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Yeni Tanımlanan Bir Tür Olan Aubrieta alshehbazii Dönmez, Uğurlu ve M.A. Koch’ un Antikarsinojenik Etkilerinin, Antioksidan Özelliklerinin ve Fitokimyasal Bileşenlerinin Tespiti

Yıl 2025, Cilt: 28 Sayı: 3, 650 - 660

Laçine Aksoy , Ömer Hazman , Mustafa Abdullah Yılmaz , Ahmet Büyükben , Mustafa Kargıoğlu , Beyza Çakal , Beyza Gümüş , Feyza Efiloğlu

https://doi.org/10.18016/ksutarimdoga.vi.1616833

Öz

Aubrieta alshehbazii, Elşahbaz obrizyası olarak bilinen endemik bir türdür. Tanımlanması yeni yapıldığından hakkında pek çalışma bulunmayan bu türün, antioksidatif, antikanserojenik etkileri ile fenolik madde içeriğinin belirlenmesi amacıyla çalışma gerçekleştirilmiştir. Antioksidatif özelliğinin belirlenmesi için DPPH radikal savıcı etkisi, total antioksidan ve oksidan kapasitesi ölçülmüştür. Antikanserojenik etki kapsamında sağlıklı HGF hücreleri ve akciğer kanser (A549) hücreleri kullanılmıştır. Bitkinin içerdiği fenolik maddeler ise LC-ESI-MS/MS ile belirlenmiştir. Analizler sonucunda bitkinin 0.1 µM ve 0.5 µM konsantrasyonda sentetik antioksidan olan BHT den istatistiksel anlamlılıkta (sırasıyla p= 0.008 ve p=0.016)) yüksek bir DPPH radikali savıcı etkiye sahip bulunmuştur. Türün total antioksidan kapasitesi standart antioksidanlardan düşüktür. Düşük konsantrasyonlarda ekstraktın A549 hücreleri üzeirne etkileri görülmezken, yüksek konsantrasyonlarda hem HGF hücreleri ve hem de A549 hücreleri üzerine sitotoksik etki gösterdiği belirlenmiştir. Fenolik içerik analizleri sonucunda yapısında en çok bulunan bileşenler, fumarik asit, kafeik asit, kuersetin, kinik asit, rosmarinik asit ve klorojenik asittir. Sonuç olarak tür radikal savıcı etkisi ile ön plana çıkmaktadır. Bu etkinin hangi bileşenden kaynaklandığının belirlenmesine yönelik çalışmalar yapılması önerilmektedir.

