Redirecting to http://dergipark.org.tr/_fragment?_hash=C_Zz9_jiIMDKXf0MV_QJVdCZr57kvYHLsuKyF36edLE&_path=id%3D1192081%26_format%3Dhtml%26_locale%3Dtr%26_controller%3DApp%255CController%255CSite%255CArticleController%253A%253AesiArticleStats.
Araştırma Makalesi
BibTex RIS Kaynak Göster

Mentha pulegium ekstraktı güçlü in vitro antimikrobiyal ve sitotoksik etki göstermiştir

Yıl 2023, Cilt: 26 Sayı: 6, 1291 - 1304, 31.12.2023

Semih Dalkılıç , Lütfiye Kadıoğlu Dalkılıç , Songül Fidan , Mustafa Timurkaan , Lütfü Uygur , Gökhan Akay , İsmail Korkmaz

https://doi.org/10.18016/ksutarimdoga.vi.1192081
Cited By: 2

Öz

Mentha pulegium tıbbi açıdan önemli ve iyi bilinen bir bitkidir ve tıbbi, beslenme ve baharat gibi çeşitli amaçlar için kullanılır. Bu çalışmada M. pulegium ekstraktının antimikrobiyal, antioksidan ve sitotoksik özelliklerini görmek için analiz edildi. M. pulegium'un antimikrobiyal aktivitesi agar kuyucuk yöntemi kullanılarak test edildi. MIC, MBC ve antimikrobiyal aktivite Staphylococcus aureus (ATCC 25923), Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25322), Bacillus megaterium (DSM32) ve Candida albicans (FMC17) mikroorganizmaları üzerinde test edildi. Pozitif kontrol olarak Klindamisin (2 µg) ve Amoksisilin (30 µg), negatif kontrol olarak Dimetilsülfoksit (DMSO) kullanıldı. 3-(4,5-dimetiltiyazol-2-il) -2,5-difenil tetrazolyum bromür (MTT) test yöntemi kullanılarak aseton, kloroform ve metanol gibi çözücülerden elde edilen farklı konsantrasyonlarda ekstraktların sitotoksik aktivitesi; ekstraktların farklı konsantrasyonlarına maruz kaldıktan sonra µg/ml sitotoksik aktivite ve hücre ölüm şekilleri; Aseton, kloroform ve metanol gibi çözücülerden 3-(4,5-dimetiltiyazol-2-il) -2,5-difenil tetrazolyum bromür (MTT) test yöntemi kullanılarak aseton, kloroform ve metanol insan meme kanseri (MDA-MB-231), insan pankreas kanseri (PANC1), insan yumurtalık kanseri (OVCAR3) ve insan akciğer kanseri (A549) hücre hatları buna göre belirlendi. Sonuç olarak M. pulegium ekstraktının güçlü bir antimikrobiyal aktivite spektrumuna ve sitotoksik etkiye sahip olduğu belirlenmiştir.

