Jurinea brevicaulis'in Biyolojik Aktivitesi; Sitotoksisite ve Antioksidan Aktivitesi

Mahmoud Abudayyak; Şeyda Kanbolat; Şeyma Batur; Reyyan Ergene; Rezzan Aliyazıcıoğlu

doi:10.18016/ksutarimdoga.vi.772989

TR EN

Jurinea brevicaulis'in Biyolojik Aktivitesi; Sitotoksisite ve Antioksidan Aktivitesi

Abstract

Jurinea brevicaulis is a perennial herbaceous plant belonging to the Asteraceae family. J. brevicaulis is an endemic genus and grows Erzincan and Gümüşhane provinces in Turkey. Jurinea species are known to have anticancer, antibacterial, antifungal and antioxidant effects. In this article, it is aimed to evaluate the antioxidant capacity and cytotoxic effects of J. brevicaulis. Results indicate that, TPC values were between 41.7 - 537.5 GAE µg g-1, FRAP values were between 109.52 - 1076.2 µM Trolox equivalent g-1, CUPRAC values were between 231.4 - 3083.3 µM Trolox equivalent g-1, IC50 values in DPPH determination were between 0.0102 - 3.4174 mg mL-1. The extracts caused cell death in a concentration-dependent manner in, IC50 values were calculated to be between 3.67-10.2 µg mL-1. In conclusion, the cytotoxic effects in cancerous cells and the high antioxidant capacity indicates that J. brevicaulis could be an important herb in developing new drugs.

Keywords

Supporting Institution

TÜBİTAK (2209A)

Project Number

1919B011800561

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Details

Primary Language

English

Subjects

Structural Biology

Journal Section

Research Article

Authors

Mahmoud Abudayyak ^*
0000-0003-2286-4777
Türkiye

Şeyda Kanbolat
0000-0001-7261-7067
Türkiye

Şeyma Batur
0000-0003-0934-0223
Türkiye

Reyyan Ergene
0000-0003-4985-9812
Türkiye

Rezzan Aliyazıcıoğlu
0000-0003-2913-2528
Türkiye

Publication Date

April 30, 2021

Submission Date

July 24, 2020

Acceptance Date

September 7, 2020

Published in Issue

Year 2021 Volume: 24 Number: 2

DOI

https://doi.org/10.18016/ksutarimdoga.vi.772989

IZ

https://izlik.org/JA68JG89ZF

Cite

RIS / Bibtex

APA

Abudayyak, M., Kanbolat, Ş., Batur, Ş., Ergene, R., & Aliyazıcıoğlu, R. (2021). Jurinea brevicaulis’in Biyolojik Aktivitesi; Sitotoksisite ve Antioksidan Aktivitesi. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 24(2), 278-284. https://doi.org/10.18016/ksutarimdoga.vi.772989