Anahtar Kelimeler

Aubrieta alshehbazii DPPH Sitotoksik Total antioksidan kapasite LC-ESI-MS/MS

Kaynakça

  • Al-Shehbaz, I. A., Beilstein, M. A. & Kellogg, E. A. (2006). Systematics and phylogeny of the Brassicaceae (Cruciferae): an overview. Plant Systematics and Evolution, 259, 89-120. https://doi.org/10.1007/s00606-006-0415-z
  • Al-Shehbaz, I.A., Mutlu, B. & Dönmez, A.A. (2007). The Brassicaceae (Cruciferae) of Turkey, updated. Turkish Journal of Botany, 31(4), 327-336.
  • Ancev, M., & Goranova, V. (2009). Aubrieta (Brassicaceae) in the Bulgarian flora. Phytologia Balcanica, 15(1), 43-50.
  • Awika J. M., Rooney L. W., Wu X. L., Prior R. L., & Cisneros-Zevallos L. (2003). Screening methods to measure antioxidant activity of sorghum (Sorghum bicolor) and sorghum products. Journal of Agricultural and Food Chemistry, 51(23), 6657-6662. https://doi.org/10.1021/jf034790i
  • Balkir, Ş., Hazman, Ö., Aksoy, L., Yılmaz, M. A., Çakır, O., Kara, R. & Erol, İ. (2023). Phytochemical profile, antioxidant and antimicrobial potency of aerial parts of Salvia tomentosa Miller. Acta Chimica Slovenica,70(2), 218-225. 70(2):218-225. https://doi.org/10.17344/acsi.2023.8008
  • Chahardehi, A. M., Ibrahim, D., & Sulaiman, S. F. (2009). Antioxidant activity and total phenolic content of some medicinal plants in urticaceae family. Journal of Applied Biological Sciences, 3(2), 27-31.
  • Damasceno, S. S., Dantas, B. B., Ribeiro-Filho, J., Antônio, M. A. D., & Galberto, M. C. J. (2017). Chemical properties of caffeic and ferulic acids in biological system: implications in cancer therapy. a review. Current Pharmaceutical Design, 23(20), 3015-3023. https://doi.org/10.2174/1381612822666161208145508
  • Dönmez, A. A., Aydın, Z. U., & Koch, M. A. (2017). Aubrieta alshehbazii (Brassicaceae), a new species from Central Turkey. Phytotaxa, 299(1), 103-110. https://doi.org/10.11646/phytotaxa.299.1.8
  • Erel, O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical Biochemistry, 37(4), 277-285. https://doi.org/10.1016/j.clinbiochem.2003.11.015
  • Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry, 38, 1103-1111. https://doi.org/10.1016/j.clinbiochem.2005.08.008
  • Eruygur, N., Büyükyıldırım, T., Kırcı, D., Ayaz, F., Dogu, S., & Bagcı, Y. (2024). Evaluation of the in vitro enzyme inhibition and antioxidant activity of Clinopodium betulifolium (Boiss. & Balansa) Kuntze. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 27(6), 1282-1288. https://doi.org/10.18016/ ksutarimdoga.vi.1403319
  • Genaro-Mattos, T.C., Maurício, Â.Q., Rettori, D., Alonso, A., & Hermes-Lima, M. (2015). Antioxidant activity of caffeic acid against iron-induced free radical generation-A chemical approach. PLoS one, 10, e0129963. https://doi.org/10.1371/journal.pone.0129963
  • Ghorani-Azam, A., Sepahi, S., Riahi-Zanjani, B., Ghamsari, A.A., Mohajeri, S.A., & Balali-Mood, M. (2018). Plant toxins and acute medicinal plant poisoning in children: A systematic literature review. Journal of Research in Medical Sciences, 23, 26. https://doi.org/10.4103/jrms.JRMS_629_17
  • Greenwell, M., & Rahman, P.K. (2015). Medicinal Plants: Their Use in Anticancer Treatment. International Journal of Pharmaceutical Sciences and Research, 6(10), 4103-4112. https://doi.org/10.13040/IJPSR.0975-8232.6(10).4103-12
  • Güçlü, G., Ergül, M., Uçar, E., Eruygur, N., Ataş, M., & Akpulat, H.A. (2022). Anticancer, Antioxidant, Antimicrobial and Enzyme Inhibitory Activities of Inula aucheriana. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 25(5), 946-954. https://doi.org/10.18016/ksutarimdoga.vi.985837
  • Günay, E., Celik, S., Sarinc-Ulasli, S., Özyürek, A., Hazman, Ö., Günay, S., Özdemir, M., & Ünlü, M. (2016). Comparison of the Anti-inflammatory effects of proanthocyanidin, quercetin, and damnacanthal on benzo(a)pyrene exposed A549 alveolar cell line. Inflammation, 39(2), 744-751. https://doi.org/10.1007/s10753-015-0301-3
  • Görmez, G., Yüksek, V., Usta, A., Dede, S., & Gümüş, S. (2024). Phenolic Contents, Antioxidant Activities, LC MS Profiles of Mespilus germanica Leaf Extract and Effects on mRNA Transcription Levels of Apoptotic, Autophagic, and Necrotic Genes in MCF7 and A549 Cancer Cell Lines. Cell Biochemistry and Biophysics, 82(3), 2141-2155. https://doi.org/10.1007/s12013-024-01321-w
  • Hazman, Ö., Aksoy, L., Büyükben, A., Kara, R., Kargioğlu, M., Kumral, Z. B., & Erol, I. (2021). Evaluation of antioxidant, cytotoxic, antibacterial effects and mineral levels of Verbascum lasianthum Boiss. ex Bentham. Anais da Academia Brasileira de Ciências, 93, e20210865. https://doi.org/10.1590/0001-3765202120210865
  • Karl, R. & Koch, M. A. (2013). A world-wide perspective on crucifer speciation and evolution: phylogeny, biogeography and trait evolution in tribe Arabideae. Annals of Botany, 112(6), 983-1001. https://doi.org/10.1093/aob/mct165
  • Kaska, A., & Deniz, N., Mammadov, R. (2017). Antioxidative capacities and phenolic compounds of various extracts of Aubrieta deltoidea. Deutscher Wissenschaftsherold, 3, 42-46. https://doi.org/10.19221/2017312