Anahtar Kelimeler

Antimikrobiyal Antioksidan Apoptoz Sitotoksik Mentha pulegium

Proje Numarası

1919B012001186

Kaynakça

  • 1. Awouafack MD, McGaw LJ, Gottfried S, Mbouangouere R, Tane P, Spiteller M, et al. Antimicrobial activity and cytotoxicity of the ethanol extract, fractions and eight compounds isolated from Eriosema robustum (Fabaceae). BMC Complementary and Alternative Medicine. 2013;13(1):1-9. https://doi.org/10.1186/1472-6882-13-289
  • 2. Ahmed A, Ayoub K, Chaima AJ, Hanaa L, Abdelaziz C. Effect of drying methods on yield, chemical composition and bioactivities of essential oil obtained from Moroccan Mentha pulegium L. Biocatalysis and Agricultural Biotechnology. 2018;16:638-643. https://doi.org/10.1016/j.bcab.2018.10.016
  • 3. Andersson DI, Hughes D. Persistence of antibiotic resistance in bacterial populations. FEMS Microbiology Reviews. 2011;35(5):901-911. https://doi.org/10.1111/j.1574-6976.2011.00289.x
  • 4. Benlarbi KH, Elmtili N, Macías FA, Galindo JCG. Influence of in vitro growth conditions in the production of defence compounds in Mentha pulegium L. Phytochemistry Letters. 2014;8:233-244. https://doi.org/10.1016/j.phytol.2014.03.007
  • 5. Buys SS, Partridge E, Greene MH, Prorok PC, Reding D, Riley TL, Hartge P, Fagerstrom RM, Ragard LR, Chia D, Izmirlian G, Fouad M, Johnson CC, Gohagan JK, PLCO Project Team. Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: findings from the initial screen of a randomized trial. American Journal of Obstetrics and Gynecology. 2005;193(5):1630–1639. https://doi.org/10.1016/j.ajog.2005.05.005
  • 6. Chalchat JC, Gorunovic MS, Maksimovic ZA, Petrovic SD. Essential oil of wild growing Mentha Pulegium L. from Yugoslavia. Journal of Essential Oil Research. 2000;12(5):598-600. https://doi.org/10.1080/10412905.2000.9712166
  • 7. Cevatemre B. Fenretinid ve indol-3-karbinol kombinasyonunun meme kanseri hücre soyları üzerindeki sitotoksik/apoptotik etkilerinin araştırılması [Master's thesis]. Bursa: Uludağ Üniversitesi; 2012. Türkçe.
  • 8. Cowan MM. Plant products as antimicrobial agents. Clinical Microbiology Reviews. 1999;12(4):564–582. https://doi.org/10.1128/CMR.12.4.564
  • 9. Coşkun MD. Nf-kb ve oksidatif stresin inhibisyonu ile peripheral nöropatinin iyileştirilmesi ve kanser kemoterapi sonuçlarının geliştirilmesi [Doctoral thesis]. Bursa: Uludağ Üniversitesi; 2017.Türkçe.
  • 10. Caceres A, Cano O, Samayoa B, Aguilar L. Plants used in guatemala for the treatment of gastrointestinal disorders. 1. Screening of 84 plants against enterobacteria. Journal of Ethnopharmacology. 1990;30(1):55–73. https://doi.org/10.1016/0378-8741(90)90017-n
  • 11. Çöteli E, Erden Y, Karataş F. Yarpuz (Mentha Pulegium L.) bitkisindeki malondialdehit, glutatyon ve vitamin miktarları ile total antioksidan kapasitesinin araştırılması. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2013;17(2):4-10. Türkçe. https://dergipark.org.tr/en/pub/sdufenbed/issue/20801/222003
  • 12. Dorman HJD, Koşar M, Kahlos K, Holm Y, Hiltunen R. Antioxidant properties and composition of aqueous extracts from Mentha species, hybrids, varieties, and cultivars. Journal of Agricultural and Food Chemistry. 2003;51(16):4563–4569. https://doi.org/10.1021/jf034108k
  • 13. Dalkılıç S, Dalkılıç LK, Korkmaz İ. Geleneksel kahvaltılık zahterin antimikrobiyal etkisi. Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2020;10(1):128-133. Türkçe. https://doi.org/10.17714/gumusfenbil.579489 14. Duru ME, Oztürk M, Uğur A, Ceylan O. The constituents of essential oil and in vitro antimicrobial activity of Micromeria cilicica from Turkey. Journal of Ethnopharmacology. 2000;94(1):43–48. https://doi.org/10.1016/j.jep.2004.03.053
  • 15. Dutta D, Chakraborty A, Mukherjee B, Gupta S. Aptamer-conjugated apigenin nanoparticles to target colorectal carcinoma: a promising safe alternative of colorectal cancer chemotherapy. ACS Applied Bio Materials. 2018;1(5):1538-1556. https://doi.org/10.1021/acsabm.8b00441
