Bakır Oksit Nanopartikülü Etkisinde Kalan Memelilerde (Rattus norvegicus var. albinos) Bazı Metabolik Tepkilerin Incelenmesi

Esin Gülnaz Canlı

doi:10.18016/ksutarimdoga.vi.632772

EN TR

Investigation of Some Metabolic Responses in Mammals (Rattus norvegicus var. albinos) Exposed to Copper Oxide Nanoparticles

Abstract

In this study, different doses (control (0), 0.5, 5, 50 mg/kg b.w./day) of CuO nanoparticle (NP) were administered to female rats via oral gavage for 14 days. Following the exposures, the activities of ATPases in the kidney, brain and small intestine and activity of acetylcholinesterase (AChE) in the brain were measured. Levels of different glutathione forms (total GSH, rGSH, GGSG) and TBARS (thiobarbituric acid reactive substances) were also measured in the liver of rats. The accumulation of CuO NPs in the tissues were demonstrated following capture of tissue images by a transmission electron microscope (TEM). Data demonstrated that activity of AChE in the brain decreased significantly (P<0.05). ATPase activity in the brain and small intestine did not change significantly (P>0.05), though there were significant decreases (P<0.05) in ATPase activity in the kidney. Levels of glutathione forms did not change significantly, except the highest dose. Similarly, levels of TBARS increased significantly (P<0.05) at the highest dose. TEM images showed that CuO NPs were able to accumulate in the tissues, emphasizing occurred alterations in enzymatic and non-enzymatic biomarkers were due to CuO NP accumulation in the tissues.

Keywords

Metal,Copper oxide,Nanoparticle,Mammale,Biomarker,TEM

Destekleyen Kurum

Çukurova Üniversitesi

Proje Numarası

FDK-2017-8197

Teşekkür

Bu çalışmanın verilerinin bir kısmı Çukurova Üniversitesi Araştırma Fonu tarafından desteklenen projeye (FDK-2017-8197) aittir. Fizikçi hocam Prof. Dr. Cebrail Gümüş’e nanopartikül karakterizasyonu konusunda ve Doktora Tez Danışmanım Prof. Dr. Hasan. B. İla’ya desteklerinden dolayı çok teşekkür ederim.

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Yapısal Biyoloji

Bölüm

Araştırma Makalesi

Yazarlar

Esin Gülnaz Canlı
0000-0002-0132-3712
Türkiye

Yayımlanma Tarihi

30 Nisan 2020

Gönderilme Tarihi

14 Ekim 2019

Kabul Tarihi

5 Aralık 2019

Yayımlandığı Sayı

Yıl 1970 Cilt: 23 Sayı: 2

DOI

https://doi.org/10.18016/ksutarimdoga.vi.632772

IZ

https://izlik.org/JA35AJ66EP

Kaynak Göster

RIS / Bibtex

APA

Canlı, E. G. (2020). Bakır Oksit Nanopartikülü Etkisinde Kalan Memelilerde (Rattus norvegicus var. albinos) Bazı Metabolik Tepkilerin Incelenmesi. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 23(2), 304-315. https://doi.org/10.18016/ksutarimdoga.vi.632772

Cited By

METAL OKSİT NANOPARTİKÜLLERİN GENOTOKSİK ETKİLERİ

International Journal of Advances in Engineering and Pure Sciences

https://doi.org/10.7240/jeps.875709

Bakır Oksit Nanopartikülü Etkisinde Kalan Memelilerde (Rattus norvegicus var. albinos) Bazı Metabolik Tepkilerin Incelenmesi

Investigation of Some Metabolic Responses in Mammals (Rattus norvegicus var. albinos) Exposed to Copper Oxide Nanoparticles

Abstract

Keywords