Evaluation of the Lifespan of Fruit Fly Drosophila melanogaster Exposed to Dioxins

Deniz Altun Çolak; Handan Uysal

doi:10.18016/ksudobil.402236

Araştırma Makalesi

Dioksinlere Maruz Bırakılan Meyve Sineği Drosophila melanogaster’in Ömür Uzunluklarının Değerlendirilmesi

Yıl 2018, Cilt: 21 Sayı: 5, 715 - 724, 31.10.2018

Deniz Altun Çolak , Handan Uysal

https://doi.org/10.18016/ksudobil.402236

Cited By: 1

Öz

Poliklorlu
dibenzo-p- dioksinler (PCDDs) yanma prosesi sırasında ve endüstriyel süreçlerin
yan ürünleri olarak ortaya çıkan kalıcı organik kirleticilerdir. Bu çalışmada, 2,3,7,8-TCDD, 1,2,3,7,8-PeCDD, 1,2,3,7,8,9-H_XCDD
ve 1,2,3,4,6,7,8,9-OCDD’nin (1, 2.5, 5 ve 10µg/mL medium) Drosophila melanogaster’in yaşam
oranı ve ömür uzunluğu üzerine olan olası toksik etkileri in vivo olarak
araştırılmıştır. Dioksinlerin ömür uzunluğu üzerine etkisi, D.
melanogaster‘in dişi ve erkek populasyonlarında ayrı ayrı çalışılmıştır.
Tüm uygulama gruplarında, dioksinlere maruz
kalan hem dişi hem de erkek populasyonlarda ömür uzunluğunun konsantrasyon
artışına paralel olarak azalmıştır (p<0.05). Sonuç olarak, yaşam oranı ve ömür uzunluğu üzerine dioksinlerin
toksik etki sıralamasının 2,3,7,8-TCDD> 1,2,3,7,8-PeCDD> 1,2,3,7,8,9-H_XCDD>
1,2,3,4,6,7,8,9-OCDD şeklinde olduğu gözlenmiştir.

Anahtar Kelimeler

Dioksin , Drosophila melanogaster , Ömür uzunluğu , Larval ölüm oranı , Oksidatif stres

