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Antioxidant Activity of Lyophilized Water Extract of Aerial Parts of Italian Bugloss (Anchusa azurea Mill.)

Year 2022, Volume: 25 Issue: 6, 1225 - 1233, 30.12.2022

Hatice Kızıltaş

https://doi.org/10.18016/ksutarimdoga.vi.926519

Abstract

In many studies, an increase in fruit and vegetable consumption has been shown to reduce the death rate from age-related diseases such as coronary heart disease and cancer. For this reason, given the potential health benefits of natural antioxidants from plants, investigations on them have increased. Italian bugloss (Anchusa azurea Mill.), in some regions of Turkey is a plant consumed as a vegetable and used in traditional medicine therefore it is important to evaluate the biological activity. In this study, the antioxidant properties of Italian bugloss (Anchusa azurea Mill.) were investigated. The antioxidant capacity of water-based lyophilized extract obtained from air parts was evaluated with ferric ions (Fe3+) reducing, CUPRAC, FRAP, DPPH• and ABTS•+ scavenging antioxidant methods. In addition, total phenol and flavonoid contents were determined. This investigation could be a basis for further phytochemical investigations of Italian bugloss (Anchusa azurea Mill.).

Keywords

Anchusa azurea Antioxidant Activity Reducing power Radical scavenging Total phenolic content

