Variations in Essential Oil Compositions and Cyclooxygenase (COX) Inhibiting Potential of Ruta chalepensis L. Essential Oils Obtained at Different Phenological Stages

İlker Demirbolat

doi:10.18016/ksutarimdoga.vi.1734360

TR EN

Farklı Fenolojik Evrelerde Elde Edilen Ruta chalepensis L. Uçucu Yağlarının Kimyasal Kompozisyonları ve Siklooksijenaz (COX) İnhibisyon Potansiyellerindeki Değişiklikler

Öz

Bu çalışma, farklı gelişim aşamalarında elde edilen Ruta chalepensis L. uçucu yağlarının verimi, bileşimi ve COX inhibitör aktivitesini incelemektedir. Uçucu yağ verimi, bitkinin olgunlaşmasıyla azalmış ve en düşük seviye çiçeklenme sonrası dönemde gözlemlenmiştir. Kimyasal analizler terpen bileşenleri içermediğini ortaya koymuş ve alifatik ketonlarda belirgin değişimler görülmüştür. Vejetatif dönemde 2-nonanone baskın olup (%58), olgun bitkilerde bu oran 26%'ya düşmüştür. Buna karşılık, 2-undecanone oranı 34%'ten 63%'e yükselmiştir. Bu sonuçlar daha uzun zincirli molekül biyosentezinde gelişimsel bir değişimi göstermektedir. COX-1/2 inhibitör testleri, ibuprofenin enzim aktivitesini 73,53% oranında engellediğini gösterirken, R. chalepensis uçucu yağları belirgin şekilde daha düşük inhibitör aktivite sergilemiştir. Bu sonuçlar, uçucu yağın bitkinin geleneksel anti-inflamatuar tıbbi kullanımından sorumlu olmadığını ve terapötik etkilerinin diğer bileşenlerden kaynaklanabileceğini göstermektedir.

Anahtar Kelimeler

Variations in Essential Oil Compositions and Cyclooxygenase (COX) Inhibiting Potential of Ruta chalepensis L. Essential Oils Obtained at Different Phenological Stages

Abstract

This study examines the yield, composition, and COX inhibitory activity of essential oils from Ruta chalepensis L. obtained at various developmental stages. Essential oil yield decreased with plant maturity, reaching its lowest level during the post-flowering stage. Chemical analysis revealed the absence of terpenes, with notable shifts in aliphatic ketones. At the vegetative stage, 2-nonanone was dominant (58%), but declined to 26% in mature plants. In contrast, 2-undecanone increased from 34% to 63%, indicating a developmental shift in longer chain molecule biosynthesis. COX-1/2 inhibition assays showed that ibuprofen inhibited enzyme activity by 73.53%, whereas R. chalepensis essential oils exhibited significantly lower inhibition, suggesting weak anti-inflammatory activity. These results indicate that the essential oil does not account for the plant’s anti-inflammatory traditional medicinal use, and other constituents may be responsible for its therapeutic effects.

Keywords

Destekleyen Kurum

YOK

Etik Beyan

Etik kurul onayı gerektirmemektedir.

Teşekkür

YOK

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Bitki Biyokimyası

Bölüm

Araştırma Makalesi

Yazarlar

İlker Demirbolat ^*
0000-0002-8756-1884
Türkiye

Erken Görünüm Tarihi

21 Ocak 2026

Yayımlanma Tarihi

21 Ocak 2026

Gönderilme Tarihi

3 Temmuz 2025

Kabul Tarihi

8 Eylül 2025

Yayımlandığı Sayı

Yıl 2026 Cilt: 29 Sayı: 2

DOI

https://doi.org/10.18016/ksutarimdoga.vi.1734360

IZ

https://izlik.org/JA47FJ69JS

Kaynak Göster

RIS / Bibtex

APA

Demirbolat, İ. (2026). Variations in Essential Oil Compositions and Cyclooxygenase (COX) Inhibiting Potential of Ruta chalepensis L. Essential Oils Obtained at Different Phenological Stages. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 29(2), 285-290. https://doi.org/10.18016/ksutarimdoga.vi.1734360

Farklı Fenolojik Evrelerde Elde Edilen Ruta chalepensis L. Uçucu Yağlarının Kimyasal Kompozisyonları ve Siklooksijenaz (COX) İnhibisyon Potansiyellerindeki Değişiklikler

Öz

Anahtar Kelimeler

Variations in Essential Oil Compositions and Cyclooxygenase (COX) Inhibiting Potential of Ruta chalepensis L. Essential Oils Obtained at Different Phenological Stages

Abstract

Keywords

Destekleyen Kurum

Etik Beyan

Teşekkür

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Erken Görünüm Tarihi

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

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