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Investigation of the Antidiabetic, Antitrosinase, Antioxidant, and Cytotoxic Effects of Different Extracts Prepared from Opuntia ficus-indica (L.) Mill. plant

Yıl 2024, Cilt: 27 Sayı: Ek Sayı 1 (Suppl 1), 185 - 193, 25.12.2024

Leyla Paşayeva , Sena Kıcalı , Ayşe Kübra Karaboğa Arslan

https://doi.org/10.18016/ksutarimdoga.vi.1463666

Öz

The Flora of Türkiye contains many plant species and varieties due to its different climate and ecological conditions. It has great economic potential in terms of cultivated and natural medicinal plants. In this study, the effects of extracts obtained from the fruit part of the O. ficus-indica plant by different extraction methods were examined on antidiabetic, antityrosinase, antioxidant, and cell viability. For this purpose, after drying the fruits, the extracts were prepared with %70 methanol by maceration and ultrasound-assisted extraction methods. Then the α-amylase, α-glucosidase, and tyrosinase inhibitory effects as well as antioxidant capacities with DPPH and ABTS methods and cell viability of extracts were determined on RL95-2 and A549 cancer cells. As a result, it was shown that, the inhibitory effect of the extract prepared by ultrasound-assisted extraction method on α-amylase (IC50=395.123±3.477 µg ml-1) and tyrosinase enzyme (IC50=551.633±1.159 µg ml-1 and ABTS radical scavenging activity (0.522±0.041 µMTrolox/gextract) was found to be higher than the other extract. It was also determined that the total phenolic and flavonoid content of the same extract was higher ((181.189±4,576 mgGAE/extract and 125.635±1.946 mgCA/extract). The effects of the extracts on α-glucosidase and tyrosinase enzymes and cell viability were found to be moderate. In conclusion, further studies are needed to understand which compounds were related to α-amylase inhibitory effect and antioxidant activity and mechanisms of action.

Anahtar Kelimeler

Dikenli incir Hypoglycemic effect Cell viability

Proje Numarası

Bu çalışma Erciyes Üniversitesi Bilimsel Araştırma Projeleri (BAP) Koordinasyon Birimi tarafından TLO-2023-12968 kodlu proje ile desteklenmiştir.

