Quantification of Some Phenolic Compounds in Consolida thirkeana (Boiss.) Bornm. by HPLC and Validation of Method

Derya Çiçek Polat; Muhammed Mesud Hürkul

doi:10.18016/ksutarimdoga.vi.1210096

Araştırma Makalesi

Quantification of Some Phenolic Compounds in Consolida thirkeana (Boiss.) Bornm. by HPLC and Validation of Method

Yıl 2024, Cilt: 27 Sayı: 1, 68 - 74, 28.02.2024

Derya Çiçek Polat Muhammed Mesud Hürkul

https://doi.org/10.18016/ksutarimdoga.vi.1210096

Öz

Consolida species have traditional uses in the treatment of various diseases, especially skin diseases. There is also traditional use of some Consolida species in Turkey. Phenolic compounds have significant pharmacological effects, therefore it is important to know their amount in plants. Consolida thirkeana is endemic to Turkey and known as “boz mahmuz” and no study had conducted in terms of phenolic compounds. Therefore, some phenolic amount, which has been done for the first time for C. thikeana, was analyzed. In this study, C. thirkeana was analyzed quantitatively for caffeic acid, chlorogenic acid, hyperosit, and rutin by using HPLC and the method was validated (linearity, precision, accuracy, recovery, limits of detection (LOD), and limits of quantification (LOQ)). While chlorogenic acid (0.098%), caffeic acid (0.107%), rutin (0.078%), and hyperoside (0.134%) were detected in the aerial part, only rutin (0.007%) was detected in the root. As a result of this study, this endemic species was evaluated in terms of some phenolic compounds. It is thought that phenolic compounds can be determined on other Consolida species with this method.