  • 16. Erarslan ZB, Ecevit Genç G, Kültür Ş. Medicinal plants traditionally used to treat skin diseases in Turkey–eczema, psoriasis, vitiligo. Journal of Faculty of Pharmacy of Ankara University. 2020;44(1):137-166. https://doi.org/10.33483/jfpau.586114
  • 17. Erdogan EA, Everest A, Kaplan E. Antimicrobial activities of aqueous extracts and essential oils of two endemic species from Turkey. Indian Journal of Traditional Knowledge. 2013;12(2):221-4.
  • 18. Ebana RUB, Etim OE, Edet UO, John RS, Osom AO. Comparative evaluation of phytochemicals and antibacterial activity of the roots and leaves of anthocleista vogelii on some clinical ısolates. Asian Journal of Research in Botany. 2018;1(1):1-8. https://journalajrib.com/index.php/AJRIB/article/view/1118
  • 19. Faydaoğlu E, Sürücüoğlu M. Tıbbi ve aromatik bitkilerin antimikrobiyal, antioksidan aktiviteleri ve kullanım olanakları. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2013;6(2):233-265. Türkçe. https://dergipark.org.tr/en/pub/erzifbed/issue/6027/80707
  • 20. Greenwell M, Rahman PKSM. Medicinal plants: their use in anticancer treatment. International Journal of Pharmaceutical Sciences And Research. 2015;6(10):4103. https://dx.doi.org/10.13040%2FIJPSR.0975-8232.6(10).4103-12
  • 21. González-Tejero MR, Casares-Porcel M, Sánchez-Rojas CP, Ramiro-Gutiérrez JM, Molero-Mesa J, Pieroni A, et al. Medicinal plants in the Mediterranean area: synthesis of the results of the project Rubia. Journal of Ethnopharmacology. 2008; 116(2):341–357. https://doi.org/10.1016/j.jep.2007.11.045
  • 22. Gülçin İ, Gören AC, Taslimi P, Alwasel SH, Kılıc O, Bursal E. Anticholinergic, antidiabetic and antioxidant activities of Anatolian pennyroyal (Mentha pulegium)-analysis of its polyphenol contents by LC-MS/MS. Biocatalysis and Agricultural Biotechnology. 2020;23:101441. https://doi.org/10.1016/j.bcab.2019.101441
  • 23. Hassan E, Ullah H. Antibacterial and antifungal activities of the medicinal plant veronica biloba. Journal of Chemistry. 2019. https://doi.org/10.1155/2019/5264943
  • 24. Hesham HM, Lasheen DS, Abouzid KA. Chimeric HDAC inhibitors: Comprehensive review on the HDAC-based strategies developed to combat cancer. Medicinal Research Reviews. 2018;38(6):2058-2109. https://doi.org/10.1002/med.21505
  • 25. Hemeg HA, Moussa IM, Ibrahim S, Dawoud TM, Alhaji JH, Mubarak AS, et al. Antimicrobial effect of different herbal plant extracts against different microbial population. Saudi Journal of Biological Sciences. 2020; 27(12):3221–3227. https://doi.org/10.1016/j.sjbs.2020.08.015
  • 26. . Kurt H, Keşkek ŞÖ, Çil T, Canataroğlu A. Meme kanserli hastalarda tamamlayıcı/alternatif tedavi kullanımı. Türk Onkoloji Dergisi. 2013; 28(1):10-15. Türkçe. https://doi.org/10.5505/tjoncol.2013.827
  • 27. Lowy FD. Antimicrobial resistance: the example of Staphylococcus aureus. The Journal of Clinical Investigation. 2003;111(9):1265-1273. https://doi.org/10.1172/JCI18535
  • 28. Liu Q, Meng X, Li Y, Zhao CN, Tang GY, Li HB. Antibacterial and antifungal activities of spices. International Journal of Molecular Sciences. 2017;18(6):1283. https://doi.org/10.3390/ijms18061283
  • 29. Liu J, Chen H, Miller DS, Saavedra JE, Keefer LK, Johnson DR, Klaassen CD, Waalkes MP. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Molecular Pharmacology. 2001;60(2):302–309. https://doi.org/10.1124/mol.60.2.302
  • 30. McGaw LJ, Eloff JN. Ethnoveterinary use of southern African plants and scientific evaluation of their medicinal properties. Journal of Ethnopharmacology. 2008;119(3):559-574. https://doi.org/10.1016/j.jep.2008.06.013
  • 31. Mamadalieva NZ, Hussain H, Xiao J. Recent advances in genus Mentha: Phytochemistry, antimicrobial effects, and food applications. Food Frontiers. 2020;1(4):435-458. https://doi.org/10.1002/fft2.53
  • 32. Marzouk B, Fredj MBH, Chraief I, Mastouri M, Boukef K, Marzouk Z. Chemical composition and antimicrobial activity of essential oils from tunisian Mentha pulegium L. Journal of Food Agriculture and Environment. 2008;6(1):78
  • 33. Mensor LL, Menezes FS, Leitão GG, Reis AS, Santos TC, Coube CS, Leitão SG. Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytotherapy Research. 2001;15(2):127–130. https://doi.org/10.1002/ptr.687
