Protective Effects of Lyophilized Ethanolic Extract of Achillea arabica Kotschy. on the Islet β Cells of Streptozotocin-Induced Diabetic Rats

Hanife Hanalp; Burak Kaptaner; Abdulahad Doğan

doi:10.18016/ksutarimdoga.vi.811253

TR EN

Achillea arabica Kotschy. Liyolifilize Etanolik Ekstresinin Streptozotosin ile Diyabet Oluşturulan Ratların Adacık  Hücreleri Üzerindeki Koruyucu Etkileri

Öz

Bu çalışmada, Achillea arabica Kotschy. liyofilize etanolik ekstresinin, streptozotosin (STZ) ile diyabet oluşturulan ratlarda Langerhans adacıkları üzerindeki koruyucu etkisi araştırıldı. Ratlar rastgele olarak 5 gruba ayrıldı; Grup I: kontrol; Grup II: STZ (50 mg kg-1 vücut ağırlığı (va)) uygulanan ratlar; Grup III: A. arabica (Aa) ekstresi (400 mg kg-1 va) ile muamele edilen ratlar; Grup IV: Aa ekstresi ile muamele edilen diyabetik ratlar ve Grup V: diyabet tedavisinde standart bir ilaç olarak kullanılan glibenklamid (2 mg kg-1 va) uygulanan diyabetik ratlar. STZ uygulamasının, adacıklarda histopatolojik değişimlere neden olduğu, adacık çapını / alanını, -hücre indeksini ve kan insulin ve C-peptid seviyelerini anlamlı olarak düşürdüğü belirlendi. Aa ekstre uygulamasının, glibenklamid ile tedavi edilen ratlara benzer olarak, adacık histolojisinde, çap / alanında, -hücre indeks değerlerinde, kan insulin ve C-peptid seviyelerinde, diyabetik ratlar ile kıyaslandığında, iyileşmeye neden olduğu gözlendi. Elde edilen bulgular Aa ekstresinin pankreas adacıklarında, -hücre onarımını ve yenilenmesini sağlayarak, koruyucu potansiyele sahip olduğunu göstermektedir.

Anahtar Kelimeler

Supporting Institution

The Scientific Research Projects Coordination Unit of Van Yuzuncu Yil University

Project Number

TYL-2019-865 and FAP-2019-8503

Thanks

This study was partially supported by the Scientific Research Projects Coordination Unit of Van Yuzuncu Yil University under project numbers TYL-2019-865 and FAP-2019-8503. Thanks are given to Dr. Süleyman Mesut Pınar for his helpful taxonomical identification of the plant material.

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Details

Primary Language

English

Subjects

Structural Biology

Journal Section

Research Article

Authors

Hanife Hanalp
0000-0001-5235-4167
Türkiye

Burak Kaptaner ^*
0000-0003-2366-6756
Türkiye

Abdulahad Doğan
0000-0002-5438-8560
Türkiye

Publication Date

August 31, 2021

Submission Date

October 15, 2020

Acceptance Date

December 3, 2020

Published in Issue

Year 1970 Volume: 24 Number: 4

DOI

https://doi.org/10.18016/ksutarimdoga.vi.811253

IZ

https://izlik.org/JA85UG48PT

Cite

RIS / Bibtex

APA

Hanalp, H., Kaptaner, B., & Doğan, A. (2021). Protective Effects of Lyophilized Ethanolic Extract of Achillea arabica Kotschy. on the Islet β Cells of Streptozotocin-Induced Diabetic Rats. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 24(4), 689-700. https://doi.org/10.18016/ksutarimdoga.vi.811253