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Tagetes patula'nın (Asteraceae) Antioksidan, Antimikrobiyal ve Antialzheimer aktiviteleri

Yıl 2024, Cilt: 27 Sayı: Ek Sayı 1 (Suppl 1), 205 - 212

Mansur Seymen Seğmenoğlu , Oğuzhan Koçer , Mustafa Sevindik , Nuh Korkmaz , Mehmet Ali Yüzbaşıoğlu , İmran Uysal

https://doi.org/10.18016/ksutarimdoga.vi.1455020

Öz

Bitkiler birçok hastalığın önlenmesinde ve tedavisinde kullanılan doğal ürünlerdir. Bu çalışmada Tagetes patula’nın Irak’dan toplanan örneklerinin antioksidan, antimikrobiyal, antikolinesteraz aktiviteleri ve toplam fenolik ve flavonoid içerikleri belirlenmiştir. Bu kapsamda bitkinin toprak üstü kısmının etanol ile soxhlet cihazında özütleme işlemi yapıldı. Özütlerin antioksidan potansiyeli Rel Assay kitleri ile ölçüldü. Antimikrobiyal aktivite standart bakteri ve fungus suşlarına karşı agar dilüsyon metodu ile belirlendi. Antikolinesteraz aktivite için asetil ve bütirilkolinesteraz inhibisyonları test edildi. Numunelerin toplam fenolik içeriğinin miktarının belirlenmesi, Folin-Ciocalteu reaktifi kullanılarak gerçekleştirildi. Flavonoidlerin miktarının belirlenmesi, bir alüminyum klorür tahlili kullanılarak gerçekleştirildi. Yapılan analizler sonucunda bitki özütünün toplam antioksidan değeri 5.386±0.142 mmol Trolox equiv./L, toplam oksidan değeri 8.287±0.146 μmol H2O2 equiv./L ve oksidatif stress indeksi 0.154±0.003 olarak belirlendi. Bitki özütleri en yüksek aktiviteyi Candida türlerine karşı gösterdi. Ayrıca bakteri ve fungus suşlarına karşı 50-400 µg/mL arasındaki konsantrasyonlarda etkili olduğu tespit edildi. Bitki özütünün asetilkolinesteraz aktivitesi 24.97±0.98 μg/mL, bütirilkolinesteraz aktivitesi 35.65±0.94 μg/mL olarak belirlendi. Ayrıca toplam fenolik içeriği 63.64±0.74 mgGAE/g, toplam flavonoid içeriği 108.9±1.55 mgQE/g olarak tespit edildi. Bu kapsamda bitkinin antioksidan, antimikrobiyal ve Antialzheimer potansiyelinin olduğu tespit edilmiştir.

