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Capparis sicula'nın in vitro Antioksidan, Antimikrobiyal Özellikleri ve COX-1/COX-2 Enzim Inhibisyon Aktivitesinin Belirlenmesi

Yıl 2023, Cilt: 26 Sayı: 6, 1221 - 1229, 31.12.2023

Nağihan Acar , Fatih Çağlar Çelikezen , İbrahim Halil Şahin , Mehmet Fırat , Recep Koçyiğit , Oğuz Ayhan Kireçci

https://doi.org/10.18016/ksutarimdoga.vi.1139197

Öz

Sentetik ilaçlar birçok yan etkiye ve yüksek maliyete neden olduğundan daha az yan etkisi olan ve nispeten daha ucuz olan bitkisel bazlı ilaçların geliştirilmesi artan bir ilgi görmüştür. Capparis sicula halk arasında bazı hastalıkların tedavisinde geleneksel olarak kullanılmaktadır. Bu amaçla sunulan çalışmada Capparis sicula bitkisinin metanol ekstraktının antioksidan ve antimikrobiyal özellikleri ile COX-1 ve COX-2 enzimleri üzerindeki inhibisyon etkileri araştırılmıştır. Çalışmada Capparis sicula bitkisinin antioksidan özellikleri DPPH ve CUPRAC yöntemleri ile belirlenirken, antimikrobiyal özellikleri disk difüzyon yöntemi ile belirlenmiştir. Capparis sicula'nın COX-1 ve COX-2 enzimleri üzerindeki etkisi ise, ticari kitler kullanılarak kolorimetrik olarak belirlendi. Sonuçlar, Capparis sicula'nın önemli bir antioksidan etkiye sahip olduğunu, ancak standart Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli ve Candida albicans suşları üzerinde herhangi bir antimikrobiyal etkiye sahip olmadığını gösterdi. Ayrıca COX-1 enzimi üzerindeki inhibisyon etkisi ilk kez %4.23, COX-2 enzimi üzerindeki inhibisyon etkisi ise %23.21 olarak tespit edilmiştir. Sonuç olarak, ilaç, gıda ve kozmetik endüstrileri, Capparis sicula'yı önemli bir doğal hammadde kaynağı olarak kullanabilir.

Anahtar Kelimeler

Antiinflamatuar Antioksidant Antimikrobiyal Capparis sicula COX-1

Proje Numarası

2020.07

Kaynakça

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  • Abdu-Allah, H.H., Abdelmoez, A.A., Tarazi, H., El-Shorbagi, ANA. & El-Awady, R. (2020). Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem, 94, 103378
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Determination of in Vitro Antioxidant, Antimicrobial Properties and COX-1/COX-2 Enzyme Inhibition Activity of Capparis Sicula

Yıl 2023, Cilt: 26 Sayı: 6, 1221 - 1229, 31.12.2023

Nağihan Acar , Fatih Çağlar Çelikezen , İbrahim Halil Şahin , Mehmet Fırat , Recep Koçyiğit , Oğuz Ayhan Kireçci

https://doi.org/10.18016/ksutarimdoga.vi.1139197

Öz

Since synthetic drugs cause many side effects and have a high cost, there has been increasing interest in the development of herbal-based drugs that have fewer side effects and are relatively inexpensive. Capparis sicula is traditionally used in the treatment of some diseases among people. For this purpose, the antioxidant and antimicrobial properties of the methanol extract of the Capparis sicula plant and its inhibitory effects on COX-1 and COX-2 enzymes were investigated. In the study, the antioxidant properties of the Capparis sicula plant were determined by DPPH and CUPRAC methods, while its antimicrobial properties were determined by the disk diffusion method. The effect of Capparis sicula on COX-1 and COX-2 enzymes was determined colorimetrically using commercial kits. The results showed that Capparis sicula had a significant antioxidant effect, but did not have any antimicrobial effect on standard strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. In addition, the inhibitory effect on the COX-1 enzyme was 4.23% for the first time, and the inhibition effect on the COX-2 enzyme was determined as 23.21%. As a result, the pharmaceutical, food and cosmetic industries can use Capparis sicula as an important source of natural raw materials.

