Araştırma Makalesi
Yıl 2022,
Cilt: 25 Sayı: Ek Sayı 1, 97 - 107, 30.12.2022
Öz
Bu araştırmada intraperitonal yolla uygulanan sodyum pirition (35 ve 70 mg kg-1, ip) ve serum fizyolojik (salin) (%0.09 NaCl 0.5 ml kg-1, ip)uygulanmasının sıçanlar üzerine 24 ve 96 saatlik sürelerde böbrek ve karaciğer dokuları üzerine histolojik etkileri araştırılmıştır. Araştırma sonucunda, kontrol grubu ile karşılaştırıldığında intraperitonal yolla uygulanan sodyum piritionun doz ve süre artışına bağlı histopatolojik değişimlere neden olan sitotoksik etkisinin olabileceği kanısına varılmıştır.
Anahtar Kelimeler
Kaynakça
- Borg-Neczak K, Tjälve H 1991. Effect of sodium pyrithione on the tissue-disposition of nickel in rats, guinea-pigs and ferrets. Acta Veterinaria Scandinavica 87: 353–355.
- Chan SY, Ochs S, Worth RM 1980. The requirement for calcium ions and the effect of other ions on axoplasmic transport in mammalian nerve, The Journal of Physiology 301: 477–504.
- Chandler CJ, Segel IH 1978. Mechanism of the antimicrobial action of Pyrithione: Effects on membrane transport, ATP-levels and protein synthesis. Antimicrobial Agents Chemother 14: 60–68.
- Dinning AJ, Al-Adham ISI, Austin P, Charlton M, Collier PJ 1998. Pyrithione biocide interactions with bacterial phospholipid head groups. Journal of Applied Microbiology 85(1): 132-140.
- Durmaz E, Giray BK 2013. Çevresel bir endokrin bozucu: Bisfenol A ve toksik etkilerinin değerlendirilmesi. Çocuk Saglıgı ve Hastalıkları Dergisi 56(4): 192-199.
- Gibson WB, Jeffcoat AR, Turan TS, Wendt RH, Hughes PF, Twine ME 1982. Zinc pyridinethione: serum metabolites of zinc pyridinethione in rabbits, rats, monkeys, and dogs after oral dosing. Toxicology and Applied Pharmacology 62: 237–250.
- Göktekin E, Barlas N 2008. Histopathological effects of 4-tert-octylphenol treatment through the pregnancy period, on the pituitary, adrenal, 93 pancreas, thyroid and parathyroid glands of offspring rats at adulthood. Environmental Toxicology and Pharmacology 26: 199-205.
- Knox RJ, Magoski, NS, Wing D, Barbee SJ, Kaczmarek LK 2004. Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia. Journal of Neurobiology 60: 411–423.
- Knox,RJ, Keen KL, Luchansky L, Terasawa E, Freyer H, Barbee SJ, Kaczmarek LK 2008. Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons. Biochemical and Biophysical Research Communications 366(1): 48-53.
- Lee MM 2007. Endocrine Disrupters. A Current Review of Pediatric Endocrinology 109-118.
- Mattson MP, Engle MG, Rychlik B 1991. Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons. Molecular and Chemical Neuropathology 15:117–142.
- McConkey DJ, Orrenius S 1997. The role of calcium in the regulation of apoptosis, Biochemical and Biophysical Research Communications 239: 357–366.
- Mitoma C, Steeger T, Rogers J, Thomas D, Wedig JH 1983. Metabolic disposition of pyrithiones. Fundamental and Applied Toxicology 3: 256–263.
- Moe RA, Kirpan J, Linegar CR 1960, Toxicology of hydroxypyridinethione. Toxicology and Applied Pharmacology 2: 156–170.
- Möller M, Adam W, Saha-Möller CR, Stopper H 2002. Studies on cytotoxic and genotoxic effects of N-hydroxypyridine-2-thione (Omadine) in L5178Y mouse lymphoma cells. Toxicology Letters 136(1): 77-84.
- Nicotera P, Orrenius S 1998. The role of calcium in apoptosis. Cell Calcium 23: 173–180.
- Olin Corporation 1989. Sodium Omadine, disposition and metabolism in rats after oral and intravenous administration. Arthur D Little, Report No.: ADL 59798A, Unpublished report, August 25, 1989.
- Ross JF, Lawhorn GT 1990. ZPT-related distal axonopathy: behavioral and electrophysiologic correlates in rats. Neurotoxicology Teratology 12: 153–159.
- Sahenk Z, Mendell JR 1980. Axoplasmic transport in zinc pyridinethione neuropathy: evidence for an abnormality in distal turn-around. Brain Research 186: 343–353.
- Stoker TE, Parks LG, Gray LE, Cooper RL 2000. Endocrine-disrupting chemicals: Prepubertal exposures and effects on sexual maturation and thyroid function in the male rat. A focus on the EDSTAC recommendations. Endocrine Disrupter Screening and Testing Advisory Committee. Critical Reviews in Toxicology 30:197–252.
- Snyder DR, De Jesus CPV, Towfighi J, Jacoby RO, Wedig JH 1979. Neurological microscopic and enzyme-histochemical assessment of zinc pyrithione toxicity. Toxicology 17:651– 660.
- Tabb MM, Blumberg B 2006. New models of action for endocrine disrupting chemicals. Molecular Endocrinology 20:475-482.
- Ziller SA 1977. Absorption, excretion and tissue distribution of 2-pyridinethiol-1-oxide. Food and Cosmetics Toxicology 15: 49–54.