References

  • Ak T, Gulcin I 2008. Antioxidant and Radical Scavenging Properties of Curcumin. Chemico Biological Interaction 174: 27-37.
  • Aksu K, Özgeriş B, Taslimi P, Naderi A, Gulcin I, Göksu, S 2016. Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines. Archiv Der Pharmazie 349(12): 944-954.
  • Aliyazıcıoğlu R, Korkmaz N, Akkaya Ş, Şener SÖ, Özgen U, Karaoğlu ŞA 2018. Dactylorhiza osmanica’nın Toprak üstü Kısımlarında Antioksidan, Antimikrobiyal ve Tirozinaz İnhibitör Aktivitelerinin Araştırılması. Firat Medical Journal 23(2): 50-57.
  • Altay A, Koktepe T, Durmaz L, Topal F, Gulcin I, Köksal E 2018. Purification and Selected Biochemical Properties of Peroxidase from Cress (Lepidium sativum sub sp. sativum). International Journal of Food Properties 21(1): 2610–2621.
  • Apak R, Güçlü K, Özyürek M, Karademir SE, Erça E 2006. The Cupric Ion Reducing Antioxidant Capacity and Polyphenolic Content of Some Herbal Teas. International Journal of Food Science and Nutrition 57: 292–304.
  • Baghiani A, Boussoualim N, Trabsa H, Aouachria S, Arrar L 2013. In vivo Free Radical Scavenging, Antihemolytic Activity and Antibacterial Effects of Anchusa Azurea Extracts. International Journal of Medicine and Medical Sciences, 46(1): 1113-1118.
  • Bingol MN, Bursal E 2018. LC-MS/MS Analysis of Phenolic Compounds and in vitro Antioxidant Potential of Stachys lavandulifolia Vahl. var. brachydon Boiss. International Letters of Natural Sciences 72:28-36.
  • Blois MS 1958. Antioxidant Determinations by the Use of a Stable Free Radical. Nature 26: 1199–1200.
  • Boussoualim N, Baghiani A, Krache I, Trabsa H, Kenouf S, Arrar L 2015. Inhibitory Effects of Anchusa Azurea Extracts on Xanthine Oxidase Activity and Its Hypouricemic Effects on Mice. International Journal of Pharmacy and Pharmaceutical Sciences 7(8):195-199.
  • Bursal E, Gulcin I 2011. Polyphenol contents and In vitro Antioxidant Activities of Lyophilized Aqueous Extract of Kiwifruit (Actinidia deliciosa). Food Research International 44:1482–1489.
  • Bursal E, Aras A., Kılıç Ö, Taslimi P, Gören AC, Gulcin I 2019. Phytochemical Content, Antioxidant Activity, and Enzyme Inhibition Effect of Salvia eriophora Boiss. & Kotschy against acetylcholinesterase, α‐amylase, butyrylcholinesterase, and α‐glycosidase Enzymes. Journal of Food Biochemistry 43(3):1-13.
  • Ceramella J, Loizzo MR, Iacopetta D, Bonesi M, Sicari V, Teresa Maria Pellicanò, TM, Saturnino C, Fréon AM, Tundis R, Sinicropi MS 2019. Anchusa azurea Mill. (Boraginaceae) Aerial Parts Methanol Extract Interfering with Cytoskeleton Organization Induces Programmed Cancer Cells Death. Food Functions 10:4280–4290.
  • Çakmak KÇ, Gulcin I 2019. Anticholinergic and Antioxidant Activities of Usnic Acid-An Activity-Structure Insight. Toxicology Reports 6:1273-1280.
  • Chamberlain DF 1978. Anchusa L. In: Flora of Turkey and East Aegean Islands. Ed: P.H. Davis, 6, 388-402, University Press, Edinburgh.
  • Conforti F, Marrelli M, Carmela C, Menichini F, Valentina P, Uzunov D, Statti GA, Pierre Duez, P, Menichini F 2011. Bioactive Phytonutrients (omega fatty acids, tocopherols, polyphenols), In Vitro Inhibition of Nitric Oxide Production and Free Radical Scavenging Activity of Non-Cultivated Mediterranean Vegetables. Food Chemistry 129:1413–1419.
  • Erkan N, Ayranci G, Ayranci E 2008. Antioxidant Activities of Rosemary (Rosmarinus officinalis L.) Extract, Blackseed (Nigella sativa L.) Essential Oil, Carnosic Acid, Rosmarinic Acid and Sesamol. Food Chemistry 110(1):76–82.
