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Protective Effects of Lyophilized Ethanolic Extract of Achillea arabica Kotschy. on the Islet β Cells of Streptozotocin-Induced Diabetic Rats

Yıl 2021, Cilt: 24 Sayı: 4, 689 - 700, 31.08.2021

Hanife Hanalp Burak Kaptaner , Abdulahad Doğan

https://doi.org/10.18016/ksutarimdoga.vi.811253
Cited By: 3

Öz

In this study, an evaluation of the protective effect of lyophilized ethanolic Achillea arabica Kotschy. extract was investigated on the islets of Langerhans in streptozotocin (STZ)-induced diabetic rats. The rats were divided randomly into 5 groups: Group I: control; Group II: rats treated with STZ (50 mg kg-1 body weight (bw)); Group III: rats treated with A. arabica (Aa) extract (400 mg kg-1 bw); Group IV: rats with DM treated with Aa extract; and Group V: rats with DM treated with glibenclamide (2 mg kg-1 bw) which is a standard drug used in the treatment of DM. STZ treatment caused histopathological changes in the islet and significantly lowered the islet diameter/area, -cell index values, and blood insulin and C-peptide levels. Administration of the extract of Aa improved the islet histology, diameter/area, and -cell index values, and caused significant increases in insulin and C-peptide levels similar to the rats treated with glibenclamide when compared to the diabetic rats. Our findings suggested that the Aa extract possessed protective potential on the pancreatic islets due to its repairing or regeneration impact on -cells.

Anahtar Kelimeler

Diabetes Achillea arabica Streptozotocin Rat Histopathology

Destekleyen Kurum

The Scientific Research Projects Coordination Unit of Van Yuzuncu Yil University

Proje Numarası

TYL-2019-865 and FAP-2019-8503

Teşekkür

This study was partially supported by the Scientific Research Projects Coordination Unit of Van Yuzuncu Yil University under project numbers TYL-2019-865 and FAP-2019-8503. Thanks are given to Dr. Süleyman Mesut Pınar for his helpful taxonomical identification of the plant material.