Anahtar Kelimeler

Consolida sp., HPLC, Phenolics, Ranunculaceae, Validation

Kaynakça

Acıkara, Ö. B., Ilhan, M., Kurtul, E., Šmejkal, K., & Akkol, E. K. (2019). Inhibitory activity of Podospermum canum and its active components on collagenase, elastase, and hyaluronidase enzymes. Bioorganic Chemistry, 93, 103330. https://doi.org/ 10.1016/j.bioorg.2019.103330
Ayla, S., Okur, M. E., Günal, M. Y., Özdemir, E. M., Çiçek Polat, D., Yoltaş, A., Biçeroğlu,Ö. & Karahüseyinoğlu, S. (2019). Wound healing effects of methanol extract of Laurocerasus officinalis roem. Biotechnic & Histochemistry, 94(3), 180-188. https://doi.org/10.1080/10520295.2018.1539242
Baytop, T. (1999). Therapy with medicinal plants in Turkey (past and present). Istanbul Nobel Tıp Publisher. Bender, O. & Atalay, A. (2021). Cancer: Polyphenol chlorogenic acid, antioxidant profile, and breast cancer. Academic Press.
Birková, A., Hubková, B., Bolerázska, B., Mareková, M. & Čižmárová, B. (2020). Caffeic acid: a brief overview of its presence, metabolism, and bioactivity. Bioactive Compounds in Health and Disease, 3(4), 74-81. https://doi.org/10.31989/ bchd.v3i4.692
Bitiş, L., Süzgeç, S., Meriçli, F., Özçelik, H., Zapp, J., Becker, H. & Meriçli, A. H. (2006). Alkaloids from Consolida olopetala. Pharmaceutical Biology, 44(4), 244-246.https://doi.org/10.1080/1388020600713691
Çiçek Polat, D. & Coşkun, M. (2016). Quantitative determination by HPLC-DAD of icariin, epimedin A, epimedin B, and epimedin C in Epimedium (Berberidaceae) species growing in Turkey. Natural Product Communications, 11(11), 1665-1666.
Çiçek Polat, D., Yılmaz Sarıaltın, S., Çoban, T. & Coşkun, M. (2019). Comparison of Walnut (Juglans regia L.) and Olive (Olea europaea L.) Leaves in Terms of Antioxidant and Anti-inflammatory Activity. Adıyaman University Journal of Sciences, 9(2), 242-251. https://doi.org/10.37094/adyujsci. 586664
Díaz, J. G., Carmona, A.J., Torres, F., Quintana, J., Estevez, F. & Herz, W. (2008). Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana. Planta Medica, 74(2),171. https://doi.org/10.1055/s-2008-1034278
Dürüst, N., Özden, S., Umur, E., Dürüst, Y. & Küçükislamoğlu, M. (2001). The isolation of carboxylic acids from the flowers of Delphinium formosum. Turkish Journal of Chemistry, 25(1), 93-97.
Ertuğrul, K., Arslan, E. & Tugay, O. (2010). Characterization of Consolida SF Gray (Ranunculaceae) taxa in Turkey by seed storage protein electrophoresis. Turkish Journal of Biochemistry, 35(2), 99-104.
Gullón, B., Lú-Chau, T. A., Moreira, M. T., Lema, J.M. & Eibes, G. (2017). Rutin: A review on extraction, identification and purification methods, biological activities, and approaches to enhance its bioavailability. Trends in Food Sciences & Technology, 67,220-235. https://doi.org/10.1016/ j.tifs.2017.07.008
Güner, A., Aslan, S., Ekim, T., Vural, M. & Babaç, M.T. (2012). Türkiye Bitkileri Listesi (Damarlı Bitkiler). Flora Dizisi I. Istanbul: Nezahat Gökyigit Botanik Bahçesi Yayınları.
Hürkul, M. (2021). Leaf, stem and root anatomy of Consolida thirkeana (Boiss.) Bornm. (Ranunculaceae). Journal of Research in Pharmacy, 25(4),415-419. https://dx.doi.org/10.29228/jrp.32
ICH Expert Working Group. 2005. ICH Guideline Q2(R1) Validation of analytical procedures: text and methodology. European Medicine Agency.
Jabbour, F. & Renner, S. S. (2011). Consolida and Aconitella are an annual clade of Delphinium (Ranunculaceae) that diversified in the mediterranean basin and the irano‐turanian region. Taxon, 60(4),1029-1040. https://doi.org/ 10.1002/tax.604007
Kendir, G., Köroğlu, A. & Dinç, E. (2021). Simultaneous spectrophotometric quantitation of rutin and chlorogenic acid in leaves of Ribes uva-crispa L. by one-dimensional continuous wavelet transforms. Journal of the Chilean Chemical Society, 66(1), 5041-5046. http://dx.doi.org/ 10.4067/S0717-97072021000105041
Kostic, D. A., Velickovic, J.M. & Mitic, S. S., Mitic, M.N., Randjelovic, S.S., Arsic, B.B. & Pavlovic, A.N. (2013). Correlation among phenolic, toxic metals and antioxidant activity of the extracts of plant species from Southeast Serbia. Bulletin of the Chemical Society of Ethiopia, 27(2),169-178. https://doi.org/10.4314/bcse.v27i2.2