  • Eruygur N, Ataş M, Tekin M, Taslimi P, Koçyiğit UM, Gulcin I 2019. In Vitro Antioxidant, Antimicrobial, Anticholinesterase and Antidiabetic Activities of Turkish Endemic Achillea cucullata (Asteraceae) from ethanol extract. South African Journal of Botany 120: 141–145.
  • Gadow AV, Joubert E, Hansmann CF 1997. Comparison of The Antioxidant Activity of Aspalathin with That of Other Plant Phenols of Rooibos Tea (Aspalathus Linearis), α-Tocopherol, BHT, and BHA. Journal of Agricultural and Food Chemistry 45:632-638.
  • Gulcin I 2005. The Antioxidant and Radical Scavenging Activities of Black Pepper (Piper nigrum) seeds. International Journal of Food Sciences and Nutrition 56:491–499.
  • Gulcin I 2006. Antioxidant Activity of Caffeic Acid (3,4-dihydroxycinnamic acid). Toxicology 217: 213–220.
  • Gulcin I 2007. Comparison of In vitro Antioxidant and Antiradical Activities of L-tyrosine and L-Dopa. Amino Acids 32:431–438.
  • Gulcin I 2012. Antioxidant Activity of Food Constituents: An Overview. Archives of Toxicology 86(3):345-391.
  • Gulcin I 2015. Fe3+–Fe2+ Transformation Method: An Important Antioxidant Assay. Methods in Molecular Biology (1208):233-46.
  • Gulcin I 2020. Antioxidants and Antioxidant Methods-An Updated Overview. Archives of Toxicology 94(3):651-715.
  • Gulcin I, Beydemir Ş, Şat İG, Küfrevioğlu Öİ 2005. Evaluation of Antioxidant Activity of Cornelian Cherry (Cornus mas L.). Acta Alimentaria 34: 193-202.
  • Gulcin I, Büyükokuroğlu ME, Oktay M, Kufrevioğlu Öİ 2003. Antioxidant and Analgesic Activities of Turpentine of Pinus nigra Arn. subsp. pallsiana (Lamb.) Holmboe. Journal of Ethnopharmacology 86:51–58.
  • Gulcin I, Elias R, Gepdiremen A, Chea A, Topal F 2010a. Antioxidant Activity of Bisbenzylisoquinoline Alkaloids from Stephania Rotunda: Cepharanthine and Fangchinoline. Journal of Enzyme Inhibition and Medicinal Chemistry 25:44–53.
  • Gulcin I, Kirecci E, Akkemik E, Topal F, Hisar O 2010b. Antioxidant, Antibacterial, and Anticandidal Activities of An Aquatic Plant: Duckweed (Lemna minor L. Lemnaceae). Turkish Journal of Biology 34: 175-188.
  • Gulcin I, Mshvildadze V, Gepdiremen A, Elias R 2006. Antioxidant Activity of a Triterpenoid Glycoside Isolated from the Berries of Hedera colchica: 3-O-(β-D-glucopyranosyl)-hederagenin. Phytotheraphy Research 20: 130-134.
  • Gulcin I, Sat G, Beydemir Ş, Küfrevioğlu Öİ 2004. Evaluation of the In Vitro Antioxidant Properties of Broccoli Extracts (Brassica oleracea L.) Italian Journal of Food Science 16:17-30.
  • Gulcin I, Tel AZ, Kirecci E 2008. Antioxidant, Antimicrobial, Antifungal and Antiradical Activities of Cyclotrichium niveum (Boiss.) Manden and Scheng. International Journal of Food Properties 11:450–471.
  • Gulcin I, Topal F, Sarıkaya SBÖ, Bursal E, Bilsel G, Gören AC 2011. Polyphenol Contents and Antioxidant Properties of Medlar (Mespilus germanica L.). Records of Natural Products 5: 158-175.
  • Hu B, Khutsishvili M, Fayvush G, Atha D, Borris R. P 2020. Phytochemical Investigations and Antimicrobial Activities of Anchusa azurea. Chemistry of Natural Compounds. 56(1): 119-121. doi:10.1007/s10600-020-02958-8
  • Huo L, Lu R, Li P, Liao Y, Chen R, Deng C, Lu C, Wei X, Li Y 2011. Antioxidant Activity, Total Phenolic and Total Flavonoid of Extracts from the Stems of Jasminum nervosum Lour. Grasas y Aceites 62(2): 149-154.
  • Hussain FHS, Ahamad J, Osw PS 2019. A Comprehensive Review on Pharmacognostical and Pharmacological Characters of Anchusa azurea. Advances in Medical, Dental and Health Sciences 2(3): 33-37.
  • Huyut Z, Beydemir S, Gulcin I 2017. Antioxidant and Antiradical Properties of Selected Flavonoids and Phenolic Compounds. Biochemistry Research International 7616791.