Kaynakça

  • Abd El-Fattah AI, Ali SA, Aly HF, Abd-Alla HI, Shalaby NM, Saleh MH 2018. Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats. J Complement Med Res 7(2): 115–130. https://doi.org/10.5455/jcmr. 20180121122758
  • Abd-Alla HI, Shalaby NM, Hamed MA, El-Rigal NS, Al-Ghamdi SN, Bouajila J 2016. Phytochemical composition, protective and therapeutic effect on gastric ulcer and α-amylase inhibitory activity of Achillea biebersteinii Afan. Arch Pharm Res 39(1): 10–20. https://doi.org/10.1007/s12272-014-0544-9
  • Abdel Aziz MT, El-Asmar MF, Rezq AM, Mahfouz SM, Wassef MA, Fouad HH, Hanan HA, Taha FM 2013. The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study). Diabetol Metab Syndr 5(1): 75. https://doi.org/10.1186/1758-5996-5-75.
  • Ahmed OM, Moneim AA, Yazid IA, Mahmoud AM 2010. Antihyperglycemic, antihyperlipidemic and antioxidant effects and the probable mechanisms of action of Ruta graveolens infusion and rutin in nicotinamide-streptozotocin-induced diabetic rats. Diabetol Croat 39(1): 15–35.
  • Akkol EK, Koca U, Pesin I, Yilmazer D 2011. Evaluation of the wound healing potential of Achillea biebersteinii Afan. (Asteraceae) by in vivo excision and incision models. Evid Based Complement Alternat Med 474026. http://dx.doi:10.1093/ecam/nep039
  • Al-Marby A, Ejike CE, Nasim MJ, Awadh-Ali NA, Al-Badani RA, Alghamdi GM, Jacob C 2016. Nematicidal and antimicrobial activities of methanol extracts of 17 plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula. J Intercult Ethnopharmacol 5(2): 114–121. https://doi.org/10.5455/jice.20160217040157
  • Al-Said MS, Mothana RA, Al-Yahya MM, Rafatullah S, Al-Sohaibani MO, Khaled JM, Alatar A, Alharbi NS, Kurkcuoglu M, Baser HC 2016. GC-MS analysis: in vivo hepatoprotective and antioxidant activities of the essential oil of Achillea biebersteinii afan. Growing in Saudi Arabia. Evid Based Complement Alternat Med 1867048. http://dx.doi.org/10.1155/2016/1867048
  • Al-Sokari SS, Ali NAA, Monzote L, Al-Fatimi MA 2015. Evaluation of antileishmanial activity of Albaha medicinal plants against Leishmania amazonensis. Biomed Res Int 938747. http://dx.doi.org/10.1155/ 2015/938747
  • Baharara J, Namvar F, Ramezani T, Mousavi M, Mohamad R 2015. Silver nanoparticles biosynthesized using Achillea biebersteinii flower extract: apoptosis induction in MCF-7 cells via caspase activation and regulation of Bax and Bcl-2 gene expression. Molecules 20(2):2693–2706. https://doi.org/10.3390/molecules20022693
  • Bariş Ö, Güllüce M, Şahin F, Özer H, Kiliç H, Özkan H, Sökmen M, Özbek T 2006. Biological activities of the essential oil and methanol extract of Achillea biebersteinii Afan. (Asteraceae). Turk J Biol 30(2): 65–73. https://dergipark.org.tr/tr/pub/tbtkbiology/ issue/11725/139995
  • Bashi DS, Fazly Bazzaz BS, Sahebkar A, Karimkhani MM, Ahmadi A 2012. Investigation of optimal extraction, antioxidant, and antimicrobial activities of Achillea biebersteinii and A. wilhelmsii. Pharm Biol 50(9): 1168–1176. https://doi.org/10.3109/ 13880209.2012.662235
  • Bnouham M, Ziyyat A, Mekhfi H, Tahri A, Legssyer A 2006. Medicinal plants with potential antidiabetic activity-A review of ten years of herbal medicine research (1990–2000). J. Diabetes Metab Disord 14(1): 1–25. https://doi.org/10.1159/000497588
  • Cersosimo E, Solis-Herrera C, Trautmann ME, Malloy J, Triplitt LC 2014. Assessment of pancreatic β-cell function: review of methods and clinical applications. Curr Diabetes Rev 10(1):2–42. https://doi.org/10.2174/1573399810666140214093600
  • Conforti F, Loizzo MR, Statti GA, Menichini F 2005. Comparative radical scavenging and antidiabetic activities of methanolic extract and fractions from Achillea ligustica ALL. Biol Pharm Bull 28(9): 1791–1794. https://doi.org/10.1248/bpb.28.1791
