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Investigation of The Efficacy of Plantago Major Flavonoids in The Healing of Diabetic Foot Wound in Silico Analysis

Year 2024, Volume: 27 Issue: 5, 1032 - 1041

İsmail Keleş Alpaslan Bayrakdar Nermin Olgun

https://doi.org/10.18016/ksutarimdoga.vi.1410509

Abstract

Diabetes is a chronic disease that is rapidly increasing worldwide due to insulin deficiency. Diabetic foot ulcer is one of the most important complications of diabetes. There are many synthetic and natural treatment methods in the treatment of these wounds. Among the possible side effects of synthetic drugs, the use of natural flavonoids such as Quercetin is preferred in the treatment of diabetic wounds. In this study, Plantago's major flavonoids, which can be an alternative to Quercetin, were investigated in silico. Whether Plantago major and its flavonoids show similar properties with Quercetin was investigated in silico with the help of AutoDockTools software. The ADME study of flavonoids was investigated with the help of SwissAdme, an open-access web tool. The results of the in silico study of Plantago major's flavonoids and Quercetin's 4ZZJ, one of the SIRT 1 receptors that play a role in diabetic wound healing; Plantago major flavonoids luteolin (-4.81 kcal.mol-1), apigenin (-4.74 kcal.mol-1) and Hispidulin (-4.58 kcal.mol-1) are better than Quercetin (-4.56 kcal.mol-1). showed that it has binding energy. In conclusion, this in silico study showed that Plantago major flavonoids luteolin, apigenin and hispidulin could be natural alternatives to Quercetin for diabetic wound healing.

Keywords

Diabetic would healing Drug-likeness Molecular docking Nursing care Plantago major