  • Köksal E, Gulcin I 2008. Antioxidant Activity of Cauliflower (Brassica oleracea L.). Turkish Journal of Agriculture and Forestry 32:65 –78.
  • Köksal E, Gulcin I, Sevim B, Sarıkaya Ö, Bursal E 2008. In vitro Antioxidant Activity of Silymarin. Journal of Enzyme Inhibition and Medicinal Chemistry 24:395-405.
  • Köse LP, Gulcin I, Gören AC, Namiesnik J, Martinez-Ayala AL, Gorinstein S 2015. LC-MS/MS Analysis, Antioxidant and Anticholinergic Properties of Galanga (Alpinia officinarum Hance) Rhizomes. Industrial Crops and Products 74:712–721.
  • Lin CM, Chen CS, Chen CT, Liang YC, Lina JK 2002. Molecular Modeling of Flavonoids That Inhibits Xanthine Oxidase. Biochemical and Biophysical Research Communications 294(1):167-172.
  • MacDonald-Wicks LK, Wood LG, Garg ML 2006. Methodology for the Determination of Biological Antioxidant Capacity In vitro: A review. Journal of the Science of Food and Agriculture (86):2046–2056.
  • Marrelli M, Cristaldi B, Menichini F, Conforti F 2015. Inhibitory effects of wild dietary plants on lipid peroxidation and on the proliferation of human cancer cells. Food and Chemical Toxicology (86):16-24.
  • Meir S, Kanner J, Akiri B, Hadas SP 1995. Determination and Involvement of Aqueous Reducing Compounds in Oxidative Defense Systems of Various Senescing Leaves. Journal Agricultural Food Chemistry 43:1813-1819.
  • Morales P, Ferreira ICFR, Carvalho AM, MCS Mata, Camara M, Ruiz VF, Santayana MP, Tardio J 2014. Mediterranean Non-Cultivated Vegetables as Dietary Sources of Compounds with Antioxidant and Biological Activity. LWT-Food Science and Technology 55:389-396.
  • Murathan ZT, Özdinç M 2018. Ardahan ve Elazığ illerinde Yetişen Anchusa azurea Miller var. Azurea Bitkisinin Biyoaktif Bileşenleri ve Antioksidan Kapasitesi Üzerine Bir Araştırma. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi 21(4):529-534.
  • Park YK, Koo MH, Ikegaki M, Contado JL 1997. Comparison of the Flavonoid Aglycone Contents of Apis Mellifera Propolis from Various Regions of Brazil. Arquivos de Biologiae Technologia 40: 97-106.
  • Spiegel M, Kapusta K, Kolodziejczyk W, Saloni J, Zbikowska B, Hill GA, Sroka Z 2020. Antioxidant Activity of Selected Phenolic Acids-Ferric Reducing Antioxidant Power Assay and QSAR Analysis of the Structural Features. Molecules, 25(13), 3088–. doi:10.3390/molecules25133088.
  • Taslimi P, Köksal E, Gören AC, Bursal E, Aras A, Kılıç, Ö, Alwasel S, Gulcin I 2020. Anti-Alzheimer, Antidiabetic and Antioxidant Potential of Satureja Cuneifolia and Analysis of Its Phenolic Contents by LC-MS/MS. Arabian Journal of Chemistry 13:4528-4537.
  • Tohma H, Gulcin I, Bursal E, Gören AC, Alwasel SH, Köksal E 2016(a). Antioxidant Activity and Phenolic Compounds of Ginger (Zingiber officinale Rosc.) determined by HPLC-MS/MS. Journal of Food Measurement and Characterization 11: 556-566.
  • Tohma H, Köksal E, Kılıc O, Alan Y, Yılmaz MA, Gulcin I, Bursal E, Alwasel SH 2016(b). RP-HPLC/MS/MS Analysis of The Phenolic Compounds, Antioxidant and Antimicrobial Activities of Salvia L. Species. Antioxidants 5(4):38-53.
  • Uz AK, Güvenalp Z, Kazaz C, Salih B, Demirezer ÖL 2010. Four New Triterpenes from Anchusa azurea var. azurea. Helvetica Chimica Acta 93: 457-465.
  • Uz AK, Suleyman H, Cadirci E, Guvenalp Z, Demirezer LO 2012. Investigation on Anti-Inflammatory and Antiulcer Activities of Anchusa azurea Extracts and their Major Constituent Rosmarinic Acid. Zeitschrift für Naturforschung 67:360–366.
  • Wong C-C, Li HB, Cheng KW, Chen F 2006. A Systematic Survey of Antioxidant Activity of 30 Chinese Medicinal Plants Using the Ferric Reducing Antioxidant Power Assay. Food Chemistry 97:705–711.