  • Khan, T., Ali, M., Khan, A., Nisar, P., Jan, S. A., Afridi, S., & Shinwari, Z. K. (2019). Anticancer plants: A review of the active phytochemicals, applications in animal models, and regulatory aspects. Biomolecules, 10(1), 47. https://doi.org/10.3390/biom10010047
  • Koch, M. & Kiefer, C. (2006). Molecules and migration: biogeographical studies in cruciferous plants. Plant Systematics and Evolution, 259(2-4), 121-142. https://doi.org/10.1007/s00606-006-0416-y
  • Li, A. S. H., Bandy, B., Tsang, S. S., Davison, A. J. (2000). DNA-breaking versus DNA-protecting activity of four phenolic compounds in vitro. Free Radical Research 33, 551-566. https://doi.org/10.1080/10715760000301091
  • Lin, C. L., Chen, R. F., Chen, J. Y. F., Chu, Y. C., Wang, H. M., Chou, H. L., Chang, W. C., Fong, Y., Chang, W. T., Wu, C. Y., & Chiu, C. C. (2012). protective effect of caffeic acid on paclitaxel induced anti-proliferation and apoptosis of lung cancer cells involves NF-kappa B pathway. International Journal of Molecular Sciences, 13, 6236-6245. https://doi.org/10.3390/ijms13056236
  • Mandrich, L., & Caputo, E. (2020). Brassicaceae-derived anticancer agents: Towards a green approach to beat cancer. Nutrients,12(3), 868.
  • Miceli, N., Cavò, E., Ragusa, M., Cacciola, F., Mondello, L., Dugo, L., Acquaviva, R., Malfa, G. A., Marino, A., D’Arrigo, M., & Taviano, M. F. (2020). Brassica incana Ten. (Brassicaceae): Phenolic constituents, antioxidant and cytotoxic properties of the leaf and flowering top extracts. Molecules, 25(6), 1461. https://doi.org/10.3390/molecules25061461
  • Min, J., Shen, H., Xi, W., Wang, Q., Yin, L., Zhang, Y. F., Yu, Y., Yang, Q., & Wang, Z. N. (2018). Synergistic anticancer activity of combined use of caffeic acid with paclitaxel enhances apoptosis of non-small-cell lung cancer H1299 cells in vivo and in vitro. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 48, 1433-1442. https://doi.org/10.1159/000492253
  • Molole, G. J., Gure, A. & Abdissa, N. (2022). Determination of total phenolic content and antioxidant activity of Commiphora mollis (Oliv.) Engl. resin. BMC Chemistry, 16, 48. https://doi.org/10.1186/s13065-022-00841-x
  • Mutlu, B. & Karakuş, Ş. (2015). A new species of Sisymbrium (Brassicaceae) from Turkey: Morphological and molecular evidences. Turkish Journal of Botany, 39, 325-333. https://doi.org/10.3906/bot-1404-28
  • Neamtu, A. A., Maghiar, T. A., Alaya, A., Olah N. K., Turcus V., Pelea, D., Totolici, B. D., Neamtu, C., Maghiar, A. M., & Mathe, E. (2022). A comprehensive view on the quercetin impact on colorectal cancer. Molecules, 27(6), 1873. https://doi.org/10.3390/molecules27061873
  • Pal, S. K., & Shukla, Y. (2003). Herbal medicine: Current status and the future. Asian Pacific Journal of Cancer Prevention, 4, 281-288.
  • Prior, R. L., Wu, X., & Schaich, K. (2005). Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. Journal of Agricultural and Food Chemistry, 53(10), 4290-4302. https://doi.org/10.1021/jf0502698
  • Reyes-Farias, M., & Carrasco-Pozo, C. (2019). The anti-cancer effect of quercetin: molecular implications in cancer metabolism. International Journal of Molecular Sciences, 20(13), 3177. https://doi.org/10.3390/ijms20133177
  • Sidoryk, K., Jaromin, A., Filipczak, N., Cmoch, P., & Cybulski, M. (2018). Synthesis and antioxidant activity of caffeic acid derivatives. Molecules, 23, 2199. https://doi.org/10.3390/molecules23092199
  • Silva, T., Oliveira, C., & Borges, F. (2014). Caffeic acid derivatives, analogs and applications: A patent review (2009-2013). Expert Opinion on Therapeutic Patents, 24(11), 1257-1270. https://doi.org/10.1517/13543776.2014.959492
  • Slinkard, K., & Singleton V. L. (1977). Total Phenol Analysis: Automation and comparison with manual methods. American Journal of Enology and Viticulture, 28, 49-55. https://doi.org/10.5344/ajev.1977.28.1.49
  • Son, S., & Lewis, B.A. (2002). Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure–activity relationship. Journal of Agricultural and Food Chemistry, 50, 468-472. https://doi.org/10.1021/jf010830b
  • Tang S. M., Deng X. T., Zhou J., Li Q. P., Ge X. X., & Miao L. (2020). Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Biomedicine & Pharmacotherapy, 121, 109604. https://doi.org/10.1016/j.biopha.2019.109604
  • Tosovic, J. (2017). Spectroscopic features of caffeic acid: Theoretical study. Kragujevac Journal of Science, 39, 99-108.
  • Xu, D. P., Li, Y., Meng, X., Zhou, T., Zhou, Y., Zheng, J., Zhang, J. J., & Li, H. B. (2017). Natural Antioxidants in Foods and Medicinal Plants: Extraction, Assessment and Resources. International Journal of Molecular Sciences, 18(1), 96. https://doi.org/10.3390/ijms18010096
  • Yılmaz, M. A. (2020). Simultaneous quantitative screening of 53 phytochemicals in 33 species of medicinal and aromatic plants: A detailed, robust and comprehensive LC-MS/MS method validation. Industrial Crops and Products, 149, 112347. https://doi.org/10.1016/j.indcrop.2020.112347
  • Yüzbaşıoğlu, S., Koch, M. A. & Al-Shehbaz, I. A. (2015). Proof of a knowledge database concept. Aubrieta ekimii (Brassicaceae), a new species from NW Anatolia (Turkey): morphological and molecular support. Plant Systematics And Evolution, 301, 2043-2055. https://doi.org/10.1007/s00606-015-1212-3