  • 34. Nascimento GGF, Locatelli J, Freitas PC, Silva GL. Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria. Brazilian Journal of Microbiology. 2000;31(4):247-256. https://doi.org/10.1590/S1517-83822000000400003
  • 35. Pucci C, Martinelli C, Ciofani G. Innovative approaches for cancer treatment: current perspectives and new challenges. Ecancer Medical Science. 2019;13:961. https://dx.doi.org/10.3332%2Fecancer.2019.961
  • 36. Sofowora A, Ogunbodede E, Onayade A. The role and place of medicinal plants in the strategies for disease prevention. African Journal of Traditional, Complementary and Alternative Medicines. 2013;10(5):210-229. https://doi.org/10.4314/ajtcam.v10i5.2
  • 37. Sakagami Y, Kajimura K. Bactericidal activities of disinfectants against vancomycin-resistant enterococci. The Journal of Hospital İnfection. 2002;50(2):140–144. https://doi.org/10.1053/jhin.2001.1150
  • 38. Swamy MK, Akhtar MS, Sinniah UR. Antimicrobial properties of plant essential oils against human pathogens and their mode of action: an updated review. Evidence-Based Complementary and Alternative Medicine. 2016. https://doi.org/10.1155/2016/3012462
  • 39. Salem N, Bachrouch O, Sriti J, Msaada K, Khammassi S, Hammami M, Selmi S, Boushih E, Koorani S, Abderraba M, Marzouk B, Limam F. Fumigant and repellent potentials of Ricinus communis and Mentha pulegium essential oils against Tribolium castaneum and Lasioderma serricorne. International Journal of Food Properties. 2017;20:2899-2913. https://doi.org/10.1080/10942912.2017.1382508
  • 40. Stockert JC, Blázquez-Castro A, Cañete M, Horobin RW, Villanueva A. MTT assay for cell viability: Intracellular localization of the formazan product is in lipid droplets. Acta Histochemica. 2012;114(8):785–796. https://doi.org/10.1016/j.acthis.2012.01.006
  • 41. Soylu EN, Çebi A. Scenedesmus sp.’nin DPPH (1, 1-difenil-2-pikrilhidrazil) serbest radikal süpürücü aktivitesi. Karadeniz Fen Bilimleri Dergisi. 2017;7(2):146-151. Türkçe. https://doi.org/10.31466/kfbd.353777
  • 42. Sharma OP, Bhat TK. DPPH antioxidant assay revisited. Food Chemistry. 2009;113(4):1202-1205. https://doi.org/10.1016/j.foodchem.2008.08.008
  • 43. Shoeb M. Anti-cancer agents from medicinal plants. Bangladesh Journal of Pharmacology. 2006;1(2):35-41. https://doi.org/10.3329/bjp.v1i2.486
  • 44. Şekerli M, Kılıç N, Duman DC. Liken metabolitlerinin antikanser aktivite etkisinin moleküler düzeydeki mekanizmaları. Türk Hijyen ve Deneysel Biyoloji Dergisi. 2017;74(1): 95-102. Türkçe. https://dx.doi.org/10.5505/TurkHijyen.2016.24650
  • 45. Top R, Erden Y, Tekin S. Bazı önemli tıbbi bitkilerin antioksidan ve antikanser etkilerinin araştırılması. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi. 2019;8(2):435-442. Türkçe. https://doi.org/10.17798/bitlisfen.485413
  • 46. Talbaoui A, Aneb M, Bouyahya A, Boury HE, Amzazi S, Benjouad A, et al. In vitro cytotoxic effects and antibacterial activity of Moroccan medicinal plants Aristolochia longa and Lavandula multifida. European Journal of Medicinal Plants. 2016;16(2): 1-13. http://dx.doi.org/10.9734/ejmp
  • 47. Tariq A, Sadia S, Pan K, Ullah I, Mussarat S, Sun F. A systematic review on ethnomedicines of anti-cancer plants. Phytotherapy Research. 2017;31(2):202–264. https://doi.org/10.1002/ptr.5751
  • 48. Ugboko HU, Nwinyi OC, Oranusi SU, Fatoki TH, Omonhinmin A. Antimicrobial importance of medicinal plants in Nigeria. The Scientific World Journal. 2020. https://doi.org/10.1155/2020/7059323
  • 49. Wińska K, Mączka W, Łyczko J, Grabarczyk M, Czubaszek A, Szumny A. Essential oils as antimicrobial agents-myth or real alternative. Molecules. 2019; 24(11):2130. https://doi.org/10.3390/molecules24112130
  • 50. . Wink M. Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective. Phytochemistry. 2003;64(1):3–19. https://doi.org/10.1016/s0031-9422(03)00300-5
  • 51. Woopen H, Sehouli J. Current and future options in the treatment of malignant ascites in ovarian cancer. Anticancer Research. 2009;29(8):3353–3359.