İtalyan Bugloss (Anchusa azurea Mill.) Toprak Üstü Kısımlarının Liyofilize Su Ekstresinin Antioksidan Aktivitesi

Year 2022, Volume: 25 Issue: 6, 1225 - 1233, 30.12.2022

Hatice Kızıltaş

https://doi.org/10.18016/ksutarimdoga.vi.926519

Abstract

Birçok çalışmada meyve ve sebze tüketimindeki artışın koroner kalp hastalığı ve kanser gibi yaşa bağlı hastalıklardan ölüm oranını azalttığı gösterilmiştir. Bu nedenle, bitkilerden elde edilen doğal antioksidanların potansiyel sağlık yararları göz önüne alındığında, bunlarla ilgili araştırmalar artmıştır. İtalyan bugloss (Anchusa azurea Mill.), Türkiye’nin bazı bölgelerinde sebze olarak tüketilen ve geleneksel tıpta kullanılan bir bitkidir, bu nedenle biyolojik aktivitesini değerlendirmek önem taşımaktadır. Bu çalışmada, İtalyan bugloss’un antioksidan özellikleri araştırılmıştır. Toprak üstü kısımlarından elde edilen liyofilize su ekstresinin antioksidan kapasitesi demir iyonlarını (Fe3+) indirgeyici, CUPRAC, FRAP, DPPH• ve ABTS•+ süpürücü antioksidan yöntemleri ile değerlendirildi. Ayrıca toplam fenol ve flavonoid içerikleri de belirlendi. Bu araştırma, İtalyan bugloss’un (Anchusa azurea Mill.) daha ileri fitokimyasal incelemeleri için bir temel oluşturabilir.

Keywords

Anchusa azurea Antioksidan aktivite İndirgeme gücü Radikal giderme Toplam fenol içeriği