  • Coskun O, Kanter M, Korkmaz A, Oter S 2005. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol Res 51(2): 117–123. https://doi.org/10.1016 /j.phrs. 2004.06.002
  • Doğan A 2020. D Investigation of the erythrocyte fragility, hematological and antioxidant effects of oleander (Nerium oleander L.) flower ethanolic lyophilized extract in diabetic rats. KSU J. Agric Nat 23 (6): 1495-1502. https://doi.org/10.18016/ ksutarimdoga.vi.712369
  • Doğan A, Çelik İ 2016. Healing effects of sumac (Rhus coriaria) in streptozotocin-induced diabetic rats. Pharm Biol 54(10): 2092–2102. https://doi.org/ 10.3109/13880209.2016.1145702
  • Dogan A, Dalar A, Sadullahoglu C, Battal A, Uzun Y, Celik I, Demirel K 2018. Investigation of the protective effects of horse mushroom (Agaricus arvensis Schaeff.) against carbon tetrachloride-induced oxidative stress in rats. Mol Biol Rep 45(5): 787–797. https://doi.org/10.1007/s11033-018-4218-4
  • Dos Santos JM, Tewari, S., Mendes, RH 2019. The role of oxidative stress in the development of diabetes mellitus and its complications. J Diabetes Res 4189813. https://doi.org/10.1155/2019/4189813
  • Dra LA, Sellami S, Rais H, Aziz F, Aghraz A, Bekkouche K, Markouk M, Larhsini M 2019. Antidiabetic potential of Caralluma europaea against alloxan-induced diabetes in mice. Saudi J Biol Sci 26(6): 1171–1178. https://doi.org/10.1016/ j.sjbs.2018.05.028
  • Duman H 2000. Achillea L., in: Güner A, Özhatay N, Ekim T, Başer KHC, editors. Flora of Turkey and the East Aegean Islands, Edinburgh University Press, Edinburgh. 11: pp 158–159.
  • Fujita T, Sezik E, Tabata M, Yesilada E, Honda G, Takeda Y, Tanaka T, Takaishi Y 1995. Traditional medicine in Turkey VII. Folk medicine in middle and west Black Sea regions. Econ Bot 49(4): 406422. https://doi.org/10.1007/BF02863092
  • Giacco F, Brownlee M 2010. Oxidative stress and diabetic complications. Circ Res 107(9): 1058–1070. https://doi.org/10.1161/CIRCRESAHA.110.223545
  • Grunberger G, Sima AA 2004. The C-peptide signaling. J. Diabetes Res 5(1): 25–36. https://doi.org/10.1080/ 15438600490424497
  • Hammad HM, Albu C, Matar SA, Litescu SC, Al Jaber HI, Abualraghib AS, Afifi FU 2013. Biological activities of the hydro-alchoholic and aqueous extracts of Achillea biebersteinii Afan. (Asteraceae) grown in Jordan. Afr J Pharm Pharmacol 7(25): 1686–1694. https://doi.org/10.5897/AJPP2012.1490
  • Hii CST, Howell SL 1985. Effects of flavonoids on insulin secretion and 45Ca2+ handling in rat islets of Langerhans. J Endocrinol 107(1): 1–8. https:// doi.org/10.1677/joe.0.1070001
  • Honda G, Yesilada E, Tabata M, Sezik E, Fujita T, Takeda Y. Takaishi Y, Tanaka T 1996. Traditional medicine in Turkey VI. Folk medicine in west Anatolia: Afyon, Kütahya, Denizli, Muğla, Aydın provinces. J. Ethnopharmacol 53: 75–87. https://doi.org/10.1016/S0378-8741(96)01426-2
  • Hosseini A, Shafiee-Nick R, Ghorbani A 2015. Pancreatic beta cell protection/regeneration with phytotherapy. Braz J Pharm Sci 51(1): 1–16. https://doi.org/10.1590/S1984-82502015000100001
  • Huber-Morath A 1975. Achillea L., in: Davis PH, editor. Flora of Turkey and the East Aegean Islands, Edinburgh University Press, Edinburgh, 5: pp 224–252.
  • Ibeha BO, Ezeaja MI 2011. Preliminary study of antidiabetic activity of the methanolic leaf extract of Axonopus compressus (P. Beauv) in alloxan-induced diabetic rats. J. Ethnopharmacol 138: 713–716. https://doi.org/10.1016/j.jep.2011.10.009
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Achillea arabica Kotschy. Liyolifilize Etanolik Ekstresinin Streptozotosin ile Diyabet Oluşturulan Ratların Adacık  Hücreleri Üzerindeki Koruyucu Etkileri