Kaynakça

  • Arıtuluk, Z. (2012). Halk arasında diyabete karşı kullanılan bitkiler Türkiye-II. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, 32(2), 179-208.
  • Association, A. D. (2010). Diagnosis and classification of diabetes mellitus. Diabetes care, 33(Supplement_1), S62-S69. https://doi.org/ 10.2337/dc10-S062
  • Atiya, A., Majrashi, T. A., Begum, M. Y., Abdul Qadir, S. F., Alqahtani, A. S., Ali Alosman, A. S., Alahmari, A. A., Mesfer Al Aldabsh, A. N., Alshahrani, A. T., & Alshahrani, R. R. M. (2023). Influence of solvent selection and extraction methods on the determination of polyphenols, antioxidant, lipoxygenase and tyrosinase inhibition activities of Opuntia ficus-indica fruits peel and pulp collected from the Kingdom of Saudi Arabia (KSA). Nat Prod Res, 37(3), 514-521. https://doi.org/10.1080/ 14786419.2021.1983571
  • Belviranlı, B., Al‐Juhaimi, F., Özcan, M. M., Ghafoor, K., Babiker, E. E., & Alsawmahi, O. N. (2019). Effect of location on some physico‐chemical properties of prickly pear (Opuntia ficus‐indica L.) fruit and seeds. Journal of Food Processing and Preservation, 43(3), e13896.
  • Berraaouan, A., Abderrahim, Z., Hassane, M., Abdelkhaleq, L., Mohammed, A., & Mohamed, B. (2015). Evaluation of protective effect of cactus pear seed oil (Opuntia ficus-indica L. Mill.) against alloxan-induced diabetes in mice. Asian Pac J Trop Med, 8(7), 532-537. https://doi.org/10.1016/ j.apjtm.2015.06.013
  • Bourhia, M., Elmandaoui, H., Ullah, R., Ibenmoussa, S., & Shahat, A. A. (2020). Physicochemical evaluation of the fruit pulp of spp growing in the Mediterranean area under hard climate conditions. Open Chemistry, 18(1), 565-575. https://doi.org/ 10.1515/chem-2020-0097
  • Butterweck, V., Semlin, L., Feistel, B., Pischel, I., Bauer, K., & Verspohl, E. J. (2011). Comparative evaluation of two different Opuntia ficus-indica extracts for blood sugar lowering effects in rats. Phytother Res, 25(3), 370-375. https://doi.org/ 10.1002/ptr.3271
  • Cano, M. P., Gomez-Maqueo, A., Fernandez-Lopez, R., Welti-Chanes, J., & Garcia-Cayuela, T. (2019). Impact of high hydrostatic pressure and thermal treatment on the stability and bioaccessibility of carotenoid and carotenoid esters in astringent persimmon (Diospyros kaki Thunb, var. Rojo Brillante). Food Res Int, 123, 538-549. https://doi.org/10.1016/j.foodres.2019.05.017
  • Chavez-Santoscoy, R. A., Gutierrez-Uribe, J. A., & Serna-Saldivar, S. O. (2009). Phenolic composition, antioxidant capacity and in vitro cancer cell cytotoxicity of nine prickly pear (Opuntia spp.) juices. Plant Foods Hum Nutr, 64(2), 146-152. https://doi.org/10.1007/s11130-009-0117-0
  • Dumanoğlu, Z., Güzel, Ü., & Çakır, A. (2020). Doğu Akdeniz bölgesinde yetişen dikenli incir (Opuntia ficus-indica L.) tohumlarının bazı fiziksel özelliklerinin belirlenmesi üzerine bir araştırma. Türk Doğa ve Fen Dergisi, 9(Özel Sayı), 28-33.
  • El-Beltagi, H. S., Mohamed, H. I., Elmelegy, A. A., Eldesoky, S. E., & Safwat, G. (2019). Phytochemical screening, antimicrobial, antiaxidant, anticancer activities and nutritional values of cactus (Opuntia ficus indica) pulp and peel. Fresenius Environmental Bulletin, 28(2a), 1545-1562. <Go to ISI>://WOS:000461270800063
  • El Mannoubi, I. (2021). Effect of extraction solvent on phenolic composition, antioxidant and antibacterial activities of skin and pulp of Tunisian red and yellow–orange Opuntia ficus indica fruits. Journal of Food Measurement and Characterization, 15(1), 643-651.
  • Fatullayev, H., Pasayeva, L., Celik, I., Ince, U., & Tugay, O. (2023). Phytochemical composition, in vitro antimicrobial, antioxidant, enzyme ınhibition activities, in silico molecular docking dynamics simulations of Centaurea lycaonica: a computational and experimental approach. ACS omega, 8(25), 22854-22865. https://doi.org/10.1021/ acsomega.3c01819
  • Ferrari, M., Fornasiero, M. C., & Isetta, A. M. (1990). MTT colorimetric assay for testing macrophage cytotoxic activity in vitro. J Immunol Methods, 131(2), 165-172. https://doi.org/10.1016/0022-1759(90)90187-z
  • Floegel, A., Kim, D. O., Chung, S. J., Koo, S. I., & Chun, O. K. (2011). Comparison of ABTS/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods. Journal of food composition and analysis, 24(7), 1043-1048. https://doi.org/10.1016/j.jfca.2011.01.008
  • Frati, A. C., Jimenez, E., & Ariza, C. R. (1990). Hypoglycemic effect of Opuntia-ficus-indica in non-insulin-dependent Diabetes-Mellitus patients. Phytotherapy Research, 4(5), 195-197. https://doi.org/DOI 10.1002/ptr.2650040507
  • Giraldo-Silva, L., Ferreira, B., Rosa, E., & Dias, A. C. P. (2023). Opuntia ficus-indica fruit: a systematic review of its phytochemicals and pharmacological activities. Plants (Basel), 12(3), 543. https://doi.org/10.3390/plants12030543
  • Gómez‐Maqueo, A., Ortega‐Hernández, É., Serrano‐Sandoval, S. N., Jacobo‐Velázquez, D. A., García‐Cayuela, T., Cano, M. P., & Welti‐Chanes, J. (2020). Addressing key features involved in bioactive extractability of vigor prickly pears submitted to high hydrostatic pressurization. Journal of food process engineering, 43(1), e13202. https://doi.org/ 10.1111/jfpe.13202
  • Gouws, C. A., D'Cunha, N. M., Georgousopoulou, E. N., Mellor, D. D., & Naumovski, N. (2019). The effect of different drying techniques on phytochemical content and in vitro antioxidant properties of Australian-grown prickly pears (Opuntia ficus indica). Journal of Food Processing and Preservation, 43(3), e13900. https://doi.org/ 10.1111/jfpp.13900
  • Güven, L., & Gülçin, İ. (2024). Determination of metabolic profiling by LC-MS/MS, evaluation of antioxidant activities, and enzyme inhibition effects of Helichrysum plicatum subsp. pseudopliacatum. KSÜ J. Agric Nat, 27(3), 501-514.
  • Hwang, S. H., Kang, I. J., & Lim, S. S. (2017). Antidiabetic effect of fresh nopal (Opuntia ficus-indica) in low-dose streptozotocin-induced diabetic rats fed a high-fat diet. Evid Based Complement Alternat Med, 2017, 4380721. https://doi.org/ 10.1155/2017/4380721
  • Ishtiaque, S., Naz, S., Siddiqi, R., Umer Abdullah, S., Khan, K., Ahmed, J., & Badaruddin, M. (2014). Antioxidant activities and total phenolics contents from extracts of Terminalia catappa, Carrisa carandas, and Opuntia ficus indica fruits. Recent Innovations in Chemical Engineering (Formerly Recent Patents on Chemical Engineering), 7(2), 106-112. https://doi.org/10.2174/2211334707666 150306 230804
  • Kaewnarin, K., Suwannarach, N., Kumla, J., & Lumyong, S. (2016). Phenolic profile of various wild edible mushroom extracts from Thailand and their antioxidant properties, anti-tyrosinase and hyperglycaemic inhibitory activities. Journal of Functional Foods, 27, 352-364. https://doi.org/ 10.1016/j.jff.2016.09.008
  • Karaboğa-Arslan, A. K., & Yerer, M. B. (2018). α-Chaconine and α-Solanine inhibit RL95-2 endometrium cancer cell proliferation by reducing expression of Akt (Ser473) and ERα (Ser167). Nutrients, 10(6), 672. https://doi.org/10.3390/ nu10060672
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Opuntia ficus-indica (L.) Mill. Bitkisinden Hazırlanan Farklı Ekstrelerin Antidiyabetik, Antitrozinaz, Antioksidan ve Sitotoksik Etkisinin Araştırılması