Anahtar Kelimeler

Antiinflammatory Antioxidant Antimicrobial Capparis sicula COX-1

Destekleyen Kurum

Bitlis Eren Üniversitesi BAP

Proje Numarası

2020.07

Teşekkür

This study was produced from Nagihan ACAR's master's thesis with the same name. The present study was supported by Bitlis Eren University Scientific Research Projects Coordinatorship as project numbered BEBAP 2020.07.

Kaynakça

  • Abbas, J.A., El-Oglah, A.A. & Mahasneh, A.M. (1992). Herbal plants in the traditionalmedicine of Bahrain. Econ Bot, 46, 158-163.
  • Abdu-Allah, H.H., Abdelmoez, A.A., Tarazi, H., El-Shorbagi, ANA. & El-Awady, R. (2020). Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem, 94, 103378
  • Abdu-Allah, H.H., Abdelmoez, A.A., Tarazi, H., El-Shorbagi, ANA. & El-Awady, R. (2020). Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem, 94, 103378
  • Ageel, A.M., Parmar, N.S., Mossa, J.S., Yahya, M.A.A., Said, M.S.A. & Tariq, M. (1986). Anti-inflammatory activity of some Saudi Arabian medicinal plants. Agents Action, 17, 383-384.
  • Ageel, A.M., Parmar, N.S., Mossa, J.S., Yahya, M.A.A., Said, M.S.A. & Tariq, M. (1986). Anti-inflammatory activity of some Saudi Arabian medicinal plants. Agents Action, 17, 383-384.
  • Aichi-Yousfi, H., Meddeb, E., Rouissi, W., Hamrouni, L., Rouz, S., Rejeb, M.N. & Ghrabi-Gammar, Z. (2016). Phenolic composition and antioxidant activity of aqueous andethanolic leaf extracts of six Tunisian species of genus Capparis –Capparaceae. Indus Crop Prod, 92, 218–226.
  • Al-Said, M.S., Abdelsattar, E.A., Khalifa, S.I. & Al-Feraly, F.S. (1988). Isolation and identification of an anti-inflammatory principle from Capparis spinosa. Die Pharmazie, 43, 640-641. Anjuma, S., Asif, M., Zia, K., Jahan, B., Ashraf, M., Hussainb, S., Hayat, M.Q., Shahd, M.R. & Tahir, M.N. (2020). Biological and phytochemical studies on Capparis decidua (Forssk) Edgew from Cholistan desert. Nat Prod Res, 34(16), 2315–2318.
  • Apak, R., Güçlü, K., Özyürek, M. & Karademir, S.E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamin C and E, using their cupricion reducing capability in the precence of neocuproine: CUPRAC Method. J of Agr and Food Chem, 52, 7970-7981.
  • Apak, R., Güçlü, K., Özyürek, M. & Karademir, S.E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamin C and E, using their cupricion reducing capability in the precence of neocuproine: CUPRAC Method. J of Agr and Food Chem, 52, 7970-7981.
  • Argentieri, M., Macchia, F., Papadia, P., Fanizzi, F.P. & Avato, P. (2012). Bioactive compounds from Capparis spinosa subsp rupestris. Ind Crop Prod, 36(1), 65-69.
  • Arslan, R. & Bektas, N. (2010). Antinociceptive effect of methanol extract of Capparis ovata in mice. Pharma Biol, 48(10), 1185- 1190.
  • Arulmozhi, P., Vijayakumar, S., Praseetha, P.K. & Jayanthi, S. (2019a). Extraction methods and computational approaches for evaluation of antimicrobial compounds from Capparis zeylanica L. Anal Biochem, 572, 33-44.
  • Arulmozhi, P., Vijayakumar, S., Praseetha, P.K. & Jayanthi, S. (2019a). Extraction methods and computational approaches for evaluation of antimicrobial compounds from Capparis zeylanica L. Anal Biochem, 572, 33-44.
  • Arulmozhi, P., Vijayakumar, S. & Kumar, T. (2018). Phytochemical analysis and antimicrobial activity of some medicinal plants against selected pathogenic microorganisms. Microbe Pathog, 123, 219-226.
