Öz
Lamiaceae familyasının altında sınıflandırılan Ziziphora türleri güçlü aromatik özelliğe sahiptir. Halk hekimliğinde Ziziphora türleri yatıştırıcı, midevi, afrodizyak, şişkinlik ve gaz giderici olarak kullanılmıştır. Mevcut çalışmada Ziziphora capitata L. türünün çiçek, yaprak, dal, karışık ve kök kısmlarının etanol ekstrelerinin fenolik ve flavanoid içeriği LC-MS/MS cihazı ile belirlenmiştir. Ayrıca ekstrelerin antioksidan, sitotoksik etkileri ile enzim inhibisyon aktiviteleri (antihipertansif, AchE (asetilkolinesteraz), BchE (bütirilkolinesteraz), elastaz, tirozinaz, kollajenaz ve üreaz) belirlenmiştir. LC-MS/MS sonuçlarına göre Z. capitata türünün çiçek, yaprak, dal, karışık ve kök ekstrelerinde kinik asidin (sırasıyla, 25578, 5842, 25171, 14055, 10597 µg g-1,) diğer bileşenlerden daha yüksek içeriğe sahip olduğu tespit edilmiştir. Ayrıca rosmarinik asit (17097 µg g-1), sinarozit (8432) ve hesperidin (8067) bileşiklerinin majör bileşenler olduğu bulunmuştur. DPPH, ABTS ve CUPRAC yöntemlerinde türün çiçek ekstresinin güçlü antioksidan aktivitesi (sırasıyla: IC50: 37.18±1.36 µg mL-1; 9.89±0.45; A0.5:16.27±0.02) sergilediği görülmüştür. Z. capitata türünün yaprak ekstresinin HT-29 (kolon kanseri hücre hattı) üzerine (% canlılık: 9.26±0.69) güçlü sitotoksik etki gösterdiği belirlenmiştir. Bütirilkolinesteraz (BChE) enzim inhibisyon aktivitesinde türün kök kısmının (%inhibison: 40.56±0.88) diğer kısımlarından daha yüksek aktivite sergilediği görülmüştür. Z. capitata türünün etanol ekstrelerinin asetilkolinesteraz, üreaz, tirozinaz, elastaz, kollajenaz ve antihipertansif enzim aktivitesi göstermediği veya düşük aktivite gösterdiği belirlenmiştir. Sonuç olarak, Z. capitata türünün çiçek ekstresinin incelenen parametreler açısından daha iyi sonuçlara sahip olduğu, yaprak ekstresinin ise kolon kanseri hücre hattı üzerindeki sitotoksik etkisinden dolayı türün ilaç endüstürisinde kullanılabilmesi için in vitro ve in vivo olarak detaylı araştırmalara tabi tutulması gerektiği düşünülmektedir.
Anahtar Kelimeler
Ziziphora capitata LC-MS/MS Antioksidan Sitotoksik Kinik asit
Etik Beyan
Bu çalışma, sadece bitkisel örneklerin toplanması ve bitkisel bileşiklerin kimyasal analizlerinin yapılması üzerine odaklanmıştır. İnsan ya da hayvan denekleri kullanılmadığı ve herhangi bir etik müdahale gerektiren deneysel süreç gerçekleştirilmediği için, etik kurul izni gerektirmemektedir.