Yıl 2021, Cilt: 24 Sayı: 4, 689 - 700, 31.08.2021

Hanife Hanalp Burak Kaptaner , Abdulahad Doğan

https://doi.org/10.18016/ksutarimdoga.vi.811253
Cited By: 3

Öz

Bu çalışmada, Achillea arabica Kotschy. liyofilize etanolik ekstresinin, streptozotosin (STZ) ile diyabet oluşturulan ratlarda Langerhans adacıkları üzerindeki koruyucu etkisi araştırıldı. Ratlar rastgele olarak 5 gruba ayrıldı; Grup I: kontrol; Grup II: STZ (50 mg kg-1 vücut ağırlığı (va)) uygulanan ratlar; Grup III: A. arabica (Aa) ekstresi (400 mg kg-1 va) ile muamele edilen ratlar; Grup IV: Aa ekstresi ile muamele edilen diyabetik ratlar ve Grup V: diyabet tedavisinde standart bir ilaç olarak kullanılan glibenklamid (2 mg kg-1 va) uygulanan diyabetik ratlar. STZ uygulamasının, adacıklarda histopatolojik değişimlere neden olduğu, adacık çapını / alanını, -hücre indeksini ve kan insulin ve C-peptid seviyelerini anlamlı olarak düşürdüğü belirlendi. Aa ekstre uygulamasının, glibenklamid ile tedavi edilen ratlara benzer olarak, adacık histolojisinde, çap / alanında, -hücre indeks değerlerinde, kan insulin ve C-peptid seviyelerinde, diyabetik ratlar ile kıyaslandığında, iyileşmeye neden olduğu gözlendi. Elde edilen bulgular Aa ekstresinin pankreas adacıklarında, -hücre onarımını ve yenilenmesini sağlayarak, koruyucu potansiyele sahip olduğunu göstermektedir.