Mentha pulegium extracts showed strong antimicrobial and cytotoxic effects in vitro.

Yıl 2023, Cilt: 26 Sayı: 6, 1291 - 1304, 31.12.2023

Semih Dalkılıç , Lütfiye Kadıoğlu Dalkılıç , Songül Fidan , Mustafa Timurkaan , Lütfü Uygur , Gökhan Akay , İsmail Korkmaz

https://doi.org/10.18016/ksutarimdoga.vi.1192081
Cited By: 2

Öz

Mentha pulegium is a medicinally important and well-known plant and used for various purposes such as medicinal, nutritional and spice. We are analyzed to observe the antimicrobial, antioxidant and cytotoxic properties of M. pulegium extracts in this study. The antimicrobial activity of M. pulegium was tested using the agar well method. MIC, MBC and antimicrobial activity were tested on Staphylococcus aureus (ATCC 25923), Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25322), Bacillus megaterium (DSM32) and Candida albicans (FMC17) microorganisms. Clindamycin (2 µg) and Amoxicillin (30 µg) were used as positive control and Dimethylsulfoxide (DMSO) as negative control. Cytotoxic activity of extracts at different concentrations obtained from solvents such as acetone, chloroform and methanol using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test method; µg/ml cytotoxic activity and cell death patterns after exposure to different concentrations of the extracts on human breast cancer (MDA-MB-231), human pancreatic cancer (PANC1), human ovarian cancer (OVCAR3) and human lung cancer (A549) cell lines determined accordingly. As a result, it was determined that M. pulegium extract has a strong antimicrobial activity spectrum and cytotoxic effect.

Anahtar Kelimeler

Antimicrobial Antioxidant Apoptosis Cytotoxicity Mentha pulegium

Destekleyen Kurum

TÜBİTAK

Proje Numarası

1919B012001186

Teşekkür

Thanks to Prof. Dr. Mustafa Kaplan, Fırat University Faculty of Medicine Department of Parasitology, for contributing to the laboratory environment in the realization of this study.

