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Investigation of the Biological Activities of Alcea calvertii

Yıl 2022, , 955 - 964, 31.10.2022

Mahmoud Abudayyak , Şeyda Kanbolat , Reyyan Ergene , Şeyma Batur , Rezzan Aliyazıcıoğlu

https://doi.org/10.18016/ksutarimdoga.vi.890659
Cited By: 1

Öz

Herbs are widely used in the treatment of diseases as colds, infections, and cancer. In this work, we evaluate Alcea calvertii, which is a perennial herbaceous plant belonging to the Malvaceae family. It spreads in Anatolia and Mediterranean region and has important uses in terms of ethnobotany. In this study, it was aimed to evaluate the cytotoxic potentials and to investigate the antioxidant activities of methanol, water, chloroform, and ethyl acetate extracts of the aerial parts of Alcea calvertii. For that, the antioxidant activity of Alcea calvertii was determined by four different methods [total phenolic content (TPC), ferric reducing antioxidant power (FRAP), copper reducing antioxidant capacity (CUPRAC) and 2,2-diphenylpicrylhydrazil (DPPH) radical scavenging activity. The cytotoxicity potential of extracts was assessed in the human lung cancer cell line (A549) by MTT assay. It was observed that the highest antioxidant activity was in the methanol extract and the antioxidant activity increased with increasing extract concentration; The TPC values were between 62.5 - 414.6 GAE µg mL-1, the FRAP values were between 115.7 - 1321.4 µM Trolox equivalent g-1, CUPRAC values were between 177.1 - 1321.4 µM Trolox equivalent g-1, and IC50 values in DPPH determination were between 0.0089 - 3.5370 mg mL-1. The extracts caused cytotoxicity in a concentration dependent manner, the IC50 values were calculated to be between 36.8 - 62.64 µg mL-1. It is concluded that Alcea calvertii could be an important herb in developing new drugs.

Anahtar Kelimeler

Alcea calvertii Antioxidant Capacity cytotoxicity

Destekleyen Kurum

TÜBİTAK 2209A

Proje Numarası

1919B011800561

Kaynakça

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  • Ahmadi M, Rad AK, Rajaei Z, Hadjzadeh MAR, Mohammadian N, Tabasi NS 2012. Alcea rosea Root Extract As A Preventive And Curative Agent In Ethylene Glycol-Induced Urolithiasis In Rats. Indian Journal of Pharmacology 44:304–307.
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Alcea calvertii'nin Biyolojik Aktivitelerinin İncelenmesi

Yıl 2022, , 955 - 964, 31.10.2022

Mahmoud Abudayyak , Şeyda Kanbolat , Reyyan Ergene , Şeyma Batur , Rezzan Aliyazıcıoğlu

https://doi.org/10.18016/ksutarimdoga.vi.890659
Cited By: 1

Öz

Bitkiler ve bitkisel ilaçlar soğuk algınlığı, enfeksiyonlar ve kanser gibi farklı hastalıkların tedavisinde kullanılmaktadır. Alcea calvertii, Malvaceae familyasına ait çok yıllık otsu bir bitkidir. Anadolu ve Akdeniz bölgesinde yayılan bu bitki etnobotanik açısından önemli bir yere sahiptir. Bu çalışmada, Alcea calvertii bitkisinin topraküstü kısımlarının metanol, su, kloroform ve etil asetat ekstrelerinin antioksidan aktiviteleri ile bu ekstrelerin sitotoksik potansiyellerinin incelenmesi amaçlanmıştır. Bu kapsamda, Alcea calvertii’nin antioksidan aktivitesi dört farklı yöntem [toplam fenolik içeriği (TPC), ferrik indirgeyici antioksidan gücü (FRAP), bakır indirgeyici antioksidan kapasitesi (CUPRAC) ve 2,2-difenilpikrilhidrazil (DPPH) radikal süpürme aktivitesini] ile tespit edilmiştir. İnsan akciğer kanseri hücre hattındaki (A549) sitotoksik potansiyeli ise MTT testi ile belirlenmiştir. En yüksek antioksidan aktivitenin metanol ekstresinde olduğu ve artan ekstre konsantrasyonu ile antioksidan aktivitenin arttığı gözlenmiştir; TPC değerlerinin 62,5- 414,6 GAE µg mL-1, FRAP değerlerinin 115,7- 1321,4 µM Trolox eşdeğeri g-1, CUPRAC değerlerinin 177,1 - 1321,4 µM Trolox eşdeğeri g-1, DPPH tespitinde IC50 değerlerinin 0,0089- 3,5370 mg mL-1 arasında hesaplanmıştır. Ekstreler konsantrasyona bağlı olarak hücre ölümüne neden olmuştur ve IC50 değerleri 36,8-62,64 µg mL-1 arasında bulunmuştur. Bu sonuçlar umut verici olup daha kapsamlı çalışmalar ile incelenmesinin önemli olduğu düşünülmektedir.

