Rice Bran as a Novel Dietary Supplement Improves Lifespan, Antioxidant Defense, and Locomotor Performance in Drosophila melanogaster Meigen (Diptera: Drosophilidae)

Mehmet Fidan

doi:10.18016/ksutarimdoga.vi.1872695

TR EN

Pirinç Kepeği ile Desteklenmiş Diyetin Drosophila melanogaster Meigen (Diptera: Drosophilidae)'de Yaşam Süresi ve Fonksiyonel Yaşlanma Üzerindeki Etkileri

Abstract

Yaşlanma, azalan fizyolojik fonksiyonlar ve zayıflayan antioksidan savunma sistemleri ile karakterizedir. Biyoaktif bileşikler açısından zengin, besin değeri yüksek bir yan ürün olan pirinç kepeği, bu sistemleri modüle etme potansiyeline sahiptir, ancak yaşlanma üzerindeki in vivo etkileri henüz yeterince araştırılmamıştır. Bu çalışmada, pirinç kepeği ile desteklenmiş diyetin Drosophila melanogaster Meigen’de yaşam süresi, antioksidan enzim aktivitesi ve fonksiyonel kapasite üzerindeki etkisi araştırılmıştır. Yetişkin erkek sinekler kontrol veya pirinç kepeği ile desteklenmiş diyetlerle (%0.5, %1.0 veya %2.5 a/a) beslenmiştir. Hayatta kalma, süperoksit dismutaz (SOD), katalaz (CAT) ve glutatyon peroksidaz (GPx) aktiviteleri ile lokomotor fonksiyon değerlendirilmiştir. Optimal pirinç kepeği dozajı, ortalama yaşam süresini %18-22 oranında ve median sağkalımı anlamlı şekilde uzatmıştır (p < 0.01); buna antioksidan enzim aktivitelerindeki artış eşlik etmiştir: SOD (%25-30), CAT (%20-25) ve GPx (%15-20) (p < 0.05). Desteklenmiş sinekler, kontrollere kıyasla azalmış lokomotor gerileme ve korunmuş tırmanma yeteneği sergilemişlerdir (p < 0.05). Bu bulgular, pirinç kepeği ile desteklenmiş diyetin, dengeli antioksidan regülasyonu aracılığıyla D. melanogaster'da ömür uzunluğunu ve fonksiyonel sürdürülebilirliği desteklediğini göstermekte ve optimize edilmiş redoks homeostazının sağlıklı yaşam süresinin kritik bir belirleyicisi olduğunu desteklemektedir.

Keywords

Ethical Statement

Geçerli değildir. Bu çalışmada, etik kurul onayı gerektirmeyen bir omurgasız model organizma olan Drosophila melanogaster kullanılmıştır.

Rice Bran as a Novel Dietary Supplement Improves Lifespan, Antioxidant Defense, and Locomotor Performance in Drosophila melanogaster Meigen (Diptera: Drosophilidae)

Abstract

Aging is characterized by declining physiological functions and weakened antioxidant defenses. Rice bran, a nutrient-dense byproduct rich in bioactive compounds, offers potential to modulate these systems, yet its in vivo effects on aging remain underexplored. We investigated the impact of dietary rice bran supplementation on lifespan, antioxidant enzyme activity, and functional capacity in Drosophila melanogaster Meigen (Diptera: Drosophilidae). Adult male flies were fed control or rice bran-supplemented diets (0.5%, 1.0%, or 2.5% w/w). Survival, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, and locomotor function were assessed. Optimal rice bran dosage significantly extended mean lifespan by 18–22% and median survival (p < 0.01), accompanied by increased antioxidant enzyme activities: SOD (25–30%), CAT (20–25%), and GPx (15–20%) (p < 0.05). Supplemented flies exhibited attenuated locomotor decline and preserved climbing ability compared to controls (p < 0.05). These findings demonstrate that dietary rice bran promotes longevity and functional maintenance in D. melanogaster through balanced antioxidant regulation, supporting optimized redox homeostasis as a critical determinant of healthspan.