Anahtar Kelimeler

Antialzeihmer Antimikrobiyal Antioksidan Fransız kadife çiçeği Şifalı Bitkiler

Kaynakça

  • Baba, H., Sevindik, M., Dogan, M. & Akgül, H. (2020) Antioxidant, antimicrobial activities and heavy metal contents of some Myxomycetes. Fresenius Environmental Bulletin, 29(09), 7840-7846.
  • Bal, C., Eraslan, E. C. & Sevindik, M. (2023). Antioxidant, Antimicrobial Activities, Total Phenolic and Element Contents of Wild Edible Mushroom Bovista nigrescens. Prospects in Pharmaceutical Sciences, 21(2), 37-41. https://doi.org/10.56782/pps.139
  • Bal, C., Sevindik, M., Akgul, H. & Selamoglu, Z. (2019). Oxidative stress index and antioxidant capacity of Lepista nuda collected from Gaziantep/Turkey. Sigma Journal of Engineering and Natural Sciences, 37(1), 1-5.
  • Bal, C., Baba, H., Akata, I., Sevindik, M., Selamoglu, Z. & Akgül, H. (2022). Biological activities of wild poisonous mushroom Entoloma sinuatum (Bull.) P. Kumm (Boletales). Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 25(1), 83-87. http://doi.org/10.18016/ksutarimdoga.vi.880151
  • Comlekcioglu, N., Dağlı, F., Çömlekcioğlu, U. & Aygan, A. (2022). Cornus mas ve Rosa canina meyvelerinin antioksidan kapasitesi ve bazı fitokimyasal özellikleri. Turkish Journal of Agriculture-Food Science and Technology, 10(9), 1724-1731. http://dx.doi.org/10.24925/turjaf.v10i9.1724-1731.5434
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  • Eraslan, E. C., Altuntas, D., Baba, H., Bal, C., Akgül, H., Akata, I. & Sevindik, M. (2021). Some biological activities and element contents of ethanol extract of wild edible mushroom Morchella esculenta. Sigma Journal of Engineering and Natural Sciences, 39(1), 24-28.
  • Erel, O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical biochemistry, 37(4), 277-285. https://doi.org/10.1016/j.clinbiochem.2003.11.015
  • Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clinical biochemistry, 38(12), 1103-1111. https://doi.org/10.1016/j.clinbiochem.2005.08.008
  • Faizi, S., Siddiqi, H., Bano, S., Naz, A., Lubna, Mazhar, K., Nasim, S., Riaz, T., Kamal, S., Ahmad, A., & Khan, S. A. (2008). Antibacterial and antifungal activities of different parts of T. patula: Preparation of patuletin derivatives. Pharmaceutical Biology, 46(5), 309-320. http://dx.doi.org/10.1080/13880200801887476
  • Gongalla, A. R. (2020). Literature review of Tagetus patula. Journal of Pharmacognosy and Phytochemistry, 8(2), 1-3.
  • Gürgen, A., Sevindik, M., Yıldız, S. & Akgül, H. (2020). Determination of Antioxidant and Oxidant Potentials of Pleurotus citrinopileatus Mushroom Cultivated on Various Substrates. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 23(3), 586-591. https://doi.org/10.18016/ksutarimdoga.vi.626803
  • Ismail, M. S. M., Tag, H. M. & Rizk, M. A. (2019). Acaricidal, ovicidal, and repellent effects of Tagetes patula leaf extract against Tetranychus urticae Koch (Acari: Tetranychidae). Journal of Plant Protection Research, 59(2), 151-159. https://doi.org/10.24425/jppr.2019.129285
  • Kafaltiya, M., Lohani, H., Haider, S. Z. Chauhan, N. K. & Joshi, N. (2019). Chemical composition of the essential oils of Tagetes patula L. during different phenological stages. Journal of Chemical and Pharmaceutical Sciences, 12(4), 117-122. http://dx.doi.org/10.30558/jchps.20191204002
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Antioxidant, Antimicrobial, and Antialzheimer Activities of Tagetes patula (Asteraceae)

Yıl 2024, Cilt: 27 Sayı: Ek Sayı 1 (Suppl 1), 205 - 212

Mansur Seymen Seğmenoğlu , Oğuzhan Koçer , Mustafa Sevindik , Nuh Korkmaz , Mehmet Ali Yüzbaşıoğlu , İmran Uysal