Kubes, J., Skalicky, M., Hejnak, V., Tumova, L., Martin, J. & Martinkova, J. (2018). The first genistin absorption screening into vacuoles of Trifolium pratense L. Plant Soil and Environment, 64(6), 290-296. https://doi.org/10.17221/134/2018-PSE
Li, W., Sun, Y., Liang, W., Fitzloff, J. F. & van Breemen R. B. (2003). Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 17(9), 978-982. https://doi.org/ 10.1002/rcm.1008
Magnani, C., Isaac, V. L. B., Correa, M.A. & Salgado, H. R. N. (2014). Caffeic acid: a review of its potential use in medications and cosmetics. Analytical Methods, 6(10), 3203-3210. https://doi.org/ 10.1039/ C3AY41807C
Marín, C., Boutaleb-Charki, S., Díaz, J.G., Huertas, O., Rosales, M. J., Pérez-Cordon, G., Guitierrez-Sánchez, R. & Sánchez-Moreno, M. (2009). Antileishmaniasis activity of flavonoids from Consolida oliveriana. Journal of Natural Product, 72(6), 1069-1074. https://doi.org/10.1021/ np8008122
Marín, C., Díaz, J. G., Maiques, D.I., Ramírez-Macías, I., Rosales, M.J., Guitierrez-Sánchez, R., Cañas, R. & Sánchez-Moreno, M. (2017). Antitrypanosomatid activity of flavonoid glycosides isolated from Delphinium gracile, D. staphisagria, Consolida oliveriana and from Aconitum napellus subsp. lusitanicum. Phytochemistry Letters, 19,196-209. https://doi.org/10.1016/j.phytol.2016.12.010
Mendoza, L., Matsuhiro, B., Aguirre, M.J., Isaacs, M., Sotes, G., Cotoras, M. & Melo, R. (2011). Characterization of phenolic acids profile from chilean red wines by high-performance liquid chromatography. Journal of The Chilean Chemical Society, 56(2), 688-691. http://dx.doi.org/ 10.4067/S0717-97072011000200014
Mericli, F., Mericli, A. H., Tan, N., Özçelik, H. & Ulubelen, A. (1999). Further diterpenoid alkaloids from Consolida stenocarpa. Scientia Pharmazeutica, 31(12),313-318.
Mericli, F., Mericli, A.H., Desai, H.K., Ulubelen, A. & Pelletier, S.W. (2001). Diterpenoid alkaloids from Consolida regalis SF Gray subsp. paniculata (Host) Soo var. paniculata. Scientia Pharmazeutica, 69, 63-67.
Mericli, A. H., Yazici, S., Eroglu-Ozkan, E., Sen, B., Kurtoglu.S., Ozcelik, H., Zapp, J., Kiemer, A. K. & Mericli, F. (2012). Norditerpenoid alkaloids from Consolida thirkeana and Consolida sulphurea. Chemistry of Natural Compound, 48(3), 525.
Munz, P. A. (1967). A synopsis of african species of Delphinium and Consolida. Journal of the Arnold Arboretum, 48(1), 30-55.
Naveed, M., Hejazi, V., Abbas, M., Kamboh, A. A., Khan, G. J., Shumzaid, M., Ahmad, F., Babazadeh, D., FangFang, X., Modarresi-Ghazani, F., WenHua, L. & XiaoHui, Z. (2018). Chlorogenic acid (CGA): a pharmacological review and call for further research. Biomedicine & Pharmacotherapy, 97, 67-74. https://doi.org/10.1016/j.biopha.2017.10.064
Okur, M. E., Ayla, Ş., Karadağ, A. E., Polat, D. Ç., Demirci, S. & Seçkin. İ. (2020). Opuntia ficus indica fruits ameliorate cisplatin-induced nephrotoxicity in mice. Biological and Pharmaceutical Bulletin, 43(5), 831-838. https://doi.org/10.1248/bpb.b19-01044
Ouerfelli, M., Majdoub, N., Aroussi, J., Almajano, M.P. & Bettaieb Ben Kaâb, L. (2021). Phytochemical screening and evaluation of the antioxidant and anti-bacterial activity of Woundwort (Anthyllis vulneraria L.). Brazilian Journal of Botany, 44(3), 549-559. https://doi.org/10.1007/s40415-021-00736-6
Pakravan, M., Dastpak, A., Sonboli, A. & Khalaj, Z. (2018). A taxonomic reassessment of Consolida (Ranunculaceae) species: insight from morphological and molecular data. Journal of Genetic Resours, 4(1), 14-25. https://doi.org/ 0.22080/jgr.2018.13872.1098
Raza, A., Xu, X., Sun, H., Tang, J. & Quyang, Z. (2017). Pharmacological activities, and pharmacokinetic study of hyperoside: a short review. Tropical Journal of Pharmaceutical Research, 16(2), 483-489. https://doi.org/10.4314/tjpr.v16i2.30
Rocchetti, G., Zengin, G., Cakmak, Y.S., Mahomoodally, M.F., Kaya, M. F., Alsheikh, S.M., Glamocilja, J., Sokovic, M., Lobine, D. & Lucini, L. (2020). A UHPLC-QTOF-MS screening provides new insights into the phytochemical composition and biological properties of six Consolida species from Turkey. Industrial Crop and Products, 158, 112966. https://doi.org/10.1016/ j.indcrop.2020. 112966
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Consolida thirkeana (Boiss.) Bornm.’daki Bazı Fenolik Bileşiklerin YPSK ile Miktarı Tayini ve Yöntemin Validasyonu