Determination of the Anticarcinogenic Effects, Antioxidative Features and Phytochemical Components of a Newly Identified Species Aubrieta alshehbazii Dönmez, Uğurlu & M.A. Koch

Yıl 2025, Cilt: 28 Sayı: 3, 650 - 660

Laçine Aksoy , Ömer Hazman , Mustafa Abdullah Yılmaz , Ahmet Büyükben , Mustafa Kargıoğlu , Beyza Çakal , Beyza Gümüş , Feyza Efiloğlu

https://doi.org/10.18016/ksutarimdoga.vi.1616833

Öz

Aubrieta alshehbazii is an endemic species known as Elşahbaz Obrizyası. A study was conducted to determine the antioxidative, anticarcinogenic effects and phenolic substance content of this species, which is not well-studied due to its new definition. DPPH radical scavenging effect, total antioxidant and oxidant capacity were measured to determine its antioxidant properties. Healthy HGF cells and lung cancer (A549) cells were used within the scope of the anticarcinogenic effect. Phenolic substances contained in the plant were determined by LC-ESI-MS/MS. As a result of the analysis, it was found that the plant had a statistically significant (p=0.008 and p=0.016) higher DPPH radical scavenging effect than the synthetic antioxidant BHT at 0.1 µM and 0.5 µM concentrations. The total antioxidant capacity of the species is lower than standard antioxidants. While no effects of the extract on A549 cells were observed at low concentrations, it was determined that it had a cytotoxic effect on both HGF cells and A549 cells at high concentrations. As a result of the phenolic content analysis, the most abundant components in its structure are fumaric acid, caffeic acid, quercetin, quinic acid, rosmarinic acid and chlorogenic acid. As a result, the species stands out with its radical scavenging effect. It is recommended that studies be conducted to determine which component is responsible for this effect.