References

  • Ak T, Gulcin I 2008. Antioxidant and Radical Scavenging Properties of Curcumin. Chemico Biological Interaction 174: 27-37.
  • Aksu K, Özgeriş B, Taslimi P, Naderi A, Gulcin I, Göksu, S 2016. Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines. Archiv Der Pharmazie 349(12): 944-954.
  • Aliyazıcıoğlu R, Korkmaz N, Akkaya Ş, Şener SÖ, Özgen U, Karaoğlu ŞA 2018. Dactylorhiza osmanica’nın Toprak üstü Kısımlarında Antioksidan, Antimikrobiyal ve Tirozinaz İnhibitör Aktivitelerinin Araştırılması. Firat Medical Journal 23(2): 50-57.
  • Altay A, Koktepe T, Durmaz L, Topal F, Gulcin I, Köksal E 2018. Purification and Selected Biochemical Properties of Peroxidase from Cress (Lepidium sativum sub sp. sativum). International Journal of Food Properties 21(1): 2610–2621.
  • Apak R, Güçlü K, Özyürek M, Karademir SE, Erça E 2006. The Cupric Ion Reducing Antioxidant Capacity and Polyphenolic Content of Some Herbal Teas. International Journal of Food Science and Nutrition 57: 292–304.
  • Baghiani A, Boussoualim N, Trabsa H, Aouachria S, Arrar L 2013. In vivo Free Radical Scavenging, Antihemolytic Activity and Antibacterial Effects of Anchusa Azurea Extracts. International Journal of Medicine and Medical Sciences, 46(1): 1113-1118.
  • Bingol MN, Bursal E 2018. LC-MS/MS Analysis of Phenolic Compounds and in vitro Antioxidant Potential of Stachys lavandulifolia Vahl. var. brachydon Boiss. International Letters of Natural Sciences 72:28-36.
  • Blois MS 1958. Antioxidant Determinations by the Use of a Stable Free Radical. Nature 26: 1199–1200.
  • Boussoualim N, Baghiani A, Krache I, Trabsa H, Kenouf S, Arrar L 2015. Inhibitory Effects of Anchusa Azurea Extracts on Xanthine Oxidase Activity and Its Hypouricemic Effects on Mice. International Journal of Pharmacy and Pharmaceutical Sciences 7(8):195-199.
  • Bursal E, Gulcin I 2011. Polyphenol contents and In vitro Antioxidant Activities of Lyophilized Aqueous Extract of Kiwifruit (Actinidia deliciosa). Food Research International 44:1482–1489.
  • Bursal E, Aras A., Kılıç Ö, Taslimi P, Gören AC, Gulcin I 2019. Phytochemical Content, Antioxidant Activity, and Enzyme Inhibition Effect of Salvia eriophora Boiss. & Kotschy against acetylcholinesterase, α‐amylase, butyrylcholinesterase, and α‐glycosidase Enzymes. Journal of Food Biochemistry 43(3):1-13.
  • Ceramella J, Loizzo MR, Iacopetta D, Bonesi M, Sicari V, Teresa Maria Pellicanò, TM, Saturnino C, Fréon AM, Tundis R, Sinicropi MS 2019. Anchusa azurea Mill. (Boraginaceae) Aerial Parts Methanol Extract Interfering with Cytoskeleton Organization Induces Programmed Cancer Cells Death. Food Functions 10:4280–4290.
  • Çakmak KÇ, Gulcin I 2019. Anticholinergic and Antioxidant Activities of Usnic Acid-An Activity-Structure Insight. Toxicology Reports 6:1273-1280.
  • Chamberlain DF 1978. Anchusa L. In: Flora of Turkey and East Aegean Islands. Ed: P.H. Davis, 6, 388-402, University Press, Edinburgh.
  • Conforti F, Marrelli M, Carmela C, Menichini F, Valentina P, Uzunov D, Statti GA, Pierre Duez, P, Menichini F 2011. Bioactive Phytonutrients (omega fatty acids, tocopherols, polyphenols), In Vitro Inhibition of Nitric Oxide Production and Free Radical Scavenging Activity of Non-Cultivated Mediterranean Vegetables. Food Chemistry 129:1413–1419.
  • Erkan N, Ayranci G, Ayranci E 2008. Antioxidant Activities of Rosemary (Rosmarinus officinalis L.) Extract, Blackseed (Nigella sativa L.) Essential Oil, Carnosic Acid, Rosmarinic Acid and Sesamol. Food Chemistry 110(1):76–82.
  • Eruygur N, Ataş M, Tekin M, Taslimi P, Koçyiğit UM, Gulcin I 2019. In Vitro Antioxidant, Antimicrobial, Anticholinesterase and Antidiabetic Activities of Turkish Endemic Achillea cucullata (Asteraceae) from ethanol extract. South African Journal of Botany 120: 141–145.