Yıl 2024, Cilt: 27 Sayı: 1, 68 - 74, 28.02.2024

Derya Çiçek Polat Muhammed Mesud Hürkul

https://doi.org/10.18016/ksutarimdoga.vi.1210096

Öz

Consolida türleri başta deri hastalıkları olmak üzere çeşitli hastalıkların tedavisinde geleneksel kullanıma sahiptir. Türkiye'de de bazı Consolida türlerinin geleneksel kullanımı mevcuttur. Fenolik bileşiklerin önemli farmakolojik etkileri bulunmaktadır, bu nedenle bitkilerde miktarlarının bilinmesi önemli bir yere sahiptir. Consolida thirkeana, Türkiye'de “boz mahmuz” olarak bilinen endemik bir türdür ve fenolik bileşikler açısından herhangi bir çalışmaya rastlanmamıştır. Bu nedenle C. thikeana için bazı fenolik bileşiklerin miktar tayini yapılmıştır. Bu çalışmada, C. thirkeana, YPSK kullanılarak kafeik asit, klorojenik asit, hiperosit ve rutin açısından kantitatif olarak analiz edilmiş ve yöntemin validasyonu (doğrusallık, kesinlik, doğruluk, geri kazanım, tespit limitleri ve ölçüm limitleri) gerçekleştirilmiştir. Toprak üstü kısımlarında, klorojenik asit (%0,098), kafeik asit (%0,107), rutin (%0,078) ve hiperosit (%0,134) tespit edilirken, toprak altı kısmı sadece rutin (%0,007) tespit edilmiştir. Bu çalışma sonucunda bu endemik tür bazı fenolik bileşikler açısından değerlendirilmiştir. Bu yöntem kullanılarak diğer Consolida türleri üzerinde fenolik bileşiklerin tayininin yapılabileceği düşünülmektedir.

