Year 2020, Volume 23 , Issue 1, Pages 148 - 156 2020-02-28

Doğu Anadolu, Türkiye’de Yetişen Üç Centaurea L. Türünün in vitro Biyolojik Değerlendirilmesi ve Fitokimyasal Özellikleri
In Vitro Biological Evaluation and Phytochemical Contents of Three Centaurea L. Species Growing from Eastern Anatolia in Turkey

Serhat KESER [1] , Fatma KESER [2] , İsmail TURKOGLU [3] , Omer KAYGILI [4] , Suat TEKIN [5] , Ersin DEMIR [6] , Mustafa KARATEPE [7] , Okkes YILMAZ [8] , Sevda KIRBAG [9] , Suleyman SANDAL [10] , Semra TURKOGLU [11]


Centaurea türleri halk arasında tıbbi bitkiler olarak soğuk algınlığı, apse, peptik ülser, hemoroit, diyabet vb. hastalıkların tedavisinde kullanılmaktadırlar. Sunulan çalışmada, üç Centaurea türünün antiradikal özellikleri, fitokimyasal içerikleri, antimikrobiyal ve antiproliferatif aktiviteleri incelenmiştir. Centaurea saligna (K.Koch) Wagenitz metanol (99.94%), Centaurea virgata Lam. metanol (98.23%) ve su (98.10%) ekstraktları standart antioksidan trolokstan (96.79%) daha yüksek ABTS yok etme aktivitesi göstermiştir. Centaurea kurdica Reichardt ekstraktları trolokstan daha düşük antiradikal aktivite göstermiştir. Centaurea ekstraktları bazı mikroorganizmalara karşı antimikrobiyal aktivite göstermiştir. Centaurea türlerinin yüksek miktarda toplam flavonoit, fenolik ve proantosiyanidin, fenolik asitler, fitosteroller ve doymamış yağ asitleri içerdiği belirlenmiştir. Ayrıca bu üç Centaurea ekstraktları MCF-7, HCT-116 ve LNCaP kanser hücre serileri üzerinde çok yüksek antiproliferatif özellik göstermiştir.

Centaurea L. species were used as medicinal plants among the people for treatment of the common cold, abscesses, peptic ulcers, hemorrhoid and diabetes etc.. In the present study, antiradical properties, phytochemical contents, antimicrobial and antiproliferative activities of three Centaurea species were investigated. Centaurea saligna (K.Koch) Wagenitz methanol (99.94%), Centaurea virgata Lam. methanol (98.23%) and water (98.10%) extracts were showed higher ABTS scavenging than trolox (96.79%). Centaurea kurdica Reichardt extracts showed lower activity than trolox for all the antiradical assays. Centaurea extracts exhibited antimicrobial activity against to some microorganisms. It was determined that these Centaurea species contain high amount of total flavonoid, phenolic and proanthocyanidin, phenolic acids, phytosterols and unsaturated fatty acids. Also, three Centaurea extracts showed very high antiproliferative property on LNCaP, HCT-116, MCF-7 cancer cell lines.

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Primary Language en
Subjects Biology
Journal Section RESEARCH ARTICLE
Authors

Orcid: 0000-0002-9678-1053
Author: Serhat KESER (Primary Author)
Institution: FIRAT UNIVERSITY
Country: Turkey


Orcid: 0000-0001-6870-0546
Author: Fatma KESER
Institution: FIRAT UNIVERSITY
Country: Turkey


Orcid: 0000-0001-7454-7605
Author: İsmail TURKOGLU
Institution: FIRAT UNIVERSITY
Country: Turkey


Orcid: 0000-0002-2321-1455
Author: Omer KAYGILI
Institution: FIRAT UNIVERSITY
Country: Turkey


Orcid: 0000-0002-2757-1802
Author: Suat TEKIN
Institution: INONU UNIVERSITY
Country: Turkey


Orcid: 0000-0002-7676-5953
Author: Ersin DEMIR
Institution: DUZCE UNIVERSITY
Country: Turkey


Orcid: 0000-0001-6358-5913
Author: Mustafa KARATEPE
Institution: FIRAT UNIVERSITY
Country: Turkey


Orcid: 0000-0002-8276-4498
Author: Okkes YILMAZ
Institution: FIRAT UNIVERSITY
Country: Turkey


Orcid: 0000-0002-4337-8236
Author: Sevda KIRBAG
Institution: FIRAT UNIVERSITY
Country: Turkey


Orcid: 0000-0002-8916-3329
Author: Suleyman SANDAL
Institution: INONU UNIVERSITY
Country: Turkey


Orcid: 0000-0001-7682-0513
Author: Semra TURKOGLU
Institution: FIRAT UNIVERSITY
Country: Turkey


Supporting Institution TÜBİTAK
Project Number 114Z124
Thanks This study was supported by TUBITAK, under grant number 114Z124.
Dates

Application Date : July 9, 2019
Acceptance Date : September 26, 2019
Publication Date : February 28, 2020

APA KESER, S , KESER, F , TURKOGLU, İ , KAYGILI, O , TEKIN, S , DEMIR, E , KARATEPE, M , YILMAZ, O , KIRBAG, S , SANDAL, S , TURKOGLU, S . (2020). In Vitro Biological Evaluation and Phytochemical Contents of Three Centaurea L. Species Growing from Eastern Anatolia in Turkey. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi , 23 (1) , 148-156 . DOI: 10.18016/ksutarimdoga.vi.589279