Bakır Oksit Nanopartikülü Etkisinde Kalan Memelilerde (Rattus norvegicus var. albinos) Bazı Metabolik Tepkilerin Incelenmesi

Esin Gülnaz Canlı

doi:10.18016/ksutarimdoga.vi.632772

EN TR

Investigation of Some Metabolic Responses in Mammals (Rattus norvegicus var. albinos) Exposed to Copper Oxide Nanoparticles

Abstract

In this study, different doses (control (0), 0.5, 5, 50 mg/kg b.w./day) of CuO nanoparticle (NP) were administered to female rats via oral gavage for 14 days. Following the exposures, the activities of ATPases in the kidney, brain and small intestine and activity of acetylcholinesterase (AChE) in the brain were measured. Levels of different glutathione forms (total GSH, rGSH, GGSG) and TBARS (thiobarbituric acid reactive substances) were also measured in the liver of rats. The accumulation of CuO NPs in the tissues were demonstrated following capture of tissue images by a transmission electron microscope (TEM). Data demonstrated that activity of AChE in the brain decreased significantly (P<0.05). ATPase activity in the brain and small intestine did not change significantly (P>0.05), though there were significant decreases (P<0.05) in ATPase activity in the kidney. Levels of glutathione forms did not change significantly, except the highest dose. Similarly, levels of TBARS increased significantly (P<0.05) at the highest dose. TEM images showed that CuO NPs were able to accumulate in the tissues, emphasizing occurred alterations in enzymatic and non-enzymatic biomarkers were due to CuO NP accumulation in the tissues.

Keywords

Metal,Copper oxide,Nanoparticle,Mammale,Biomarker,TEM

Supporting Institution

Çukurova Üniversitesi

Project Number

FDK-2017-8197

Thanks

Bu çalışmanın verilerinin bir kısmı Çukurova Üniversitesi Araştırma Fonu tarafından desteklenen projeye (FDK-2017-8197) aittir. Fizikçi hocam Prof. Dr. Cebrail Gümüş’e nanopartikül karakterizasyonu konusunda ve Doktora Tez Danışmanım Prof. Dr. Hasan. B. İla’ya desteklerinden dolayı çok teşekkür ederim.

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Details

Primary Language

Turkish

Subjects

Structural Biology

Journal Section

Research Article

Authors

Esin Gülnaz Canlı
0000-0002-0132-3712
Türkiye

Publication Date

April 30, 2020

Submission Date

October 14, 2019

Acceptance Date

December 5, 2019

Published in Issue

Year 1970 Volume: 23 Number: 2

DOI

https://doi.org/10.18016/ksutarimdoga.vi.632772

IZ

https://izlik.org/JA35AJ66EP

Cite

RIS / Bibtex

APA

Canlı, E. G. (2020). Bakır Oksit Nanopartikülü Etkisinde Kalan Memelilerde (Rattus norvegicus var. albinos) Bazı Metabolik Tepkilerin Incelenmesi. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 23(2), 304-315. https://doi.org/10.18016/ksutarimdoga.vi.632772

Cited By

METAL OKSİT NANOPARTİKÜLLERİN GENOTOKSİK ETKİLERİ

International Journal of Advances in Engineering and Pure Sciences

https://doi.org/10.7240/jeps.875709

Investigation of Some Metabolic Responses in Mammals (Rattus norvegicus var. albinos) Exposed to Copper Oxide Nanoparticles

Investigation of Some Metabolic Responses in Mammals (Rattus norvegicus var. albinos) Exposed to Copper Oxide Nanoparticles

Abstract

Keywords