Anahtar Kelimeler

Aubrieta alshehbazii DPPH Cytotoxic Total antioksidan capacity LC-ESI-MS/MS

Kaynakça

  • Al-Shehbaz, I. A., Beilstein, M. A. & Kellogg, E. A. (2006). Systematics and phylogeny of the Brassicaceae (Cruciferae): an overview. Plant Systematics and Evolution, 259, 89-120. https://doi.org/10.1007/s00606-006-0415-z
  • Al-Shehbaz, I.A., Mutlu, B. & Dönmez, A.A. (2007). The Brassicaceae (Cruciferae) of Turkey, updated. Turkish Journal of Botany, 31(4), 327-336.
  • Ancev, M., & Goranova, V. (2009). Aubrieta (Brassicaceae) in the Bulgarian flora. Phytologia Balcanica, 15(1), 43-50.
  • Awika J. M., Rooney L. W., Wu X. L., Prior R. L., & Cisneros-Zevallos L. (2003). Screening methods to measure antioxidant activity of sorghum (Sorghum bicolor) and sorghum products. Journal of Agricultural and Food Chemistry, 51(23), 6657-6662. https://doi.org/10.1021/jf034790i
  • Balkir, Ş., Hazman, Ö., Aksoy, L., Yılmaz, M. A., Çakır, O., Kara, R. & Erol, İ. (2023). Phytochemical profile, antioxidant and antimicrobial potency of aerial parts of Salvia tomentosa Miller. Acta Chimica Slovenica,70(2), 218-225. 70(2):218-225. https://doi.org/10.17344/acsi.2023.8008
  • Chahardehi, A. M., Ibrahim, D., & Sulaiman, S. F. (2009). Antioxidant activity and total phenolic content of some medicinal plants in urticaceae family. Journal of Applied Biological Sciences, 3(2), 27-31.
  • Damasceno, S. S., Dantas, B. B., Ribeiro-Filho, J., Antônio, M. A. D., & Galberto, M. C. J. (2017). Chemical properties of caffeic and ferulic acids in biological system: implications in cancer therapy. a review. Current Pharmaceutical Design, 23(20), 3015-3023. https://doi.org/10.2174/1381612822666161208145508
  • Dönmez, A. A., Aydın, Z. U., & Koch, M. A. (2017). Aubrieta alshehbazii (Brassicaceae), a new species from Central Turkey. Phytotaxa, 299(1), 103-110. https://doi.org/10.11646/phytotaxa.299.1.8
  • Erel, O. (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clinical Biochemistry, 37(4), 277-285. https://doi.org/10.1016/j.clinbiochem.2003.11.015
  • Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clinical Biochemistry, 38, 1103-1111. https://doi.org/10.1016/j.clinbiochem.2005.08.008
  • Eruygur, N., Büyükyıldırım, T., Kırcı, D., Ayaz, F., Dogu, S., & Bagcı, Y. (2024). Evaluation of the in vitro enzyme inhibition and antioxidant activity of Clinopodium betulifolium (Boiss. & Balansa) Kuntze. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 27(6), 1282-1288. https://doi.org/10.18016/ ksutarimdoga.vi.1403319
  • Genaro-Mattos, T.C., Maurício, Â.Q., Rettori, D., Alonso, A., & Hermes-Lima, M. (2015). Antioxidant activity of caffeic acid against iron-induced free radical generation-A chemical approach. PLoS one, 10, e0129963. https://doi.org/10.1371/journal.pone.0129963
  • Ghorani-Azam, A., Sepahi, S., Riahi-Zanjani, B., Ghamsari, A.A., Mohajeri, S.A., & Balali-Mood, M. (2018). Plant toxins and acute medicinal plant poisoning in children: A systematic literature review. Journal of Research in Medical Sciences, 23, 26. https://doi.org/10.4103/jrms.JRMS_629_17
  • Greenwell, M., & Rahman, P.K. (2015). Medicinal Plants: Their Use in Anticancer Treatment. International Journal of Pharmaceutical Sciences and Research, 6(10), 4103-4112. https://doi.org/10.13040/IJPSR.0975-8232.6(10).4103-12
  • Güçlü, G., Ergül, M., Uçar, E., Eruygur, N., Ataş, M., & Akpulat, H.A. (2022). Anticancer, Antioxidant, Antimicrobial and Enzyme Inhibitory Activities of Inula aucheriana. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 25(5), 946-954. https://doi.org/10.18016/ksutarimdoga.vi.985837
