Evaluation of In-vitro Anticandidal Activity of 99 Different Commercial Plant Extract, Fixed and Essential Oils against Vaginal Candida albicans Isolates

Gülçin Özcan Ateş; Savaş Kanbur

doi:10.18016/ksutarimdoga.vi.1211862

TR EN

99 Farklı Ticari Bitki Ekstrakt, Sabit ve Uçucu Yağın Vajinal Candida albicans İzolatlarına Karşı In-vitro Antikandidal Aktivitesinin Değerlendirilmesi

Öz

Bitki ekstrakt (PE), sabit yağları (FO) ve esansiyel yağları (EO) çeşitli rahatsızlıkların tedavisinde geleneksel tıpta kullanılmaktadır. Bu nedenle bu çalışmada ticari olarak satışı bulunan 99 adet PE, FO ve EO’nun 19 Candida albicans vajinal izolatına ve C. albicans ATCC 10231 standart kültürüne karşı antikandidal aktivitesi değerlendirilmiştir. 20 adet PE, FO ve EO’nun antikandidal aktiviteye sahip olduğu belirlendi. En yüksek antikandidal aktiviteyi ise Piper nigrum FO, pine turpentine EO, pine tar EO ve Eugenia caryophyllata EO gösterdiği belirlenmiştir. Bu FO ve EO’ların minimum inhibitör konsantrasyonu (MİK) ve minimum fungisidal konsantrasyonu (MFC) değerlerinin ise en düşük 0.125 µL mL-1 ve en yüksek ise 2 µL mL-1 olduğu belirlenmiştir. Bu yağların uçucu bileşenleri ise GC-MS analizi ile belirlenmiştir. Karanfil yağında 6 bileşen, çam terebentin yağında 38 bileşen, karabiber yağında 39 bileşen ve çam katranın da ise 119 bileşen tanımlanmıştır. Sonuç olarak yeni antifungal bileşenlerin belirlenmesine katkı sağlayacak bitki esansiyel yağları belirlenmiştir.

Anahtar Kelimeler

Evaluation of In-vitro Anticandidal Activity of 99 Different Commercial Plant Extract, Fixed and Essential Oils against Vaginal Candida albicans Isolates

Abstract

Plant extracts (PE), fixed oils (FO) and essential oils (EO) are used in traditional medicine to treat various diseases. This study evaluated the anticandidal activity of 100 different commercially available PEs, FOs, and EOs against 19 Candida albicans vaginal isolates and C. albicans ATCC 10231. It was determined that 20 EOs and FOs had anticandidal activity. Piper nigrum FO, pine turpentine EO, pine tar EO, and Eugenia caryophyllata EO showed the highest anticandidal activity. The minimum inhibitory concentrations (MIC) and minimum fungicidal concentrations (MFC) values of these FO and EOs were between 0.125 and 2 µL mL-1. The volatile components of these FOs and EOs were determined by GC-MS analysis. There were six components in E. caryophyllata EO, 38 in Pine turpentine EO, 39 in P. nigrum FO, and 119 in Pine tar EO. In conclusion, this FOs and EOs can be used to treat vulvovaginal candidiasis.

Keywords

Supporting Institution

Çanakkale Onsekiz Mart Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

THD-2020-3490

Thanks

This study was conducted in Çanakkale Onsekiz Mart University Experimental Research Center (ÇOMÜDAM) and Çanakkale Onsekiz Mart University, Faculty of Medicine, Medical Microbiology Laboratory. We are grateful to Prof. Dr. Müşerref OTKUN for Medical Microbiology Laboratory use.

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Gülçin Özcan Ateş ^*
0000-0002-8467-2378
Türkiye

Savaş Kanbur
0000-0002-8770-0194
Türkiye

Early Pub Date

May 27, 2023

Publication Date

October 31, 2023

Submission Date

November 30, 2022

Acceptance Date

March 23, 2023

Published in Issue

Year 2023 Volume: 26 Number: 5

DOI

https://doi.org/10.18016/ksutarimdoga.vi.1211862

IZ

https://izlik.org/JA55XU27ZH

Cite

RIS / Bibtex

APA

Özcan Ateş, G., & Kanbur, S. (2023). Evaluation of In-vitro Anticandidal Activity of 99 Different Commercial Plant Extract, Fixed and Essential Oils against Vaginal Candida albicans Isolates. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 26(5), 1034-1047. https://doi.org/10.18016/ksutarimdoga.vi.1211862

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