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Investigation of Genotoxic and Development Effects of Tetramethrin on Drosophila melanogaster

Yıl 2024, Cilt: 27 Sayı: 2, 304 - 315, 01.04.2024

Burcin Yalcin , Merve Güneş , Ayşen Yağmur Kurşun , Ghada Tagorti , Ezgi Golal , Bülent Kaya

https://doi.org/10.18016/ksutarimdoga.vi.1224968

Öz

The adverse effects of tetramethrin residues, a synthetic pyrethroid used in many insecticide formulations, on environmental health and living organisms are a matter of concern. The aim of this study was to evaluate the genotoxic and developmental effects of tetramethrin in a non-target organism, Drosophila melanogaster. Thus, its effect on DNA damage was evaluated using the Comet assay in hemocytes, and its mutagenic and recombinogenic effects were evaluated using Drosophila wing SMART. Also, the effects of tetramethrin on Drosophila development were evaluated by measuring larval weight, larval length, and fecundity. Results showed that tetramethrin induced a decrease in the larval weight and length only at a high concentration. Moreover, a decrease in fecundity in a dose-dependent manner was observed. According to the Comet assay results, DNA damage was not induced because there was no significant increase in % DNA. However, tetramethrin caused genotoxicity by inducing mitotic recombination in the SMART assay.

Anahtar Kelimeler

Comet Genotoxicity Larval development Pyrethroid SMART

Kaynakça

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Tetramethrin'in Drosophila melanogaster’ de Genotoksik ve Gelişim Üzerine Etkilerinin Araştırılması

Yıl 2024, Cilt: 27 Sayı: 2, 304 - 315, 01.04.2024

Burcin Yalcin , Merve Güneş , Ayşen Yağmur Kurşun , Ghada Tagorti , Ezgi Golal , Bülent Kaya

https://doi.org/10.18016/ksutarimdoga.vi.1224968

Öz

Birçok insektisit formülasyonunda kullanılan sentetik bir piretroid olan tetramethrin kalıntılarının çevre sağlığı ve canlı organizmalar üzerindeki olumsuz etkileri endişe konusudur. Bu çalışmanın amacı, tetrametrin'in hedef dışı bir organizma olan Drosophila melanogaster üzerindeki genotoksik ve gelişimsel etkilerini değerlendirmektir. Bu nedenle Drosophila hemositlerinde komet testi kullanılarak DNA hasarı üzerindeki etkisi, Drosophila kanat SMART kullanılarak da mutasjenik ve rekombinojenik etkileri değerlendirilmiştir. Ayrıca tetramethrin'in Drosophila gelişimi üzerindeki etkileri larva ağırlığı, larva uzunluğu ve yumurta verimi ölçülerek değerlendirilmiştir. Sonuçlar, tetrametrin'in sadece yüksek konsantrasyonda larva ağırlığında ve uzunluğunda bir azalmaya neden olduğunu göstermiştir. Ayrıca yumurta veriminde konsantrasyona bağlı bir şekilde azalma gözlenmiştir. Komet testi sonuçlarına göre, % DNA'da anlamlı bir artış olmadığı için DNA hasarı indüklenmemiştir. Ancak tetrametrin, SMART testinde mitotik rekombinasyonu indükleyerek genotoksisiteye neden olmuştur.