Anahtar Kelimeler

Streptozotosin Achillea arabica Rat Diyabet Histopatoloji

Proje Numarası

TYL-2019-865 and FAP-2019-8503

Kaynakça

  • Abd El-Fattah AI, Ali SA, Aly HF, Abd-Alla HI, Shalaby NM, Saleh MH 2018. Therapeutic potential of Achillea fragrantissima extracts in amelioration of high-fat diet and low dose streptozotocin diabetic rats. J Complement Med Res 7(2): 115–130. https://doi.org/10.5455/jcmr. 20180121122758
  • Abd-Alla HI, Shalaby NM, Hamed MA, El-Rigal NS, Al-Ghamdi SN, Bouajila J 2016. Phytochemical composition, protective and therapeutic effect on gastric ulcer and α-amylase inhibitory activity of Achillea biebersteinii Afan. Arch Pharm Res 39(1): 10–20. https://doi.org/10.1007/s12272-014-0544-9
  • Abdel Aziz MT, El-Asmar MF, Rezq AM, Mahfouz SM, Wassef MA, Fouad HH, Hanan HA, Taha FM 2013. The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study). Diabetol Metab Syndr 5(1): 75. https://doi.org/10.1186/1758-5996-5-75.
  • Ahmed OM, Moneim AA, Yazid IA, Mahmoud AM 2010. Antihyperglycemic, antihyperlipidemic and antioxidant effects and the probable mechanisms of action of Ruta graveolens infusion and rutin in nicotinamide-streptozotocin-induced diabetic rats. Diabetol Croat 39(1): 15–35.
  • Akkol EK, Koca U, Pesin I, Yilmazer D 2011. Evaluation of the wound healing potential of Achillea biebersteinii Afan. (Asteraceae) by in vivo excision and incision models. Evid Based Complement Alternat Med 474026. http://dx.doi:10.1093/ecam/nep039
  • Al-Marby A, Ejike CE, Nasim MJ, Awadh-Ali NA, Al-Badani RA, Alghamdi GM, Jacob C 2016. Nematicidal and antimicrobial activities of methanol extracts of 17 plants, of importance in ethnopharmacology, obtained from the Arabian Peninsula. J Intercult Ethnopharmacol 5(2): 114–121. https://doi.org/10.5455/jice.20160217040157
  • Al-Said MS, Mothana RA, Al-Yahya MM, Rafatullah S, Al-Sohaibani MO, Khaled JM, Alatar A, Alharbi NS, Kurkcuoglu M, Baser HC 2016. GC-MS analysis: in vivo hepatoprotective and antioxidant activities of the essential oil of Achillea biebersteinii afan. Growing in Saudi Arabia. Evid Based Complement Alternat Med 1867048. http://dx.doi.org/10.1155/2016/1867048
  • Al-Sokari SS, Ali NAA, Monzote L, Al-Fatimi MA 2015. Evaluation of antileishmanial activity of Albaha medicinal plants against Leishmania amazonensis. Biomed Res Int 938747. http://dx.doi.org/10.1155/ 2015/938747
  • Baharara J, Namvar F, Ramezani T, Mousavi M, Mohamad R 2015. Silver nanoparticles biosynthesized using Achillea biebersteinii flower extract: apoptosis induction in MCF-7 cells via caspase activation and regulation of Bax and Bcl-2 gene expression. Molecules 20(2):2693–2706. https://doi.org/10.3390/molecules20022693
  • Bariş Ö, Güllüce M, Şahin F, Özer H, Kiliç H, Özkan H, Sökmen M, Özbek T 2006. Biological activities of the essential oil and methanol extract of Achillea biebersteinii Afan. (Asteraceae). Turk J Biol 30(2): 65–73. https://dergipark.org.tr/tr/pub/tbtkbiology/ issue/11725/139995
  • Bashi DS, Fazly Bazzaz BS, Sahebkar A, Karimkhani MM, Ahmadi A 2012. Investigation of optimal extraction, antioxidant, and antimicrobial activities of Achillea biebersteinii and A. wilhelmsii. Pharm Biol 50(9): 1168–1176. https://doi.org/10.3109/ 13880209.2012.662235
  • Bnouham M, Ziyyat A, Mekhfi H, Tahri A, Legssyer A 2006. Medicinal plants with potential antidiabetic activity-A review of ten years of herbal medicine research (1990–2000). J. Diabetes Metab Disord 14(1): 1–25. https://doi.org/10.1159/000497588
  • Cersosimo E, Solis-Herrera C, Trautmann ME, Malloy J, Triplitt LC 2014. Assessment of pancreatic β-cell function: review of methods and clinical applications. Curr Diabetes Rev 10(1):2–42. https://doi.org/10.2174/1573399810666140214093600
  • Conforti F, Loizzo MR, Statti GA, Menichini F 2005. Comparative radical scavenging and antidiabetic activities of methanolic extract and fractions from Achillea ligustica ALL. Biol Pharm Bull 28(9): 1791–1794. https://doi.org/10.1248/bpb.28.1791
  • Coskun O, Kanter M, Korkmaz A, Oter S 2005. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol Res 51(2): 117–123. https://doi.org/10.1016 /j.phrs. 2004.06.002
  • Doğan A 2020. D Investigation of the erythrocyte fragility, hematological and antioxidant effects of oleander (Nerium oleander L.) flower ethanolic lyophilized extract in diabetic rats. KSU J. Agric Nat 23 (6): 1495-1502. https://doi.org/10.18016/ ksutarimdoga.vi.712369