Anahtar Kelimeler

Alcea calvertii Antioksidan Kapasite Sitotoksisite

Proje Numarası

1919B011800561

Kaynakça

  • Abd El-Salam NM, Radwan MM, Wanas A, Shenouda M, Sallam S, Piacente S, ElSohly M, Ghazy N 2016. Phytochemical And Biological Evaluation of Alcea rosea L., Growing In Egypt. Planta Medica 82:2–3.
  • Abdel-salam NA, Ghazy NM, Sallam SM, Radwan MM, Wanas AS, ElSohly MA, El-Demellawy MA, Abdel-Rahman NM, Piacente S, Shenouda ML 2018. Flavonoids Of Alcea rosea L. And Their Immune Stimulant, Antioxidant and Cytotoxic Activities On Hepatocellular Carcinoma Hepg-2 Cell Line. Natural Product Research 32:702–706.
  • Abudayyak M, Ozdemir Nath E, Ozhan G 2015. Toxic Potentials of Ten Herbs Commonly Used Aphrodisiac Effect in Turkey. Turkish Journal of Medical Sciences 44: 496-506.
  • Ahmadi M, Rad AK, Rajaei Z, Hadjzadeh MAR, Mohammadian N, Tabasi NS 2012. Alcea rosea Root Extract As A Preventive And Curative Agent In Ethylene Glycol-Induced Urolithiasis In Rats. Indian Journal of Pharmacology 44:304–307.
  • Ahmed S, Hasan MM, Mahmood ZA 2016. Antiurolithiatic Plants in Different Countries and Cultures. Journal of Pharmacognosy and Phytochemistry 5: 102-115.
  • Akan H, Bakır Sade Y 2015. Ethnobotanical Investigation of Kahta (Adıyaman) Center and Narince Village [Kahta (Adıyaman) Merkezi ve Narince Köyü’nün Etnobotanik Açıdan Araştırılması] Bitlis Eren University Journal of Science 4(2): 219-248.
  • Alpertunga B, Kara M, Abudayyak M, Oztas E, Ozden S, Özhan G 2014. Effects of prochloraz on DNA damage, lipid peroxidation and antioxidant system in vitro, Toxicology Mechanisms and Methods, 24:4, 268-275
  • Alhage J, Elbitar H 2018. In Vitro Screening for Antioxidant and Antimicrobial Properties of Three Lebanese Medicinal Plants Crude Extracts 2019. Pharmacognosy Research 11(2):127–133.
  • Alley MC, Scudiero DA, Monks A, Hursey ML, Czerwinski MJ, Fine DL, Abbott BJ, Mayo JG, Shoemaker RH, Boyd MR 1988. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Research 48: 589–601.
  • Al-Snafi AE 2013. The Pharmaceutical importance of Althaea officinalis and Althaea rosea: A review. International Journal of PharmTech Research 5:1378–1385
  • Altundag E, Ozturk M 2011. Ethnomedicinal Studies on The Plant Resources of East Anatolia, Turkey. Procedia - Social and Behavioral Sciences 19: 756-777.
  • Anlas C, Ustuner O, Alkan F, Bakirel T, Aydogan M, Erel S 2017. a Comparative Study on the Antioxidant Activities and Phenolic Contents of Different Extracts of a Chillea nobilis Subsp Sipylea and Alcea apterocarpa (Fenzl) Boiss, Endemic Plants in Turkey. Fresenius Environmental Bulletin 26:1423–1430.
  • Apak R, Güçlü K, Ozyürek M, Karademir SE, Erça E 2006. The cupric ion reducing antioxidant capacity and polyphenolic content of some herbal teas. international journal food science nutrition 57:292-304.
  • Asami S, Manabe H, Miyake J, Tsurudome Y, Hirano T, Yamaguchi R, et al 1997. Cigarette smoking induces an increase in oxidative DNA damage, 8- hydroxydeoxyguanosine, in a central site of the human lung. Carcinogenesis 18:1763–1766.
  • Azab A 2016. Alcea: traditional medicine, current research and future opportunities. European Chemical Bulletin 6 (5): 505-514.
  • Azadeh Z, Saeidi K, Lorigooini Z, Kiani M, Maggi F 2020. Organ-Oriented Phytochemical Profiling and Radical Scavenging Activity of Alcea spp. (Malvaceae) from Iran. SN Applied Sciences 2:1–9. https://doi.org/10.1007/s42452-020-2410-3