Anahtar Kelimeler

Consolida sp., YPSK, Fenolikler, Ranunculaceae, Validasyon

Kaynakça

Acıkara, Ö. B., Ilhan, M., Kurtul, E., Šmejkal, K., & Akkol, E. K. (2019). Inhibitory activity of Podospermum canum and its active components on collagenase, elastase, and hyaluronidase enzymes. Bioorganic Chemistry, 93, 103330. https://doi.org/ 10.1016/j.bioorg.2019.103330
Ayla, S., Okur, M. E., Günal, M. Y., Özdemir, E. M., Çiçek Polat, D., Yoltaş, A., Biçeroğlu,Ö. & Karahüseyinoğlu, S. (2019). Wound healing effects of methanol extract of Laurocerasus officinalis roem. Biotechnic & Histochemistry, 94(3), 180-188. https://doi.org/10.1080/10520295.2018.1539242
Baytop, T. (1999). Therapy with medicinal plants in Turkey (past and present). Istanbul Nobel Tıp Publisher. Bender, O. & Atalay, A. (2021). Cancer: Polyphenol chlorogenic acid, antioxidant profile, and breast cancer. Academic Press.
Birková, A., Hubková, B., Bolerázska, B., Mareková, M. & Čižmárová, B. (2020). Caffeic acid: a brief overview of its presence, metabolism, and bioactivity. Bioactive Compounds in Health and Disease, 3(4), 74-81. https://doi.org/10.31989/ bchd.v3i4.692
Bitiş, L., Süzgeç, S., Meriçli, F., Özçelik, H., Zapp, J., Becker, H. & Meriçli, A. H. (2006). Alkaloids from Consolida olopetala. Pharmaceutical Biology, 44(4), 244-246.https://doi.org/10.1080/1388020600713691
Çiçek Polat, D. & Coşkun, M. (2016). Quantitative determination by HPLC-DAD of icariin, epimedin A, epimedin B, and epimedin C in Epimedium (Berberidaceae) species growing in Turkey. Natural Product Communications, 11(11), 1665-1666.
Çiçek Polat, D., Yılmaz Sarıaltın, S., Çoban, T. & Coşkun, M. (2019). Comparison of Walnut (Juglans regia L.) and Olive (Olea europaea L.) Leaves in Terms of Antioxidant and Anti-inflammatory Activity. Adıyaman University Journal of Sciences, 9(2), 242-251. https://doi.org/10.37094/adyujsci. 586664
Díaz, J. G., Carmona, A.J., Torres, F., Quintana, J., Estevez, F. & Herz, W. (2008). Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana. Planta Medica, 74(2),171. https://doi.org/10.1055/s-2008-1034278
Dürüst, N., Özden, S., Umur, E., Dürüst, Y. & Küçükislamoğlu, M. (2001). The isolation of carboxylic acids from the flowers of Delphinium formosum. Turkish Journal of Chemistry, 25(1), 93-97.
Ertuğrul, K., Arslan, E. & Tugay, O. (2010). Characterization of Consolida SF Gray (Ranunculaceae) taxa in Turkey by seed storage protein electrophoresis. Turkish Journal of Biochemistry, 35(2), 99-104.
Gullón, B., Lú-Chau, T. A., Moreira, M. T., Lema, J.M. & Eibes, G. (2017). Rutin: A review on extraction, identification and purification methods, biological activities, and approaches to enhance its bioavailability. Trends in Food Sciences & Technology, 67,220-235. https://doi.org/10.1016/ j.tifs.2017.07.008
Güner, A., Aslan, S., Ekim, T., Vural, M. & Babaç, M.T. (2012). Türkiye Bitkileri Listesi (Damarlı Bitkiler). Flora Dizisi I. Istanbul: Nezahat Gökyigit Botanik Bahçesi Yayınları.
Hürkul, M. (2021). Leaf, stem and root anatomy of Consolida thirkeana (Boiss.) Bornm. (Ranunculaceae). Journal of Research in Pharmacy, 25(4),415-419. https://dx.doi.org/10.29228/jrp.32
ICH Expert Working Group. 2005. ICH Guideline Q2(R1) Validation of analytical procedures: text and methodology. European Medicine Agency.
Jabbour, F. & Renner, S. S. (2011). Consolida and Aconitella are an annual clade of Delphinium (Ranunculaceae) that diversified in the mediterranean basin and the irano‐turanian region. Taxon, 60(4),1029-1040. https://doi.org/ 10.1002/tax.604007
Kendir, G., Köroğlu, A. & Dinç, E. (2021). Simultaneous spectrophotometric quantitation of rutin and chlorogenic acid in leaves of Ribes uva-crispa L. by one-dimensional continuous wavelet transforms. Journal of the Chilean Chemical Society, 66(1), 5041-5046. http://dx.doi.org/ 10.4067/S0717-97072021000105041
