Investigation of The Efficacy of Plantago Major Flavonoids in The Healing of Diabetic Foot Wound in Silico Analysis

İsmail Keleş; Alpaslan Bayrakdar; Nermin Olgun

doi:10.18016/ksutarimdoga.vi.1410509

TR EN

Diyabetik Ayak Yarası Iyileşmeside Plantago Majör Flovonoidlerin Etkinliğinin In Silico Olarak Araştırılması

Öz

Diyabet, insülin eksikliğine bağlı olarak tüm dünyada hızla artan kronik bir hastalıktır. Diyabetik ayak ülseri diyabetin en önemli komplikasyonlarından biridir. Bu yaraların tedavisinde sentetik ve doğal birçok tedavi yöntemi bulunmaktadır. Sentetik ilaçların olası yan etkilerinden dolayı Quercetin gibi doğal flavonoidlerin kullanımı diyabetik yaraların tedavisinde tercih edilmektedir. Bu çalışmada Quercetine alternatif olabilecek Plantago major flavonoidleri in silico olarak araştırılması amaçlanmıştır. Plantago major ve flavonoidlerinin Quercetin ile benzer özellikler gösterip göstermediği AutoDockTools yazılımı yardımıyla in silico olarak araştırılmıştır. Flavonoidlerin ADME çalışması, açık erişimli bir web aracı olan SwissAdme yardımıyla araştırılmıştır. Plantago major'un flavonoidleri ile Quercetin'in diyabetik yara iyileşmesinde rol oynayan SIRT 1 reseptörlerinden 4ZZJ'nin in silico çalışmasının sonuçları; Plantago major flovonoidlerinden luteolin (-4,81 kcal.mol-1), apigenin (-4,74 kcal.mol-1) ve Hispidulin'in (-4,58 kcal.mol-1) Quercetin'den (-4,56 kcal.mol-1) daha iyi bağlanma enerjisine sahip olduğunu göstermektedir. Sonuç olarak, bu in silico çalışma Plantago major flavonoidleri luteolin, apigenin ve hispidulinin diyabetik yara iyileşmesi için Quercetine doğal alternatifler olabileceğini göstermiştir

Anahtar Kelimeler

Investigation of The Efficacy of Plantago Major Flavonoids in The Healing of Diabetic Foot Wound in Silico Analysis

Abstract

Diabetes is a chronic disease that is rapidly increasing worldwide due to insulin deficiency. Diabetic foot ulcer is one of the most important complications of diabetes. There are many synthetic and natural treatment methods in the treatment of these wounds. Among the possible side effects of synthetic drugs, the use of natural flavonoids such as Quercetin is preferred in the treatment of diabetic wounds. In this study, Plantago's major flavonoids, which can be an alternative to Quercetin, were investigated in silico. Whether Plantago major and its flavonoids show similar properties with Quercetin was investigated in silico with the help of AutoDockTools software. The ADME study of flavonoids was investigated with the help of SwissAdme, an open-access web tool. The results of the in silico study of Plantago major's flavonoids and Quercetin's 4ZZJ, one of the SIRT 1 receptors that play a role in diabetic wound healing; Plantago major flavonoids luteolin (-4.81 kcal.mol-1), apigenin (-4.74 kcal.mol-1) and Hispidulin (-4.58 kcal.mol-1) are better than Quercetin (-4.56 kcal.mol-1). showed that it has binding energy. In conclusion, this in silico study showed that Plantago major flavonoids luteolin, apigenin and hispidulin could be natural alternatives to Quercetin for diabetic wound healing.

Keywords

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Eczacılık ve İlaç Bilimleri (Diğer)

Bölüm

Araştırma Makalesi

Yazarlar

İsmail Keleş ^*
0000-0002-6575-8029
Türkiye

Alpaslan Bayrakdar
0000-0001-7967-2245
Türkiye

Nermin Olgun
0000-0002-8704-4588
Türkiye

Erken Görünüm Tarihi

2 Temmuz 2024

Yayımlanma Tarihi

17 Eylül 2024

Gönderilme Tarihi

26 Aralık 2023

Kabul Tarihi

8 Şubat 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 27 Sayı: 5

DOI

https://doi.org/10.18016/ksutarimdoga.vi.1410509

IZ

https://izlik.org/JA86RX23NN

Kaynak Göster

RIS / Bibtex

APA

Keleş, İ., Bayrakdar, A., & Olgun, N. (2024). Investigation of The Efficacy of Plantago Major Flavonoids in The Healing of Diabetic Foot Wound in Silico Analysis. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 27(5), 1032-1041. https://doi.org/10.18016/ksutarimdoga.vi.1410509

Diyabetik Ayak Yarası Iyileşmeside Plantago Majör Flovonoidlerin Etkinliğinin In Silico Olarak Araştırılması

Öz

Anahtar Kelimeler

Investigation of The Efficacy of Plantago Major Flavonoids in The Healing of Diabetic Foot Wound in Silico Analysis

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Erken Görünüm Tarihi

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

e-ISSN: 2619-9149