  • Beğen HA and Yüksel E 2018. The flora of Alanbaşı and Bakırtepe villages (Yusufeli, Artvin, Turkey) and its surroundings. Turkish Journal of Biodiversity 1:17–23.
  • Benzie IFF, Strain JJ 1996. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Analytical Biochemistry 239: 70-6.
  • Boyzal ME and Mert EM 2018. Antiurolithiatic Activity of Medicinal Plants in Turkey. (Assessment of Working Postures of Nursery Workers in Seedling Production Activities (Ed. Christov I, Strauss E, Gad A, Curebal I) 152-162.
  • Byahatti VV, Vasantakumar Pai K, D’Souza MG 2010. Effect of Phenolic Compound from Bergenia cliata (Haw.) Stemb. Leaves on Experimental Kidney Stones. Ancient science of life 30: 14-17.
  • Chan K 2003. Some aspects of toxic contaminants in herbal medicines, Chemosphere 52: 1361–1371. Dalar A, Mukemre M, Unal M, Ozgokce F 2018. Traditional Medicinal Plants of Ağrı Province, Turkey. Journal of Ethnopharmacology 226:56–72.
  • Dar PA, Ali F, Sheikh IA, Ganie SA, Dar TA 2017. Amelioration of Hyperglycaemia and Modulation of Antioxidant Status By Alcea Rosea Seeds in Alloxan-Induced Diabetic Rats. Pharmaceutical Biology 55:1849–1855 . https://doi.org/10.1080/ 13880209.2017.1333127
  • Dhalla NS, Temsah RM, Netticadan T 2000. Role of oxidative stress in cardiovascular diseases. Journal of Hypertension 18: 655–673.
  • Doğan A, Tuzlacı E 2015. Some Local Plant Names of Tunceli [Tunceli’nin Bazı Yöresel Bitki Adları]. Eurasscience Journal 3: 22-33.
  • Ertas A, Boga M, Gazioglu I, Yesil Y, Hasimi N, Ozaslan C, Yilmaz H, Kaplan M 2016. Fatty acid, Essential Oil and Phenolic Compositions of Alcea Pallida and Alcea apterocarpa With Antioxidant, Anticholinesterase and Antimicrobial Activities. Chiang Mai Journal of Science 43:89–99 .
  • Esmaeili S, Irani M, Zehan HM, Keramatian B, Harandi ZT, Hamzeloo-Moghadam M 2016. Cytotoxic Activity of Some Ethnic Medicinal Plants From Southwest of Iran. Research Journal of Pharmacognosy 3:43–47
  • Fahimi Z, Cheraghi j, Pilehvarian AA, Sayehmiri K, Kjosarvi A 2012. Effects of Alcea angulate Roots Alcoholic Extract on Blood Lipid of Male Rabbit. Journal of Ilam University of medical Sciences 20:23-32.
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Toplam 71 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji
Bölüm ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar

Mahmoud Abudayyak 0000-0003-2286-4777

Şeyda Kanbolat 0000-0001-7261-7067

Reyyan Ergene 0000-0003-4985-9812

Şeyma Batur 0000-0003-0934-0223

Rezzan Aliyazıcıoğlu 0000-0003-0143-8795

Proje Numarası 1919B011800561
Yayımlanma Tarihi 31 Ekim 2022
Gönderilme Tarihi 13 Mart 2021
Kabul Tarihi 28 Ekim 2021
Yayımlandığı Sayı Yıl 2022

Kaynak Göster

APA Abudayyak, M., Kanbolat, Ş., Ergene, R., Batur, Ş., vd. (2022). Investigation of the Biological Activities of Alcea calvertii. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 25(5), 955-964. https://doi.org/10.18016/ksutarimdoga.vi.890659

Cited By

Comparison of Antioxidant Activity, Metal Chelating Power and Antibacterial Activity in Different Tissues of Alcea calvertii (Boiss.) Boiss.
Bitlis Eren Üniversitesi Fen Bilimleri Dergisi
https://doi.org/10.17798/bitlisfen.1349138

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