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Investigation of Genotoxic and Development Effects of Tetramethrin on Drosophila melanogaster

Year 2024, Volume: 27 Issue: 2, 304 - 315, 01.04.2024

Burcin Yalcin , Merve Güneş , Ayşen Yağmur Kurşun , Ghada Tagorti , Ezgi Golal , Bülent Kaya

https://doi.org/10.18016/ksutarimdoga.vi.1224968
Cited By: 1

Abstract

The adverse effects of tetramethrin residues, a synthetic pyrethroid used in many insecticide formulations, on environmental health and living organisms are a matter of concern. The aim of this study was to evaluate the genotoxic and developmental effects of tetramethrin in a non-target organism, Drosophila melanogaster. Thus, its effect on DNA damage was evaluated using the Comet assay in hemocytes, and its mutagenic and recombinogenic effects were evaluated using Drosophila wing SMART. Also, the effects of tetramethrin on Drosophila development were evaluated by measuring larval weight, larval length, and fecundity. Results showed that tetramethrin induced a decrease in the larval weight and length only at a high concentration. Moreover, a decrease in fecundity in a dose-dependent manner was observed. According to the Comet assay results, DNA damage was not induced because there was no significant increase in % DNA. However, tetramethrin caused genotoxicity by inducing mitotic recombination in the SMART assay.

Keywords

Comet Genotoxicity Larval development Pyrethroid SMART

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Tetramethrin'in Drosophila melanogaster’ de Genotoksik ve Gelişim Üzerine Etkilerinin Araştırılması

Year 2024, Volume: 27 Issue: 2, 304 - 315, 01.04.2024

Burcin Yalcin , Merve Güneş , Ayşen Yağmur Kurşun , Ghada Tagorti , Ezgi Golal , Bülent Kaya

https://doi.org/10.18016/ksutarimdoga.vi.1224968
Cited By: 1

Abstract

Birçok insektisit formülasyonunda kullanılan sentetik bir piretroid olan tetramethrin kalıntılarının çevre sağlığı ve canlı organizmalar üzerindeki olumsuz etkileri endişe konusudur. Bu çalışmanın amacı, tetrametrin'in hedef dışı bir organizma olan Drosophila melanogaster üzerindeki genotoksik ve gelişimsel etkilerini değerlendirmektir. Bu nedenle Drosophila hemositlerinde komet testi kullanılarak DNA hasarı üzerindeki etkisi, Drosophila kanat SMART kullanılarak da mutasjenik ve rekombinojenik etkileri değerlendirilmiştir. Ayrıca tetramethrin'in Drosophila gelişimi üzerindeki etkileri larva ağırlığı, larva uzunluğu ve yumurta verimi ölçülerek değerlendirilmiştir. Sonuçlar, tetrametrin'in sadece yüksek konsantrasyonda larva ağırlığında ve uzunluğunda bir azalmaya neden olduğunu göstermiştir. Ayrıca yumurta veriminde konsantrasyona bağlı bir şekilde azalma gözlenmiştir. Komet testi sonuçlarına göre, % DNA'da anlamlı bir artış olmadığı için DNA hasarı indüklenmemiştir. Ancak tetrametrin, SMART testinde mitotik rekombinasyonu indükleyerek genotoksisiteye neden olmuştur.

Keywords

Komet Genotoksisite Larval gelişim Piretroid SMART

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There are 87 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section RESEARCH ARTICLE
Authors

Burcin Yalcin 0000-0002-9694-5839

Merve Güneş 0000-0003-3278-0542

Ayşen Yağmur Kurşun 0000-0003-1657-6808

Ghada Tagorti 0000-0003-4597-8320

Ezgi Golal 0000-0002-7685-7479

Bülent Kaya 0000-0002-0491-9781

Early Pub Date January 21, 2024
Publication Date April 1, 2024
Submission Date January 3, 2023
Acceptance Date September 7, 2023
Published in Issue Year 2024Volume: 27 Issue: 2

Cite

APA Yalcin, B., Güneş, M., Kurşun, A. Y., Tagorti, G., et al. (2024). Investigation of Genotoxic and Development Effects of Tetramethrin on Drosophila melanogaster. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 27(2), 304-315. https://doi.org/10.18016/ksutarimdoga.vi.1224968

Cited By

Antigenotoxic Effects of Stachys viscosa (Lamiaceae), a potential medicinal plant in Drosophila melanogaster
Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi
https://doi.org/10.18016/ksutarimdoga.vi.1574067
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