Destekleyen Kurum
Dicle Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü
Proje Numarası
ECZACILIK.24.007 ve FEN.24.005
Kaynakça
- Abad, M. H. K., & Nadaf, M. (2023). The ethnobotanical properties and medicinal application of essential oils of Ziziphora persica Bunge from different habitats: A review. Journal of Essential Oil Research, 35(2), 177-196. https://doi.org/10.1080/10412905.2022.2147593
- Aghajani, Z., Assadian, F., Masoudi, S., Chalabian, F., Esmaeili, A., Tabatabaei-Anaraki, M., & Rustaiyan, A. (2008). Chemical composition and in vitro antibacterial activities of the oil of Ziziphora clinopodioides and Z. capitata subsp. capitata from Iran. Chemistry of Natural Compounds, 44(3), 387-389. https://doi.org/10.1007/s10600-008-9073-4
- Ahmadi, A., Gandomi, H., Derakhshandeh, A., Misaghi, A., & Noori, N. (2021). Phytochemical composition and in vitro safety evaluation of Ziziphora clinopodioides Lam. ethanolic extract: Cytotoxicity, genotoxicity and mutagenicity assessment. Journal of Ethnopharmacology, 266, 113428. https://doi.org/10.1016/j.jep.2020.113428
- Akdeniz, M., Yener, I., Yilmaz, M. A., Kandemir, S. I., Tekin, F., & Ertas, A. (2021). A potential species for cosmetic and pharmaceutical industries: Insight to chemical and biological investigation of naturally grown and cultivated Salvia multicaulis Vahl. Industrial Crops and Products, 168, 113566. https://doi.org/10.1016/j.indcrop.2021.113566
- Apak, R., Güçlü, K., Özyürek, M., & Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. Journal of Agricultural and Food Chemistry, 52(26), 7970-7981. https://doi.org/10.1021/jf048741x
- Baytop, T. (1999). Therapy with medicinal plants in Turkey. Past and Present, 2, 348-349.
- Blois, M.S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181, 1199-1200.
- Bozyel, M. E., Merdamert Bozyel, E., Canlı, K., & Altuner, E. M. (2019). Anticancer uses of medicinal plants in Turkish traditional medicine. KSU Journal of Agriculture and Nature, 22, 465-484. https://doi.org/10.18016/ksutarimdoga.vi.550334
- Christaki, E., Bonos, E., Giannenas, I., & Florou-Paneri, P. (2012). Aromatic plants as a source of bioactive compounds. Agriculture, 2(3), 228-243. https://doi.org/10.3390/agriculture2030228
- Ellman, G. L., Courtney, K. D., Andres Jr, V., & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2), 88-95. https://doi.org/10.1016/0006-2952(61)90145-9
- Ebrahimi, S. N., Hadian, J., & Sonboli, A. (2009). Chemical composition of the essential oil of Ziziphora capitata L. from Iran. Journal of Essential Oil Bearing Plants, 12(6), 678-682. https://doi.org/10.1080/0972060X.2009.10643774
- Ghazanfari, T., Yaraee, R., Shams, J., Rahmati, B., Radjabian, T., & Hakimzadeh, H. (2013). Cytotoxic effect of four herbal medicines on gastric cancer (AGS) cell line. Food and Agricultural İmmunology, 24(1), 1-7. https://doi.org/10.1080/09540105.2011. 637549
- Gurib-Fakim, A. (2006). Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine, 27(1), 1-93. https://doi.org/ 10.1016/j.mam.2005.07.008
- Hearing, V. J., & Jiménez, M. (1987). Mammalian tyrosinase—the critical regulatory control point in melanocyte pigmentation. International Journal of Biochemistry, 19(12), 1141-1147. https://doi.org/ 10.1016/0020-711X(87)90095-4
- Kaya, A., & Dirmenci, T. (2012). Nutlet morphology of Turkish Ziziphora L. (Lamiaceae). Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 146(3), 560-563. https://doi.org/10.1080/11263504.2012.692337
- Kraunsoe, J. A., Claridge, T. D., & Lowe, G. (1996). Inhibition of human leukocyte and porcine pancreatic elastase by homologues of bovine pancreatic trypsin inhibitor. Biochemistry, 35(28), 9090-9096. https://doi.org/10.1021/bi953013b
- Kwon, Y. I. I., Vattem, D. A., & Shetty, K. (2006). Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension. Asia Pacific Journal of Clinical Nutrition, 15(1), 107.