Yıl 2022,
Cilt: 25 Sayı: Ek Sayı 1, 97 - 107, 30.12.2022
Öz
In this study, the histological effects of intraperitoneally applied sodium pyrithione (35 and 70 mg kg-1, ip) and saline (0.09% NaCl 0.5 ml kg-1, ip) on the kidney and liver tissues of rats in 24 and 96 hours were investigated. As a result of the study, it was concluded that intraperitoneally applied sodium pyrithione may have a cytotoxic effect that causes histopathological changes due to the increase in dose and duration ,when compared to the control group,.
Anahtar Kelimeler
Kaynakça
- Borg-Neczak K, Tjälve H 1991. Effect of sodium pyrithione on the tissue-disposition of nickel in rats, guinea-pigs and ferrets. Acta Veterinaria Scandinavica 87: 353–355.
- Chan SY, Ochs S, Worth RM 1980. The requirement for calcium ions and the effect of other ions on axoplasmic transport in mammalian nerve, The Journal of Physiology 301: 477–504.
- Chandler CJ, Segel IH 1978. Mechanism of the antimicrobial action of Pyrithione: Effects on membrane transport, ATP-levels and protein synthesis. Antimicrobial Agents Chemother 14: 60–68.
- Dinning AJ, Al-Adham ISI, Austin P, Charlton M, Collier PJ 1998. Pyrithione biocide interactions with bacterial phospholipid head groups. Journal of Applied Microbiology 85(1): 132-140.
- Durmaz E, Giray BK 2013. Çevresel bir endokrin bozucu: Bisfenol A ve toksik etkilerinin değerlendirilmesi. Çocuk Saglıgı ve Hastalıkları Dergisi 56(4): 192-199.
- Gibson WB, Jeffcoat AR, Turan TS, Wendt RH, Hughes PF, Twine ME 1982. Zinc pyridinethione: serum metabolites of zinc pyridinethione in rabbits, rats, monkeys, and dogs after oral dosing. Toxicology and Applied Pharmacology 62: 237–250.
- Göktekin E, Barlas N 2008. Histopathological effects of 4-tert-octylphenol treatment through the pregnancy period, on the pituitary, adrenal, 93 pancreas, thyroid and parathyroid glands of offspring rats at adulthood. Environmental Toxicology and Pharmacology 26: 199-205.
- Knox RJ, Magoski, NS, Wing D, Barbee SJ, Kaczmarek LK 2004. Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia. Journal of Neurobiology 60: 411–423.
- Knox,RJ, Keen KL, Luchansky L, Terasawa E, Freyer H, Barbee SJ, Kaczmarek LK 2008. Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons. Biochemical and Biophysical Research Communications 366(1): 48-53.
- Lee MM 2007. Endocrine Disrupters. A Current Review of Pediatric Endocrinology 109-118.
- Mattson MP, Engle MG, Rychlik B 1991. Effects of elevated intracellular calcium levels on the cytoskeleton and tau in cultured human cortical neurons. Molecular and Chemical Neuropathology 15:117–142.
- McConkey DJ, Orrenius S 1997. The role of calcium in the regulation of apoptosis, Biochemical and Biophysical Research Communications 239: 357–366.
- Mitoma C, Steeger T, Rogers J, Thomas D, Wedig JH 1983. Metabolic disposition of pyrithiones. Fundamental and Applied Toxicology 3: 256–263.
- Moe RA, Kirpan J, Linegar CR 1960, Toxicology of hydroxypyridinethione. Toxicology and Applied Pharmacology 2: 156–170.
- Möller M, Adam W, Saha-Möller CR, Stopper H 2002. Studies on cytotoxic and genotoxic effects of N-hydroxypyridine-2-thione (Omadine) in L5178Y mouse lymphoma cells. Toxicology Letters 136(1): 77-84.
- Nicotera P, Orrenius S 1998. The role of calcium in apoptosis. Cell Calcium 23: 173–180.
- Olin Corporation 1989. Sodium Omadine, disposition and metabolism in rats after oral and intravenous administration. Arthur D Little, Report No.: ADL 59798A, Unpublished report, August 25, 1989.
- Ross JF, Lawhorn GT 1990. ZPT-related distal axonopathy: behavioral and electrophysiologic correlates in rats. Neurotoxicology Teratology 12: 153–159.
- Sahenk Z, Mendell JR 1980. Axoplasmic transport in zinc pyridinethione neuropathy: evidence for an abnormality in distal turn-around. Brain Research 186: 343–353.
- Stoker TE, Parks LG, Gray LE, Cooper RL 2000. Endocrine-disrupting chemicals: Prepubertal exposures and effects on sexual maturation and thyroid function in the male rat. A focus on the EDSTAC recommendations. Endocrine Disrupter Screening and Testing Advisory Committee. Critical Reviews in Toxicology 30:197–252.
- Snyder DR, De Jesus CPV, Towfighi J, Jacoby RO, Wedig JH 1979. Neurological microscopic and enzyme-histochemical assessment of zinc pyrithione toxicity. Toxicology 17:651– 660.
- Tabb MM, Blumberg B 2006. New models of action for endocrine disrupting chemicals. Molecular Endocrinology 20:475-482.
- Ziller SA 1977. Absorption, excretion and tissue distribution of 2-pyridinethiol-1-oxide. Food and Cosmetics Toxicology 15: 49–54.
Toplam 23 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Yapısal Biyoloji |
| Bölüm | ARAŞTIRMA MAKALESİ (Research Article) |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Aralık 2022 |
| Gönderilme Tarihi | 14 Temmuz 2021 |
| Kabul Tarihi | 23 Aralık 2021 |
| Yayımlandığı Sayı | Yıl 2022Cilt: 25 Sayı: Ek Sayı 1 |
2022-JIF = 0.500
2022-JCI = 0.170
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