Kaynakça

Altarawneh M, Dlugogorski BZ, Kennedy EM, Mackie JC 2009. Mechanisms for formation, chlorination, dechlorination, and destruction of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). Progress in Energy and Combustion Science, 35: 245-274.
Arima A, Kato H, Ooshima Y, Tateishi T, Inoue A, Muneoka A, Ihara T, Kamimura S, Fukusato T, Kubota S, Sumida H Yasuda M 2009. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces a reduction in epididymal and ejaculated sperm number in rhesus monkeys. Reproductive Toxicology, 28: 495-502.
Baker TR, Peterson RE, Heideman W 2014. Using zebrafish as a model system for studying the transgenerational effects of dioxin. Toxicological Sciences, 138: 403-411.
Butleri RA, Kelley ML, Powell WH, Hahn ME, Van Beneden RJ 2001. An aryl hydrocarbon receptor (AHR) homologue from the soft-shell clam, Mya arenaria: evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-naphthoflavone binding. Gene, 278: 223-234.
Céspedes MA, Galindo MI, Couso JP 2010. Dioxin toxicity in vivo results from an increase in the dioxin-independent transcriptional activity of the aryl hydrocarbon receptor. PLoS One, 5: e15382.
Couture LA, Harris MW, Birnbaum LS 1990. Characterization of the peak period of sensitivity for the induction of hydronephrosis in C57BL/6N mice following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundamental Applied Toxicology, 15: 42-50.
Duncan DM, Burgess EA, Duncan I 1998. Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor. Genes and Development, 12: 1290-1303
Emmons RB, Duncan D, Estes PA, Kiefel P, Mosher JT, Sonnenfeld, Ward MP, Duncan I, Crews ST 1999. The spineless-aristapedia and tango bHLH-PAS proteins interact to control antennal and tarsal development in Drosophila. Development, 126: 3937-3945.
EPA (U.S. Environmental Protection Agency) 2000. Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds. Draft Final Report Washington, DC: EPA.
Fiedler H 2007. National PCDD/PCDF release inventories under the Stockholm Convention on Persistent Organic Pollutants. Chemosphere, 67: 96-108.
Flesch-Janys D, Berger J, Gum P, Manz A, Nagel S, Waltsgott H, Dwyer JH 1995. Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide-producing plant in Hamburg, Federal Republic of Germany. American Journal of Epidemiology, 142: 1165-1175.
Hahn ME 1998. The aryl hydrocarbon receptor: a comparative perspective. Comparative Biochemistry and Physiology. Pharmacology, Toxicology, and Endocrinology, 121: 23-53.
Hahn ME 2002. Aryl hydrocarbon receptors: diversity and evolution, Chemico-Biological Interactions, 141: 131-160.
Hassoun EA, Wilt SC, Devito MJ, Van Birgelen A, Alsharif NZ, Birnbaum LS, Stohs SJ 1998. Induction of oxidative stress in brain tissues of mice after subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences: An Official Journal of The Society of Toxicology, 42: 23-27.
Holt E, Weber R, Stevenson G, Gaus C 2010. Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) impurities in pesticides: a neglected source of contemporary relevance. Environmental Science and Technology, 44: 5409-5415.
Humblet O, Birnbaum L, Rimm E, Mittleman MA, Hauser R 2008. Dioxins and cardiovascular disease mortality. Environmental Health Perspectives, 116: 1443-1448.
Hung PC, Chang CC, Chang SH, Chang MB 2015. Characteristics of PCDD/F emissions from secondary copper smelting industry. Chemosphere, 118: 148-155.
IARC (International Agency for Research on Cancer) 1997. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. vol. 69, Polychlorinated Dibenzo-para-Dioxins and Polychlorinated Dibenzofurans, Lyon, France: World Health Organization.
Ishida T, Hori M, Ishii Y, Oguri K, Yamada H 2005. Effects of dioxins on stress-responsive systems and their relevance to toxicity. Journal of Dermatological Science Supplement, 1: 105-112.
Nilsson B, Ramel C 1974. Genetic tests on Drosophila melanogaster with polychlorinated biphenyls (PCB). Hereditas, 77: 319-322. Olson J, Holscher M, Neal R 1980. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the golden Syrian hamster. Toxicology and Applied Pharmacology, 55: 67-78.
Qin H, Zhai Z, Powell-Coffman JA 2006. The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior. Journal of Developmental Biology, 98: 606-615.
Pesatori AC, Zocchetti C, Guercilena S, Consonni D, Turrini D, Bertazzi PA 1998. Dioxin exposure and non-malignant health effects: a mortality study. Occupational and Environmental Medicine, 55: 126-131.
Pohjanvirta R 2009. Transgenic mouse lines expressing rat AH receptor variants-a new animal model for research on AH receptor function and dioxin toxicity mechanisms. Toxicology and Applied Pharmacology, 236: 166-182.
Rebourcet D, Odet F, Vérot A, Combe E, Meugnier E, Pesenti S, Leduque P, Déchaud H, Magre S, Le Magueresse-Battistoni B 2010. The effects of an in utero exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification of Ccl5 as a potential marker. International Journal of Andrology, 33: 413-424.
Rosińczuk J, Dymarek R, Całkosiński I 2018. The protective action of tocopherol and acetylsalicylic acid on the behavior of rats treated with dioxins. Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University, 27: 5-14.
Schecter A, Birnbaum L, Ryan JJ, Constable JD 2006. Dioxins: an overview. Environmental Research, 101: 419-428.
Shertzer HG, Nebert DW, Puga A, Ary M, Sonntag D, Dixon K, Robinson LJ, Cianciolo E, Dalton TP 1998. Dioxin causes a sustained oxidative stress response in the mouse, Biochemical and Biophysical Research Communications, 253: 44-48.
Stohs SJ 1990. Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Free Radical Biology and Medicine, 9: 79-90.
Sutter CH, Rahman M, Sutter TR 2006. Uncertainties related to the assignment of a toxic equivalency factor for 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin. Regulatory Toxicology and Pharmacology, 44: 219-225.
Terrell ML, Hartnett KP, Marcus M 2011. Can environmental or occupational hazards alter the sex ratio at birth? A systematic review. Emerging Health Threats Journal, 4: 7109.
Theobald HM, Kimmel GL, Peterson RE 2003. Dioxins and Health. Wiley, Hoboken, NJ, pp. 329-432.
USEPA (United States Environmental Protection Agency) 2004. Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds. National Academy Sciences (NAS) Review Draft, Part I: Estimating Exposure to Dioxin-Like Compounds, vol 1: Sources of Dioxin-Like Compounds in the United States, Washington, DC, National Center for Environmental Assessment, US.
Weber R, Gaus C, Tysklind M, Johnston P, Forter M, Hollert H, Heinisch E, Holoubek I, Lloyd-Smith M, Masunaga S, Moccarelli P, Santillo D, Seike N, Symons R, Torres JPM, Verta M, Varbelow G, Vijgen J, Watson A, Costner P, Woelz J, Wycisk P, Zennegg M 2008. Dioxin-and POP-contaminated sites-contemporary and future relevance and challenges. Environmental Science and Pollution Research, 15: 363-393.
Yang CY, Chiou SL, Wang JD, Guo YL 2015. Health related quality of life and polychlorinated biphenyls and dibenzofurans exposure: 30 years follow-up of Yucheng cohort. Environmental Research, 137: 59-64.
Yoshida R, Ogawa Y 2000. Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: an application of oxidative stress markers to cancer risk assessment of dioxins. Industrial Health, 38: 5-14.
Zhang B, Zhang H, Jin J, Ni Y, Chen J 2012. PCDD/Fs-induced oxidative damage and antioxidant system responses in tobacco cell suspension cultures. Chemosphere, 88: 798-805.