Kaynakça

  • 1. Awouafack MD, McGaw LJ, Gottfried S, Mbouangouere R, Tane P, Spiteller M, et al. Antimicrobial activity and cytotoxicity of the ethanol extract, fractions and eight compounds isolated from Eriosema robustum (Fabaceae). BMC Complementary and Alternative Medicine. 2013;13(1):1-9. https://doi.org/10.1186/1472-6882-13-289
  • 2. Ahmed A, Ayoub K, Chaima AJ, Hanaa L, Abdelaziz C. Effect of drying methods on yield, chemical composition and bioactivities of essential oil obtained from Moroccan Mentha pulegium L. Biocatalysis and Agricultural Biotechnology. 2018;16:638-643. https://doi.org/10.1016/j.bcab.2018.10.016
  • 3. Andersson DI, Hughes D. Persistence of antibiotic resistance in bacterial populations. FEMS Microbiology Reviews. 2011;35(5):901-911. https://doi.org/10.1111/j.1574-6976.2011.00289.x
  • 4. Benlarbi KH, Elmtili N, Macías FA, Galindo JCG. Influence of in vitro growth conditions in the production of defence compounds in Mentha pulegium L. Phytochemistry Letters. 2014;8:233-244. https://doi.org/10.1016/j.phytol.2014.03.007
  • 5. Buys SS, Partridge E, Greene MH, Prorok PC, Reding D, Riley TL, Hartge P, Fagerstrom RM, Ragard LR, Chia D, Izmirlian G, Fouad M, Johnson CC, Gohagan JK, PLCO Project Team. Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: findings from the initial screen of a randomized trial. American Journal of Obstetrics and Gynecology. 2005;193(5):1630–1639. https://doi.org/10.1016/j.ajog.2005.05.005
  • 6. Chalchat JC, Gorunovic MS, Maksimovic ZA, Petrovic SD. Essential oil of wild growing Mentha Pulegium L. from Yugoslavia. Journal of Essential Oil Research. 2000;12(5):598-600. https://doi.org/10.1080/10412905.2000.9712166
  • 7. Cevatemre B. Fenretinid ve indol-3-karbinol kombinasyonunun meme kanseri hücre soyları üzerindeki sitotoksik/apoptotik etkilerinin araştırılması [Master's thesis]. Bursa: Uludağ Üniversitesi; 2012. Türkçe.
  • 8. Cowan MM. Plant products as antimicrobial agents. Clinical Microbiology Reviews. 1999;12(4):564–582. https://doi.org/10.1128/CMR.12.4.564
  • 9. Coşkun MD. Nf-kb ve oksidatif stresin inhibisyonu ile peripheral nöropatinin iyileştirilmesi ve kanser kemoterapi sonuçlarının geliştirilmesi [Doctoral thesis]. Bursa: Uludağ Üniversitesi; 2017.Türkçe.
  • 10. Caceres A, Cano O, Samayoa B, Aguilar L. Plants used in guatemala for the treatment of gastrointestinal disorders. 1. Screening of 84 plants against enterobacteria. Journal of Ethnopharmacology. 1990;30(1):55–73. https://doi.org/10.1016/0378-8741(90)90017-n
  • 11. Çöteli E, Erden Y, Karataş F. Yarpuz (Mentha Pulegium L.) bitkisindeki malondialdehit, glutatyon ve vitamin miktarları ile total antioksidan kapasitesinin araştırılması. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2013;17(2):4-10. Türkçe. https://dergipark.org.tr/en/pub/sdufenbed/issue/20801/222003
  • 12. Dorman HJD, Koşar M, Kahlos K, Holm Y, Hiltunen R. Antioxidant properties and composition of aqueous extracts from Mentha species, hybrids, varieties, and cultivars. Journal of Agricultural and Food Chemistry. 2003;51(16):4563–4569. https://doi.org/10.1021/jf034108k
  • 13. Dalkılıç S, Dalkılıç LK, Korkmaz İ. Geleneksel kahvaltılık zahterin antimikrobiyal etkisi. Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2020;10(1):128-133. Türkçe. https://doi.org/10.17714/gumusfenbil.579489 14. Duru ME, Oztürk M, Uğur A, Ceylan O. The constituents of essential oil and in vitro antimicrobial activity of Micromeria cilicica from Turkey. Journal of Ethnopharmacology. 2000;94(1):43–48. https://doi.org/10.1016/j.jep.2004.03.053
  • 15. Dutta D, Chakraborty A, Mukherjee B, Gupta S. Aptamer-conjugated apigenin nanoparticles to target colorectal carcinoma: a promising safe alternative of colorectal cancer chemotherapy. ACS Applied Bio Materials. 2018;1(5):1538-1556. https://doi.org/10.1021/acsabm.8b00441
  • 16. Erarslan ZB, Ecevit Genç G, Kültür Ş. Medicinal plants traditionally used to treat skin diseases in Turkey–eczema, psoriasis, vitiligo. Journal of Faculty of Pharmacy of Ankara University. 2020;44(1):137-166. https://doi.org/10.33483/jfpau.586114
  • 17. Erdogan EA, Everest A, Kaplan E. Antimicrobial activities of aqueous extracts and essential oils of two endemic species from Turkey. Indian Journal of Traditional Knowledge. 2013;12(2):221-4.
  • 18. Ebana RUB, Etim OE, Edet UO, John RS, Osom AO. Comparative evaluation of phytochemicals and antibacterial activity of the roots and leaves of anthocleista vogelii on some clinical ısolates. Asian Journal of Research in Botany. 2018;1(1):1-8. https://journalajrib.com/index.php/AJRIB/article/view/1118
  • 19. Faydaoğlu E, Sürücüoğlu M. Tıbbi ve aromatik bitkilerin antimikrobiyal, antioksidan aktiviteleri ve kullanım olanakları. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2013;6(2):233-265. Türkçe. https://dergipark.org.tr/en/pub/erzifbed/issue/6027/80707
  • 20. Greenwell M, Rahman PKSM. Medicinal plants: their use in anticancer treatment. International Journal of Pharmaceutical Sciences And Research. 2015;6(10):4103. https://dx.doi.org/10.13040%2FIJPSR.0975-8232.6(10).4103-12
  • 21. González-Tejero MR, Casares-Porcel M, Sánchez-Rojas CP, Ramiro-Gutiérrez JM, Molero-Mesa J, Pieroni A, et al. Medicinal plants in the Mediterranean area: synthesis of the results of the project Rubia. Journal of Ethnopharmacology. 2008; 116(2):341–357. https://doi.org/10.1016/j.jep.2007.11.045
  • 22. Gülçin İ, Gören AC, Taslimi P, Alwasel SH, Kılıc O, Bursal E. Anticholinergic, antidiabetic and antioxidant activities of Anatolian pennyroyal (Mentha pulegium)-analysis of its polyphenol contents by LC-MS/MS. Biocatalysis and Agricultural Biotechnology. 2020;23:101441. https://doi.org/10.1016/j.bcab.2019.101441
  • 23. Hassan E, Ullah H. Antibacterial and antifungal activities of the medicinal plant veronica biloba. Journal of Chemistry. 2019. https://doi.org/10.1155/2019/5264943
  • 24. Hesham HM, Lasheen DS, Abouzid KA. Chimeric HDAC inhibitors: Comprehensive review on the HDAC-based strategies developed to combat cancer. Medicinal Research Reviews. 2018;38(6):2058-2109. https://doi.org/10.1002/med.21505