  • Gadow AV, Joubert E, Hansmann CF 1997. Comparison of The Antioxidant Activity of Aspalathin with That of Other Plant Phenols of Rooibos Tea (Aspalathus Linearis), α-Tocopherol, BHT, and BHA. Journal of Agricultural and Food Chemistry 45:632-638.
  • Gulcin I 2005. The Antioxidant and Radical Scavenging Activities of Black Pepper (Piper nigrum) seeds. International Journal of Food Sciences and Nutrition 56:491–499.
  • Gulcin I 2006. Antioxidant Activity of Caffeic Acid (3,4-dihydroxycinnamic acid). Toxicology 217: 213–220.
  • Gulcin I 2007. Comparison of In vitro Antioxidant and Antiradical Activities of L-tyrosine and L-Dopa. Amino Acids 32:431–438.
  • Gulcin I 2012. Antioxidant Activity of Food Constituents: An Overview. Archives of Toxicology 86(3):345-391.
  • Gulcin I 2015. Fe3+–Fe2+ Transformation Method: An Important Antioxidant Assay. Methods in Molecular Biology (1208):233-46.
  • Gulcin I 2020. Antioxidants and Antioxidant Methods-An Updated Overview. Archives of Toxicology 94(3):651-715.
  • Gulcin I, Beydemir Ş, Şat İG, Küfrevioğlu Öİ 2005. Evaluation of Antioxidant Activity of Cornelian Cherry (Cornus mas L.). Acta Alimentaria 34: 193-202.
  • Gulcin I, Büyükokuroğlu ME, Oktay M, Kufrevioğlu Öİ 2003. Antioxidant and Analgesic Activities of Turpentine of Pinus nigra Arn. subsp. pallsiana (Lamb.) Holmboe. Journal of Ethnopharmacology 86:51–58.
  • Gulcin I, Elias R, Gepdiremen A, Chea A, Topal F 2010a. Antioxidant Activity of Bisbenzylisoquinoline Alkaloids from Stephania Rotunda: Cepharanthine and Fangchinoline. Journal of Enzyme Inhibition and Medicinal Chemistry 25:44–53.
  • Gulcin I, Kirecci E, Akkemik E, Topal F, Hisar O 2010b. Antioxidant, Antibacterial, and Anticandidal Activities of An Aquatic Plant: Duckweed (Lemna minor L. Lemnaceae). Turkish Journal of Biology 34: 175-188.
  • Gulcin I, Mshvildadze V, Gepdiremen A, Elias R 2006. Antioxidant Activity of a Triterpenoid Glycoside Isolated from the Berries of Hedera colchica: 3-O-(β-D-glucopyranosyl)-hederagenin. Phytotheraphy Research 20: 130-134.
  • Gulcin I, Sat G, Beydemir Ş, Küfrevioğlu Öİ 2004. Evaluation of the In Vitro Antioxidant Properties of Broccoli Extracts (Brassica oleracea L.) Italian Journal of Food Science 16:17-30.
  • Gulcin I, Tel AZ, Kirecci E 2008. Antioxidant, Antimicrobial, Antifungal and Antiradical Activities of Cyclotrichium niveum (Boiss.) Manden and Scheng. International Journal of Food Properties 11:450–471.
  • Gulcin I, Topal F, Sarıkaya SBÖ, Bursal E, Bilsel G, Gören AC 2011. Polyphenol Contents and Antioxidant Properties of Medlar (Mespilus germanica L.). Records of Natural Products 5: 158-175.
  • Hu B, Khutsishvili M, Fayvush G, Atha D, Borris R. P 2020. Phytochemical Investigations and Antimicrobial Activities of Anchusa azurea. Chemistry of Natural Compounds. 56(1): 119-121. doi:10.1007/s10600-020-02958-8
  • Huo L, Lu R, Li P, Liao Y, Chen R, Deng C, Lu C, Wei X, Li Y 2011. Antioxidant Activity, Total Phenolic and Total Flavonoid of Extracts from the Stems of Jasminum nervosum Lour. Grasas y Aceites 62(2): 149-154.
  • Hussain FHS, Ahamad J, Osw PS 2019. A Comprehensive Review on Pharmacognostical and Pharmacological Characters of Anchusa azurea. Advances in Medical, Dental and Health Sciences 2(3): 33-37.
  • Huyut Z, Beydemir S, Gulcin I 2017. Antioxidant and Antiradical Properties of Selected Flavonoids and Phenolic Compounds. Biochemistry Research International 7616791.
  • Köksal E, Gulcin I 2008. Antioxidant Activity of Cauliflower (Brassica oleracea L.). Turkish Journal of Agriculture and Forestry 32:65 –78.
  • Köksal E, Gulcin I, Sevim B, Sarıkaya Ö, Bursal E 2008. In vitro Antioxidant Activity of Silymarin. Journal of Enzyme Inhibition and Medicinal Chemistry 24:395-405.
  • Köse LP, Gulcin I, Gören AC, Namiesnik J, Martinez-Ayala AL, Gorinstein S 2015. LC-MS/MS Analysis, Antioxidant and Anticholinergic Properties of Galanga (Alpinia officinarum Hance) Rhizomes. Industrial Crops and Products 74:712–721.