Evaluation of the Lifespan of Fruit Fly Drosophila melanogaster Exposed to Dioxins

Yıl 2018, Cilt: 21 Sayı: 5, 715 - 724, 31.10.2018

Deniz Altun Çolak , Handan Uysal

https://doi.org/10.18016/ksudobil.402236

Cited By: 1

Öz

The polychlorinated dibenzo-p-dioxins (PCDDs) formed during combustion processes and as
by-products of industrial processes are persistent organic pollutants. In the
present study, the PCDDs of 2,3,7,8-TCDD, 1,2,3,7,8-PeCDD, 1,2,3,7,8,9-H_XCDD
and 1,2,3,4,6,7,8,9-OCDD (1,
2.5, 5 and 10µg/mL medium) were
evaluated for their possible toxicity on the survival rate of Drosophila melanogaster, in vivo. The
effects of different concentrations of dioxins were separately administered to
female and male populations of D.
melanogaster. In all application groups, both the survival rate and each
population’s longevity decreased, depending on the concentration of dioxins (p<0.05). In conclusion, the toxic
effect for the survival rate and longevity was observed in the following order:
2,3,7,8-TCDD> 1,2,3,7,8-PeCDD> 1,2,3,7,8,9-H_XCDD>
1,2,3,4,6,7,8,9-OCDD.

Anahtar Kelimeler

Dioxins , Drosophila melanogaster , longevity , larval mortality rate , oxidative stress

