Investigation of Genotoxic and Development Effects of Tetramethrin on Drosophila melanogaster

Burcin Yalcin; Merve Güneş; Ayşen Yağmur Kurşun; Ghada Tagorti; Ezgi Golal; Bülent Kaya

doi:10.18016/ksutarimdoga.vi.1224968

TR EN

Tetramethrin'in Drosophila melanogaster’ de Genotoksik ve Gelişim Üzerine Etkilerinin Araştırılması

Öz

Birçok insektisit formülasyonunda kullanılan sentetik bir piretroid olan tetramethrin kalıntılarının çevre sağlığı ve canlı organizmalar üzerindeki olumsuz etkileri endişe konusudur. Bu çalışmanın amacı, tetrametrin'in hedef dışı bir organizma olan Drosophila melanogaster üzerindeki genotoksik ve gelişimsel etkilerini değerlendirmektir. Bu nedenle Drosophila hemositlerinde komet testi kullanılarak DNA hasarı üzerindeki etkisi, Drosophila kanat SMART kullanılarak da mutasjenik ve rekombinojenik etkileri değerlendirilmiştir. Ayrıca tetramethrin'in Drosophila gelişimi üzerindeki etkileri larva ağırlığı, larva uzunluğu ve yumurta verimi ölçülerek değerlendirilmiştir. Sonuçlar, tetrametrin'in sadece yüksek konsantrasyonda larva ağırlığında ve uzunluğunda bir azalmaya neden olduğunu göstermiştir. Ayrıca yumurta veriminde konsantrasyona bağlı bir şekilde azalma gözlenmiştir. Komet testi sonuçlarına göre, % DNA'da anlamlı bir artış olmadığı için DNA hasarı indüklenmemiştir. Ancak tetrametrin, SMART testinde mitotik rekombinasyonu indükleyerek genotoksisiteye neden olmuştur.

Anahtar Kelimeler

Investigation of Genotoxic and Development Effects of Tetramethrin on Drosophila melanogaster

Abstract

The adverse effects of tetramethrin residues, a synthetic pyrethroid used in many insecticide formulations, on environmental health and living organisms are a matter of concern. The aim of this study was to evaluate the genotoxic and developmental effects of tetramethrin in a non-target organism, Drosophila melanogaster. Thus, its effect on DNA damage was evaluated using the Comet assay in hemocytes, and its mutagenic and recombinogenic effects were evaluated using Drosophila wing SMART. Also, the effects of tetramethrin on Drosophila development were evaluated by measuring larval weight, larval length, and fecundity. Results showed that tetramethrin induced a decrease in the larval weight and length only at a high concentration. Moreover, a decrease in fecundity in a dose-dependent manner was observed. According to the Comet assay results, DNA damage was not induced because there was no significant increase in % DNA. However, tetramethrin caused genotoxicity by inducing mitotic recombination in the SMART assay.

Keywords

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Yapısal Biyoloji

Bölüm

Araştırma Makalesi

Yazarlar

Burcin Yalcin
0000-0002-9694-5839
Türkiye

Merve Güneş
0000-0003-3278-0542
Türkiye

Ayşen Yağmur Kurşun
0000-0003-1657-6808
Türkiye

Ghada Tagorti
0000-0003-4597-8320
Türkiye

Ezgi Golal
0000-0002-7685-7479
Türkiye

Bülent Kaya ^*
0000-0002-0491-9781
Türkiye

Erken Görünüm Tarihi

21 Ocak 2024

Yayımlanma Tarihi

1 Nisan 2024

Gönderilme Tarihi

3 Ocak 2023

Kabul Tarihi

7 Eylül 2023

Yayımlandığı Sayı

Yıl 2024 Cilt: 27 Sayı: 2

DOI

https://doi.org/10.18016/ksutarimdoga.vi.1224968

IZ

https://izlik.org/JA36BP97LH

Kaynak Göster

RIS / Bibtex

APA

Yalcin, B., Güneş, M., Kurşun, A. Y., Tagorti, G., Golal, E., & Kaya, B. (2024). Investigation of Genotoxic and Development Effects of Tetramethrin on Drosophila melanogaster. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 27(2), 304-315. https://doi.org/10.18016/ksutarimdoga.vi.1224968

Cited By

Antigenotoxic Effects of Stachys viscosa (Lamiaceae), a potential medicinal plant in Drosophila melanogaster

Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi

https://doi.org/10.18016/ksutarimdoga.vi.1574067

Tetramethrin'in Drosophila melanogaster’ de Genotoksik ve Gelişim Üzerine Etkilerinin Araştırılması

Öz

Anahtar Kelimeler

Investigation of Genotoxic and Development Effects of Tetramethrin on Drosophila melanogaster

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Erken Görünüm Tarihi

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Antigenotoxic Effects of Stachys viscosa (Lamiaceae), a potential medicinal plant in Drosophila melanogaster

e-ISSN: 2619-9149