- Li, T. S. C. (2006). The range of medicinal herbs and spices. In Handbook of herbs and spices (pp. 113-125). Woodhead Publishing. https://doi.org/ 10.1533/9781845691717.2.113
- Mohammadhosseini, M., Akbarzadeh, A., Hashemi-Moghaddam, H., Shahnama, M., Fahimi, B., & Azami, S. (2016). Gas chromatographic-mass spectrometric analysis of volatiles obtained by HS-SPME-GC-MS technique from aerial parts of Ziziphora capitata L., and evaluation for biological activity. Oriental Journal of Chemistry, 32(3), 1439. http://dx.doi.org/10.13005/ojc/320318
- Mojarrab, M., Lagzian, M. S., Emami, S. A., Asili, J., & Tayarani-Najaran, Z. (2013). In vitro anti-proliferative and apoptotic activity of different fractions of Artemisia armeniaca. Revista Brasileira de Farmacognosia, 23(5), 783-788. https://doi.org/10.1590/S0102-695X2013000500010
- Moreno, M. I. N., Isla, M. I., Sampietro, A. R., & Vattuone, M. A. (2000). Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. Journal of Ethnopharmacology, 71(1-2), 109-114. https://doi.org/10.1016/S0378-8741(99)00189-0
- Ozkan, E. E., Boğa, M., Yılmaz, M. A., Kara, E. M., & Yeşil, Y. (2020). LC-MS/MS analyses of Ziziphora clinopodioides Lam. from Turkey: Antioxidant, anticholinesterase, antimicrobial and, anticancer activities. İstanbul Journal of Pharmacy, 50(1), 33-41. https://doi.org/10.26650/IstanbulJPharm.2019. 0064
- Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., & Rice-Evans, C. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine, 26(9-10), 1231-1237. https://doi.org/ 10.1016/S0891-5849(98)00315-3
- Sarikurkcu, C., Kakouri, E., Sarikurkcu, R. T., & Tarantilis, P. A. (2019). Study on the chemical composition, enzyme inhibition and antioxidant activity of Ziziphora taurica subsp. cleonioides. Applied Sciences, 9(24), 5515. https://doi.org/ 10.3390/app9245515
- Satıl, F., & Selvi, S. (2020). Ethnobotanical features of Ziziphora L. (Lamiaceae) taxa in Turkey. International Journal of Nature and Life Sciences, 4(1), 56-65.
- Selvi, S., Satil, F., Martin, E., Çelenk, S., & Dirmenci, T. (2015). Some evidence for infrageneric classification in Ziziphora L.(Lamiaceae: Mentheae). Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 149(2), 415-423. https://doi.org/10.1080/11263504. 2013.853701
- Sezik, E. (1988). Türkiye'de halk ilacı ve çay olarak kullanılan bitkiler üzerinde morfololojik ve anatomik araştırmalar ve Ziziphora taurıca bieb subsp. cleonioides (Boiss.) Davis. Uludağ Üniversitesi Eğitim Fakülteleri Dergisi, 3(2), 65-73. https://acikerisim.uludag.edu.tr/items/72ff9580-b25c-4a6b-991c-4a57fdd9646c
- Slinkard, K., & Singleton, V. L. (1977). Total phenol analysis: automation and comparison with manual methods. American Journal of Enology and Viticulture, 28(1), 49-55. https://doi.org/10.5344/ ajev.1977.28.1.49
- Singh, R. (2015). Medicinal plants: A review. Journal of Plant Sciences, 8(2), 50-55. https://doi.org/10.11648/j.jps.s.2015030101.18
- Taheri, A., Ganjeali, A., Arefi-Oskouie, A., Çirak, C., & Cheniany, M. (2023). The variability of phenolic constituents and antioxidant properties among wild populations of Ziziphora clinopodioides Lam. Physiology and Molecular Biology of Plants, 29(2), 221-237.https://doi.org/10.1007/s12298-023-01283-
- Thring, T. S., Hili, P., & Naughton, D. P. (2009). Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BMC Complementary and Alternative Medicine, 9, 1-11. https://doi.org/10.1186/1472-6882-9-27
- Tomczyk, M., Ceylan, O., Locatelli, M., Tartaglia, A., Ferrone, V., & Sarikurkcu, C. (2019). Ziziphora taurica subsp. taurica: Analytical characterization and biological activities. Biomolecules, 9(8), 367. https://doi.org/10.3390/biom9080367