Yıl 2024, Cilt: 27 Sayı: Ek Sayı 1 (Suppl 1), 185 - 193, 25.12.2024

Leyla Paşayeva , Sena Kıcalı , Ayşe Kübra Karaboğa Arslan

https://doi.org/10.18016/ksutarimdoga.vi.1463666

Öz

Türkiye farklı iklim ve ekolojik koşullara sahip olması nedeniyle floranın çok sayıda bitki türü ve çeşidi içermesi bakımından doğadan toplanan ve kültürü yapılan tıbbi bitkiler açısından büyük bir ekonomik potansiyele sahiptir. Çalışmada Opuntia ficus-indica bitkisinin meyve kısmından farklı ekstraksiyon yöntemleriyle elde edilen ekstrelerin antidiyabetik, antitirozinaz, antioksidan ve hücre canlılığı üzerine etkileri incelenmiştir. Bu amaçla meyve kısmı kurutulduktan sonra %70’lik metanol ile maserasyon ve ses dalgaları-destekli sıvı ekstraksiyonu yöntemleriyle hazırlanan ekstrelerin α-amilaz, α-glikozidaz, tirozinaz inhibitör etkileri yanında antioksidan kapasiteleri DPPH ve ABTS yöntemleri ve hücre canlılığı üzerine etkileri ise RL95-2 ve A549 kanser hücrelerinde tayin edilmiştir. Sonuç olarak ekstrelerden ses dalgaları-destekli sıvı ekstraksiyonu yöntemiyle hazırlanan ekstrenin α-amilaz (IC50=395.123±3.477 µg ml-1) ve tirozinaz enzimi üzerinde inhibisyon etkisinin (IC50=551.633±1.159 µg ml-1), ABTS radikal süpürücü aktivitesinin (0.522±0.041 µMTrolox/gekstre) diğer ekstreden daha yüksek olduğu görülmüştür. Ayrıca aynı ekstresinin toplam fenolik medde ve flavonoit miktarının da daha yüksek olduğu belirlenmiştir ((181.189±4.576 mgGAE/gekstre ve 125.635±1.946 mgCA /gekstre ). Ekstrelerin α-glikozidaz, antitirozinaz ve hücre canlılığı üzerine etkileri orta düzeyde bulunmuştur. Bu çalışmanın sonuçları ile özellikle ses dalgaları-destekli sıvı ekstraksiyonu yöntemiyle hazırlanan ekstrenin α-amilaz inhibitör etki ve antioksidan etkisinin hangi bileşiklerden kaynaklandığını ve etki mekanizmalarını belirlemek için daha ileri çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