Anahtar Kelimeler

Komet Genotoksisite Larval gelişim Piretroid SMART

Kaynakça

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  • United States Environmental Protection Agency (US EPA). (2010). Reregistration Eligibility Decision (RED) Document for Tetramethrin. Prevention, Pesticides and Toxic Substances. EPA 738-R-08-012; 2010.
  • United States Environmental Protection Agency (US EPA). (2016). Washington, D.C. 20460, Office of Chemical Safety and Pollution Prevention. Preliminary Comparative Environmental Fate and Ecological Risk Assessment for the Registration Review of Eight Synthetic Pyrethroids and Pyrethrins DP No. D425791; 2016.
  • United States Environmental Protection Agency (US EPA). (2019). Washington, D.C. 20460, Office of Chemical Safety and Pollution Prevention. Tetramethrin Updated Human Health Risk Assessment. DP No. 453657; 2019.
  • United States Environmental Protection Agency (US EPA). (2020). Tetramethrin. Interim Registration Review Decision, Case Number 2660; 2020.
  • Wang, W., Warren, M. & Bradley, A. (2007). Induced mitotic recombination of p53 in vivo. Proceedings of the National Academy of Sciences of the United States of America, 104(11), 4501–4505. https://doi.org/10.1073/pnas.0607953104
  • Würgler, F.E. & Vogel, E.W. (1986). In vivo mutagenicity testing using somatic cells of Drosophila melanogaster. In: F.J. de Serres (Ed.), Chemical Mutagens, Vol. 10, Plenum, New York, p. 1-72.
  • Yan, Y., Yang, Y., You, J., Yang, G., Xu, Y., Huang, N., Wang, X., Ran, D., Yuan, X., Jin, Y., Fan, Y., Lei, J., Li, W., & Gu, H. (2011). Permethrin modulates cholinergic mini-synaptic currents by partially blocking the calcium channel. Toxicology letters, 201(3), 258–263. https://doi.org/10.1016/j.toxlet. 2011.01.009
  • Yavuz, O., Aksoy, A., Das, Y. K., Gulbahar, M. Y., Guvenc, D., Atmaca, E., Yarim, F. G., & Cenesiz, M. (2015). Subacute oral toxicity of combinations of selected synthetic pyrethroids, piperonyl butoxide, and tetramethrin in rats. Toxicology and industrial health, 31(4), 289–297. https://doi.org/ 10.1177/ 0748233712469651
  • Yavuz, O., Aksoy, A., Das, Y. K., Gulbahar, M. Y., Yarim, G. F., Cenesiz, M., Atmaca, E., & Guvenc, D. (2010). Repeated-dose 14-day dermal toxicity of different combinations of some synthetic pyrethroid insecticides, piperonyl butoxide, and tetramethrin in rats. Cutaneous and ocular toxicology, 29(1), 16–25. https://doi.org/10.3109/15569520903415076
  • Yuan, L., Lin, J., Xu, Y., Peng, Y., Clark, J. M., Gao, R., Park, Y., & Sun, Q. (2019). Deltamethrin promotes adipogenesis via AMPKα and ER stress-mediated pathway in 3T3- L1 adipocytes and Caenorhabditis elegans. Food and chemical toxicology, 134, 110791. https://doi.org/ 10.1016/j.fct.2019.110791
  • Zaller, J.G. & Brühl, C.A. (2019). Editorial: Non-target effects of pesticides on organisms inhabiting agroecosystems. Frontiers in Environmental Science, 7, 75. https://doi.org/10.3389/fenvs. 2019.00075.
  • Zhang, D., Park, Z.Y., Park, J.A., Kim, S.K., Jeong, D., Cho, S.H., Shim, J.H., Kim, J.S., El-Aty, A.M. & Shin, H.C. (2016). A combined liquid chromatography-triple-quadrupole mass spectrometry method for the residual detection of veterinary drugs in porcine muscle, milk, and eggs. Environmental Monitoring and Assessment, 188(6), 348. https://doi.org/10.1007/s10661-016-5344-x.
  • Zhong, M., Zhai, Q., Zhang, R., Yin, H., Li, J., Ma, Z., Fang, L., Zhang, C., & Li, Y. (2021). Effect of pyrethroid pesticides on the testis of male rats: A meta-analysis. Toxicology and industrial health, 37(4), 229–239. https://doi.org/10.1177/074823372 11000979
  • Zordan, M., Osti, M., Pesce, M. & Costa, R. (1994). Chloral hydrate is recombinogenic in the wing spot test in Drosophila melanogaster. Mutation Research, 322(2), 111-116. https://doi.org/10.1016/ 0165-1218(94)00017-4.
Toplam 87 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji
Bölüm ARAŞTIRMA MAKALESİ (Research Article)
Yazarlar

Burcin Yalcin 0000-0002-9694-5839

Merve Güneş 0000-0003-3278-0542

Ayşen Yağmur Kurşun 0000-0003-1657-6808

Ghada Tagorti 0000-0003-4597-8320

Ezgi Golal 0000-0002-7685-7479

Bülent Kaya 0000-0002-0491-9781

Erken Görünüm Tarihi 21 Ocak 2024
Yayımlanma Tarihi 1 Nisan 2024
Gönderilme Tarihi 3 Ocak 2023
Kabul Tarihi 7 Eylül 2023
Yayımlandığı Sayı Yıl 2024Cilt: 27 Sayı: 2

Kaynak Göster

APA Yalcin, B., Güneş, M., Kurşun, A. Y., Tagorti, G., vd. (2024). Investigation of Genotoxic and Development Effects of Tetramethrin on Drosophila melanogaster. Kahramanmaraş Sütçü İmam Üniversitesi Tarım Ve Doğa Dergisi, 27(2), 304-315. https://doi.org/10.18016/ksutarimdoga.vi.1224968
 Kapak Resmi İndir

21082



2022-JIF = 0.500

2022-JCI = 0.170

Uluslararası Hakemli Dergi (International Peer Reviewed Journal)

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      Yılda 6 sayı yayınlanır. (Published 6 times a year)


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