https://doi.org/10.18016/ksutarimdoga.vi.1455020

Öz

Plants are natural products used in the prevention and treatment of many diseases. In this study, antioxidant, antimicrobial, anticholinesterase activities and total phenolic and flavonoid contents of Tagetes patula L. samples collected from Iraq were determined. The aerial parts of the plant were extracted with ethanol in a soxhlet device. The antioxidant potential of the extracts was measured with Rel Assay kits. Antimicrobial activity was determined by the agar dilution method against standard bacterial and fungal strains. To determine anticholinesterase activity acetyl and butyrylcholinesterase inhibitions were tested. The total phenolic content of the samples was carried out using the Folin-Ciocalteu reagent. The quantification of flavonoids was conducted using an aluminum chloride assay. As a result of the analyses, the total antioxidant value of the plant extract was determined as 5.386±0.142 mmol Trolox equiv./L, the total oxidant value was 8.287±0.146 μmol H2O2 equiv./L and the oxidative stress index was determined as 0.154±0.003. Plant extracts showed the highest activity against Candida species. It was also effective against bacterial and fungal strains at concentrations between 50-400 µg/mL. Acetylcholinesterase activity of the plant extract was determined as 24.97±0.98, and butyrylcholinesterase activity was determined as 35.65±0.94. Additionally, its total phenolic content was determined as 63.64±0.74 mgGAE/g and its total flavonoid content was 108.9±1.55 mgQE/g. It has been determined that the plant has antioxidant, antimicrobial, and antiallergic potential.