  • Doğan A, Çelik İ 2016. Healing effects of sumac (Rhus coriaria) in streptozotocin-induced diabetic rats. Pharm Biol 54(10): 2092–2102. https://doi.org/ 10.3109/13880209.2016.1145702
  • Dogan A, Dalar A, Sadullahoglu C, Battal A, Uzun Y, Celik I, Demirel K 2018. Investigation of the protective effects of horse mushroom (Agaricus arvensis Schaeff.) against carbon tetrachloride-induced oxidative stress in rats. Mol Biol Rep 45(5): 787–797. https://doi.org/10.1007/s11033-018-4218-4
  • Dos Santos JM, Tewari, S., Mendes, RH 2019. The role of oxidative stress in the development of diabetes mellitus and its complications. J Diabetes Res 4189813. https://doi.org/10.1155/2019/4189813
  • Dra LA, Sellami S, Rais H, Aziz F, Aghraz A, Bekkouche K, Markouk M, Larhsini M 2019. Antidiabetic potential of Caralluma europaea against alloxan-induced diabetes in mice. Saudi J Biol Sci 26(6): 1171–1178. https://doi.org/10.1016/ j.sjbs.2018.05.028
  • Duman H 2000. Achillea L., in: Güner A, Özhatay N, Ekim T, Başer KHC, editors. Flora of Turkey and the East Aegean Islands, Edinburgh University Press, Edinburgh. 11: pp 158–159.
  • Fujita T, Sezik E, Tabata M, Yesilada E, Honda G, Takeda Y, Tanaka T, Takaishi Y 1995. Traditional medicine in Turkey VII. Folk medicine in middle and west Black Sea regions. Econ Bot 49(4): 406422. https://doi.org/10.1007/BF02863092
  • Giacco F, Brownlee M 2010. Oxidative stress and diabetic complications. Circ Res 107(9): 1058–1070. https://doi.org/10.1161/CIRCRESAHA.110.223545
  • Grunberger G, Sima AA 2004. The C-peptide signaling. J. Diabetes Res 5(1): 25–36. https://doi.org/10.1080/ 15438600490424497
  • Hammad HM, Albu C, Matar SA, Litescu SC, Al Jaber HI, Abualraghib AS, Afifi FU 2013. Biological activities of the hydro-alchoholic and aqueous extracts of Achillea biebersteinii Afan. (Asteraceae) grown in Jordan. Afr J Pharm Pharmacol 7(25): 1686–1694. https://doi.org/10.5897/AJPP2012.1490
  • Hii CST, Howell SL 1985. Effects of flavonoids on insulin secretion and 45Ca2+ handling in rat islets of Langerhans. J Endocrinol 107(1): 1–8. https:// doi.org/10.1677/joe.0.1070001
  • Honda G, Yesilada E, Tabata M, Sezik E, Fujita T, Takeda Y. Takaishi Y, Tanaka T 1996. Traditional medicine in Turkey VI. Folk medicine in west Anatolia: Afyon, Kütahya, Denizli, Muğla, Aydın provinces. J. Ethnopharmacol 53: 75–87. https://doi.org/10.1016/S0378-8741(96)01426-2
  • Hosseini A, Shafiee-Nick R, Ghorbani A 2015. Pancreatic beta cell protection/regeneration with phytotherapy. Braz J Pharm Sci 51(1): 1–16. https://doi.org/10.1590/S1984-82502015000100001
  • Huber-Morath A 1975. Achillea L., in: Davis PH, editor. Flora of Turkey and the East Aegean Islands, Edinburgh University Press, Edinburgh, 5: pp 224–252.
  • Ibeha BO, Ezeaja MI 2011. Preliminary study of antidiabetic activity of the methanolic leaf extract of Axonopus compressus (P. Beauv) in alloxan-induced diabetic rats. J. Ethnopharmacol 138: 713–716. https://doi.org/10.1016/j.jep.2011.10.009
  • Jarald E, Joshi SB., Jain DC 2008. Diabetes vs. herbal medicines. Iranian J Pharmacol Ther 7(1): 97–107. https://doi.org/10.1016/j.jep.2011.10.009
  • Kaptaner B 2019. Immunohistochemical distribution of insulin-, glucagon- and somatostatin-containing cells in the pancreas of Lake Van fish (Alburnus tarichi Güldenstädt, 1814) (Cyprinidae). Eur J Histochem 63(1): 2999. https://doi.org/ 10.4081/ejh.2019.2999
  • Konyalioglu S, Karamenderes C 2005. The protective effects of Achillea L. species native in Turkey against H2O2-induced oxidative damage in human erythrocytes and leucocytes. J. Ethnopharmacol 102(2): 221–227. https://doi.org/10.1016/j.jep.2005. 06.018
  • Li D, Peng C, Xie X, Mao Y, Li M, Cao Z, Fan D 2014. Antidiabetic effect of flavonoids from Malus toringoides (Rehd.) Hughes leaves in diabetic mice and rats. J Ethnopharmacol 153(3): 561–567. https://doi.org/10.1016/j.jep.2014.02.026
  • Motavalizadehkakhky A, Shafaghat A, Zamani HA, Akhlaghi H, Mohammadhosseini M, Mehrzad J, Ebrahimi Z 2013. Compositions and the in vitro antimicrobial activities of the essential oils and extracts of two Achillea species from Iran. J Med Plant Res 7(19): 1280–1292. https://doi.org/ 10.5897/JMPR12.300
  • Oh YS 2015. Plant-derived compounds targeting pancreatic beta cells for the treatment of diabetes. Evid Based Complement Alternat Med 629863. http://dx.doi.org/10.1155/2015/629863