  • Assadi, S., Shafiee, S.M., Erfani, M. & Akmali, M. (2021). Antioxidative and antidiabetic effects of Capparis spinosa fruit extract on high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats. Biomed Pharmacother, 138, 111391.
  • Barry, A.L. & Thornsberry, C. (1985). Susceptibility Tests: Diffusion Test Procedures. In: Lennette EH, Balows A, Hausler WJ Jr, Shadomy HJ (ed.) Manual of clinical microbiology, 4th edn, American Society for Microbiology, Washington, D.C. 978-987.
  • Bektas, N., Arslan, R., Goger, F., Kirimer, N. & Ozturk, Y. (2012a). Investigation for anti-inflammatory and anti-thrombotic activitiesof methanol extract of Capparis ovata buds and fruits. J of Ethnopharm, 142, 48–52.
  • Bindu, S., Mazumder, S. & Bandyopadhyay, U. (2020). Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective. Biochem Pharmacol 180, 114147
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  • Ghule, B.V., Murugananthan, G. Yeole, P.G. (2007). Analgesic and antipyretic effects of Capparis zeylanica leaves. Phytoterapia, 78, 365–369.
  • Grice, H.C. (1986). Safety evaluation of butylated hydroxy toluene (BHT) in the liver, lung and the gastrointestinal tract. Food Chem Toxicol, 24, 1127–1130
  • Güner, A., Özhatay, N., Ekim, T. & Başer, K.H.C. (2000). Flora of Turkey and the East Aegean Islands, Edinburgh Univ. Pres. Edinburgh
  • Gurib-Fakim, A. (2006). Medicinal plants: traditions of yesterday and drugs of tomorrow. Mole Aspect Med, 27(1), 1-9
  • Husseini, H.F., Hasani-Rnjbar, S., Nayebi, N., Heshmat, R., Sigaroodi, F.K. & Ahvazi, M. (2001). Capparis spinosa L. (Caper) fruit extract in treatment of type 2 diabetic patients: A randomized double-blind placebo- controlled clinical trial. Complement Ther Med, 21(5), 447-452.
  • Husseini, H.F., Hasani-Rnjbar, S., Nayebi, N., Heshmat, R., Sigaroodi, F.K. & Ahvazi, M. (2001). Capparis spinosa L. (Caper) fruit extract in treatment of type 2 diabetic patients: A randomized double-blind placebo- controlled clinical trial. Complement Ther Med, 21(5), 447-452.
  • Igbe, I., Ching, F.P. & Eromon, A. (2010). Anti inflammatory activity of aqueous fruit pulp extract of Hunteria umbellata K. Schum in acute and chronic inflammation. Acta Pol Pharm, 67, 81-85.
  • Inocencio, C., Rivera, D., Alcaraz, F. & Tomas-Barberan, F.A. (2000). Flavonoid content of commercial capers (Capparis spinosa, C. sicula and C. orientalis) produced in Mediterranean countries. Eur Food Res Technol, 212, 70-74.
  • Khoshneviszadeh, M., Shahraki, O., Khoshneviszadeh, M., Foroumadi, A., Firuzi, O., Edraki, N., Nadri, H., Moradi, A., Shafiee, A. & Miri, R. (2016). Structure-based design, synthesis, molecular docking study and biological evaluation of 1, 2, 4- triazine derivatives acting as COX/15-LOX inhibitors with anti-oxidant activities. J Enzym Inhib Med Chem, 31, 1602-1611.
  • Lee, J.L., Mukhtar, H., Bickers, D.R., Kopelovich, L. Athar, M. (2003). Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicol Appl Pharmacol, 192, 294-306.
  • Liu, H., Zhu, Y., Wang, T., Qi, J. & Liu, X. (2018). Enzyme-site blocking combined with optimization of molecular docking for efficient discovery of potential tyrosinase specific inhibitors from Puerariae lobatae radix. Molecules, 23(10), 2612.
  • Mahasneh, A.M., Abbas, J.A. & El-Oqlah, A.A. (1996). Antimicrobial activity of extracts of herbal plants used inthe traditional medicine of Bahrain. Phytother Res 10, 251–253.