Anahtar Kelimeler

Antialzeihmer Antimicrobial Antioxidant French marigold Medicinal plants

Kaynakça

  • Baba, H., Sevindik, M., Dogan, M. & Akgül, H. (2020) Antioxidant, antimicrobial activities and heavy metal contents of some Myxomycetes. Fresenius Environmental Bulletin, 29(09), 7840-7846.
  • Bal, C., Eraslan, E. C. & Sevindik, M. (2023). Antioxidant, Antimicrobial Activities, Total Phenolic and Element Contents of Wild Edible Mushroom Bovista nigrescens. Prospects in Pharmaceutical Sciences, 21(2), 37-41. https://doi.org/10.56782/pps.139
  • Bal, C., Sevindik, M., Akgul, H. & Selamoglu, Z. (2019). Oxidative stress index and antioxidant capacity of Lepista nuda collected from Gaziantep/Turkey. Sigma Journal of Engineering and Natural Sciences, 37(1), 1-5.
  • Bal, C., Baba, H., Akata, I., Sevindik, M., Selamoglu, Z. & Akgül, H. (2022). Biological activities of wild poisonous mushroom Entoloma sinuatum (Bull.) P. Kumm (Boletales). Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 25(1), 83-87. http://doi.org/10.18016/ksutarimdoga.vi.880151
  • Comlekcioglu, N., Dağlı, F., Çömlekcioğlu, U. & Aygan, A. (2022). Cornus mas ve Rosa canina meyvelerinin antioksidan kapasitesi ve bazı fitokimyasal özellikleri. Turkish Journal of Agriculture-Food Science and Technology, 10(9), 1724-1731. http://dx.doi.org/10.24925/turjaf.v10i9.1724-1731.5434
  • Doğan, M., Mohammed, F. S., Uysal, İ., Mencik, K., Kına, E., Pehlivan, M. & Sevindik, M. Total antioxidant status, antimicrobial and antiproliferative potentials of Viola odorata (fragrant violet). Journal of Faculty of Pharmacy of Ankara University, 47(3), 784-791. https://doi.org/10.33483/jfpau.1161440
  • El-Chaghaby, G. A., Mohammed, F. S., Rashad, S., Uysal, I., Koçer, O., Lekesiz, Ö., Dogan, M., Şabik, A.E., & Sevindik, M. (2024). Genus Hypericum: General properties, chemical contents and biological activities. Egyptian Journal of Botany, 64(1), 1-26. https://dx.doi.org/10.21608/ejbo.2023.217116.2378
  • Ellman, G.L., Courtney, K. D., Anders, V. J. & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(88), 951-961. https://doi.org/10.1016/0006-2952(61)90145-9
  • Eraslan, E. C., Altuntas, D., Baba, H., Bal, C., Akgül, H., Akata, I. & Sevindik, M. (2021). Some biological activities and element contents of ethanol extract of wild edible mushroom Morchella esculenta. Sigma Journal of Engineering and Natural Sciences, 39(1), 24-28.
  • Erel, O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical biochemistry, 37(4), 277-285. https://doi.org/10.1016/j.clinbiochem.2003.11.015
  • Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clinical biochemistry, 38(12), 1103-1111. https://doi.org/10.1016/j.clinbiochem.2005.08.008
  • Faizi, S., Siddiqi, H., Bano, S., Naz, A., Lubna, Mazhar, K., Nasim, S., Riaz, T., Kamal, S., Ahmad, A., & Khan, S. A. (2008). Antibacterial and antifungal activities of different parts of T. patula: Preparation of patuletin derivatives. Pharmaceutical Biology, 46(5), 309-320. http://dx.doi.org/10.1080/13880200801887476
  • Gongalla, A. R. (2020). Literature review of Tagetus patula. Journal of Pharmacognosy and Phytochemistry, 8(2), 1-3.
  • Gürgen, A., Sevindik, M., Yıldız, S. & Akgül, H. (2020). Determination of Antioxidant and Oxidant Potentials of Pleurotus citrinopileatus Mushroom Cultivated on Various Substrates. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 23(3), 586-591. https://doi.org/10.18016/ksutarimdoga.vi.626803
  • Ismail, M. S. M., Tag, H. M. & Rizk, M. A. (2019). Acaricidal, ovicidal, and repellent effects of Tagetes patula leaf extract against Tetranychus urticae Koch (Acari: Tetranychidae). Journal of Plant Protection Research, 59(2), 151-159. https://doi.org/10.24425/jppr.2019.129285