  • 25. Hemeg HA, Moussa IM, Ibrahim S, Dawoud TM, Alhaji JH, Mubarak AS, et al. Antimicrobial effect of different herbal plant extracts against different microbial population. Saudi Journal of Biological Sciences. 2020; 27(12):3221–3227. https://doi.org/10.1016/j.sjbs.2020.08.015
  • 26. . Kurt H, Keşkek ŞÖ, Çil T, Canataroğlu A. Meme kanserli hastalarda tamamlayıcı/alternatif tedavi kullanımı. Türk Onkoloji Dergisi. 2013; 28(1):10-15. Türkçe. https://doi.org/10.5505/tjoncol.2013.827
  • 27. Lowy FD. Antimicrobial resistance: the example of Staphylococcus aureus. The Journal of Clinical Investigation. 2003;111(9):1265-1273. https://doi.org/10.1172/JCI18535
  • 28. Liu Q, Meng X, Li Y, Zhao CN, Tang GY, Li HB. Antibacterial and antifungal activities of spices. International Journal of Molecular Sciences. 2017;18(6):1283. https://doi.org/10.3390/ijms18061283
  • 29. Liu J, Chen H, Miller DS, Saavedra JE, Keefer LK, Johnson DR, Klaassen CD, Waalkes MP. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Molecular Pharmacology. 2001;60(2):302–309. https://doi.org/10.1124/mol.60.2.302
  • 30. McGaw LJ, Eloff JN. Ethnoveterinary use of southern African plants and scientific evaluation of their medicinal properties. Journal of Ethnopharmacology. 2008;119(3):559-574. https://doi.org/10.1016/j.jep.2008.06.013
  • 31. Mamadalieva NZ, Hussain H, Xiao J. Recent advances in genus Mentha: Phytochemistry, antimicrobial effects, and food applications. Food Frontiers. 2020;1(4):435-458. https://doi.org/10.1002/fft2.53
  • 32. Marzouk B, Fredj MBH, Chraief I, Mastouri M, Boukef K, Marzouk Z. Chemical composition and antimicrobial activity of essential oils from tunisian Mentha pulegium L. Journal of Food Agriculture and Environment. 2008;6(1):78
  • 33. Mensor LL, Menezes FS, Leitão GG, Reis AS, Santos TC, Coube CS, Leitão SG. Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytotherapy Research. 2001;15(2):127–130. https://doi.org/10.1002/ptr.687
  • 34. Nascimento GGF, Locatelli J, Freitas PC, Silva GL. Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria. Brazilian Journal of Microbiology. 2000;31(4):247-256. https://doi.org/10.1590/S1517-83822000000400003
  • 35. Pucci C, Martinelli C, Ciofani G. Innovative approaches for cancer treatment: current perspectives and new challenges. Ecancer Medical Science. 2019;13:961. https://dx.doi.org/10.3332%2Fecancer.2019.961
  • 36. Sofowora A, Ogunbodede E, Onayade A. The role and place of medicinal plants in the strategies for disease prevention. African Journal of Traditional, Complementary and Alternative Medicines. 2013;10(5):210-229. https://doi.org/10.4314/ajtcam.v10i5.2
  • 37. Sakagami Y, Kajimura K. Bactericidal activities of disinfectants against vancomycin-resistant enterococci. The Journal of Hospital İnfection. 2002;50(2):140–144. https://doi.org/10.1053/jhin.2001.1150
  • 38. Swamy MK, Akhtar MS, Sinniah UR. Antimicrobial properties of plant essential oils against human pathogens and their mode of action: an updated review. Evidence-Based Complementary and Alternative Medicine. 2016. https://doi.org/10.1155/2016/3012462
  • 39. Salem N, Bachrouch O, Sriti J, Msaada K, Khammassi S, Hammami M, Selmi S, Boushih E, Koorani S, Abderraba M, Marzouk B, Limam F. Fumigant and repellent potentials of Ricinus communis and Mentha pulegium essential oils against Tribolium castaneum and Lasioderma serricorne. International Journal of Food Properties. 2017;20:2899-2913. https://doi.org/10.1080/10942912.2017.1382508
  • 40. Stockert JC, Blázquez-Castro A, Cañete M, Horobin RW, Villanueva A. MTT assay for cell viability: Intracellular localization of the formazan product is in lipid droplets. Acta Histochemica. 2012;114(8):785–796. https://doi.org/10.1016/j.acthis.2012.01.006
  • 41. Soylu EN, Çebi A. Scenedesmus sp.’nin DPPH (1, 1-difenil-2-pikrilhidrazil) serbest radikal süpürücü aktivitesi. Karadeniz Fen Bilimleri Dergisi. 2017;7(2):146-151. Türkçe. https://doi.org/10.31466/kfbd.353777
  • 42. Sharma OP, Bhat TK. DPPH antioxidant assay revisited. Food Chemistry. 2009;113(4):1202-1205. https://doi.org/10.1016/j.foodchem.2008.08.008
  • 43. Shoeb M. Anti-cancer agents from medicinal plants. Bangladesh Journal of Pharmacology. 2006;1(2):35-41. https://doi.org/10.3329/bjp.v1i2.486
  • 44. Şekerli M, Kılıç N, Duman DC. Liken metabolitlerinin antikanser aktivite etkisinin moleküler düzeydeki mekanizmaları. Türk Hijyen ve Deneysel Biyoloji Dergisi. 2017;74(1): 95-102. Türkçe. https://dx.doi.org/10.5505/TurkHijyen.2016.24650
  • 45. Top R, Erden Y, Tekin S. Bazı önemli tıbbi bitkilerin antioksidan ve antikanser etkilerinin araştırılması. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi. 2019;8(2):435-442. Türkçe. https://doi.org/10.17798/bitlisfen.485413
  • 46. Talbaoui A, Aneb M, Bouyahya A, Boury HE, Amzazi S, Benjouad A, et al. In vitro cytotoxic effects and antibacterial activity of Moroccan medicinal plants Aristolochia longa and Lavandula multifida. European Journal of Medicinal Plants. 2016;16(2): 1-13. http://dx.doi.org/10.9734/ejmp
  • 47. Tariq A, Sadia S, Pan K, Ullah I, Mussarat S, Sun F. A systematic review on ethnomedicines of anti-cancer plants. Phytotherapy Research. 2017;31(2):202–264. https://doi.org/10.1002/ptr.5751
  • 48. Ugboko HU, Nwinyi OC, Oranusi SU, Fatoki TH, Omonhinmin A. Antimicrobial importance of medicinal plants in Nigeria. The Scientific World Journal. 2020. https://doi.org/10.1155/2020/7059323
  • 49. Wińska K, Mączka W, Łyczko J, Grabarczyk M, Czubaszek A, Szumny A. Essential oils as antimicrobial agents-myth or real alternative. Molecules. 2019; 24(11):2130. https://doi.org/10.3390/molecules24112130
  • 50. . Wink M. Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective. Phytochemistry. 2003;64(1):3–19. https://doi.org/10.1016/s0031-9422(03)00300-5
  • 51. Woopen H, Sehouli J. Current and future options in the treatment of malignant ascites in ovarian cancer. Anticancer Research. 2009;29(8):3353–3359.
Toplam 50 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji
Bölüm ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar

