Research Article
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Pyracantha angustifolia'nın Fitokimyasal Analizi: Gümüş Nanopartiküllerinin Sentezi, Karakterizasyonu, Antimikrobiyal Aktivitesi Ve In Silico Çalışmaları

Year 2026, Volume: 29 Issue: 1, 1 - 14

Yunus Başar , Aybek Yiğit , Mesude Figen Dönmez , İbrahim Demirtas , Mehmet Hakkı Alma

https://doi.org/10.18016/ksutarimdoga.vi.1593890

Abstract

Nanoteknoloji çeşitli endüstrilerde hızla ilerlemekte ve çevre dostu nanopartikül (NP) sentez yöntemlerine olan ihtiyacı vurgulamaktadır. Bu çalışmada, gıda ve ilaçlarda uygulamaları olan bir bitki olan ateş dikeni olarak da bilinen Pyracantha angustifolia (PA) kullanılarak gümüş nanopartiküller (AgNP'ler) sentezlendi. AgNP'ler UV, FT-IR, FE-SEM, FESEM-EDX ile karakterize edilmiş ve antibakteriyel aktiviteleri Erwinia caratovora ve Clavibacter michiganensis'e karşı test edilmiştir. PA sulu özütünün fitokimyasal analizi, sırasıyla LC-ESI-MS/MS ve GC-MS/MS kullanılarak hesperidin (1240,3564 ng/ml) ve palmitik asit metil esteri (%30,79) ana bileşenler olarak tanımlandı. PA'nın AgNP'leri E. caratovora ve C. michiganensis patojenlerine karşı yüksek antibakteriyel aktivite gösterdi. İn silico çalışmalar hespiridinin DNA giraz ile etkileşimini doğruladı (MolDock skoru; -123,43, bağlanma enerjileri; -7,00 kcal/mol ve ΔG bağlanma değerleri; 15,051 kj/mol), bu da onun antibakteriyel ajan olarak potansiyelini destekledi.

Keywords

Pyracantha angustifolia Gümüş nanopartikül Antibakteriyel aktivite Hesperidin İn silico

Project Number

YİP0723İ01

References

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Phytochemical Analysis of Pyracantha angustifolia: Synthesis of Silver Nanoparticles, Characterization, Antimicrobial Activity, and In Silico Studies

Year 2026, Volume: 29 Issue: 1, 1 - 14

Yunus Başar , Aybek Yiğit , Mesude Figen Dönmez , İbrahim Demirtas , Mehmet Hakkı Alma

https://doi.org/10.18016/ksutarimdoga.vi.1593890

Abstract

Nanotechnology is rapidly advancing across various industries, highlighting the need for environmentally friendly nanoparticle (NP) synthesis methods. In this study, silver nanoparticles (AgNPs) were synthesized using Pyracantha angustifolia (PA), also known as firethorn, a plant with applications in food and pharmaceuticals. The AgNPs were characterized via UV-VIS, FT-IR, FE-SEM, FESEM-EDX, and their antibacterial activity was tested against Erwinia caratovora and Clavibacter michiganensis. Phytochemical analysis of PA aqueous extract identified hesperidin (1240.3564 ng/ml) and palmitic acid methyl ester (30.79%) as major components using LC-ESI-MS/MS and GC-MS/MS, respectively. AgNPs of PA showed high antibacterial activity against the pathogens E. caratovora and C. michiganensis. In silico studies confirmed hespiridin’s interaction with DNA gyrase (MolDock score; -123.43, binding energies; -7.00 kcal/mol and ΔG binding values; 15.051 kj/mol), supporting its potential as an antibacterial agent.

Keywords

Pyracantha angustifolia Silver nanoparticles Antibacterial activity Hesperidin In silico