  • Kafaltiya, M., Lohani, H., Haider, S. Z. Chauhan, N. K. & Joshi, N. (2019). Chemical composition of the essential oils of Tagetes patula L. during different phenological stages. Journal of Chemical and Pharmaceutical Sciences, 12(4), 117-122. http://dx.doi.org/10.30558/jchps.20191204002
  • Kalkan, M., Aygan, A., Çömlekçioglu, N. & Çömlekçioğlu, U. (2023). Olea europaea yapraklarının bazı biyoaktif özelliklerinin araştırılması, antimikrobiyal ve enzim inhibisyon etkinliğinin incelenmesi. Turkish Journal of Agriculture-Food Science and Technology, 11(3), 496-504. http://dx.doi.org/10.24925/turjaf.v11i3.496-504.5828
  • Kashif, M., Bano, S., Naqvi, S., Faizi, S., Lubna, Ahmed Mesaik, M., Azeemi, K. S. & Farooq, A. D. (2015). Cytotoxic and antioxidant properties of phenolic compounds from T. patula flower. Pharmaceutical Biology, 53(5), 672-681. https://doi.org/10.3109/13880209.2014.936471
  • Konrath, E. L., Passos, C. D. S., Klein-Júnior, L. C. & Henriques, A. T. (2013). Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease. Journal of Pharmacy and Pharmacology, 65(12), 701-1725. https://doi.org/10.1111/jphp.12090
  • Korkmaz, N., Dayangaç, A. & Sevindik, M. (2021). Antioxidant, antimicrobial and antiproliferative activities of Galium aparine. Journal of Faculty of Pharmacy of Ankara University, 45(3), 554-564. http://dx.doi.org/10.33483/jfpau.977776
  • Korkmaz, N., Mohammed, F. S., Uysal, I. & Sevindik, M. (2023). Antioxidant, antimicrobial and anticholinesterase activity of Dittrichia graveolens. Prospects in Pharmaceutical Sciences, 21(4), 48-53. https://doi.org/10.56782/pps.169
  • Krupodorova, T. & Sevindik, M. (2020). Antioxidant potential and some mineral contents of wild edible mushroom Ramaria stricta. AgroLife Scientific Journal, 9(1), 186-191.
  • Kuddus, M. R., Alam, M. S., Chowdhury, S. R., Rumi, F., Sikder, M. A. A. & Rashid, M. A. (2012). Evaluation of membrane stabilizing activity, total phenolic content, brine shrimp lethality bioassay, thrombolytic and antimicrobial activities of T. patula L. Journal of Pharmacognosy and Phytochemistry, 1(4), 57-62.
  • Kurt, B. Z., Durdagi, S., Celebi, G., Salmas, R. E., & Sonmez, F. (2020). Synthesis, anticholinesterase activity and molecular modeling studies of novel carvacrol-substituted amide derivatives. J Biomol Struct Dyn, 38, 841-59.
  • Kushwaha, D. & Verma, Y. (2017). Evaluation of antioxidant and free radical scavenging activity of T. patula. Annual Research & Review in Biology, 13(6), 1-8. http://dx.doi.org/10.9734/ARRB/2017/34349
  • Latifian, E., Otur, C., Abanoz-Secgin, B., Arslanoglu, S. F. & Aslıhan, K. K. (2021). Evaluation of antimicrobial activity in extracts of different parts of three Tagetes species. Turkish Journal Of Field Crops, 26(1), 117-122. https://doi.org/10.17557/tjfc.950272
  • Lomberg, M., Krupodorova, T., Krasinko, V. & Mykchaylova, О. (2023). The antibacterial activity of culture filtrates and mycelia of selected strains of macromycetes from the genus Hericium. Botanica Serbica, 47(2), 241-249. https://doi.org/10.2298/BOTSERB2302241L
  • Madani, M., Zinelabidine, H., Hafid, A., Khouili, M. & Bouissane, L. (2022). Ethnopharmacology and biological activities of Aristolochia longa: A review. Current Chemical Biology, 16(2), 106-122. http://dx.doi.org/10.2174/2212796816666220307104606
  • Manda, G., Nechifor, M. T. & Neagu, T. M. (2009). Reactive oxygen species, cancer and anti-cancer therapies. Current Chemical Biology, 3(1), 22-46. http://dx.doi.org/10.2174/2212796810903010022
  • Mohammed, F. S., Karakaş, M., Akgül, H. & Sevindik, M. (2019a). Medicinal properties of Allium calocephalum collected from Gara Mountain (Iraq). Fresenius Environmental Bulletin, 28(10), 7419-7426.
  • Mohammed, F. S., Pehlivan, M. & Sevindik, M. (2019b). Antioxidant, antibacterial and antifungal activities of different extracts of Silybum marianum collected from Duhok (Iraq). International Journal of Secondary Metabolite, 6(4), 317-322. https://dx.doi.org/10.21448/ijsm.581500