Keywords

Ethical Statement

Not applicable. This study used Drosophila melanogaster, an invertebrate model organism that does not require ethics committee approval.

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Details

Primary Language

English

Subjects

Entomology

Journal Section

Research Article

Authors

Mehmet Fidan ^*
0000-0001-9016-6730
Türkiye

Early Pub Date

September 20, 2026

Publication Date

-

Submission Date

January 27, 2026

Acceptance Date

May 6, 2026

Published in Issue

Year 2026 Number: Advanced Online Publication

DOI

https://doi.org/10.18016/ksutarimdoga.vi.1872695

IZ

https://izlik.org/JA48MG36CS

Cite

RIS / Bibtex

APA

Fidan, M. (2026). Rice Bran as a Novel Dietary Supplement Improves Lifespan, Antioxidant Defense, and Locomotor Performance in Drosophila melanogaster Meigen (Diptera: Drosophilidae). Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, Advanced Online Publication, 160-174. https://doi.org/10.18016/ksutarimdoga.vi.1872695

AMA

1.Fidan M. Rice Bran as a Novel Dietary Supplement Improves Lifespan, Antioxidant Defense, and Locomotor Performance in Drosophila melanogaster Meigen (Diptera: Drosophilidae). KSU J. Agric Nat. 2026;(Advanced Online Publication):160-174. doi:10.18016/ksutarimdoga.vi.1872695

Chicago

Fidan, Mehmet. 2026. “Rice Bran As a Novel Dietary Supplement Improves Lifespan, Antioxidant Defense, and Locomotor Performance in Drosophila Melanogaster Meigen (Diptera: Drosophilidae)”. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, no. Advanced Online Publication: 160-74. https://doi.org/10.18016/ksutarimdoga.vi.1872695.

EndNote

Fidan M (September 1, 2026) Rice Bran as a Novel Dietary Supplement Improves Lifespan, Antioxidant Defense, and Locomotor Performance in Drosophila melanogaster Meigen (Diptera: Drosophilidae). Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi Advanced Online Publication 160–174.

IEEE

[1]M. Fidan, “Rice Bran as a Novel Dietary Supplement Improves Lifespan, Antioxidant Defense, and Locomotor Performance in Drosophila melanogaster Meigen (Diptera: Drosophilidae)”, KSU J. Agric Nat., no. Advanced Online Publication, pp. 160–174, Sept. 2026, doi: 10.18016/ksutarimdoga.vi.1872695.

ISNAD

Fidan, Mehmet. “Rice Bran As a Novel Dietary Supplement Improves Lifespan, Antioxidant Defense, and Locomotor Performance in Drosophila Melanogaster Meigen (Diptera: Drosophilidae)”. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi. Advanced Online Publication (September 1, 2026): 160-174. https://doi.org/10.18016/ksutarimdoga.vi.1872695.

JAMA

1.Fidan M. Rice Bran as a Novel Dietary Supplement Improves Lifespan, Antioxidant Defense, and Locomotor Performance in Drosophila melanogaster Meigen (Diptera: Drosophilidae). KSU J. Agric Nat. 2026;:160–174.

MLA

Fidan, Mehmet. “Rice Bran As a Novel Dietary Supplement Improves Lifespan, Antioxidant Defense, and Locomotor Performance in Drosophila Melanogaster Meigen (Diptera: Drosophilidae)”. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, no. Advanced Online Publication, Sept. 2026, pp. 160-74, doi:10.18016/ksutarimdoga.vi.1872695.

Vancouver

1.Mehmet Fidan. Rice Bran as a Novel Dietary Supplement Improves Lifespan, Antioxidant Defense, and Locomotor Performance in Drosophila melanogaster Meigen (Diptera: Drosophilidae). KSU J. Agric Nat. 2026 Sep. 1;(Advanced Online Publication):160-74. doi:10.18016/ksutarimdoga.vi.1872695