  • Mahasneh, A.M., Abbas, J.A. & El-Oqlah, A.A. (1996). Antimicrobial activity of extracts of herbal plants used inthe traditional medicine of Bahrain. Phytother Res 10, 251–253.
  • Marrelli, M., Loizzo, M.R., Nicoletti, M., Menichini, F. & Conforti, F. (2014). In vitro investigation of the potential health benefits of wild Mediterranean dietary plants as anti-obesity agents with α amylase and pancreatic lipase inhibitory activities. Sci Food Agric, 94, 2217-2224.
  • Marrelli, M., Loizzo, M.R., Nicoletti, M., Menichini, F. & Conforti, F. (2014). In vitro investigation of the potential health benefits of wild Mediterranean dietary plants as anti-obesity agents with α amylase and pancreatic lipase inhibitory activities. Sci Food Agric, 94, 2217-2224.
  • Mazarei, F., Jooyandeh, H., Noshad, M. & Hojjati, M. (2017). Polysaccharide of caper (Capparis spinosa L.) Leaf: Extraction optimization, antioxidant potential and antimicrobial activity. Int J Biol Macromol, 95, 224-231.
  • Orhan, I.E., Senol, F.S., Haznedaroglu, M.Z., Koyu, H., Erdem, S.A., Yılmaz, G., Cicek, M., Yaprak, A.E., Ari, E. & Kucukboyaci, N. (2017). Neurobiological evaluation of thirty-one medicinal plant extracts using microtiter enzyme assays. Clin. Phytosci, 2(9). https://doi.org/10.1186/s40816-016-0023-6.
  • Özcan, K. (2020). Antibacterial, antioxidant and enzyme inhibition activity capacities of Doronicum macrolepis (FREYN&SINT): An endemic plant from Turkey. Saudi Pharm, 28, 95–100.
  • Panda, S.S., Girgis, A.S., Thomas, S.J., Capito, J.E., George, R.F., Salman, A., El-Manawaty, M.A. & Samir, A. (2020). Synthesis, pharmacological profile and 2D-QSAR studies of curcumin amino acid conjugates as potential drug candidates. Eur J Med Chem, 196, 112293
  • Preetha, S., Roy, A. & Rajeshkumar, S. (2020a). In-vitro free radical scavenging, antibacterial, cytotoxicity of ethanolic/hydroethanolic extract of Capparis decidua. Int J Pharm Res, 2912-2921.
  • Rahimi, V.R., Rajabian, A., Rajabi, H., Vosough, E.M., Mirkarimi, H.R., Hasanpour, M., Iranshahi, M., Rakhshandeh, H. & Askari, V.R. (2020). The effects of hydro-ethanolic extract of Capparis spinosa (C. spinosa) on lipopolysaccharide (LPS)- induced inflammation and cognitive impairment: Evidence from in vivo and in vitro studies. J of Ethnopharm, 256, 112706.
  • Raikar, P. & Shingade, S. (2018). Synthesis, characterization and screening of pyrazoline derivatives for anti-inflammatory activity. IJPSR, 9, 2446 – 2450.
  • Singh, P., Mishra, G., Sangeeta Srivastava, S., Jha, K.K. & Khosa, R.L. 2011. Traditional uses, phytochemistry and pharmacological properties of Capparis decidua: An Overview. Der Pharm Lett, 3(2), 71-82.
  • Song, B.R., Lee, S.J., Kim, J.E., Choi, H.J., Bae, S.J., Choi, Y.J., Gong, J.E., Noh, J.K., Kim, H.S., Kang, H.G., Hong, J.T. & Hwang, D.Y. (2020). Anti-inflammatory effects of Capparis ecuadorica extract in phthalic-anhydride -induced atopic dermatitis of IL-4/Luc/CNS-1 transgenic mice. Pharm Biol, 58(1), 1263-1276.
  • Subramanian, S.K. & Ramani, P. (2020a). Antioxidant and cytotoxic activities of Indian caper (Capparis brevispina DC (Capparaceae) leaf extracts. Eur J Integr Med, 33, 101038. Tekulu, G.H., Hiluf, T., Brhanu, H., Araya, E.M., Bitew, H. & Haile, T. (2020). Anti-inflammatory and anti-nociceptive property of Capparis tomentosa Lam. root extracts. J Ethnopharm, 253, 1126542.