- Tural, B., Ertaş, E., Batıbay, H., Tural, S. (2024). Comparative Study on Silver Nanoparticle Synthesis Using Male and Female Pistacia Khinjuk Leaf Extracts: Enhanced Efficacy of Female Leaf Extracts. ChemistrySelect, 9(30), e202402117. https://doi.org/10.1002/slct.202402117
- Yilmaz, M. A. (2020). Simultaneous quantitative screening of 53 phytochemicals in 33 species of medicinal and aromatic plants: A detailed, robust and comprehensive LC–MS/MS method validation. Industrial Crops and Products, 149, 112347. https://doi.org/10.1016/j.indcrop.2020.112347
- Youssif, Y. M., Elhagali, G. A., Zahran, M. A., Ahmed, F. A., & Ragab, A. (2024). Utilising UPLC-QTOF-MS/MS to determine the phytochemical profile and in vitro cytotoxic potential of Ziziphora capitata L. with molecular docking simulation. Natural Product Research, 1-9. https://doi.org/10.1080/ 14786419.2024.2335666
- Yu, M., Gouvinhas, I., Rocha, J., & Barros, A. I. (2021). Phytochemical and antioxidant analysis of medicinal and food plants towards bioactive food and pharmaceutical resources. Scientific Reports, 11(1), 10041. https://doi.org/10.1038/s41598-021-89437-4
- Zahid, H., Rizwani, G., Kamil, A., Shareef, H., Tasleem, S., & Khan, A. (2015). Anti-urease activity of Mimusops elengi Linn (Sapotaceae). European Journal of Medicinal Plants, 6(4), 223-230. http://dx.doi.org/10.9734/ejmp/2015/12240
Öz
The Ziziphora species, classified under the Lamiaceae family, have a strong aromatic property. Ziziphora species have been used in folk medicine as sedative, gastric, aphrodisiac, bloating, and degassing. In the current study, the phenolic and flavanoid content of ethanol extracts of Ziziphora capitata L. species of flower, leaf, branch, mixed, and root parts was determined by the LC-MS/MS device. In addition, the antioxidant and cytotoxic activities of the extracts, as well as their inhibitory effects on enzymes (antihypertensive, AchE (acetylcholinesterase), BchE (butyrylcholinesterase), elastase, tyrosinase, collagenase and urease), were determined. The LC-MS/MS results showed that quinic acid (25578, 5842, 25171, 14055, 10597 µg g-1, respectively) was found in higher amounts in flower, leaf, branch, mixed, and root extracts of Z. capitata species compared to other components. Additionally, rosmarinic acid (17097 µg g-1), cynaroside (8432), and hesperidin (8067) were found to be major components. It was observed that the flower extract of the species exhibited strong antioxidant activity (IC50: 37.18±1.36 µg mL-1, 9.89±0.45, A0.5:16.27±0.02, respectively) in DPPH, ABTS and CUPRAC methods. It was concluded that the leaf extract of Z. capitata species had a strong cytotoxic effect on HT-29 (colon cancer cell line) (viability %: 9.26±0.69). It was observed that the root part of the species exhibited higher activity in butyrylcholinesterase (BChE) enzyme inhibition activity (inhibition %: 40.56±0.88) than other parts. It was determined that Z. capitata extracts did not show acetylcholinesterase, urease, tyrosinase, elastase, collagenase, and antihypertensive enzyme activity or showed low activity. As a result, it is thought that the flower extract of the Z. capitata species has better results in terms of the examined parameters, whereas the leaf extract needs to be subjected to more detailed in vitro and in vivo research conducted to be used in the pharmaceutical industry as a result of its cytotoxic effect against colon cancer cell lines.