Semih Dalkılıç 0000-0002-6892-247X

Lütfiye Kadıoğlu Dalkılıç 0000-0002-6791-3811

Songül Fidan 0000-0003-1876-858X

Mustafa Timurkaan 0000-0003-1950-0489

Lütfü Uygur 0000-0002-5113-2703

Gökhan Akay 0000-0003-3892-2572

İsmail Korkmaz 0000-0003-4631-7786

Proje Numarası 1919B012001186
Erken Görünüm Tarihi 14 Haziran 2023
Yayımlanma Tarihi 31 Aralık 2023
Gönderilme Tarihi 20 Ekim 2022
Kabul Tarihi 27 Şubat 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 26 Sayı: 6

Kaynak Göster

APA Dalkılıç, S., Kadıoğlu Dalkılıç, L., Fidan, S., … Timurkaan, M. (2023). Mentha pulegium extracts showed strong antimicrobial and cytotoxic effects in vitro. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 26(6), 1291-1304. https://doi.org/10.18016/ksutarimdoga.vi.1192081

Cited By

Investigation of Cytotoxic, Antimicrobial and Antioxidant Activity of Echium vulgare L. Seed
International Journal of Nature and Life Sciences
https://doi.org/10.47947/ijnls.1379179
Investigation of Cytotoxic Effects of Tragopogon reticulatus Against HepG2 and MCF-7 Cell Lines and Antioxidant, Antimicrobial Effects Against Some Microorganisms
Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi
https://doi.org/10.47495/okufbed.1366563
 Kapak Resmi İndir

21082



2022-JIF = 0.500

2022-JCI = 0.170

Uluslararası Hakemli Dergi (International Peer Reviewed Journal)

       Dergimiz, herhangi bir başvuru veya yayımlama ücreti almamaktadır. (Free submission and publication)

      Yılda 6 sayı yayınlanır. (Published 6 times a year)


88x31.png 

Bu web sitesi Creative Commons Atıf 4.0 Uluslararası Lisansı ile lisanslanmıştır.

                 


Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi
e-ISSN: 2619-9149