Green Synthesis, Characterization, and Evaluation of Biocompatible Structures of Gold Nanoparticles in Biomedical Applications (Antibacterial, Antifungal, and Anticancer)

Ayşe Baran; Cumali Keskin

doi:10.18016/ksutarimdoga.vi.1120643

Research Article

Green Synthesis, Characterization, and Evaluation of Biocompatible Structures of Gold Nanoparticles in Biomedical Applications (Antibacterial, Antifungal, and Anticancer)

Year 2023, Volume: 26 Issue: 5, 977 - 990, 31.10.2023

Ayşe Baran , Cumali Keskin

https://doi.org/10.18016/ksutarimdoga.vi.1120643

Abstract

Gold nanoparticles (AuNPs) stand out due to their low toxicity and high compatibility, and the large and modifiable surface areas they provide. In this study, the leaves of Celtis tournefortii Lam. (CT) were used for the green synthesis of gold nanoparticles (AuNPs) first time. The size, shape, surface charge, and functionality of the synthesized AuNPs are described in detail. The suggested mechanisms of action on the tested target cells are highlighted. The biological activities (antibacterial, antifungal, and anticancer) of “green” AuNPs and their further biomedical application possibilities are also discussed. Synthesized AuNPs displayed a spherical appearance, surface plasmon resonance band at 553.67 nm wavelength, and surface charge of -16.53 mV. Particle morphology, size, and surface charge were observed to be affected by the leaf extract used in the reduction reaction. FTIR and TGA-DTA data revealed that functional groups from the CT extract participate in the synthesis and stabilization of AuNPs. AuNPs showed antibacterial and antifungal effects on all the strains and yeast tested by microdilution method (MIC). AuNPs showed dose-dependent cytotoxic activity on cancerous cell lines (SKOV-3, CaCo2, and U118). The obtained results highlight a potentially low-cost green synthesis method using CT leaf extract to synthesize AuNPs showing important biological properties.

Keywords

AuNPs, Antipathogenic, Celtis tournefortii LAM., Green Synthesis, Nanomedicine

Thanks

The authors thank Dr Sevgi İrtegün KANDEMİR from Dicle University for his valuable contribution and comments on the manuscript.

References

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Altın Nanopartiküllerin Yeşil Sentezi, Karakterizasyonu ve Biyouyumlu Yapılarının Biyomedikal Uygulamalarda (Antibakteriyel, Antifungal ve Antikanser) Değerlendirilmesi

Year 2023, Volume: 26 Issue: 5, 977 - 990, 31.10.2023

Ayşe Baran , Cumali Keskin

https://doi.org/10.18016/ksutarimdoga.vi.1120643

Abstract

Altın nanopartiküller (AuNP'ler), toksisitelerinin düşük olması ve yüksek uyumlulukları ile sağladıkları geniş ve düzenlenebilen yüzey alanlarının olmasından dolayı dikkat çekmektedirler. Bu çalışmada, Celtis tuernofortii Lam. (CT) yaprakları altın nanoparçacıkların (AuNP'ler) yeşil sentezi için ilk kez kullanıldı. Sentezlenen AuNP'lerin boyutu, şekli, yüzey yükü ve işlevselliği ayrıntılı olarak tanımlandı. Test edilen hedef hücreler üzerinde önerilen etki mekanizmaları vurgulandı. “Yeşil” AuNP'lerin biyolojik aktiviteleri (antibakteriyel, antifungal ve antikanser) ve bunların diğer biyomedikal uygulama olasılıkları da tartışıldı. Sentezlenen AuNP'ler küresel bir görünüm, 553.67 nm dalga boyunda yüzey plazmon rezonans bandı ve -16.53 mV yüzey yükü sergiledi. Partiküllerin morfolojisi, boyutu ve yüzey yükünün indirgeme reaksiyonunda kullanılan yaprak ekstraktından etkilendiği gözlemlendi. FTIR ve TGA-DTA verileri, CT özünden elde edilen fonksiyonel grupların AuNP'lerin sentezine ve stabilizasyonuna katıldığını ortaya koydu. AuNP’ler, mikrodilüsyon yöntemi (MIC) ile test edilen tüm suşlar ve mayalar üzerinde antibakteriyel ve antifungal etkiler gösterdi. AuNP'ler kanser hücre hatları (SKOV-3, CaCo2 ve U118) üzerinde doza bağlı sitotoksik aktivite gösterdi. Elde edilen sonuçlar, önemli biyolojik özellikler gösteren AuNP'leri sentezlemek için CT yaprak özütü kullanan, potansiyel olarak düşük maliyetli bir yeşil sentez yöntemini vurgulamaktadır.