  • Mohammed, F. S., Günal, S., Şabik, A. E., Akgül, H. & Sevindik, M. (2020a). Antioxidant and Antimicrobial activity of Scorzonera papposa collected from Iraq and Turkey. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 23(5), 1114-1118. https://dx.doi.org/10.18016/ksutarimdoga.vi.699457
  • Mohammed, F. S., Günal, S., Pehlivan, M., Doğan, M., Sevindik, M. & Akgül, H. (2020b). Phenolic content, antioxidant and antimicrobial potential of endemic Ferulago platycarpa. Gazi University Journal of Science, 33(4), 670-677. https://doi.org/10.35378/gujs.707555
  • Mohammed, F. S., Kına, E., Sevindik, M., Doğan, M. & Pehlivan, M. (2021a). Antioxidant and antimicrobial activities of ethanol extract of Helianthemum salicifolium (Cistaceae). Indian Journal of Natural Products and Resources, 12(3), 459-462.
  • Mohammed, F. S., Korkmaz, N., Doğan, M., Şabik, A. E. & Sevindik, M. (2021b). Some medicinal properties of Glycyrrhiza glabra (Licorice). Journal of Faculty of Pharmacy of Ankara University, 45(3), 524-534. https://doi.org/10.33483/jfpau.979200
  • Mohammed, F. S., Uysal, I. & Sevindik, M. (2023). A review on antiviral plants effective against different virus types. Prospects in Pharmaceutical Sciences, 21(2), 1-21. https://doi.org/10.56782/pps.128
  • Munhoz, V. M., Longhini, R., Souza, J. R., Zequi, J. A., Mello, E. V., Lopes, G. C. & Mello, J. C. (2014). Extraction of flavonoids from T. patula: process optimization and screening for biological activity. Revista Brasileira de Farmacognosia, 24, 576-583. http://dx.doi.org/10.1016/j.bjp.2014.10.001
  • Mushtaq, W., Baba, H., Akata, İ. & Sevindik, M. (2020). Antioxidant potential and element contents of wild edible mushroom Suillus granulatus. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 23(3), 592-595. https://doi.org/10.18016/ksutarimdoga.vi.653241
  • Negi, J. S., Bisht, V. K., Bhandari, A. K. & Sundriyal, R. C. (2013). Essential oil contents and antioxidant activity of T. patula L. Journal of Essential Oil Bearing Plants, 16(3), 364-367. https://doi.org/10.1080/0972060X.2013.794003
  • Ramakrishnan, P. Chandrasekhar, T. & Muralidharan, P. (2015). Cognitive enhancing, anti‐acetylcholinesterase, and antioxidant properties of T. patula on scopolamine‐induced amnesia in mice. International Journal of Green Pharmacy, 9(3), 167-174. http://dx.doi.org/10.4103/0973-8258.161234
  • Riaz, M., Ahmad, R., Rahman, N. U., Khan, Z., Dou, D., Sechel, G. & Manea, R. (2020). Traditional uses, Phyto-chemistry and pharmacological activities of T. patula L. Journal of Ethnopharmacology, 255, 112718. https://doi.org/10.1016/j.jep.2020.112718
  • Romagnoli, C., Bruni, R., Andreotti, E., Rai, M. K., Vicentini, C. B. & Mares, D. (2005). Chemical characterization and antifungal activity of essential oil of capitula from wild Indian T. patula L. Protoplasma, 225, 57-65. https://doi.org/10.1007/s00709-005-0084-8
  • Rueda, E. M. S., Ruiz, Y. L. R., Chamorro, N. L. & Landazuri, P. (2018). Extracts of T. patula L. (Asteraceae): a bactericidal potential against Moko. Revista Mexicana de Ciencias Agrícolas, 9(5), 949-959. https://doi.org/10.29312/remexca.v9i5.1504
  • Safar, A. A., Ghafoor, A. O. & Dastan, D. (2020). Chemical composition, antibacterial and antioxidant activities of T. patula L. essential oil raised in Erbil, Iraq. Journal of reports in pharmaceutical sciences, 9(1), 59-67. http://dx.doi.org/10.4103/jrptps.JRPTPS_68_19
  • Salachna, P., Wesołowska, A., Meller, E. & Piechocki, R. (2021). Mushroom waste biomass alters the yield, total phenolic content, antioxidant activity and essential oil composition of T. patula L. Industrial Crops and Products, 171, 113961. https://doi.org/10.1016/j.indcrop.2021.113961