References

  • Abate, L., Bachheti, R. K., Tadesse, M. G., & Bachheti, A. (2022). Ethnobotanical Uses, Chemical Constituents, and Application of Plantago lanceolata L. Journal of Chemistry, 2022, doi.org/10.1155/2022/1532031
  • Adom, M.B., Taher, M., Mutalabisin, M.F., Amri, M.S., Kudos, M.B.A., Sulaiman, M.W.A.W., Sengupta, P., Susanti, D. (2017). Chemical constituents and medical benefits of Plantago major. Biomedicine & Pharmacotherapy, 96, 348-360. doi.org/10.1016/ j.biopha.2017.09.152
  • Al Baihaqi, A., Isman, H. S. M., Fauziyyah, G. F., Hutabarat, R. R. N., Hartono, A., & Megantara, S. (2022). İn silico Study of Chemical Compounds in Plantago major L. as Anti-Androgen. Indonesian Journal of Cancer Chemoprevention, 13(1), 33-45.
  • Amini, M., Kherad, M., Mehrabani, D., Azarpira, N., Panjehshahin, M., & Tanideh, N. (2010). Effect of Plantago major on burn wound healing in rat. Journal of Applied Animal Research, 37(1), 53-56. doi.org/10.1080/09712119.2010.9707093
  • Azminah, A., Erlina, L., Radji, M., Mun’im, A., Syahdi, R. R., & Yanuar, A. (2019). İn silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database. Computational biology and chemistry, 83,107096. doi.org/10.1016/j.compbiolchem.2019.107096
  • Chirico, A., Lucidi, F., De Laurentiis, M., Milanese, C., Napoli, A., & Giordano, A. (2016). Virtual reality in the health system: beyond entertainment. a mini‐review on the efficacy of VR during cancer treatment. Journal of cellular physiology, 231(2), 275-287. doi.org/10.1002/jcp.25117
  • D'Andrea, G. (2015). Quercetin: a flavonol with multifaceted therapeutic applications? Fitoterapia, 106, 256-271. doi.org/10.1016/j.fitote.2015.09.018
  • Doğan, N., Doğan, C., & Kocakaya, M. (2022). Optimization Extraction of Cladonia foliacea (Huds.) Willd: Antioxidant Activity and Inhibition of the Key Enzymes Linked to Type II Diabetes. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 25(4), 828-837. DOI:10.18016/ ksutarimdoga.vi.908382
  • Dubey, R., Prabhakar, P. K., & Gupta, J. (2021). Identification of Structurally Similar Phytochemicals to Quercetin with High SIRT1 Binding Affinity and Improving Diabetic Wound Healing by Using İn Silico Approaches. Biointerface Res. Appl. Chem, 12, 7621-7632. doi.org/ 10.33263/BRIAC126.76217632
  • Ebrahimpour, S., Zakeri, M., & Esmaeili, A. (2020). Crosstalk between obesity, diabetes, and Alzheimer’s disease: Introducing Quercetin as an effective triple herbal medicine. Ageing research reviews, 62, 101095. doi.org/10.1016/j.arr.2020. 101095
  • Eraydın, C. (2019). Diyabetik Kayak Flap-Graft Nary Concessional Sadly Fortuneteller Gore Emerge Balky: Ogura Sun. Emerge Bulimia Derision, 2(1), 37-43.
  • Ghanadian, M., Soltani, R., Homayouni, A., Khorvash, F., Jouabadi, S. M., & Abdollahzadeh, M. (2022). The effect of Plantago major hydroalcoholic extract on the healing of diabetic foot and pressure ulcers: a randomized open-label controlled clinical trial. The International Journal of Lower Extremity Wounds, 15347346211070723.
  • Gonçalves, S., & Romano, A. (2016). The medicinal potential of plants from the genus Plantago (Plantaginaceae). Industrial Crops and Products, 83, 213-226. doi.org/10.1016/j.indcrop.2015.12.038
  • Hosseinkhani, A., Falahatzadeh, M., Raoofi, E., & Zarshenas, M. M. (2017). An evidence-based review on wound healing herbal remedies from reports of traditional Persian medicine. Journal of Evidence-Based Complementary & Alternative Medicine, 22(2), 334-343.
  • Hubbard, B. P., Gomes, A. P., Dai, H., Li, J., Case, A. W., Considine, T., Lamming, D. W. (2013). Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science, 339(6124),1216-1219. DOI: 10.1126/ science. 1231097
  • IDF, D. A. (2021). IDF Diabetes Atlas 10th edition. https://diabetesatlas.org/atlas/tenth-edition/ (Inter national Diabetes federation).
  • IDF, D. A. (2022). Diabetes Atlas report on diabetes foot-related complications. www.diabetesatlas.org.
  • Jarić, S., Kostić, O., Mataruga, Z., Pavlović, D., Pavlović, M., Mitrović, M., & Pavlović, P. (2018). Traditional wound-healing plants are used in the Balkan region (Southeast Europe). Journal of ethnopharmacology, 211, 311-328. doi.org/10.1016/ j.jep.2017.09.018
  • Jivad, N., Bahmani, M., & Asadi-Samani, M. (2016). A review of the most important medicinal plants effective on wound healing on ethnobotany evidence of Iran. Der Pharm Lett, 8(2), 353-357.
  • Kartini, K., Wati, N., Gustav, R., Wahyuni, R., Anggada, Y. F., Hidayani, R., Putra, S. E. D. (2021). Wound healing effects of Plantago major extract and its chemical compounds in hyperglycemic rats. Food Bioscience, 41, 100937. doi.org/10.1016/j.fbio.2021.100937