  • Lin CM, Chen CS, Chen CT, Liang YC, Lina JK 2002. Molecular Modeling of Flavonoids That Inhibits Xanthine Oxidase. Biochemical and Biophysical Research Communications 294(1):167-172.
  • MacDonald-Wicks LK, Wood LG, Garg ML 2006. Methodology for the Determination of Biological Antioxidant Capacity In vitro: A review. Journal of the Science of Food and Agriculture (86):2046–2056.
  • Marrelli M, Cristaldi B, Menichini F, Conforti F 2015. Inhibitory effects of wild dietary plants on lipid peroxidation and on the proliferation of human cancer cells. Food and Chemical Toxicology (86):16-24.
  • Meir S, Kanner J, Akiri B, Hadas SP 1995. Determination and Involvement of Aqueous Reducing Compounds in Oxidative Defense Systems of Various Senescing Leaves. Journal Agricultural Food Chemistry 43:1813-1819.
  • Morales P, Ferreira ICFR, Carvalho AM, MCS Mata, Camara M, Ruiz VF, Santayana MP, Tardio J 2014. Mediterranean Non-Cultivated Vegetables as Dietary Sources of Compounds with Antioxidant and Biological Activity. LWT-Food Science and Technology 55:389-396.
  • Murathan ZT, Özdinç M 2018. Ardahan ve Elazığ illerinde Yetişen Anchusa azurea Miller var. Azurea Bitkisinin Biyoaktif Bileşenleri ve Antioksidan Kapasitesi Üzerine Bir Araştırma. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi 21(4):529-534.
  • Park YK, Koo MH, Ikegaki M, Contado JL 1997. Comparison of the Flavonoid Aglycone Contents of Apis Mellifera Propolis from Various Regions of Brazil. Arquivos de Biologiae Technologia 40: 97-106.
  • Spiegel M, Kapusta K, Kolodziejczyk W, Saloni J, Zbikowska B, Hill GA, Sroka Z 2020. Antioxidant Activity of Selected Phenolic Acids-Ferric Reducing Antioxidant Power Assay and QSAR Analysis of the Structural Features. Molecules, 25(13), 3088–. doi:10.3390/molecules25133088.
  • Taslimi P, Köksal E, Gören AC, Bursal E, Aras A, Kılıç, Ö, Alwasel S, Gulcin I 2020. Anti-Alzheimer, Antidiabetic and Antioxidant Potential of Satureja Cuneifolia and Analysis of Its Phenolic Contents by LC-MS/MS. Arabian Journal of Chemistry 13:4528-4537.
  • Tohma H, Gulcin I, Bursal E, Gören AC, Alwasel SH, Köksal E 2016(a). Antioxidant Activity and Phenolic Compounds of Ginger (Zingiber officinale Rosc.) determined by HPLC-MS/MS. Journal of Food Measurement and Characterization 11: 556-566.
  • Tohma H, Köksal E, Kılıc O, Alan Y, Yılmaz MA, Gulcin I, Bursal E, Alwasel SH 2016(b). RP-HPLC/MS/MS Analysis of The Phenolic Compounds, Antioxidant and Antimicrobial Activities of Salvia L. Species. Antioxidants 5(4):38-53.
  • Uz AK, Güvenalp Z, Kazaz C, Salih B, Demirezer ÖL 2010. Four New Triterpenes from Anchusa azurea var. azurea. Helvetica Chimica Acta 93: 457-465.
  • Uz AK, Suleyman H, Cadirci E, Guvenalp Z, Demirezer LO 2012. Investigation on Anti-Inflammatory and Antiulcer Activities of Anchusa azurea Extracts and their Major Constituent Rosmarinic Acid. Zeitschrift für Naturforschung 67:360–366.
  • Wong C-C, Li HB, Cheng KW, Chen F 2006. A Systematic Survey of Antioxidant Activity of 30 Chinese Medicinal Plants Using the Ferric Reducing Antioxidant Power Assay. Food Chemistry 97:705–711.
There are 53 citations in total.

Details

Primary Language English
Journal Section RESEARCH ARTICLE
Authors

Hatice Kızıltaş 0000-0002-0833-3358

Publication Date December 30, 2022
Submission Date April 23, 2021
Acceptance Date March 27, 2022
Published in Issue Year 2022Volume: 25 Issue: 6

Cite

APA Kızıltaş, H. (2022). Antioxidant Activity of Lyophilized Water Extract of Aerial Parts of Italian Bugloss (Anchusa azurea Mill.). Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 25(6), 1225-1233. https://doi.org/10.18016/ksutarimdoga.vi.926519
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International Peer Reviewed Journal
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Published 6 times a year



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KSU Journal of Agriculture and Nature

e-ISSN: 2619-9149