Evaluation of The Effects of Pomegranate Juice on Hepato-Nephrotoxicity in Male Rats Exposed to Aluminum

Harun Çiftçi; Çiğdem Er Çalışkan; Fatih Kar; Ahmet Özkaya; Kenan Güçlü

doi:10.18016/ksutarimdoga.vi.896611

TR EN

Alüminyuma Maruz Kalmış Erkek Sıçanlarda Nar Suyunun Hepato-Nefrotoksisite Üzerine Etkilerinin Değerlendirilmesi.

Öz

Alüminyum, günümüz aşı çalışmalarında stabilizatör ve efektör olarak kullanılmaktadır. Alüminyum tüm hayatımızda olmasına rağmen kimyasal özellikler açısından uygun olmayan özelliklere sahiptir. Narın önemli biyolojik ve tıbbi özellikleri vardır. Nar suyunun AlCl3 kaynaklı hepato-nefrotoksisiteye olan etkilerini analiz etmek için sıçan serumundaki elektrolit seviyeleri, böbrek ve karaciğer fonksiyon testi ve lipid profili gibi biyokimyasal parametreleri amaçlanmıştır. Yirmi sekiz wistar albino sıçan; kontrol (Grup I), nar suyu (4 ml/kg) (Grup II), AlCl3 (8,3 mg/kg) (Grup III) ve nar suyu + AlCl3 (Grup IV) şeklinde dört gruba ayrılmıştır. Alüminyum toksisitesi ve nar suyunun koruyucu etkisi elektrolit düzeyleri açısından Mg ve Cl hariç gruplar arasında istatistiksel olarak farklı bulunmamıştır (p <0.05). AlCl3, serum AST, ALT, BUN ve CREA düzeylerini önemli ölçüde artırdığı ve ALB ve TP'yi düşürdüğü (p <0.05) görülmüştür. AlCl3 ile birlikte veya öncesinde nar suyu uygulaması, karaciğer ve böbrek fonksiyonunun serum biyobelirteçlerini neredeyse normale yakın seviyelere getirdiği görülmüştür. Lipid metabolizmasında sadece LDL ve CHOL düzeylerinde istatistiksel olarak anlamlı bir fark görülmüştür (p <0.05). Nar suyu, elektrolit seviyeleri, karaciğer ve böbrek fonksiyon testi ve lipid profili açısından alüminyum toksisitesini azalttığı sonucuna varılmıştır.

Anahtar Kelimeler

Evaluation of The Effects of Pomegranate Juice on Hepato-Nephrotoxicity in Male Rats Exposed to Aluminum

Abstract

Aluminum is used as a stabilizer and effector in today's vaccine studies. Although aluminum is in all our lives, it has unsuitable properties in terms of chemical properties. Pomegranate has notable biological and medicinal properties. We aimed to measure biochemical parameters in rat serum such as electrolyte levels, kidney and liver function test, and lipid profile to analyze the effects of pomegranate juice towards AlCl3-induced hepato-nephrotoxicity. The twenty-eight wistar albino rats divided into four groups; control (Group I), pomegranate juice (4 ml/kg) (Group II), AlCl3 (8.3 mg/kg) (Group III) and pomegranate juice + AlCl3 (Group IV). Aluminum toxicity and the protective effect of pomegranate juice did not statistically different among groups in electrolyte levels, except for Mg and Cl (p<0.05). AlCL3 considerably increased serum AST, ALT, BUN and CREA levels and decreased ALB and TP (p<0.05). Pomegranate juice administration with or before AlCl3 notably restored serum biomarkers of liver and kidney function to near-normal levels. There was only a statistically significant difference in LDL and CHOL levels in lipid metabolism (p<0.05). The pomegranate juice reduced aluminum toxicity in terms of electrolyte levels, liver and renal function test, and lipid profile.

Keywords

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

Araştırma Makalesi

Yazarlar

Harun Çiftçi
0000-0002-3210-5566
Türkiye

Çiğdem Er Çalışkan
0000-0001-5821-7489
Türkiye

Fatih Kar ^*
0000-0001-8356-9806
Türkiye

Ahmet Özkaya
0000-0002-0173-3084
Türkiye

Kenan Güçlü
0000-0002-0092-652X
Türkiye

Yayımlanma Tarihi

30 Nisan 2022

Gönderilme Tarihi

14 Mart 2021

Kabul Tarihi

7 Mayıs 2021

Yayımlandığı Sayı

Yıl 2022 Cilt: 25 Sayı: 2

DOI

https://doi.org/10.18016/ksutarimdoga.vi.896611

IZ

https://izlik.org/JA78CN48TX

Kaynak Göster

RIS / Bibtex

APA

Çiftçi, H., Er Çalışkan, Ç., Kar, F., Özkaya, A., & Güçlü, K. (2022). Evaluation of The Effects of Pomegranate Juice on Hepato-Nephrotoxicity in Male Rats Exposed to Aluminum. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 25(2), 215-222. https://doi.org/10.18016/ksutarimdoga.vi.896611