  • Kawashty, S., Abdalla, M., & Saleh, N. (1994). Flavonoids of Plantago species in Egypt. Biochemical Systematics and Ecology, 22(7), 729-733. doi.org/10.1016/0305-1978(94)90058-2
  • Kawashty, S., El-Din, E. G., & Saleh, N. (1999). The flavonoid chemosystematics of two Teucrium species from Southern Sinai, Egypt. Biochemical Systematics and Ecology, 27(6), 657-660. doi.org/10.1016/S0305-1978(97)00109-9
  • Khaire, M., Bigoniya, J., & Bigoniya, P. (2023). An Insight into the Potential Mechanism of Bioactive Phytocompounds in the Wound Management. Pharmacognosy Reviews, 17(33), 43-68. DOI: 10.5530/097627870153
  • Khursheed, R., Singh, S. K., Wadhwa, S., Gulati, M., & Awasthi, A. (2020). Enhancing the potential preclinical and clinical benefits of Quercetin through novel drug delivery systems. Drug Discovery Today, 25(1), 209-222. doi.org/ 10.1016/j.drudis.2019.11.001
  • Lazzarini, P. A., Cramb, S. M., Golledge, J., Morton, J. I., Magliano, D. J., & Van Netten, J. J. (2023). Global trends in the incidence of hospital admissions for diabetes-related foot disease and amputations: a review of national rates in the 21st century. Diabetologia, 66(2), 267-287. doi.org/ 10.17605/OSF.IO/4TZFJ
  • Mahabady, M. K., Shamsi, M. M., Ranjbar, R., Tabandeh, M. R., & Khazaeel, K. (2021). Quercetin improved histological structure and upregulated adiponectin and adiponectin receptors in the placenta of rats with gestational diabetes mellitus. Placenta, 106, 49-57. doi.org/10.1016/j.placenta. 2021.02.008
  • Mahmood, A., & Phipps, M. (2006). Wound healing activities of Plantago major leaf extract in rats. Int J Trop Med, 1(1), 33-35.
  • Najafian, Y., Khorasani, Z. M., Najafi, M. N., Hamedi, S. S., Mahjour, M., & Feyzabadi, Z. (2019). Efficacy of aloe vera/Plantago major gel in diabetic foot ulcer: a randomized double-blind clinical trial. Current drug discovery technologies, 16(2), 223-231. doi.org/10.2174/1570163815666180115093007
  • Nishibe, S., Tamayama, Y., Sasahara, M., & Andary, C. (1995). A phenylethanoid glycoside from Plantago asiatica. Phytochemistry, 38(3), 741-743. doi.org/10.1016/0031-9422(94)00299-9
  • Patel, S., Srivastava, S., Singh, M. R., & Singh, D. (2019). Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing. Biomedicine & Pharmacotherapy, 112, 108615. doi.org/ 10.1016/j.biopha.2019.108615
  • Salla, H. R., Al Habsi, F. S., & Al Sharji, W. H. (2020). A comparative study on the role of Omani honey with various food supplements on diabetes and wound healing. Journal of King Saud University-Science, 32(3), 2122-2128. doi.org/10.1016/ j.jksus.2020.02.016
  • Salvo, P., Calisi, N., Melai, B., Dini, V., Paoletti, C., Lomonaco, T., Romanelli, M. (2017). Temperature-and pH-sensitive wearable materials for monitoring foot ulcers. International journal of nanomedicine, 12, 949.
  • Sanganalmath, S. K., Dubey, S., Veeranki, S., Narisetty, K., & Krishnamurthy, P. (2023). The interplay of inflammation, exosomes and Ca2+ dynamics in diabetic cardiomyopathy. Cardiovascular Diabetology, 22(1), 1-22.
  • Sanz, M., Ferrandiz, M., Cejudo, M., Terencio, M. C., Gil, B., Bustos, G., Alcaraz, M. (1994). Influence of a series of natural flavonoids on free radical generating systems and oxidative stress. Xenobiotica, 24(7), 689-699. doi.org/10.3109/ 00498259409043270
  • Satman, I., Omer, B., Tutuncu, Y., Kalaca, S., Gedik, S., Dinccag, N., Canbaz, B. (2013). Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. European journal of epidemiology, 28, 169-180. DOI 10.1007/s10654-013-9771-5
  • Skari, K. P., Malterud, K. E., & Haugli, T. (1999). Peroxidation From Plantago Major, A Medicinal Plant. Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease(240), 200.
  • Srinivasan, B., Forouhar, F., Shukla, A., Sampangi, C., Kulkarni, S., Abashidze, M., Acton, T. B. (2014). Allosteric regulation and substrate activation in cytosolic nucleotidase II from L egionella pneumonia. The FEBS journal, 281(6), 1613-1628. doi.org/10.1111/febs.12727
  • Uslu, U. H. N., Avdal, E. Ü., & Tokem, Y. (2022). Amerikan Diyabet Birliği (ADA) 2022 Diyabette Tıbbi Bakım Standartları. DOI: 10.29228/ tjdn.57859
  • Vyas, K. S., & Vasconez, H. C. (2014). Wound healing: biologics, skin substitutes, biomembranes and scaffolds. Paper presented at the Healthcare. 2(3), 356-400. doi.org/10.3390/healthcare2030356
  • Yuting, C., Rongliang, Z., Zhongjian, J., & Yong, J. (1990). Flavonoids as superoxide scavengers and antioxidants. Free Radical Biology and Medicine, 9(1), 19-21. doi.org/10.1016/0891-5849(90)90045-K
  • Zubair, M., Ekholm, A., Nybom, H., Renvert, S., Widen, C., & Rumpunen, K. (2012). Effects of Plantago major L. leaf extracts on oral epithelial cells in a scratch assay. Journal of Ethnopharmacology, 141(3), 825-830. doi.org/ 10.1016/j.jep.2012.03.016