Anahtar Kelimeler
Ziziphora capitata LC-MS/MS Antioxidant Cytotoxic Quinic acid
Proje Numarası
ECZACILIK.24.007 ve FEN.24.005
Kaynakça
- Abad, M. H. K., & Nadaf, M. (2023). The ethnobotanical properties and medicinal application of essential oils of Ziziphora persica Bunge from different habitats: A review. Journal of Essential Oil Research, 35(2), 177-196. https://doi.org/10.1080/10412905.2022.2147593
- Aghajani, Z., Assadian, F., Masoudi, S., Chalabian, F., Esmaeili, A., Tabatabaei-Anaraki, M., & Rustaiyan, A. (2008). Chemical composition and in vitro antibacterial activities of the oil of Ziziphora clinopodioides and Z. capitata subsp. capitata from Iran. Chemistry of Natural Compounds, 44(3), 387-389. https://doi.org/10.1007/s10600-008-9073-4
- Ahmadi, A., Gandomi, H., Derakhshandeh, A., Misaghi, A., & Noori, N. (2021). Phytochemical composition and in vitro safety evaluation of Ziziphora clinopodioides Lam. ethanolic extract: Cytotoxicity, genotoxicity and mutagenicity assessment. Journal of Ethnopharmacology, 266, 113428. https://doi.org/10.1016/j.jep.2020.113428
- Akdeniz, M., Yener, I., Yilmaz, M. A., Kandemir, S. I., Tekin, F., & Ertas, A. (2021). A potential species for cosmetic and pharmaceutical industries: Insight to chemical and biological investigation of naturally grown and cultivated Salvia multicaulis Vahl. Industrial Crops and Products, 168, 113566. https://doi.org/10.1016/j.indcrop.2021.113566
- Apak, R., Güçlü, K., Özyürek, M., & Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. Journal of Agricultural and Food Chemistry, 52(26), 7970-7981. https://doi.org/10.1021/jf048741x
- Baytop, T. (1999). Therapy with medicinal plants in Turkey. Past and Present, 2, 348-349.
- Blois, M.S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181, 1199-1200.
- Bozyel, M. E., Merdamert Bozyel, E., Canlı, K., & Altuner, E. M. (2019). Anticancer uses of medicinal plants in Turkish traditional medicine. KSU Journal of Agriculture and Nature, 22, 465-484. https://doi.org/10.18016/ksutarimdoga.vi.550334
- Christaki, E., Bonos, E., Giannenas, I., & Florou-Paneri, P. (2012). Aromatic plants as a source of bioactive compounds. Agriculture, 2(3), 228-243. https://doi.org/10.3390/agriculture2030228
- Ellman, G. L., Courtney, K. D., Andres Jr, V., & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2), 88-95. https://doi.org/10.1016/0006-2952(61)90145-9
- Ebrahimi, S. N., Hadian, J., & Sonboli, A. (2009). Chemical composition of the essential oil of Ziziphora capitata L. from Iran. Journal of Essential Oil Bearing Plants, 12(6), 678-682. https://doi.org/10.1080/0972060X.2009.10643774
- Ghazanfari, T., Yaraee, R., Shams, J., Rahmati, B., Radjabian, T., & Hakimzadeh, H. (2013). Cytotoxic effect of four herbal medicines on gastric cancer (AGS) cell line. Food and Agricultural İmmunology, 24(1), 1-7. https://doi.org/10.1080/09540105.2011. 637549
- Gurib-Fakim, A. (2006). Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine, 27(1), 1-93. https://doi.org/ 10.1016/j.mam.2005.07.008
- Hearing, V. J., & Jiménez, M. (1987). Mammalian tyrosinase—the critical regulatory control point in melanocyte pigmentation. International Journal of Biochemistry, 19(12), 1141-1147. https://doi.org/ 10.1016/0020-711X(87)90095-4
- Kaya, A., & Dirmenci, T. (2012). Nutlet morphology of Turkish Ziziphora L. (Lamiaceae). Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 146(3), 560-563. https://doi.org/10.1080/11263504.2012.692337
- Kraunsoe, J. A., Claridge, T. D., & Lowe, G. (1996). Inhibition of human leukocyte and porcine pancreatic elastase by homologues of bovine pancreatic trypsin inhibitor. Biochemistry, 35(28), 9090-9096. https://doi.org/10.1021/bi953013b
- Kwon, Y. I. I., Vattem, D. A., & Shetty, K. (2006). Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension. Asia Pacific Journal of Clinical Nutrition, 15(1), 107.