Kostic, D. A., Velickovic, J.M. & Mitic, S. S., Mitic, M.N., Randjelovic, S.S., Arsic, B.B. & Pavlovic, A.N. (2013). Correlation among phenolic, toxic metals and antioxidant activity of the extracts of plant species from Southeast Serbia. Bulletin of the Chemical Society of Ethiopia, 27(2),169-178. https://doi.org/10.4314/bcse.v27i2.2
Kubes, J., Skalicky, M., Hejnak, V., Tumova, L., Martin, J. & Martinkova, J. (2018). The first genistin absorption screening into vacuoles of Trifolium pratense L. Plant Soil and Environment, 64(6), 290-296. https://doi.org/10.17221/134/2018-PSE
Li, W., Sun, Y., Liang, W., Fitzloff, J. F. & van Breemen R. B. (2003). Identification of caffeic acid derivatives in Actea racemosa (Cimicifuga racemosa, black cohosh) by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 17(9), 978-982. https://doi.org/ 10.1002/rcm.1008
Magnani, C., Isaac, V. L. B., Correa, M.A. & Salgado, H. R. N. (2014). Caffeic acid: a review of its potential use in medications and cosmetics. Analytical Methods, 6(10), 3203-3210. https://doi.org/ 10.1039/ C3AY41807C
Marín, C., Boutaleb-Charki, S., Díaz, J.G., Huertas, O., Rosales, M. J., Pérez-Cordon, G., Guitierrez-Sánchez, R. & Sánchez-Moreno, M. (2009). Antileishmaniasis activity of flavonoids from Consolida oliveriana. Journal of Natural Product, 72(6), 1069-1074. https://doi.org/10.1021/ np8008122
Marín, C., Díaz, J. G., Maiques, D.I., Ramírez-Macías, I., Rosales, M.J., Guitierrez-Sánchez, R., Cañas, R. & Sánchez-Moreno, M. (2017). Antitrypanosomatid activity of flavonoid glycosides isolated from Delphinium gracile, D. staphisagria, Consolida oliveriana and from Aconitum napellus subsp. lusitanicum. Phytochemistry Letters, 19,196-209. https://doi.org/10.1016/j.phytol.2016.12.010
Mendoza, L., Matsuhiro, B., Aguirre, M.J., Isaacs, M., Sotes, G., Cotoras, M. & Melo, R. (2011). Characterization of phenolic acids profile from chilean red wines by high-performance liquid chromatography. Journal of The Chilean Chemical Society, 56(2), 688-691. http://dx.doi.org/ 10.4067/S0717-97072011000200014
Mericli, F., Mericli, A. H., Tan, N., Özçelik, H. & Ulubelen, A. (1999). Further diterpenoid alkaloids from Consolida stenocarpa. Scientia Pharmazeutica, 31(12),313-318.
Mericli, F., Mericli, A.H., Desai, H.K., Ulubelen, A. & Pelletier, S.W. (2001). Diterpenoid alkaloids from Consolida regalis SF Gray subsp. paniculata (Host) Soo var. paniculata. Scientia Pharmazeutica, 69, 63-67.
Mericli, A. H., Yazici, S., Eroglu-Ozkan, E., Sen, B., Kurtoglu.S., Ozcelik, H., Zapp, J., Kiemer, A. K. & Mericli, F. (2012). Norditerpenoid alkaloids from Consolida thirkeana and Consolida sulphurea. Chemistry of Natural Compound, 48(3), 525.
Munz, P. A. (1967). A synopsis of african species of Delphinium and Consolida. Journal of the Arnold Arboretum, 48(1), 30-55.
Naveed, M., Hejazi, V., Abbas, M., Kamboh, A. A., Khan, G. J., Shumzaid, M., Ahmad, F., Babazadeh, D., FangFang, X., Modarresi-Ghazani, F., WenHua, L. & XiaoHui, Z. (2018). Chlorogenic acid (CGA): a pharmacological review and call for further research. Biomedicine & Pharmacotherapy, 97, 67-74. https://doi.org/10.1016/j.biopha.2017.10.064
Okur, M. E., Ayla, Ş., Karadağ, A. E., Polat, D. Ç., Demirci, S. & Seçkin. İ. (2020). Opuntia ficus indica fruits ameliorate cisplatin-induced nephrotoxicity in mice. Biological and Pharmaceutical Bulletin, 43(5), 831-838. https://doi.org/10.1248/bpb.b19-01044
Ouerfelli, M., Majdoub, N., Aroussi, J., Almajano, M.P. & Bettaieb Ben Kaâb, L. (2021). Phytochemical screening and evaluation of the antioxidant and anti-bacterial activity of Woundwort (Anthyllis vulneraria L.). Brazilian Journal of Botany, 44(3), 549-559. https://doi.org/10.1007/s40415-021-00736-6
Pakravan, M., Dastpak, A., Sonboli, A. & Khalaj, Z. (2018). A taxonomic reassessment of Consolida (Ranunculaceae) species: insight from morphological and molecular data. Journal of Genetic Resours, 4(1), 14-25. https://doi.org/ 0.22080/jgr.2018.13872.1098