  • Selamoglu, Z., Sevindik, M., Bal, C., Ozaltun, B., Sen, İ. & Pasdaran, A. (2020). Antioxidant, antimicrobial and DNA protection activities of phenolic content of Tricholoma virgatum (Fr.) P. Kumm. Biointerface Research in Applied Chemistry, 10(3), 5500-5506 https://doi.org/10.33263/BRIAC103.500506
  • Sevindik, M. (2019). The novel biological tests on various extracts of Cerioporus varius. Fresenius Environmental Bulletin, 28(5), 3713-3717.
  • Sevindik, M., Akgul, H., Pehlivan, M. & Selamoglu, Z. (2017). Determination of therapeutic potential of Mentha longifolia ssp. longifolia. Fresenius Environmental Bulletin, 26(7), 4757-4763.
  • Sevindik, M., Mohammed, F. S. & Uysal, I. (2023). Autism: plants with neuro-psychopharmacotherapeutic potential. Prospects in Pharmaceutical Sciences, 21(3), 38-48. https://doi.org/10.56782/pps.143
  • Sevindik, M., Akgül, H., Bal, C., & Selamoglu, Z. (2018). Phenolic contents, oxidant/antioxidant potential and heavy metal levels in Cyclocybe cylindracea. Indian Journal of Pharmaceutical Education and Research, 52(3), 437-441. https://doi.org/10.5530/ijper.52.3.50
  • Świątek, Ł., Sieniawska, E., Sinan, K. I., Maciejewska-Turska, M., Boguszewska, A., Polz-Dacewicz, M., Senkardes, I., Guler, G.O., Sadeer, N.B., Mahomoodally, M.F. & Zengin, G. (2021). LC-ESI-QTOF-MS/MS analysis, cytotoxic, antiviral, antioxidant, and enzyme inhibitory properties of four extracts of Geranium pyrenaicum Burm. f.: A good gift from the natural treasure. International journal of molecular sciences, 22(14), 7621. https://doi.org/10.3390%2Fijms22147621
  • Tiwari, R., Jain, R., Agrawal, O. P., & Shukla, A. K. (2023). Evaluation of total phenolic and flavonoids content and their relation with antioxidant properties of T. patula flower using in vitro assay method. BEPLS, 12(5), 204-208.
  • Tutus, A., Comlekcioglu, N., Karaman, S. & Alma, M. H. (2010). Chemical composition and fiber properties of Crambe orientalis and C. tataria. International Journal of Agriculture and Biology, 12(2), 286-290.
  • Türkmen, M. & Koçer, O. (2021). Variation of components in laurel (Laurus nobilis L.) fixed oil extracted by different methods. International Journal of Chemistry and Technology, 5(2), 167-171. https://doi.org/10.32571/ijct.1006137
  • Unal, O., Eraslan, E. C., Uysal, I., Mohammed, F. S., Sevindik, M. & Akgul, H. (2022). Biological activities and phenolic contents of Rumex scutatus collected from Turkey. Fresenius Environmental Bulletin, 31(7), 7341-7346.
  • Uysal, I., Koçer, O., Mohammed, F. S., Lekesiz, Ö., Doğan, M., Şabik, A. E., Sevindik, E., Gerçeker, F.Ö. & Sevindik, M. (2023). Pharmacological and nutritional properties: Genus Salvia. Advances in Pharmacology and Pharmacy, 11(2), 140-155. https://doi.org/10.13189/app.2023.110206
  • Xu, L., Chen, J., Qi, H. & Shi, Y. (2012). Phytochemicals and their biological activities of plants in Tagetes L. Chinese Herbal Medicines, 4(2), 103-117.
Toplam 57 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Bitki Bilimi (Diğer)
Bölüm ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar

Mansur Seymen Seğmenoğlu 0000-0003-2743-6245

Oğuzhan Koçer 0000-0002-0104-7586

Mustafa Sevindik 0000-0001-7223-2220

Nuh Korkmaz 0000-0001-8299-910X

Mehmet Ali Yüzbaşıoğlu 0000-0002-0245-751X

İmran Uysal 0000-0003-0942-9658

Erken Görünüm Tarihi 15 Eylül 2024
Yayımlanma Tarihi
Gönderilme Tarihi 20 Mart 2024
Kabul Tarihi 23 Haziran 2024
Yayımlandığı Sayı Yıl 2024Cilt: 27 Sayı: Ek Sayı 1 (Suppl 1)

Kaynak Göster

APA Seğmenoğlu, M. S., Koçer, O., Sevindik, M., Korkmaz, N., vd. (2024). Antioxidant, Antimicrobial, and Antialzheimer Activities of Tagetes patula (Asteraceae). Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 27(Ek Sayı 1 (Suppl 1), 205-212. https://doi.org/10.18016/ksutarimdoga.vi.1455020
 Kapak Resmi İndir

21082



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