Dikenli incir Hipoglisemik etki Hücre canlılığı

Destekleyen Kurum

Erciyes Üniversitesi Bilimsel Araştırma Projeleri (BAP) Koordinasyon Birimi

Proje Numarası

Bu çalışma Erciyes Üniversitesi Bilimsel Araştırma Projeleri (BAP) Koordinasyon Birimi tarafından TLO-2023-12968 kodlu proje ile desteklenmiştir.

Kaynakça

  • Arıtuluk, Z. (2012). Halk arasında diyabete karşı kullanılan bitkiler Türkiye-II. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, 32(2), 179-208.
  • Association, A. D. (2010). Diagnosis and classification of diabetes mellitus. Diabetes care, 33(Supplement_1), S62-S69. https://doi.org/ 10.2337/dc10-S062
  • Atiya, A., Majrashi, T. A., Begum, M. Y., Abdul Qadir, S. F., Alqahtani, A. S., Ali Alosman, A. S., Alahmari, A. A., Mesfer Al Aldabsh, A. N., Alshahrani, A. T., & Alshahrani, R. R. M. (2023). Influence of solvent selection and extraction methods on the determination of polyphenols, antioxidant, lipoxygenase and tyrosinase inhibition activities of Opuntia ficus-indica fruits peel and pulp collected from the Kingdom of Saudi Arabia (KSA). Nat Prod Res, 37(3), 514-521. https://doi.org/10.1080/ 14786419.2021.1983571
  • Belviranlı, B., Al‐Juhaimi, F., Özcan, M. M., Ghafoor, K., Babiker, E. E., & Alsawmahi, O. N. (2019). Effect of location on some physico‐chemical properties of prickly pear (Opuntia ficus‐indica L.) fruit and seeds. Journal of Food Processing and Preservation, 43(3), e13896.
  • Berraaouan, A., Abderrahim, Z., Hassane, M., Abdelkhaleq, L., Mohammed, A., & Mohamed, B. (2015). Evaluation of protective effect of cactus pear seed oil (Opuntia ficus-indica L. Mill.) against alloxan-induced diabetes in mice. Asian Pac J Trop Med, 8(7), 532-537. https://doi.org/10.1016/ j.apjtm.2015.06.013
  • Bourhia, M., Elmandaoui, H., Ullah, R., Ibenmoussa, S., & Shahat, A. A. (2020). Physicochemical evaluation of the fruit pulp of spp growing in the Mediterranean area under hard climate conditions. Open Chemistry, 18(1), 565-575. https://doi.org/ 10.1515/chem-2020-0097
  • Butterweck, V., Semlin, L., Feistel, B., Pischel, I., Bauer, K., & Verspohl, E. J. (2011). Comparative evaluation of two different Opuntia ficus-indica extracts for blood sugar lowering effects in rats. Phytother Res, 25(3), 370-375. https://doi.org/ 10.1002/ptr.3271
  • Cano, M. P., Gomez-Maqueo, A., Fernandez-Lopez, R., Welti-Chanes, J., & Garcia-Cayuela, T. (2019). Impact of high hydrostatic pressure and thermal treatment on the stability and bioaccessibility of carotenoid and carotenoid esters in astringent persimmon (Diospyros kaki Thunb, var. Rojo Brillante). Food Res Int, 123, 538-549. https://doi.org/10.1016/j.foodres.2019.05.017
  • Chavez-Santoscoy, R. A., Gutierrez-Uribe, J. A., & Serna-Saldivar, S. O. (2009). Phenolic composition, antioxidant capacity and in vitro cancer cell cytotoxicity of nine prickly pear (Opuntia spp.) juices. Plant Foods Hum Nutr, 64(2), 146-152. https://doi.org/10.1007/s11130-009-0117-0
  • Dumanoğlu, Z., Güzel, Ü., & Çakır, A. (2020). Doğu Akdeniz bölgesinde yetişen dikenli incir (Opuntia ficus-indica L.) tohumlarının bazı fiziksel özelliklerinin belirlenmesi üzerine bir araştırma. Türk Doğa ve Fen Dergisi, 9(Özel Sayı), 28-33.
  • El-Beltagi, H. S., Mohamed, H. I., Elmelegy, A. A., Eldesoky, S. E., & Safwat, G. (2019). Phytochemical screening, antimicrobial, antiaxidant, anticancer activities and nutritional values of cactus (Opuntia ficus indica) pulp and peel. Fresenius Environmental Bulletin, 28(2a), 1545-1562. <Go to ISI>://WOS:000461270800063
  • El Mannoubi, I. (2021). Effect of extraction solvent on phenolic composition, antioxidant and antibacterial activities of skin and pulp of Tunisian red and yellow–orange Opuntia ficus indica fruits. Journal of Food Measurement and Characterization, 15(1), 643-651.
