Chemical Content and Biological Activity Spectrum of Nigella sativa Seed Oil
Abstract
In this study, it was aimed
to investigate the chemical composition and biological activities including
antioxidant, anticholinesterase, antimicrobial and urease activity of Nigella sativa seed oil growing in Muğla
(Köyceğiz). The oil of plant was obtained using Soxhlet apparatus. Thirty-one
components of the oil were determined by Gas Chromatography-Mass Spectrometry
(GC-MS). The major components of oil were detected as palmitic acid (10.48%),
linoleic acid (8.05%), o-cyemene
(7.11%), 3,5-dimethyl cyclohexanol (6.68%), thymoquinone (6.44%), p-tert-buthyl catechol (6.28%) and
8-methyl-1-undecene (3.28%). The findings obtained from biological activity
assays showed that Nigella sativa oil
was a promising candidate that can be used in the discovery of new drugs and
the preparation of new natural drug preparations.
Keywords
Destekleyen Kurum
Proje Numarası
Teşekkür
Kaynakça
- Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. 2013. A Review on Therapeutic Potential of Nigella sativa: A Miracle herb. Asian Pacific Journal of Tropical Biomedicine, 3(5): 337-352.
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- Apak R, Güçlü K, Özyürek M, Karademir SE. 2004. Novel Total Antioxidant Capacity Index for Dietary Polyphenols and Vitamins C and E, Using Their Cupric Ion Reducing Capacity In The Presence of Neocuproine: Cuprac Method. Journal of Agricultural and Food Chemistry, 52(26): 7970-7981.
- Blois MS. 1958. Antioxidant Determinations by The Use of A Stable Free Radical. Nature, 181: 1199-1200.
- Bourgou, S., Pichette, A., Marzouk, B., Legault, J. 2010. Bioactivities of black cumin essential oil and its main terpenes from Tunisia. South African Journal of Botany, 76(2): 210-216.
- Burits M, Bucar F. 2000. Antioxidant Activity of Nigella sativa Essential Oil. Phytotherapy Research, 14(5): 323-328.
- Chaieb K, Kouidhi B, Jrah H, Mahdouani K, Bakhrouf A. 2011. Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation. BMC Complement and Alternative Medicine, 11(29): 1-6.
- Ellman GL, Courtney KD, Andres V, Featherstone RM. 1961. A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity. Biochemistry Pharmacology Behavior, 7(2): 88-95.
Ayrıntılar
Birincil Dil
İngilizce
Konular
Yapısal Biyoloji
Bölüm
Araştırma Makalesi
Yazarlar
Yusuf Sıcak
*
0000-0003-2339-5837
Türkiye
Yayımlanma Tarihi
31 Aralık 2019
Gönderilme Tarihi
9 Mart 2019
Kabul Tarihi
16 Mayıs 2019
Yayımlandığı Sayı
Yıl 2019 Cilt: 22 Sayı: 6
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