  • Günay, E., Celik, S., Sarinc-Ulasli, S., Özyürek, A., Hazman, Ö., Günay, S., Özdemir, M., & Ünlü, M. (2016). Comparison of the Anti-inflammatory effects of proanthocyanidin, quercetin, and damnacanthal on benzo(a)pyrene exposed A549 alveolar cell line. Inflammation, 39(2), 744-751. https://doi.org/10.1007/s10753-015-0301-3
  • Görmez, G., Yüksek, V., Usta, A., Dede, S., & Gümüş, S. (2024). Phenolic Contents, Antioxidant Activities, LC MS Profiles of Mespilus germanica Leaf Extract and Effects on mRNA Transcription Levels of Apoptotic, Autophagic, and Necrotic Genes in MCF7 and A549 Cancer Cell Lines. Cell Biochemistry and Biophysics, 82(3), 2141-2155. https://doi.org/10.1007/s12013-024-01321-w
  • Hazman, Ö., Aksoy, L., Büyükben, A., Kara, R., Kargioğlu, M., Kumral, Z. B., & Erol, I. (2021). Evaluation of antioxidant, cytotoxic, antibacterial effects and mineral levels of Verbascum lasianthum Boiss. ex Bentham. Anais da Academia Brasileira de Ciências, 93, e20210865. https://doi.org/10.1590/0001-3765202120210865
  • Karl, R. & Koch, M. A. (2013). A world-wide perspective on crucifer speciation and evolution: phylogeny, biogeography and trait evolution in tribe Arabideae. Annals of Botany, 112(6), 983-1001. https://doi.org/10.1093/aob/mct165
  • Kaska, A., & Deniz, N., Mammadov, R. (2017). Antioxidative capacities and phenolic compounds of various extracts of Aubrieta deltoidea. Deutscher Wissenschaftsherold, 3, 42-46. https://doi.org/10.19221/2017312
  • Khan, T., Ali, M., Khan, A., Nisar, P., Jan, S. A., Afridi, S., & Shinwari, Z. K. (2019). Anticancer plants: A review of the active phytochemicals, applications in animal models, and regulatory aspects. Biomolecules, 10(1), 47. https://doi.org/10.3390/biom10010047
  • Koch, M. & Kiefer, C. (2006). Molecules and migration: biogeographical studies in cruciferous plants. Plant Systematics and Evolution, 259(2-4), 121-142. https://doi.org/10.1007/s00606-006-0416-y
  • Li, A. S. H., Bandy, B., Tsang, S. S., Davison, A. J. (2000). DNA-breaking versus DNA-protecting activity of four phenolic compounds in vitro. Free Radical Research 33, 551-566. https://doi.org/10.1080/10715760000301091
  • Lin, C. L., Chen, R. F., Chen, J. Y. F., Chu, Y. C., Wang, H. M., Chou, H. L., Chang, W. C., Fong, Y., Chang, W. T., Wu, C. Y., & Chiu, C. C. (2012). protective effect of caffeic acid on paclitaxel induced anti-proliferation and apoptosis of lung cancer cells involves NF-kappa B pathway. International Journal of Molecular Sciences, 13, 6236-6245. https://doi.org/10.3390/ijms13056236
  • Mandrich, L., & Caputo, E. (2020). Brassicaceae-derived anticancer agents: Towards a green approach to beat cancer. Nutrients,12(3), 868.
  • Miceli, N., Cavò, E., Ragusa, M., Cacciola, F., Mondello, L., Dugo, L., Acquaviva, R., Malfa, G. A., Marino, A., D’Arrigo, M., & Taviano, M. F. (2020). Brassica incana Ten. (Brassicaceae): Phenolic constituents, antioxidant and cytotoxic properties of the leaf and flowering top extracts. Molecules, 25(6), 1461. https://doi.org/10.3390/molecules25061461
  • Min, J., Shen, H., Xi, W., Wang, Q., Yin, L., Zhang, Y. F., Yu, Y., Yang, Q., & Wang, Z. N. (2018). Synergistic anticancer activity of combined use of caffeic acid with paclitaxel enhances apoptosis of non-small-cell lung cancer H1299 cells in vivo and in vitro. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 48, 1433-1442. https://doi.org/10.1159/000492253