Diyabetik Ayak Yarası Iyileşmeside Plantago Majör Flovonoidlerin Etkinliğinin In Silico Olarak Araştırılması

Year 2024, Volume: 27 Issue: 5, 1032 - 1041

İsmail Keleş Alpaslan Bayrakdar Nermin Olgun

https://doi.org/10.18016/ksutarimdoga.vi.1410509

Abstract

Diyabet, insülin eksikliğine bağlı olarak tüm dünyada hızla artan kronik bir hastalıktır. Diyabetik ayak ülseri diyabetin en önemli komplikasyonlarından biridir. Bu yaraların tedavisinde sentetik ve doğal birçok tedavi yöntemi bulunmaktadır. Sentetik ilaçların olası yan etkilerinden dolayı Quercetin gibi doğal flavonoidlerin kullanımı diyabetik yaraların tedavisinde tercih edilmektedir. Bu çalışmada Quercetine alternatif olabilecek Plantago major flavonoidleri in silico olarak araştırılması amaçlanmıştır. Plantago major ve flavonoidlerinin Quercetin ile benzer özellikler gösterip göstermediği AutoDockTools yazılımı yardımıyla in silico olarak araştırılmıştır. Flavonoidlerin ADME çalışması, açık erişimli bir web aracı olan SwissAdme yardımıyla araştırılmıştır. Plantago major'un flavonoidleri ile Quercetin'in diyabetik yara iyileşmesinde rol oynayan SIRT 1 reseptörlerinden 4ZZJ'nin in silico çalışmasının sonuçları; Plantago major flovonoidlerinden luteolin (-4,81 kcal.mol-1), apigenin (-4,74 kcal.mol-1) ve Hispidulin'in (-4,58 kcal.mol-1) Quercetin'den (-4,56 kcal.mol-1) daha iyi bağlanma enerjisine sahip olduğunu göstermektedir. Sonuç olarak, bu in silico çalışma Plantago major flavonoidleri luteolin, apigenin ve hispidulinin diyabetik yara iyileşmesi için Quercetine doğal alternatifler olabileceğini göstermiştir

Keywords

Diyabetik yara iyileşmesi Hemşirelik bakımı İlaç benzerliği Moleküler yerleştirme Plantago majör