Kaynakça

Altarawneh M, Dlugogorski BZ, Kennedy EM, Mackie JC 2009. Mechanisms for formation, chlorination, dechlorination, and destruction of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). Progress in Energy and Combustion Science, 35: 245-274.
Arima A, Kato H, Ooshima Y, Tateishi T, Inoue A, Muneoka A, Ihara T, Kamimura S, Fukusato T, Kubota S, Sumida H Yasuda M 2009. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces a reduction in epididymal and ejaculated sperm number in rhesus monkeys. Reproductive Toxicology, 28: 495-502.
Baker TR, Peterson RE, Heideman W 2014. Using zebrafish as a model system for studying the transgenerational effects of dioxin. Toxicological Sciences, 138: 403-411.
Butleri RA, Kelley ML, Powell WH, Hahn ME, Van Beneden RJ 2001. An aryl hydrocarbon receptor (AHR) homologue from the soft-shell clam, Mya arenaria: evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-naphthoflavone binding. Gene, 278: 223-234.
Céspedes MA, Galindo MI, Couso JP 2010. Dioxin toxicity in vivo results from an increase in the dioxin-independent transcriptional activity of the aryl hydrocarbon receptor. PLoS One, 5: e15382.
Couture LA, Harris MW, Birnbaum LS 1990. Characterization of the peak period of sensitivity for the induction of hydronephrosis in C57BL/6N mice following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundamental Applied Toxicology, 15: 42-50.
Duncan DM, Burgess EA, Duncan I 1998. Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor. Genes and Development, 12: 1290-1303
Emmons RB, Duncan D, Estes PA, Kiefel P, Mosher JT, Sonnenfeld, Ward MP, Duncan I, Crews ST 1999. The spineless-aristapedia and tango bHLH-PAS proteins interact to control antennal and tarsal development in Drosophila. Development, 126: 3937-3945.
EPA (U.S. Environmental Protection Agency) 2000. Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds. Draft Final Report Washington, DC: EPA.
Fiedler H 2007. National PCDD/PCDF release inventories under the Stockholm Convention on Persistent Organic Pollutants. Chemosphere, 67: 96-108.
Flesch-Janys D, Berger J, Gum P, Manz A, Nagel S, Waltsgott H, Dwyer JH 1995. Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide-producing plant in Hamburg, Federal Republic of Germany. American Journal of Epidemiology, 142: 1165-1175.
Hahn ME 1998. The aryl hydrocarbon receptor: a comparative perspective. Comparative Biochemistry and Physiology. Pharmacology, Toxicology, and Endocrinology, 121: 23-53.
Hahn ME 2002. Aryl hydrocarbon receptors: diversity and evolution, Chemico-Biological Interactions, 141: 131-160.
Hassoun EA, Wilt SC, Devito MJ, Van Birgelen A, Alsharif NZ, Birnbaum LS, Stohs SJ 1998. Induction of oxidative stress in brain tissues of mice after subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences: An Official Journal of The Society of Toxicology, 42: 23-27.
Holt E, Weber R, Stevenson G, Gaus C 2010. Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) impurities in pesticides: a neglected source of contemporary relevance. Environmental Science and Technology, 44: 5409-5415.
Humblet O, Birnbaum L, Rimm E, Mittleman MA, Hauser R 2008. Dioxins and cardiovascular disease mortality. Environmental Health Perspectives, 116: 1443-1448.
Hung PC, Chang CC, Chang SH, Chang MB 2015. Characteristics of PCDD/F emissions from secondary copper smelting industry. Chemosphere, 118: 148-155.
IARC (International Agency for Research on Cancer) 1997. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. vol. 69, Polychlorinated Dibenzo-para-Dioxins and Polychlorinated Dibenzofurans, Lyon, France: World Health Organization.
Ishida T, Hori M, Ishii Y, Oguri K, Yamada H 2005. Effects of dioxins on stress-responsive systems and their relevance to toxicity. Journal of Dermatological Science Supplement, 1: 105-112.
Nilsson B, Ramel C 1974. Genetic tests on Drosophila melanogaster with polychlorinated biphenyls (PCB). Hereditas, 77: 319-322. Olson J, Holscher M, Neal R 1980. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the golden Syrian hamster. Toxicology and Applied Pharmacology, 55: 67-78.