  • Molole, G. J., Gure, A. & Abdissa, N. (2022). Determination of total phenolic content and antioxidant activity of Commiphora mollis (Oliv.) Engl. resin. BMC Chemistry, 16, 48. https://doi.org/10.1186/s13065-022-00841-x
  • Mutlu, B. & Karakuş, Ş. (2015). A new species of Sisymbrium (Brassicaceae) from Turkey: Morphological and molecular evidences. Turkish Journal of Botany, 39, 325-333. https://doi.org/10.3906/bot-1404-28
  • Neamtu, A. A., Maghiar, T. A., Alaya, A., Olah N. K., Turcus V., Pelea, D., Totolici, B. D., Neamtu, C., Maghiar, A. M., & Mathe, E. (2022). A comprehensive view on the quercetin impact on colorectal cancer. Molecules, 27(6), 1873. https://doi.org/10.3390/molecules27061873
  • Pal, S. K., & Shukla, Y. (2003). Herbal medicine: Current status and the future. Asian Pacific Journal of Cancer Prevention, 4, 281-288.
  • Prior, R. L., Wu, X., & Schaich, K. (2005). Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. Journal of Agricultural and Food Chemistry, 53(10), 4290-4302. https://doi.org/10.1021/jf0502698
  • Reyes-Farias, M., & Carrasco-Pozo, C. (2019). The anti-cancer effect of quercetin: molecular implications in cancer metabolism. International Journal of Molecular Sciences, 20(13), 3177. https://doi.org/10.3390/ijms20133177
  • Sidoryk, K., Jaromin, A., Filipczak, N., Cmoch, P., & Cybulski, M. (2018). Synthesis and antioxidant activity of caffeic acid derivatives. Molecules, 23, 2199. https://doi.org/10.3390/molecules23092199
  • Silva, T., Oliveira, C., & Borges, F. (2014). Caffeic acid derivatives, analogs and applications: A patent review (2009-2013). Expert Opinion on Therapeutic Patents, 24(11), 1257-1270. https://doi.org/10.1517/13543776.2014.959492
  • Slinkard, K., & Singleton V. L. (1977). Total Phenol Analysis: Automation and comparison with manual methods. American Journal of Enology and Viticulture, 28, 49-55. https://doi.org/10.5344/ajev.1977.28.1.49
  • Son, S., & Lewis, B.A. (2002). Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: structure–activity relationship. Journal of Agricultural and Food Chemistry, 50, 468-472. https://doi.org/10.1021/jf010830b
  • Tang S. M., Deng X. T., Zhou J., Li Q. P., Ge X. X., & Miao L. (2020). Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects. Biomedicine & Pharmacotherapy, 121, 109604. https://doi.org/10.1016/j.biopha.2019.109604
  • Tosovic, J. (2017). Spectroscopic features of caffeic acid: Theoretical study. Kragujevac Journal of Science, 39, 99-108.
  • Xu, D. P., Li, Y., Meng, X., Zhou, T., Zhou, Y., Zheng, J., Zhang, J. J., & Li, H. B. (2017). Natural Antioxidants in Foods and Medicinal Plants: Extraction, Assessment and Resources. International Journal of Molecular Sciences, 18(1), 96. https://doi.org/10.3390/ijms18010096
  • Yılmaz, M. A. (2020). Simultaneous quantitative screening of 53 phytochemicals in 33 species of medicinal and aromatic plants: A detailed, robust and comprehensive LC-MS/MS method validation. Industrial Crops and Products, 149, 112347. https://doi.org/10.1016/j.indcrop.2020.112347
  • Yüzbaşıoğlu, S., Koch, M. A. & Al-Shehbaz, I. A. (2015). Proof of a knowledge database concept. Aubrieta ekimii (Brassicaceae), a new species from NW Anatolia (Turkey): morphological and molecular support. Plant Systematics And Evolution, 301, 2043-2055. https://doi.org/10.1007/s00606-015-1212-3
Toplam 42 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Bitki Biyokimyası
Bölüm ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar

Laçine Aksoy 0000-0001-8086-5079

Ömer Hazman 0000-0002-2702-6847

Mustafa Abdullah Yılmaz 0000-0002-4090-7227

Ahmet Büyükben 0000-0002-5639-7217

Mustafa Kargıoğlu 0000-0003-0386-9716

Beyza Çakal 0009-0004-3244-7189

Beyza Gümüş 0009-0009-1437-0321

Feyza Efiloğlu 0009-0004-7443-6357

Erken Görünüm Tarihi 1 Mayıs 2025
Yayımlanma Tarihi
Gönderilme Tarihi 10 Ocak 2025
Kabul Tarihi 18 Mart 2025
Yayımlandığı Sayı Yıl 2025Cilt: 28 Sayı: 3

Kaynak Göster

APA Aksoy, L., Hazman, Ö., Yılmaz, M. A., Büyükben, A., vd. (2025). Yeni Tanımlanan Bir Tür Olan Aubrieta alshehbazii Dönmez, Uğurlu ve M.A. Koch’ un Antikarsinojenik Etkilerinin, Antioksidan Özelliklerinin ve Fitokimyasal Bileşenlerinin Tespiti. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 28(3), 650-660. https://doi.org/10.18016/ksutarimdoga.vi.1616833
 Kapak Resmi İndir

21082



2022-JIF = 0.500

2022-JCI = 0.170

Uluslararası Hakemli Dergi (International Peer Reviewed Journal)

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      Yılda 6 sayı yayınlanır. (Published 6 times a year)


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