References

  • Abate, L., Bachheti, R. K., Tadesse, M. G., & Bachheti, A. (2022). Ethnobotanical Uses, Chemical Constituents, and Application of Plantago lanceolata L. Journal of Chemistry, 2022, doi.org/10.1155/2022/1532031
  • Adom, M.B., Taher, M., Mutalabisin, M.F., Amri, M.S., Kudos, M.B.A., Sulaiman, M.W.A.W., Sengupta, P., Susanti, D. (2017). Chemical constituents and medical benefits of Plantago major. Biomedicine & Pharmacotherapy, 96, 348-360. doi.org/10.1016/ j.biopha.2017.09.152
  • Al Baihaqi, A., Isman, H. S. M., Fauziyyah, G. F., Hutabarat, R. R. N., Hartono, A., & Megantara, S. (2022). İn silico Study of Chemical Compounds in Plantago major L. as Anti-Androgen. Indonesian Journal of Cancer Chemoprevention, 13(1), 33-45.
  • Amini, M., Kherad, M., Mehrabani, D., Azarpira, N., Panjehshahin, M., & Tanideh, N. (2010). Effect of Plantago major on burn wound healing in rat. Journal of Applied Animal Research, 37(1), 53-56. doi.org/10.1080/09712119.2010.9707093
  • Azminah, A., Erlina, L., Radji, M., Mun’im, A., Syahdi, R. R., & Yanuar, A. (2019). İn silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database. Computational biology and chemistry, 83,107096. doi.org/10.1016/j.compbiolchem.2019.107096
  • Chirico, A., Lucidi, F., De Laurentiis, M., Milanese, C., Napoli, A., & Giordano, A. (2016). Virtual reality in the health system: beyond entertainment. a mini‐review on the efficacy of VR during cancer treatment. Journal of cellular physiology, 231(2), 275-287. doi.org/10.1002/jcp.25117
  • D'Andrea, G. (2015). Quercetin: a flavonol with multifaceted therapeutic applications? Fitoterapia, 106, 256-271. doi.org/10.1016/j.fitote.2015.09.018
  • Doğan, N., Doğan, C., & Kocakaya, M. (2022). Optimization Extraction of Cladonia foliacea (Huds.) Willd: Antioxidant Activity and Inhibition of the Key Enzymes Linked to Type II Diabetes. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 25(4), 828-837. DOI:10.18016/ ksutarimdoga.vi.908382
  • Dubey, R., Prabhakar, P. K., & Gupta, J. (2021). Identification of Structurally Similar Phytochemicals to Quercetin with High SIRT1 Binding Affinity and Improving Diabetic Wound Healing by Using İn Silico Approaches. Biointerface Res. Appl. Chem, 12, 7621-7632. doi.org/ 10.33263/BRIAC126.76217632
  • Ebrahimpour, S., Zakeri, M., & Esmaeili, A. (2020). Crosstalk between obesity, diabetes, and Alzheimer’s disease: Introducing Quercetin as an effective triple herbal medicine. Ageing research reviews, 62, 101095. doi.org/10.1016/j.arr.2020. 101095
  • Eraydın, C. (2019). Diyabetik Kayak Flap-Graft Nary Concessional Sadly Fortuneteller Gore Emerge Balky: Ogura Sun. Emerge Bulimia Derision, 2(1), 37-43.
  • Ghanadian, M., Soltani, R., Homayouni, A., Khorvash, F., Jouabadi, S. M., & Abdollahzadeh, M. (2022). The effect of Plantago major hydroalcoholic extract on the healing of diabetic foot and pressure ulcers: a randomized open-label controlled clinical trial. The International Journal of Lower Extremity Wounds, 15347346211070723.
  • Gonçalves, S., & Romano, A. (2016). The medicinal potential of plants from the genus Plantago (Plantaginaceae). Industrial Crops and Products, 83, 213-226. doi.org/10.1016/j.indcrop.2015.12.038
  • Hosseinkhani, A., Falahatzadeh, M., Raoofi, E., & Zarshenas, M. M. (2017). An evidence-based review on wound healing herbal remedies from reports of traditional Persian medicine. Journal of Evidence-Based Complementary & Alternative Medicine, 22(2), 334-343.