Raza, A., Xu, X., Sun, H., Tang, J. & Quyang, Z. (2017). Pharmacological activities, and pharmacokinetic study of hyperoside: a short review. Tropical Journal of Pharmaceutical Research, 16(2), 483-489. https://doi.org/10.4314/tjpr.v16i2.30
Rocchetti, G., Zengin, G., Cakmak, Y.S., Mahomoodally, M.F., Kaya, M. F., Alsheikh, S.M., Glamocilja, J., Sokovic, M., Lobine, D. & Lucini, L. (2020). A UHPLC-QTOF-MS screening provides new insights into the phytochemical composition and biological properties of six Consolida species from Turkey. Industrial Crop and Products, 158, 112966. https://doi.org/10.1016/ j.indcrop.2020. 112966
Satari, A., Ghasemi, S., Habtemariam, S., Asgharian, S.& Lorigooini, Z. (2021). Rutin: a flavonoid as an effective sensitizer for anticancer therapy; insights into multifaceted mechanisms and applicability for combination therapy. Evidence-Based Complementary and Alternative Medicine, 1-10. https://doi.org/10.1155/2021/9913179
Şeker Karatoprak, G., Ökdem, B., İlgün, S. & Koşar, M. (2022). Potentilla recta L.'nin Antioksidan ve Antimikrobiyal Aktivitelerinin Değerlendirilmesi. KSU Journal of Agriculture and Nature, 25(3), 439-448. https://doi.org/10.18016/ksutarimdoga.vi. 894015
Şener, B., Orhan, I. & Özçelik, B. (2007). Diterpenoid alkaloids from some turkish Consolida species and their antiviral activities. Arkivoc, 7, 265-272. https://doi.org/10.3998/ark.5550190.0008.722
Suzgec, S., Bitis, L., Sozer, U., Özçelik, H., Zapp, J., Kiemer, A.K., Mericli, F., & Mericli, A.H. (2009). Alkaloids from the aerial parts of Consolida anthoroidea and Delphinium linearilobum. Chemistry of Natural Compounds, 5(2), 287-289.
Tok, K.C. & Yayla, Ş. (2022). Gas Chromatography Mass Spectrometry (GC-MS) Analysis of Consolida thirkeana extract. Journal of Faculty of Pharmacy o Ankara University, 46(2), 444-449. https://doi.org/ 10.33483/jfpau.1102380
Ulubelen, A., Desai, H.K., Hart, B.P., Joshi, B.S., Pelletier, S.W., Mericli, A. H., Mericli, F. & Özen, H.C. (1996). Diterpenoid alkaloids from Consolida oliveriana. Journal of Natural Product, 59(9), 907-910. https://doi.org/10.1021/np960219k
Van Vuuren, S. F., Viljoen, A. M., Ozek, T., Demirci, B. & Başer, K.H.C. (2007). Seasonal and geographical variation of Heteropyxis natalensis essential oil and the effect thereof on the antimicrobial activity. South African Journal of Botany, 73(3), 441-448. https://doi.org/10.1016/j.sajb.2007.03.010
Wang, S., Sheng, F., Zou, L., Xiao, J. & Li, P. (2021). Hyperoside attenuates non-alcoholic fatty liver disease in rats via cholesterol metabolism and bile acid metabolism. Journal of Advanced Research, 34, 109-122. https://doi.org/10.1016/j.jare.2021.06.001
Yin, T., Cai, L., Ding, Z.A. (2020). Systematic review on the chemical constituents of the genus Consolida (Ranunculaceae) and their biological activities. RSC Advances, 10(58), 35072-35089. https://doi.org/ 10.1039/D0RA06811J
Zengin, G., Mahomoodally, M.F., Picot-Allain, C. M. N., Cakmak, Y. S., Uysal, S. & Aktumsek, A. (2019). In vitro tyrosinase inhibitory and antioxidant potential of Consolida orientalis, Onosma isauricum and Spartium junceum from Turkey. South African Journal of Botany, 120, 119-123. https://doi.org/10.1016/j.sajb.2018.01.010

Toplam 43 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Bitki Biyokimyası
Bölüm	ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar	Derya Çiçek Polat 0000-0002-4331-6828 Muhammed Mesud Hürkul 0000-0002-9241-2496
Erken Görünüm Tarihi	13 Ekim 2023
Yayımlanma Tarihi	28 Şubat 2024
Gönderilme Tarihi	25 Kasım 2022
Kabul Tarihi	15 Haziran 2023
Yayımlandığı Sayı	Yıl 2024Cilt: 27 Sayı: 1

Kaynak Göster

APA	Çiçek Polat, D., & Hürkul, M. M. (2024). Quantification of Some Phenolic Compounds in Consolida thirkeana (Boiss.) Bornm. by HPLC and Validation of Method. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 27(1), 68-74. https://doi.org/10.18016/ksutarimdoga.vi.1210096