  • Okur ME, Karantas ID, Siafaka PI 2017. Diabetes mellitus: a review on pathophysiology, current status of oral pathophysiology, current status of oral medications and future perspectives. Acta Pharm Sci 55(1): 61-82. http://dx.doi.org/10.23893/ 1307-2080.APS.0555
  • Okwudili OS, Chimaobi NG, Ikechukwu EM, Ndukaku OY 2017. Antidiabetic and in vitro antioxidant effects of hydromethanol extract of Paullinia pinnata root bark in alloxan-induced diabetic rat. J. Altern Complement Med 15(2): 20150017. https://doi.org/10.1515/jcim-2015-0017
  • Sekiou O, Boumendjel M, Taibi F, Boumendjel A, Messarah M 2019. Mitigating effects of antioxidant properties of Artemisia herba alba aqueous extract on hyperlipidemia and oxidative damage in alloxan-induced diabetic rats. Arch Physiol Biochem 125(2): 163–173. https://doi.org/10.1080/13813455.2018.1443470
  • Sezik E, Yeşilada E, Honda G, Takaishi Y, Takeda Y, Tanaka T 2001. Traditional medicine in Turkey X. Folk medicine in central Anatolia. J Ethnopharmacol 75(2-3): 95115. https://doi.org/ 10.1016/s0378-8741(00)00399-8
  • Szkudelski T 2001. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res. 50(6): 537–546. https:// doi.org/ 10.1002/ptr.1438.
  • Sokolovska J, Isajevs S, Sugoka O, Sharipova J, Paramonova N, Isajeva D, Rostoka E, Sjakste T, Kalvinsh I, Sjakste N 2012. Comparison of the effects of glibenclamide on metabolic parameters, GLUT1 expression, and liver injury in rats with severe and mild streptozotocin-induced diabetes mellitus. Medicina (Kaunas) 48(10): 532–543. https://doi.org/10.3390/medicina48100078
  • Sökmen A, Sökmen M, Daferera D, Polissiou M, Candan F, Ünlü M, Akpulat HA 2004. The in vitro antioxidant and antimicrobial activities of the essential oil and methanol extracts of Achillea biebersteini Afan. (Asteraceae). Phytother Res 18(6): 451-456. https://doi.org/10.1002/ptr.1438
  • Uyar A, Yaman T, Keles OF, Alkan EE, Celik I, Yener Z 2017. Protective effects of Bryonia multiflora extract on pancreatic beta cells, liver and kidney of streptozotocin-induced diabetic rats: histopathological and immunohistochemical investigations. Indian J Pharm Educ Res 51(3): 403–411. https://doi.org/10.5530/ijper.51.3s.57
  • Varasteh-Kojourian M, Abrishamchi P, Matin MM, Asili J, Ejtehadi H, Khosravitabar F 2017. Antioxidant, cytotoxic and DNA protective properties of Achillea eriophora DC. and Achillea biebersteinii Afan. extracts: a comparative study. Avicenna J Phytomed 7(2): 157–168.
  • Yaman T, Uyar A, Celik I, Alkan EE, Keles OF, Yener Z 2017. Histopathological and immune histochemical study of antidiabetic effects of Heracleum persicum extract in experimentally diabetic rats. Indian J Pharm Educ Res 51(3): 450–457. https://doi.org/10.5530/ijper.51.3s.66
  • Yang DK, Kang HS 2018. Anti-diabetic effect of cotreatment with quercetin and resveratrol in streptozotocin-induced diabetic rats. Biomol Ther 26(2): 130–138. https://doi.org/10.4062/biomolther. 2017.254
  • Yesilada, E., Honda, G., Sezik, E., Tabata, M., Goto, K, Ikeshiro, Y 1993. Traditional medicine in Turkey IV. Folk medicine in the Mediterranean subdivision. J. Ethnopharmacol 39: 31–38. https://doi.org/10.1016/0378-8741(93)90048-A
  • Zolghadri Y, Fazeli M, Kooshki M, Shomali T, Karimaghayee N, Dehghani M 2014. Achillea millefolium L. hydro-alcoholic extract protects pancreatic cells by down regulating IL-1β and iNOS gene expression in diabetic rats. Int J Mol Cell Med 3(4): 255–262. http://ijmcmed.org/article-1-221-en.html
Toplam 49 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji
Bölüm ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar

Hanife Hanalp 0000-0001-5235-4167

Burak Kaptaner 0000-0003-2366-6756

Abdulahad Doğan 0000-0002-5438-8560

Proje Numarası TYL-2019-865 and FAP-2019-8503
Yayımlanma Tarihi 31 Ağustos 2021
Gönderilme Tarihi 15 Ekim 2020
Kabul Tarihi 3 Aralık 2020
Yayımlandığı Sayı Yıl 2021Cilt: 24 Sayı: 4

Kaynak Göster

APA Hanalp, H., Kaptaner, B., & Doğan, A. (2021). Protective Effects of Lyophilized Ethanolic Extract of Achillea arabica Kotschy. on the Islet β Cells of Streptozotocin-Induced Diabetic Rats. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 24(4), 689-700. https://doi.org/10.18016/ksutarimdoga.vi.811253

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 Kapak Resmi İndir

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