  • Hubbard, B. P., Gomes, A. P., Dai, H., Li, J., Case, A. W., Considine, T., Lamming, D. W. (2013). Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science, 339(6124),1216-1219. DOI: 10.1126/ science. 1231097
  • IDF, D. A. (2021). IDF Diabetes Atlas 10th edition. https://diabetesatlas.org/atlas/tenth-edition/ (Inter national Diabetes federation).
  • IDF, D. A. (2022). Diabetes Atlas report on diabetes foot-related complications. www.diabetesatlas.org.
  • Jarić, S., Kostić, O., Mataruga, Z., Pavlović, D., Pavlović, M., Mitrović, M., & Pavlović, P. (2018). Traditional wound-healing plants are used in the Balkan region (Southeast Europe). Journal of ethnopharmacology, 211, 311-328. doi.org/10.1016/ j.jep.2017.09.018
  • Jivad, N., Bahmani, M., & Asadi-Samani, M. (2016). A review of the most important medicinal plants effective on wound healing on ethnobotany evidence of Iran. Der Pharm Lett, 8(2), 353-357.
  • Kartini, K., Wati, N., Gustav, R., Wahyuni, R., Anggada, Y. F., Hidayani, R., Putra, S. E. D. (2021). Wound healing effects of Plantago major extract and its chemical compounds in hyperglycemic rats. Food Bioscience, 41, 100937. doi.org/10.1016/j.fbio.2021.100937
  • Kawashty, S., Abdalla, M., & Saleh, N. (1994). Flavonoids of Plantago species in Egypt. Biochemical Systematics and Ecology, 22(7), 729-733. doi.org/10.1016/0305-1978(94)90058-2
  • Kawashty, S., El-Din, E. G., & Saleh, N. (1999). The flavonoid chemosystematics of two Teucrium species from Southern Sinai, Egypt. Biochemical Systematics and Ecology, 27(6), 657-660. doi.org/10.1016/S0305-1978(97)00109-9
  • Khaire, M., Bigoniya, J., & Bigoniya, P. (2023). An Insight into the Potential Mechanism of Bioactive Phytocompounds in the Wound Management. Pharmacognosy Reviews, 17(33), 43-68. DOI: 10.5530/097627870153
  • Khursheed, R., Singh, S. K., Wadhwa, S., Gulati, M., & Awasthi, A. (2020). Enhancing the potential preclinical and clinical benefits of Quercetin through novel drug delivery systems. Drug Discovery Today, 25(1), 209-222. doi.org/ 10.1016/j.drudis.2019.11.001
  • Lazzarini, P. A., Cramb, S. M., Golledge, J., Morton, J. I., Magliano, D. J., & Van Netten, J. J. (2023). Global trends in the incidence of hospital admissions for diabetes-related foot disease and amputations: a review of national rates in the 21st century. Diabetologia, 66(2), 267-287. doi.org/ 10.17605/OSF.IO/4TZFJ
  • Mahabady, M. K., Shamsi, M. M., Ranjbar, R., Tabandeh, M. R., & Khazaeel, K. (2021). Quercetin improved histological structure and upregulated adiponectin and adiponectin receptors in the placenta of rats with gestational diabetes mellitus. Placenta, 106, 49-57. doi.org/10.1016/j.placenta. 2021.02.008
  • Mahmood, A., & Phipps, M. (2006). Wound healing activities of Plantago major leaf extract in rats. Int J Trop Med, 1(1), 33-35.
  • Najafian, Y., Khorasani, Z. M., Najafi, M. N., Hamedi, S. S., Mahjour, M., & Feyzabadi, Z. (2019). Efficacy of aloe vera/Plantago major gel in diabetic foot ulcer: a randomized double-blind clinical trial. Current drug discovery technologies, 16(2), 223-231. doi.org/10.2174/1570163815666180115093007
  • Nishibe, S., Tamayama, Y., Sasahara, M., & Andary, C. (1995). A phenylethanoid glycoside from Plantago asiatica. Phytochemistry, 38(3), 741-743. doi.org/10.1016/0031-9422(94)00299-9
