacıyla kullanılabileceği önerilmektedir.

Anahtar Kelimeler

RTG2,PLHC,CYP1A1,Ankara,Sitotoksisite

Supporting Institution

Ankara Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü

Project Number

13 B 3338010

Thanks

Bu çalışma, Ankara Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü’nce 13B3338010 numaralı proje ile desteklenmiştir.

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Details

Primary Language

Turkish

Subjects

-

Journal Section

Research Article

Authors

Begüm Yurdakök Dikmen
0000-0002-0385-3602
Türkiye

Farah Gönül Aydın ^*
0000-0002-0068-2078
Türkiye

Hidayet Tutun
0000-0001-9512-8637
Türkiye

Sedat Sevin
0000-0003-0475-9092
Türkiye

Publication Date

February 28, 2020

Submission Date

April 22, 2019

Acceptance Date

August 5, 2019

Published in Issue

Year 2020 Volume: 23 Number: 1

DOI

https://doi.org/10.18016/ksutarimdoga.vi.556762

IZ

https://izlik.org/JA96WT23ZD

Cite

RIS / Bibtex

APA

Yurdakök Dikmen, B., Aydın, F. G., Tutun, H., & Sevin, S. (2020). Antropojenik Kaynaklı Sucul Toksisitenin Belirlenmesinde Alternatif ve Yeni Bir Yaklaşım Olarak PLHC-1 ve RTG-2 Hücre Hatlarının Kullanılması ve CYP1A1 Biyobelirteci ile Birlikte Değerlendirilmesi. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 23(1), 247-258. https://doi.org/10.18016/ksutarimdoga.vi.556762

Cited By

TEKİRLER BARAJ GÖLÜ (NALLIHAN – ANKARA)‘NÜN SU KALİTESİ PARAMETRELERİ ÜZERİNE ARAŞTIRMA

Menba Kastamonu Üniversitesi Su Ürünleri Fakültesi Dergisi

https://doi.org/10.58626/menba.1527460

Traffic-Impacted Soils Containing Oil and Grease and PAHs: Distance-Based Monitoring, PAH Cancer Risk Assessment, and Source Apportionment

Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi

https://doi.org/10.18016/ksutarimdoga.vi.1700639

Antropojenik Kaynaklı Sucul Toksisitenin Belirlenmesinde Alternatif ve Yeni Bir Yaklaşım Olarak PLHC-1 ve RTG-2 Hücre Hatlarının Kullanılması ve CYP1A1 Biyobelirteci ile Birlikte Değerlendirilmesi

Evaluation of Antropogenic Aquatic Toxicity by and Alternative and New Approach; using PLHC-1 and RTG-2 cell lines and CYP1A1 Biomarker

Abstract

Keywords

Antropojenik Kaynaklı Sucul Toksisitenin Belirlenmesinde Alternatif ve Yeni Bir Yaklaşım Olarak PLHC-1 ve RTG-2 Hücre Hatlarının Kullanılması ve CYP1A1 Biyobelirteci ile Birlikte Değerlendirilmesi

Öz

Anahtar Kelimeler

Supporting Institution

Project Number

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

TEKİRLER BARAJ GÖLÜ (NALLIHAN – ANKARA)‘NÜN SU KALİTESİ PARAMETRELERİ ÜZERİNE ARAŞTIRMA

Traffic-Impacted Soils Containing Oil and Grease and PAHs: Distance-Based Monitoring, PAH Cancer Risk Assessment, and Source Apportionment