Project Number

YİP0723İ01

References

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  • Başar, Y., & Erenler, R. (2024). Phytochemical analysis of Silybum marianum flowers: Quantitative analysis of natural compounds and molecular docking application [Silybum marianum çiçeklerinin fitokimyasal analizi: Doğal bileşiklerin kantitatif analizi ve moleküler yerleştirme uygulaması]. Turkish Journal of Biodiversity, 7(1), 20-31. https://doi.org/10.38059/biodiversity.1450643
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  • Chen, C., Luo, J., Qin, W., & Tong, Z. (2013). Elemental analysis, chemical composition, cellulose crystallinity, and FT-IR spectra of Toona sinensis wood. Monatshefte für Chemie - Chemical Monthly, 145, 175-185. https://doi.org/10.1007/s00706-013-1077-5
  • Chen, H., Weng, Q. Y., & Fisher, D. E. (2014). UV Signaling Pathways within the Skin. Journal of Investigative Dermatology, 134(8), 2080-2085. https://doi.org/10.1038/jid.2014.161
  • Chi, G. F., Khan, S., Başar, Y., Kuete, J. R. N., Matieta, V. Y., Kuete, J. B. T., Megaptche, J. F., Chongong, M. A., Yenigün, S., Ayimele, G. A., Mbaveng, A. T., Kuete, V., & Shaheen, F. (2025). Antibacterial flavonoids from Tetrapleura tetraptera (Fabaceae) fruit pulp, in silico studies. South African Journal of Botany, 180, 96-106. https://doi.org/10.1016/j.sajb.2025.02.026
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  • Dönmez, M. F. (2004). Erzurum ve Erzincan illerinde fasulye bitkisinde (Phaseolus vulgaris L.) görülen bakteriyel hastalık etmenlerinin tanılanması ve Pseudomonas syringae pv. phaseolicola ve Xanthomonas campestris pv. phaseoli`ye karşı çeşitli fasulye genotip/varyeteleri (Tez no 155607). [Doktora Tezi, Atatürk Üniversitesi Fen Bilimleri Enstitüsü Bitki Koruma Ana Bilim Dalı]. Yükseköğretim Kurulu Ulusal Tez Merkezi.
  • Dönmez, M. F., & Temel, I. (2023). Use of antagonistic bacteria against Xanthomonas hortorum pv. vitians causing disease in lettuce. Zemdirbyste-Agriculture. Dönmez, M. F., & Temel, I., 110(2), 69–76.
  • Dönmez, M. F., & Aliyeva, Z. (2022). Biological Control of Bean Halo Blight Disease (Pseudomonas Savastanoi Pv. Phaseolicola) with Antagonist Bacterial Strains. Gesunde Pflanzen, 75, 815-824.
  • Dönmez, M. F., Sunyar, B., & Çoruh, İ. (2021). Isolation and Identification of Bacteria Causes Diseases on the Tomato (Solanum Lycopersicum L.) in Igdır. Journal of Agriculture, 4(2), 108-129. https://doi.org/ 10.46876/ja.1015781
  • Gurunathan, S., Park, J. H., Han, J. W., & Kim, J.-H. (2015). Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy. International Journal of Nanomedicine, 10, 4203 - 4223.
  • Hennia, A., Brada, M., Nemmiche, S., Fauconnier, M.-L., & Lognay, G. (2015). Chemical composition and antibacterial activitiy of the essential oils of Algerian Myrtus communis L. Journal of Essential Oil Research, 27, 1-5. https://doi.org/10.1080/10412905.2015.1023905
  • Iacopi, E., Giangreco, F., & Piaggesi, A. (2023). Principles of Antiseptic Treatments. In M. Maruccia, G. Papa, E. Ricci, & G. Giudice (Eds.), Pearls and Pitfalls in Skin Ulcer Management (pp. 33-51). Springer International Publishing. https://doi.org/10.1007/978-3-031-45453-0_5
  • İnik, F. (2019). Iğdır ilinde kavun (Cucumis melo L.) bitkisinde bakteriyel meyve lekesi hastalığa neden olan acidovorax avenae subsp. citrulli'nin izolasyonu ve tanısı (Tez no. 710450). [Yüksek Lisans Tezi, Iğdır Üniversitesi Lisansüstü Eğitim Enstitüsü Bitki Koruma Ana Bilim Dalı]. Yükseköğretim Kurulu Ulusal Tez Merkezi.
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Details

Primary Language English
Subjects Plant Biochemistry, Food Engineering
Journal Section RESEARCH ARTICLE
Authors

Yunus Başar 0000-0002-7785-3242

Aybek Yiğit 0000-0001-8279-5908

Mesude Figen Dönmez 0000-0002-7992-8252

İbrahim Demirtas 0000-0001-8946-647X

Mehmet Hakkı Alma 0000-0001-6323-7230

Project Number YİP0723İ01
Early Pub Date October 18, 2025
Publication Date October 19, 2025
Submission Date November 30, 2024
Acceptance Date July 11, 2025
Published in Issue Year 2026 Volume: 29 Issue: 1

Cite

APA Başar, Y., Yiğit, A., Dönmez, M. F., … Demirtas, İ. (2025). Phytochemical Analysis of Pyracantha angustifolia: Synthesis of Silver Nanoparticles, Characterization, Antimicrobial Activity, and In Silico Studies. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 29(1), 1-14. https://doi.org/10.18016/ksutarimdoga.vi.1593890
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