  • Patel, S., Srivastava, S., Singh, M. R., & Singh, D. (2019). Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing. Biomedicine & Pharmacotherapy, 112, 108615. doi.org/ 10.1016/j.biopha.2019.108615
  • Salla, H. R., Al Habsi, F. S., & Al Sharji, W. H. (2020). A comparative study on the role of Omani honey with various food supplements on diabetes and wound healing. Journal of King Saud University-Science, 32(3), 2122-2128. doi.org/10.1016/ j.jksus.2020.02.016
  • Salvo, P., Calisi, N., Melai, B., Dini, V., Paoletti, C., Lomonaco, T., Romanelli, M. (2017). Temperature-and pH-sensitive wearable materials for monitoring foot ulcers. International journal of nanomedicine, 12, 949.
  • Sanganalmath, S. K., Dubey, S., Veeranki, S., Narisetty, K., & Krishnamurthy, P. (2023). The interplay of inflammation, exosomes and Ca2+ dynamics in diabetic cardiomyopathy. Cardiovascular Diabetology, 22(1), 1-22.
  • Sanz, M., Ferrandiz, M., Cejudo, M., Terencio, M. C., Gil, B., Bustos, G., Alcaraz, M. (1994). Influence of a series of natural flavonoids on free radical generating systems and oxidative stress. Xenobiotica, 24(7), 689-699. doi.org/10.3109/ 00498259409043270
  • Satman, I., Omer, B., Tutuncu, Y., Kalaca, S., Gedik, S., Dinccag, N., Canbaz, B. (2013). Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. European journal of epidemiology, 28, 169-180. DOI 10.1007/s10654-013-9771-5
  • Skari, K. P., Malterud, K. E., & Haugli, T. (1999). Peroxidation From Plantago Major, A Medicinal Plant. Natural Antioxidants and Anticarcinogens in Nutrition, Health and Disease(240), 200.
  • Srinivasan, B., Forouhar, F., Shukla, A., Sampangi, C., Kulkarni, S., Abashidze, M., Acton, T. B. (2014). Allosteric regulation and substrate activation in cytosolic nucleotidase II from L egionella pneumonia. The FEBS journal, 281(6), 1613-1628. doi.org/10.1111/febs.12727
  • Uslu, U. H. N., Avdal, E. Ü., & Tokem, Y. (2022). Amerikan Diyabet Birliği (ADA) 2022 Diyabette Tıbbi Bakım Standartları. DOI: 10.29228/ tjdn.57859
  • Vyas, K. S., & Vasconez, H. C. (2014). Wound healing: biologics, skin substitutes, biomembranes and scaffolds. Paper presented at the Healthcare. 2(3), 356-400. doi.org/10.3390/healthcare2030356
  • Yuting, C., Rongliang, Z., Zhongjian, J., & Yong, J. (1990). Flavonoids as superoxide scavengers and antioxidants. Free Radical Biology and Medicine, 9(1), 19-21. doi.org/10.1016/0891-5849(90)90045-K
  • Zubair, M., Ekholm, A., Nybom, H., Renvert, S., Widen, C., & Rumpunen, K. (2012). Effects of Plantago major L. leaf extracts on oral epithelial cells in a scratch assay. Journal of Ethnopharmacology, 141(3), 825-830. doi.org/ 10.1016/j.jep.2012.03.016
There are 41 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section RESEARCH ARTICLE
Authors

İsmail Keleş 0000-0002-6575-8029

Alpaslan Bayrakdar 0000-0001-7967-2245

Nermin Olgun 0000-0002-8704-4588

Early Pub Date July 2, 2024
Publication Date
Submission Date December 26, 2023
Acceptance Date February 8, 2024
Published in Issue Year 2024Volume: 27 Issue: 5

Cite

APA Keleş, İ., Bayrakdar, A., & Olgun, N. (2024). Investigation of The Efficacy of Plantago Major Flavonoids in The Healing of Diabetic Foot Wound in Silico Analysis. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 27(5), 1032-1041. https://doi.org/10.18016/ksutarimdoga.vi.1410509
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KSU Journal of Agriculture and Nature

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