- Li, T. S. C. (2006). The range of medicinal herbs and spices. In Handbook of herbs and spices (pp. 113-125). Woodhead Publishing. https://doi.org/ 10.1533/9781845691717.2.113
- Mohammadhosseini, M., Akbarzadeh, A., Hashemi-Moghaddam, H., Shahnama, M., Fahimi, B., & Azami, S. (2016). Gas chromatographic-mass spectrometric analysis of volatiles obtained by HS-SPME-GC-MS technique from aerial parts of Ziziphora capitata L., and evaluation for biological activity. Oriental Journal of Chemistry, 32(3), 1439. http://dx.doi.org/10.13005/ojc/320318
- Mojarrab, M., Lagzian, M. S., Emami, S. A., Asili, J., & Tayarani-Najaran, Z. (2013). In vitro anti-proliferative and apoptotic activity of different fractions of Artemisia armeniaca. Revista Brasileira de Farmacognosia, 23(5), 783-788. https://doi.org/10.1590/S0102-695X2013000500010
- Moreno, M. I. N., Isla, M. I., Sampietro, A. R., & Vattuone, M. A. (2000). Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. Journal of Ethnopharmacology, 71(1-2), 109-114. https://doi.org/10.1016/S0378-8741(99)00189-0
- Ozkan, E. E., Boğa, M., Yılmaz, M. A., Kara, E. M., & Yeşil, Y. (2020). LC-MS/MS analyses of Ziziphora clinopodioides Lam. from Turkey: Antioxidant, anticholinesterase, antimicrobial and, anticancer activities. İstanbul Journal of Pharmacy, 50(1), 33-41. https://doi.org/10.26650/IstanbulJPharm.2019. 0064
- Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., & Rice-Evans, C. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine, 26(9-10), 1231-1237. https://doi.org/ 10.1016/S0891-5849(98)00315-3
- Sarikurkcu, C., Kakouri, E., Sarikurkcu, R. T., & Tarantilis, P. A. (2019). Study on the chemical composition, enzyme inhibition and antioxidant activity of Ziziphora taurica subsp. cleonioides. Applied Sciences, 9(24), 5515. https://doi.org/ 10.3390/app9245515
- Satıl, F., & Selvi, S. (2020). Ethnobotanical features of Ziziphora L. (Lamiaceae) taxa in Turkey. International Journal of Nature and Life Sciences, 4(1), 56-65.