  • Tlili, N., Elfalleh, W., Saadaoui, E., Khaldi, A., Triki, S. & Nasri, N. (2011). The caper (Capparis L.): Ethnopharmacology, phytochemical and pharmacological properties. Fitoterapia, 82(2), 93-101.
  • Tlili, N., Elfalleh, W., Saadaoui, E., Khaldi, A., Triki, S. & Nasri, N. (2011). The caper (Capparis L.): Ethnopharmacology, phytochemical and pharmacological properties. Fitoterapia, 82(2), 93-101.
  • Tlili, N., Feriani, A., Saadoui, E., Nasri, N. & Khaldi, A. (2017). Capparis spinosa leaves extract: Source of bioantioxidants with nephroprotective and hepatoprotective effects. Biomed Pharmacother, 87,171-179.
  • Tlili, N., Khaldi, A., Triki, S. & Munne-Bosch, S. (2010). Phenolic Compounds and Vitamin Antioxidants of Caper (Capparis spinosa). Plant Food Hum Nutr, 65(3), 260-265.
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  • Vonkeman, H.E. & Van de Laar, M.A.F.J. (2010). Nonsteroidal anti-inflammatory drugs: adverse effects and their prevention. Semin Arthritis Rheum, 39, 294–312.
  • Vonkeman, H.E. & Van de Laar, M.A.F.J. (2010). Nonsteroidal anti-inflammatory drugs: adverse effects and their prevention. Semin Arthritis Rheum, 39, 294–312.
  • Wichi, H.P. (1988). Enhanced tumor development by butylated hydroxyanisole (BHA) from the prospective of effect on forestomach and oesophageal squamous epithelium. Food Chem Toxicol, 26, 717–723.
  • Wichi, H.P. (1988). Enhanced tumor development by butylated hydroxyanisole (BHA) from the prospective of effect on forestomach and oesophageal squamous epithelium. Food Chem Toxicol, 26, 717–723.
  • Zhang, Y., Shi, S., Zhao, M., Chai, X., Tu, P. & Coreosides, A.D. (2013). C14-polyacetylene glycosides from the capitula of Coreopsis tinctoria and its anti-inflammatory activity against COX-2. Phytoterapia, 87, 93–97.
  • Zhang, Y., Shi, S., Zhao, M., Chai, X., Tu, P. & Coreosides, A.D. (2013). C14-polyacetylene glycosides from the capitula of Coreopsis tinctoria and its anti-inflammatory activity against COX-2. Phytoterapia, 87, 93–97.
  • Zhou, H., Jian, R., Kang, J., Huang, X. & Li, Y. (2010). Anti-inflammatory effects of caper (Capparis spinosa L.) fruit aqueous extract and the isolation of main phytochemicals. J Agric Food Chem, 85, 12717-12721.
  • Zhou, H., Jian, R., Kang, J., Huang, X. & Li, Y. (2010). Anti-inflammatory effects of caper (Capparis spinosa L.) fruit aqueous extract and the isolation of main phytochemicals. J Agric Food Chem, 85, 12717-12721.
Toplam 70 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Bitki Biyokimyası
Bölüm ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar

Nağihan Acar 0000-0002-8186-9925

Fatih Çağlar Çelikezen 0000-0001-5489-7384

İbrahim Halil Şahin 0000-0001-7667-9310

Mehmet Fırat 0000-0001-5814-614X

Recep Koçyiğit 0000-0002-0472-743X

Oğuz Ayhan Kireçci 0000-0003-2205-4758

Proje Numarası 2020.07
Erken Görünüm Tarihi 14 Haziran 2023
Yayımlanma Tarihi 31 Aralık 2023
Gönderilme Tarihi 8 Temmuz 2022
Kabul Tarihi 31 Mart 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 26 Sayı: 6

Kaynak Göster

APA Acar, N., Çelikezen, F. Ç., Şahin, İ. H., … Fırat, M. (2023). Determination of in Vitro Antioxidant, Antimicrobial Properties and COX-1/COX-2 Enzyme Inhibition Activity of Capparis Sicula. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 26(6), 1221-1229. https://doi.org/10.18016/ksutarimdoga.vi.1139197
 Kapak Resmi İndir

21082



2022-JIF = 0.500

2022-JCI = 0.170

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