  • Fatullayev, H., Pasayeva, L., Celik, I., Ince, U., & Tugay, O. (2023). Phytochemical composition, in vitro antimicrobial, antioxidant, enzyme ınhibition activities, in silico molecular docking dynamics simulations of Centaurea lycaonica: a computational and experimental approach. ACS omega, 8(25), 22854-22865. https://doi.org/10.1021/ acsomega.3c01819
  • Ferrari, M., Fornasiero, M. C., & Isetta, A. M. (1990). MTT colorimetric assay for testing macrophage cytotoxic activity in vitro. J Immunol Methods, 131(2), 165-172. https://doi.org/10.1016/0022-1759(90)90187-z
  • Floegel, A., Kim, D. O., Chung, S. J., Koo, S. I., & Chun, O. K. (2011). Comparison of ABTS/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods. Journal of food composition and analysis, 24(7), 1043-1048. https://doi.org/10.1016/j.jfca.2011.01.008
  • Frati, A. C., Jimenez, E., & Ariza, C. R. (1990). Hypoglycemic effect of Opuntia-ficus-indica in non-insulin-dependent Diabetes-Mellitus patients. Phytotherapy Research, 4(5), 195-197. https://doi.org/DOI 10.1002/ptr.2650040507
  • Giraldo-Silva, L., Ferreira, B., Rosa, E., & Dias, A. C. P. (2023). Opuntia ficus-indica fruit: a systematic review of its phytochemicals and pharmacological activities. Plants (Basel), 12(3), 543. https://doi.org/10.3390/plants12030543
  • Gómez‐Maqueo, A., Ortega‐Hernández, É., Serrano‐Sandoval, S. N., Jacobo‐Velázquez, D. A., García‐Cayuela, T., Cano, M. P., & Welti‐Chanes, J. (2020). Addressing key features involved in bioactive extractability of vigor prickly pears submitted to high hydrostatic pressurization. Journal of food process engineering, 43(1), e13202. https://doi.org/ 10.1111/jfpe.13202
  • Gouws, C. A., D'Cunha, N. M., Georgousopoulou, E. N., Mellor, D. D., & Naumovski, N. (2019). The effect of different drying techniques on phytochemical content and in vitro antioxidant properties of Australian-grown prickly pears (Opuntia ficus indica). Journal of Food Processing and Preservation, 43(3), e13900. https://doi.org/ 10.1111/jfpp.13900
  • Güven, L., & Gülçin, İ. (2024). Determination of metabolic profiling by LC-MS/MS, evaluation of antioxidant activities, and enzyme inhibition effects of Helichrysum plicatum subsp. pseudopliacatum. KSÜ J. Agric Nat, 27(3), 501-514.
  • Hwang, S. H., Kang, I. J., & Lim, S. S. (2017). Antidiabetic effect of fresh nopal (Opuntia ficus-indica) in low-dose streptozotocin-induced diabetic rats fed a high-fat diet. Evid Based Complement Alternat Med, 2017, 4380721. https://doi.org/ 10.1155/2017/4380721
  • Ishtiaque, S., Naz, S., Siddiqi, R., Umer Abdullah, S., Khan, K., Ahmed, J., & Badaruddin, M. (2014). Antioxidant activities and total phenolics contents from extracts of Terminalia catappa, Carrisa carandas, and Opuntia ficus indica fruits. Recent Innovations in Chemical Engineering (Formerly Recent Patents on Chemical Engineering), 7(2), 106-112. https://doi.org/10.2174/2211334707666 150306 230804
  • Kaewnarin, K., Suwannarach, N., Kumla, J., & Lumyong, S. (2016). Phenolic profile of various wild edible mushroom extracts from Thailand and their antioxidant properties, anti-tyrosinase and hyperglycaemic inhibitory activities. Journal of Functional Foods, 27, 352-364. https://doi.org/ 10.1016/j.jff.2016.09.008
  • Karaboğa-Arslan, A. K., & Yerer, M. B. (2018). α-Chaconine and α-Solanine inhibit RL95-2 endometrium cancer cell proliferation by reducing expression of Akt (Ser473) and ERα (Ser167). Nutrients, 10(6), 672. https://doi.org/10.3390/ nu10060672
  • Keleş, H. (2023). Opuntia ficus-indica (L.) Miller Meyveleri Üzerinde Farmakognozik Çalışmalar. (Tez no: 780266). [Doktora Tezi, Hacettepe Üniversitesi, Sağlık Bilimleri Enstitüsü, Farmakognozi Anabilim Dalı]. Yükseköğretim Kurulu Ulusal Tez Merkezi.
  • Krishnaiah, D., Sarbatly, R., & Nithyanandam, R. (2011). A review of the antioxidant potential of medicinal plant species. Food and bioproducts processing, 89(C3), 217-233. https://doi.org/10.1016/j.fbp.2010.04.008