- Selvi, S., Satil, F., Martin, E., Çelenk, S., & Dirmenci, T. (2015). Some evidence for infrageneric classification in Ziziphora L.(Lamiaceae: Mentheae). Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 149(2), 415-423. https://doi.org/10.1080/11263504. 2013.853701
- Sezik, E. (1988). Türkiye'de halk ilacı ve çay olarak kullanılan bitkiler üzerinde morfololojik ve anatomik araştırmalar ve Ziziphora taurıca bieb subsp. cleonioides (Boiss.) Davis. Uludağ Üniversitesi Eğitim Fakülteleri Dergisi, 3(2), 65-73. https://acikerisim.uludag.edu.tr/items/72ff9580-b25c-4a6b-991c-4a57fdd9646c
- Slinkard, K., & Singleton, V. L. (1977). Total phenol analysis: automation and comparison with manual methods. American Journal of Enology and Viticulture, 28(1), 49-55. https://doi.org/10.5344/ ajev.1977.28.1.49
- Singh, R. (2015). Medicinal plants: A review. Journal of Plant Sciences, 8(2), 50-55. https://doi.org/10.11648/j.jps.s.2015030101.18
- Taheri, A., Ganjeali, A., Arefi-Oskouie, A., Çirak, C., & Cheniany, M. (2023). The variability of phenolic constituents and antioxidant properties among wild populations of Ziziphora clinopodioides Lam. Physiology and Molecular Biology of Plants, 29(2), 221-237.https://doi.org/10.1007/s12298-023-01283-
- Thring, T. S., Hili, P., & Naughton, D. P. (2009). Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BMC Complementary and Alternative Medicine, 9, 1-11. https://doi.org/10.1186/1472-6882-9-27
- Tomczyk, M., Ceylan, O., Locatelli, M., Tartaglia, A., Ferrone, V., & Sarikurkcu, C. (2019). Ziziphora taurica subsp. taurica: Analytical characterization and biological activities. Biomolecules, 9(8), 367. https://doi.org/10.3390/biom9080367
- Tural, B., Ertaş, E., Batıbay, H., Tural, S. (2024). Comparative Study on Silver Nanoparticle Synthesis Using Male and Female Pistacia Khinjuk Leaf Extracts: Enhanced Efficacy of Female Leaf Extracts. ChemistrySelect, 9(30), e202402117. https://doi.org/10.1002/slct.202402117
- Yilmaz, M. A. (2020). Simultaneous quantitative screening of 53 phytochemicals in 33 species of medicinal and aromatic plants: A detailed, robust and comprehensive LC–MS/MS method validation. Industrial Crops and Products, 149, 112347. https://doi.org/10.1016/j.indcrop.2020.112347
- Youssif, Y. M., Elhagali, G. A., Zahran, M. A., Ahmed, F. A., & Ragab, A. (2024). Utilising UPLC-QTOF-MS/MS to determine the phytochemical profile and in vitro cytotoxic potential of Ziziphora capitata L. with molecular docking simulation. Natural Product Research, 1-9. https://doi.org/10.1080/ 14786419.2024.2335666
- Yu, M., Gouvinhas, I., Rocha, J., & Barros, A. I. (2021). Phytochemical and antioxidant analysis of medicinal and food plants towards bioactive food and pharmaceutical resources. Scientific Reports, 11(1), 10041. https://doi.org/10.1038/s41598-021-89437-4
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Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Bitki Biyokimyası |
| Bölüm | ARAŞTIRMA MAKALESİ (Research Article) |
| Yazarlar | |
| Proje Numarası | ECZACILIK.24.007 ve FEN.24.005 |
| Erken Görünüm Tarihi | 26 Aralık 2024 |
| Yayımlanma Tarihi | 31 Aralık 2024 |
| Gönderilme Tarihi | 14 Kasım 2024 |
| Kabul Tarihi | 25 Aralık 2024 |
| Yayımlandığı Sayı | Yıl 2024Cilt: 27 Sayı: Ek Sayı 2 (Suppl 2) |
Kaynak Göster
2022-JIF = 0.500
2022-JCI = 0.170
Uluslararası Hakemli Dergi (International
Peer Reviewed Journal)
Dergimiz, herhangi bir başvuru veya yayımlama ücreti almamaktadır. (Free submission and publication)
Yılda 6 sayı yayınlanır. (Published 6 times a year)
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