Qin H, Zhai Z, Powell-Coffman JA 2006. The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior. Journal of Developmental Biology, 98: 606-615.
Pesatori AC, Zocchetti C, Guercilena S, Consonni D, Turrini D, Bertazzi PA 1998. Dioxin exposure and non-malignant health effects: a mortality study. Occupational and Environmental Medicine, 55: 126-131.
Pohjanvirta R 2009. Transgenic mouse lines expressing rat AH receptor variants-a new animal model for research on AH receptor function and dioxin toxicity mechanisms. Toxicology and Applied Pharmacology, 236: 166-182.
Rebourcet D, Odet F, Vérot A, Combe E, Meugnier E, Pesenti S, Leduque P, Déchaud H, Magre S, Le Magueresse-Battistoni B 2010. The effects of an in utero exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification of Ccl5 as a potential marker. International Journal of Andrology, 33: 413-424.
Rosińczuk J, Dymarek R, Całkosiński I 2018. The protective action of tocopherol and acetylsalicylic acid on the behavior of rats treated with dioxins. Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University, 27: 5-14.
Schecter A, Birnbaum L, Ryan JJ, Constable JD 2006. Dioxins: an overview. Environmental Research, 101: 419-428.
Shertzer HG, Nebert DW, Puga A, Ary M, Sonntag D, Dixon K, Robinson LJ, Cianciolo E, Dalton TP 1998. Dioxin causes a sustained oxidative stress response in the mouse, Biochemical and Biophysical Research Communications, 253: 44-48.
Stohs SJ 1990. Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Free Radical Biology and Medicine, 9: 79-90.
Sutter CH, Rahman M, Sutter TR 2006. Uncertainties related to the assignment of a toxic equivalency factor for 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin. Regulatory Toxicology and Pharmacology, 44: 219-225.
Terrell ML, Hartnett KP, Marcus M 2011. Can environmental or occupational hazards alter the sex ratio at birth? A systematic review. Emerging Health Threats Journal, 4: 7109.
Theobald HM, Kimmel GL, Peterson RE 2003. Dioxins and Health. Wiley, Hoboken, NJ, pp. 329-432.
USEPA (United States Environmental Protection Agency) 2004. Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds. National Academy Sciences (NAS) Review Draft, Part I: Estimating Exposure to Dioxin-Like Compounds, vol 1: Sources of Dioxin-Like Compounds in the United States, Washington, DC, National Center for Environmental Assessment, US.
Weber R, Gaus C, Tysklind M, Johnston P, Forter M, Hollert H, Heinisch E, Holoubek I, Lloyd-Smith M, Masunaga S, Moccarelli P, Santillo D, Seike N, Symons R, Torres JPM, Verta M, Varbelow G, Vijgen J, Watson A, Costner P, Woelz J, Wycisk P, Zennegg M 2008. Dioxin-and POP-contaminated sites-contemporary and future relevance and challenges. Environmental Science and Pollution Research, 15: 363-393.
Yang CY, Chiou SL, Wang JD, Guo YL 2015. Health related quality of life and polychlorinated biphenyls and dibenzofurans exposure: 30 years follow-up of Yucheng cohort. Environmental Research, 137: 59-64.
Yoshida R, Ogawa Y 2000. Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin: an application of oxidative stress markers to cancer risk assessment of dioxins. Industrial Health, 38: 5-14.
Zhang B, Zhang H, Jin J, Ni Y, Chen J 2012. PCDD/Fs-induced oxidative damage and antioxidant system responses in tobacco cell suspension cultures. Chemosphere, 88: 798-805.

Toplam 36 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Bölüm	ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar	Deniz Altun Çolak Handan Uysal
Yayımlanma Tarihi	31 Ekim 2018
Gönderilme Tarihi	6 Mart 2018
Kabul Tarihi	10 Mayıs 2018
Yayımlandığı Sayı	Yıl 2018 Cilt: 21 Sayı: 5

Kaynak Göster

APA	Altun Çolak, D., & Uysal, H. (2018). Evaluation of the Lifespan of Fruit Fly Drosophila melanogaster Exposed to Dioxins. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 21(5), 715-724. https://doi.org/10.18016/ksudobil.402236