  • Manzur-Valdespino, S., Ramírez-Moreno, E., Arias-Rico, J., Jaramillo-Morales, O. A., Calderón-Ramos, Z. G., Delgado-Olivares, L., Córdoba-Díaz, M., Córdoba-Díaz, D., & Cruz-Cansino, N. D. (2020). Opuntia ficus-indica L. Mill residues—properties and application possibilities in food supplements. Applied Sciences, 10(9), 3260. https://doi.org/10.3390/app10093260
  • Masmoudi, R., Mersni, R., Achour, O., Smaali, I., & Maugard, T. (2024). Phenolic composition and anti-tyrosinase activities of extracts from Tunisian Opuntia ficus-indica flowers obtained by different extraction solvents. Chemistry Africa, 1-11. https://doi.org/10.1007/s42250-024-00892-8
  • Nanok, K., & Sansenya, S. (2020). Alpha-glucosidase, alpha-amylase, and tyrosinase inhibitory potential of capsaicin and dihydrocapsaicin. J Food Biochem, 44(1), e13099. https://doi.org/10.1111/jfbc.13099
  • Naselli, F., Tesoriere, L., Caradonna, F., Bellavia, D., Attanzio, A., Gentile, C., & Livrea, M. A. (2014). Anti-proliferative and pro-apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16(INK4a) gene in human colorectal carcinoma (Caco-2) cells. Biochem Biophys Res Commun, 450(1), 652-658. https://doi.org/10.1016/j.bbrc.2014.06.029
  • Paşayeva, L., Fatullayev, H., Celik, I., Unal, G., Bozkurt, N. M., Tugay, O., & Abdellattif, M. H. (2022). Evaluation of the chemical composition, antioxidant and antidiabetic activity of Rhaponticoides iconiensis flowers: effects on key enzymes linked to type 2 diabetes in vitro, in silico and on alloxan-induced diabetic rats in vivo. Antioxidants (Basel), 11(11), 2284. https:// doi.org/10.3390/antiox11112284
  • Paşayeva, L., Eruygur, N., Ayaz, F., Tugay, O., & Fatullayev, H. (2021). Assessment of the antioxidant and enzyme inhibition activities of Cousinia iconica with focus on phytochemical investigation by LC-MS/MS. Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 155(6), 1178-1188. https://doi.org/10.1080/11263504.2020.1829736
  • Petersmann, A., Nauck, M., Muller-Wieland, D., Kerner, W., Muller, U. A., Landgraf, R., Freckmann, G., & Heinemann, L. (2018). Definition, classification and diagnosis of Diabetes Mellitus. Exp Clin Endocrinol Diabetes, 126(7), 406-410. https://doi.org/10.1055/a-0584-6223
  • Saenz, C. (2000). Processing technologies: an alternative for cactus pear (Opuntia spp.) fruits and cladodes. Journal of Arid Environments, 46(3), 209-225. https://doi.org/10.1006/jare.2000.0676
  • Serra, A. T., Poejo, J., Matias, A. A., Bronze, M. R., & Duarte, C. M. M. (2013). Evaluation of Opuntia spp. derived products as antiproliferative agents in human colon cancer cell line (HT29). Food Research International, 54(1), 892-901. https://doi.org/ 10.1016/j.foodres.2013.08.043
  • Siriwardhana, N., Shahidi, F., & Jeon, Y. J. (2006). Potential antioxidative effects of cactus pear fruit extract on radical scavenging and DNA damage reduction in human peripheral lymphocytes. Journal of food lipids, 13(4), 445-458. https://doi.org/DOI 10.1111/j.1745-4522.2006. 00065.x
  • Skelin, M., Rupnik, M., & Cencic, A. (2010). Pancreatic beta cell lines and their applications in Diabetes Mellitus Research. ALTEX-Alternatives to animal experimentation, 27(2), 105-113. https://doi.org/10.14573/altex.2010.2.105
  • Skyler, J. S. (2004). Diabetes mellitus: pathogenesis and treatment strategies. J Med Chem, 47(17), 4113-4117. https://doi.org/10.1021/jm0306273
  • Ydjedd, S., Chaalal, M., Bahri, S., Mokadem, S., & Radji, H. (2021). Antioxidant and α-amylase inhibition activities of prickly pears (Opuntia ficus indica L.) betalains extracts and application in yoghurt as natural colorants. J. Agroaliment. Processes Technol, 27(2), 140-150.
  • Zeghad, N., Ahmed, E., Belkhiri, A., Heyden, Y. V., & Demeyer, K. (2019). Antioxidant activity of Vitis vinifera, Punica granatum, Citrus aurantium and Opuntia ficus indica fruits cultivated in Algeria. Heliyon, 5(4), 1-19 e01575. https://doi.org/ 10.1016/j.heliyon.2019.e01575
Toplam 40 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Farmasotik Botanik
Bölüm ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar

Leyla Paşayeva 0000-0003-3860-7222

Sena Kıcalı 0009-0008-6179-6387

Ayşe Kübra Karaboğa Arslan 0000-0002-4689-0657

Proje Numarası Bu çalışma Erciyes Üniversitesi Bilimsel Araştırma Projeleri (BAP) Koordinasyon Birimi tarafından TLO-2023-12968 kodlu proje ile desteklenmiştir.
Erken Görünüm Tarihi 15 Eylül 2024
Yayımlanma Tarihi 25 Aralık 2024
Gönderilme Tarihi 2 Nisan 2024
Kabul Tarihi 15 Ağustos 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 27 Sayı: Ek Sayı 1 (Suppl 1)

Kaynak Göster

APA Paşayeva, L., Kıcalı, S., & Karaboğa Arslan, A. K. (2024). Opuntia ficus-indica (L.) Mill. Bitkisinden Hazırlanan Farklı Ekstrelerin Antidiyabetik, Antitrozinaz, Antioksidan ve Sitotoksik Etkisinin Araştırılması. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 27(Ek Sayı 1 (Suppl 1), 185-193. https://doi.org/10.18016/ksutarimdoga.vi.1463666
 Kapak Resmi İndir

21082



2022-JIF = 0.500

2022-JCI = 0.170

Uluslararası Hakemli Dergi (International Peer Reviewed Journal)

       Dergimiz, herhangi bir başvuru veya yayımlama ücreti almamaktadır. (Free submission and publication)

      Yılda 6 sayı yayınlanır. (Published 6 times a year)


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