EN
TR
Phenological Stage Dependent Variations in the Chemical Composition and Cyclooxygenase (COX) Inhibitory Activities of Origanum dubium Boiss. Essential Oils
Abstract
This study investigated the essential oil yield, chemical composition, and COX-1/2 inhibitory activity of Origanum dubium during different developmental stages. Essential oil yield increased from 5.53% to 8.37%, peaking at the post-flowering stage. Chemical analysis revealed that oxygenated monoterpenes dominated the oil composition, with carvacrol as the principal component, increasing significantly from 64.4% to 86.9% across growth stages. The anti-inflammatory potential was evaluated by measuring COX-1/2 inhibitory activity, using ibuprofen as a positive control (73.53% inhibition). Essential oils exhibited moderate inhibition during vegetative (52.13%) and initial flowering (57.76%) stages, but inhibition notably improved at post-flowering (68.16%), approaching ibuprofen’s efficacy. These findings suggest that the rise in carvacrol concentration correlates with enhanced COX-1/2 inhibitory activity, highlighting the therapeutic potential of O. dubium essential oils as natural anti-inflammatory agents.
Keywords
Destekleyen Kurum
Yoktur
Etik Beyan
Uygulanamaz
Teşekkür
Yoktur
Kaynakça
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Ayrıntılar
Birincil Dil
İngilizce
Konular
Bitki Biyokimyası
Bölüm
Araştırma Makalesi
Yazarlar
Erken Görünüm Tarihi
8 Şubat 2026
Yayımlanma Tarihi
8 Şubat 2026
Gönderilme Tarihi
21 Temmuz 2025
Kabul Tarihi
21 Ekim 2025
Yayımlandığı Sayı
Yıl 2026 Sayı: Advanced Online Publication
APA
Demirbolat, İ. (2026). Phenological Stage Dependent Variations in the Chemical Composition and Cyclooxygenase (COX) Inhibitory Activities of Origanum dubium Boiss. Essential Oils. Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, Advanced Online Publication, 653-657. https://doi.org/10.18016/ksutarimdoga.vi.1747383