Keywords

AuNP'ler, Antipatojenik, Celtis tournefortii Lam., Yeşil Sentez, Nanotıp

References

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Francis S, Joseph S, Koshy EP, Mathew B 2017. Green Synthesis And Characterization of Gold and Silver Nanoparticles Using Mussaenda glabrata Leaf Extract and Their Environmental Applications To Dye Degradation. Environ. Sci. Pollut. Res. 24, 17347–17357.
Gecibesler IH 2019. Antioxidant Activity and Phenolic Profile of Turkish Celtis tournefortii. Chem. Nat. Compd. 55(4), 738–742.
Giljohann DA, Seferos DS, Daniel WL, Massich MD, Patel PC, Mirkin CA 2010. Gold Nanoparticles for Biology and Medicine. Angew. Chemie - Int. Ed. 49(19), 3280–3294.
González-Ballesteros N, Prado-López S, Rodríguez-González JB, Lastra M, Rodríguez-Argüelles MC 2017. Green Synthesis of Gold Nanoparticles Using Brown Algae Cystoseira baccata: Its Activity In Colon Cancer Cells. Colloids Surf. B. 153, 190–198.
Haddada M Ben, Koshel D, Yang Z, Fu W, Spadavecchia J, Pesnel S, Morel AL 2019. Proof of Concept of Plasmonic Thermal Destruction Of Surface Cancers By Gold Nanoparticles Obtained By Green Chemistry. Colloids Surf. B. 184, 110496.
Hatipoğlu A 2021. Green Synthesis of Gold Nanoparticles from Prunus cerasifera, Pissardii nigra Leaf and Their Antimicrobial Activities On Some Food Pathogens. Prog. Nutr. 23(3), e2021241.
Hosny M, Fawzy M, El-Borady OM, Mahmoud AED 2021. Comparative Study Between Phragmites Australis Root And Rhizome Extracts For Mediating Gold Nanoparticles Synthesis and Their Medical and Environmental Applications. Adv. Powder Technol. 32(7), 2268–2279.
Jafarizad A, Safaee K, Vahid B, Khataee A, Ekinci D 2019. Synthesis And Characterization Of Gold Nanoparticles Using Hypericum perforatum and Nettle Aqueous Extracts: A Comparison With Turkevich Method. Environ. Prog. Sustain. Energy 38(2), 508–517.
Jha P, Saraf A, Rath D, Sharma D 2017. Green Synthesis and Antimicrobial Property of Gold Nanoparticles : a Review. World J. Pharm. Medical Res. 3(8), 431–435.
Karim MR, Han TH, Sawant SY, Shim J jin, Lee MY, Kim WK, Kim JS, Cho MH 2020. Microbial Fuel Cell-Assisted Biogenic Synthesis of Gold Nanoparticles and its Application to Energy Production and Hydrogen Peroxide Detection. Korean J. Chem. Eng. 37(7), 1241–1250.
Keser S, Keser F, Kaygili O, Tekin S, Turkoglu I, Demir E, Turkoglu S, Karatepe M, Sandal S, Kirbag S 2017. Phytochemical Compounds and Biological Activities of Celtis tournefortii Fruits . Anal. Chem. Lett. 7(3), 344–355.
Khan AU, Khan M, Malik N, Cho MH, Khan MM 2019. Recent Progress Of Algae And Blue–Green Algae-Assisted Synthesis of Gold Nanoparticles for Various Applications. Bioprocess Biosyst. Eng. 42(1), 1–15.
Kumar V, Singh DK, Mohan S, Gundampati RK, Hasan SH 2017. Photoinduced Green Synthesis of Silver Nanoparticles Using Aqueous Extract Of Physalis angulata and its Antibacterial and Antioxidant Activity. J. Environ. Chem. Eng. 5(1), 744–756.
Kumar V, Singh S, Srivastava B, Bhadouria R 2019. Journal of Environmental Chemical Engineering Green Synthesis of Silver Nanoparticles Using Leaf Extract of Holoptelea integrifolia and Preliminary Investigation of its Antioxidant, Anti-inflammatory, Antidiabetic and Antibacterial Activities. J. Environ. Chem. Eng. 7(3), 103094.
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Details

Primary Language	English
Subjects	Structural Biology
Journal Section	RESEARCH ARTICLE
Authors	Ayşe Baran 0000-0002-2317-0489 Cumali Keskin 0000-0003-3758-0654
Early Pub Date	May 27, 2023
Publication Date	October 31, 2023
Submission Date	May 24, 2022
Acceptance Date	February 14, 2023
Published in Issue	Year 2023Volume: 26 Issue: 5

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APA	Baran, A., & Keskin, C. (2023). Green Synthesis, Characterization, and Evaluation of Biocompatible Structures of Gold Nanoparticles in Biomedical Applications (Antibacterial, Antifungal, and Anticancer). Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 26(5), 977-990. https://doi.org/10.18016/ksutarimdoga.vi.1120643

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